ASPN/PAS
Program
Schedule
(as of
December 31, 2001) |
Saturday,
May 4, 2002
10:00am
– 12:00pm
PAS
Educational Seminars
12:00pm
– 3:00pm
PAS/PIDS
Mini Course:
Shifting
Paradigms of Neonatal Sepsis
Chair: Pablo J. Sánchez, University of Texas Southwestern
Medical Center, Dallas, TX
The
changing epidemiology of neonatal sepsis in the neonatal
intensive care unit (NICU) will be discussed, including
antibiotic utilization for both early and late onset
sepsis and benchmarking ideas for reducing nosocomial
infections.
Neonatal Sepsis on
the GBS Chemoprophylaxis Era
Barbara J.
Stoll, Emory University School of Medicine, Atlanta, GA
Fungal Infections in the NICU: New Strategies for Old
Bugs
Judith L. Rowen, University of Texas Medical Branch at
Galveston, Galveston, TX
Antimicrobial Utilization in the NICU: Strategies to
Reduce Resistance
Pablo J. Sánchez, University of Texas Southwestern
Medical Center, Dallas, TX
1:00pm
– 3:00pm
PAS
Educational Seminars
3:15pm
– 5:15pm
PAS/PIDS Topic Symposium:
Innate Immunity
Chairs: Robert
Modlin, University of California, Los Angeles, CA and
David B. Lewis, Stanford University Medical Center,
Stanford, CA
Most
microorganisms encountered in daily life by normal,
healthy children fail to cause disease. Rather, they are
destroyed within minutes or hours by defense mechanisms
that do not require priming or pre-existing experience.
This symposium will highlight advances in our
understanding of such innate immunity. Pattern recognition
by Toll-like receptors, a novel antimicrobial protein and
the role of natural killer cells in resistance to viral
infection will be discussed.
Role
of Mammalian Toll-like Receptors in Microbial Infection
Robert Modlin, University of California, Los Angeles, CA
Granulysin: A Novel Antimicrobial Peptide of CTL and NK
Cells
Carol Clayberger, Stanford University School of Medicine,
Stanford, CA
Role of Natural Killer Cells in Resistance to Viral
Infections
Wayne M. Yoloyama, Howard Hughes Medical Institute and
Washington University, St Louis, MO
5:15pm
– 7:15pm
Poster
Session I, PAS Opening Reception & Exhibits
Neonatal Infectious Diseases Posters I
PAS/PIDS
Original Science Abstracts
(Abstract session
information will be posted in mid-February)
Sunday,
May 5, 2002
8:00am
– 10:00am
PAS/PIDS Topic Symposium:
Inflammatory Disorders of the Cardiopulmonary System
Chair: James
Bristow, University of California, San Francisco, CA
Inflammatory
diseases of the cardiovascular system remain an important
cause of morbidity and mortality in infants and children.
Wile we do not think of these as genetic diseases, the
application of powerful molecular genetic tools to these
diseases has begun bear fruit. This session will provide
an update on the pathogenesis of Kawasaki syndrome, the
importance of viral infection and persistence of viral
genomes in dilated cardiomyopathy and transplant
rejection, and the mechanism of autoimmunity in congenital
complete heart block.
Viral
Myocarditis
Jeffrey A. Towbin, Baylor College of Medicine, Houston, TX
The Immunopathogenesis of Cardiac Inflammation in
Kawasaki Disease
Anne H. Rowley, Northwestern University Medical School,
Chicago, IL
Inflammatory Diseases of the Heart: Viruses and
Transplant Rejection
Neil E. Bowles, Baylor College of Medicine, Houston, TX
11:45am
– 1:45pm
Poster
Session II
Infectious Diseases Poster Session II
PAS/PIDS
Original Science Abstracts
(Abstract session
information will be posted in mid-February)
2:00pm
– 4:00pm
PAS State of the Art Plenary:
Children as Research Subjects: Ethical and Regulatory
Issues
Chair: Myron
Genel, Yale University School of Medicine, New Haven, CT
A
number of highly publicized adverse events, including the
death of two volunteers participating in non-therapeutic
research, and the federal shutdown of research at many
well recognized academic institutions because of
inadequate compliance with regulatory requirements have
intensified scrutiny of the protection afforded to human
subjects participating in research, including children.
Furthermore a Maryland court has recently decreed that
children cannot participate in research without the
potential for direct benefit. As a consequence there has
been increasing media attention and Congressional concern
regarding the adequacy of institutional oversight and
investigator attentiveness to established standards and
regulations. In addition, new regulations issued under the
Health Insurance Portability and Accountability Act of
l996 (HIPAA) threaten the capacity to conduct health
services and outcomes research. These issues will be
addressed in the 9th annual Public Policy Plenary
Symposium in an interactive format intended to stimulate
dialogue among the members of the panel and with the
audience.
Overseeing
Research in Children: New Concerns and New Regulations
Alan R. Fleischman, The New York Academy of Medicine, New
York, NY
International Health Research: Where Bioethics,
Politics and Economics Converge
Eric Meslin, Indiana University School of Medicine,
Indianapolis, IN
Compliance: What You and Your Institution Need to Know
(and Do)
Patricia Pearl O’Rourke, Partners HealthCare Systems,
Inc., Boston, MA
HIPAA, Privacy & Confidentiality and Research in
Children?
Sara Rosenbaum, George Washington University, Washington,
DC
Sponsored jointly
with the Public Policy Council of the APS, AMSPDC, SPR and
the Public Policy Committee of the APA
2:30pm
– 4:00pm
PAS/PIDS State of the Art Plenary:
Pediatric Research and the Human DNA Sequence: Approaching
Defects of Host Defenses in the Genomic Era
Chairs: Jennifer
M. Puck, National Human Genome Research Institute,
National Institute of Health, Bethesda, MD and Stephen J.
Chanock, National Cancer Institute, National Institute of
Health, Bethesda, MD
This
session will provide a framework for understanding how
genetics and genomics can accelerate progress in
understanding defects in immunity and host defenses. Host
defenses are used to demonstrate the general power of
these technologies to elucidate pathogenetic mechanisms
and predict disease susceptibility. This program will
address classical and novel approaches to discovering
genes underlying primary immunodeficiencies as well as
characterization of modifier genes. A brief overview of
the human genome, its structure, contents and relationship
to genomes of other species will be presented in order to
discuss current and future potential for understanding
pediatric diseases and treatments. Emphasis will be placed
on the continued prime importance of careful clinical
observation, as well as the ethical and practical issues
that genome science presents to society.
Finding
a Multitude of Disease Genes for Primary Immune Disorders
Jennifer M. Puck, National Human Genome Research
Institute/National Institute of Health, Bethesda, MD
The Role of Variation in the Human Genome: Single
Nucleotide Polymorphisms and Disease Modifiers
Stephen J. Chanock, National Cancer Institute, National
Institute of Health, Bethesda, MD
Application of Genomic Technology to Understanding
Human Phenotypes
Aravinda Chakravarti, Johns Hopkins University School of
Medicine, Baltimore, MD
4:15pm
– 6:15pm
PAS/PIDS
Topic Symposium:
The Molecular Basis of Clinical Manifestations of
Infection
Chair: Philip
Brunell, National Institute of Allergy and Infectious
Diseases, National Institutes of Health, Bethesda, MD
This
symposium will explore the molecular basis of the clinical
expression of infectious diseases. The effect of a variety
of different agents on the different organ systems of the
human body will be presented by experts in their fields.
Mycobacterial
Susceptibility: What We Get and Why
Steven M. Holland, National Institute of Allergy and
Infectious Disease, National Institutes of Health,
Bethesda, MD
Meningococcus
Michael Levin, (tentative)
Cryptosporidium
Anthony R. Hayward, University of Colorado Medical School,
Denver, CO
Cellular Genes That Modulate the Outcome of EBV
Infection
Jeffery I. Cohen, National Institutes of Health, Bethesda,
MD
Monday,
May 6, 2002
8:00am
– 10:00am
Infectious Diseases Abstract Session
PAS/PIDS
Original Science Abstracts
(Abstract session
information will be posted in mid-February)
10:15am
– 12:15pm
Neonatal Infectious Diseases Abstract Session
PAS/PIDS
Original Science Abstracts
(Abstract session
information will be posted in mid-February)
2:45pm
– 4:45pm
PAS/PIDS
Topic Symposium:
Antibiotic Resistance: The Race Is On
Chairs: Joseph W.
St. Geme, III, Washington University School of Medicine,
St. Louis, MO and Richard F. Jacobs, University of
Arkansas for Medical Sciences, Arkansas Children’s
Hospital, Little Rock, AR
In
recent years there has been an explosion in the prevalence
of antibiotic resistance. As a consequence, treatment
decisions now are often complicated, and treatment is more
and more commonly unsuccessful. In this symposium,
speakers will review the epidemiology of antibiotic
resistance, the current state in treating resistant
Staphylococcus aureus and resistant gram-negative
bacteria, and new approaches to antibiotic discovery.
The
Evolving Epidemiology of Antibiotic Resistance
Daniel Sahm, Focus Technologies, Inc., Herndon, VA
The Challenge of Antimicrobial Therapy for the
Staphylococci: Our Backs to the Wall
Robert S. Daum, The University of Chicago, Chicago, IL
Increasing Resistance in Gram-Negative Bacteria: The
Role of Extended Spectrum Beta Lactamases
David L. Paterson, University of Pittsburgh Medical
Center, Pittsburgh, PA
Genomic Approaches to Antibiotic Discovery
Molly Schmid, Genencor, Palo Alto, CA
Sponsored Jointly
with the Pediatric Infectious Diseases Society
5:00pm
– 6:00pm
PIDS
Business Meeting
6:00pm
PIDS
Annual Dinner and Awards Banquet
Baltimore
World Trade Center Constellation & Maryland Rooms
|
