MONDAY,
MAY 6
7:00am – 8:00am
Public Policy Legislative Breakfast
6000A Public
Policy 16th Annual Legislative Breakfast Symposium
Privacy & Confidentiality
Regulations and Their Impact on Health Research and
Academic Medicine
Jennifer Kulynych, Director,
Division of Biomedical and Health Sciences Research,
Association of Medical Colleges, Washington, DC
Sponsored Jointly with the Public Policy Council of
the APS, AMSPDC, SPR and the Public Policy Committee of
the APA
7:00
AM — 8:00am
APA Regional Breakfasts
8:00am – 10:00am
Topic Symposium
6000 Human
Brain Imaging: Insights into Development and Plasticity
Chairs: Sherin U. Devaskar,
University of California, Los Angeles, CA and Joseph J.
Volpe, Boston Children's Hospital, Harvard Medical
School, Boston, MA
State-of-the-art imaging of
the human brain has been achieved by advances in
magnetic resonance imaging (MRI) and positron emission
tomography (PET). Recent work with MRI and PET has
provided remarkable insights into the structure and the
function of the brain of infants and children during
normal development and with plasticity. In this session,
reviews of the insights obtained with such techniques as
3D-volumetric and diffusion tensor MRI, functional MRI,
and PET-based studies of brain receptors and metabolism
will be presented by leaders in the field. Emphasis will
be on the most recent findings, including considerable
unpublished work.
Introductory Overview
Joseph J. Volpe, Children's Hospital, Harvard
Medical School, Boston, MA
PET Studies of Human Brain Development,
Impoverishment and Plasticity
Harry T. Chugani, Children's Hospital of Michigan,
Wayne State University School of Medicine, Detroit, MI
3-D Volumetric and Diffusion Tensor MRI to Assess
Brain Development and Plasticity
Petra S. Huppi, Children's Hospital, University of
Geneva, Geneva, Switzerland
The Use of fMRI in Developmental Neuroimaging
Michael Rivkin, Boston Children's Hospital, Harvard
Medical School, Boston, MA
8:00am
– 10:00am
Topic Symposium
6001 New
Strategies in Pediatric Heart Failure: Basic Science to
Clinical Practice
Chair: Daniel Bernstein,
Stanford University Medical Center, Palo Alto, CA
Recent advances in molecular
cardiology have dramatically improved our understanding
of the pathophysiology of heart failure. These advances
have led to the development of new pharmacologic tools
for more effectively managing heart failure and avoiding
or postponing transplantation. However, the benefits of
these new approaches have not always been shared by
pediatric-age patients. This session will review two
major areas of recent research breakthroughs in
myocardial damage and remodeling, discuss the issues
involved in translating adult clinical trials into
pediatric practice, and introduce an initiative by
pediatricians in the Heart Failure Society to develop
pediatric heart failure management guidelines.
Role of Elastase in Myocardial Remodeling and Repair
Marlene Rabinovitch, Hospital for Sick Children,
Toronto, ON, Canada
Role of ß-Adrenergic Receptor Subtypes in
Cardioprotection/Cardiotoxicity
Daniel Bernstein, Stanford University Medical
Center, Palo Alto, CA
ß-Adrenergic Receptor Antagonists in Pediatric
Clinical Practice
Robert E. Shaddy, University of Utah School of
Medicine and Primary Children's Medical Center, Salt
Lake City, UT
Developing Guidelines for Pediatric Heart Failure
Management: The Heart Failure Society of America
Pediatric Initiative
David N. Rosenthal, Stanford University Medical
Center, Palo Alto, CA
8:00am
– 10:00am
Topic Symposium
6002 The
Scholarship of Teaching: How Can Excellence Be Judged?
Chair: Kenneth Roberts, Moses
Cone Health System, Greensboro, NC
It has been argued that the
education of future physicians is the only unique task
of an academic medical center, given that both clinical
care and research can be and are done in other settings
and institutions. Achieving this task requires excellent
clinical teachers, and such individuals constitute an
essential resource in a department of pediatrics.
Protecting and nurturing this resource by providing
appropriate recognition, promotion and compensation for
individuals who have achieved excellence as teachers is
therefore essential, but what criteria should be used to
determine excellence in teaching?
In this symposium, the presenters, all of whom are
interested in teaching and teachers, will address their
ideas regarding excellence and how it can be recognized.
Introduction: Framing the Question
Kenneth B. Roberts, Past President APA and APPD,
Moses Cone Health System, Greensboro, NC
Documentation of Excellence in Teaching: Expectations
of a Chair
F. Bruder Stapleton, University of Washington School
of Medicine, Seattle, WA
Demonstrating Excellence in Teaching
Richard Sarkin, Past President COMSEP, University at
Buffalo School of Medicine, Buffalo, NY
Discussion
8:00am
– 10:00am
Poster Symposium
6050 Advances
in Clinical Nutrition
Chairs: Michael R. Narkewicz
and David K. Rassin
8:00am – 10:00am
Platform Session
6051 Allergy,
Immunology and Rheumatology: Cytokines and Signalling
Molecules
Chairs: Terri H. Finkel and
Crystal L. Mackall
8:00am – 10:00am
Platform Session
6052 Developmental
Biology I
Chairs: Emese Pinter and
Rashmin C. Savani
8:00am – 10:00am
Platform Session
6053 Diabetes
and Endocrinology
Chairs: Michael S. Freemark and
Antoinette M. Moran
8:00am – 10:00am
Platform Session
6054 Dysmorphology
and Teratology
Chair: James W. Hanson
8:00am – 10:00am
Platform Session
6055 Infectious
Diseases: Focus on Future Vaccines
Chairs: W. Paul Glezen and Neal
A. Halsey
8:00am – 10:00am
Platform Session
6056 Injury
Chairs: Katherine Kaufer
Christoffel and Alan D. Woolf
8:00am – 10:00am
Platform Session
6057 Neonatology—Patient-Oriented
Research II
Chairs: William J. Keenan and
Robert Perelman
8:00am – 10:00am
Poster Symposium
6058 Oxidants–Antioxidants
Chairs: Richard L. Auten and
Ilene R. S. Sosenko
8:00am – 10:00am
Platform Session
6059 Underserved
Populations I
Chairs: Carrie L. Byington and
Charles Feild
9:00am – 12:00pm
Workshops
6100 Achieving
Cultural Competency in Pediatrics
The United States rapidly is
growing more culturally diverse. In several cities,
whites already are in the minority. Culture has a
profound impact on pediatrics, affecting multiple
aspects of clinical care, including outcomes, processes,
quality, satisfaction, obtaining an accurate history,
and adherence. Cultural competency is the ability to
recognize and appropriately respond to key cultural
characteristics that affect clinical care in the major
cultural groups seen in your practice. In this workshop,
participants will learn about a model of cultural
competency that can be applied to any cultural group
that might be encountered by the pediatrician. This
model is based on five aspects of culture that affect
clinical care: 1) normative cultural values; 2) language
issues; 3) folk illnesses; 4) parent beliefs; and 5)
provider practices. The Latino and African-American
cultures will be used to illustrate the most important
ways that culture impacts pediatric care, drawing on the
rich available literature and the personal experience of
the workshop leaders.
Using an evidence-based approach derived from
critical studies on Latino and African-American culture,
workshop participants will learn and master the cultural
competency model. Illustrative cases (including
videotapes) will be presented to challenge participants
and further solidify their skills. Participants can
expect to acquire practical skills for recognizing and
appropriately responding to crucial aspects of culture
and language that affect pediatric care.
G. Flores and G. Askew, Department of Pediatrics,
Boston Medical Center and Boston University Schools of
Medicine & Public Health, Boston, MA
6101 Caring
for Gay and Lesbian Youth in Pediatric Practice
Adolescents who are gay or
lesbian, or are questioning their sexual identity, may
look to health care providers for assistance with both
medical and psychosocial issues. Yet many practicing
pediatricians are uncomfortable with their skills in
caring for gay and lesbian adolescents. At the
University of Massachusetts Medical School, we have
developed a series of workshops for university and
community clinicians that provide knowledge of health
care needs of gay and lesbian youth and model supportive
interviewing techniques. Methods include slide
presentations, interactive discussion, videotapes of
interviews with gay and lesbian youth and their parents,
modeling of "live" interviews, and a
"Teaching Kit" for helping faculty to teach
students and residents about sexuality. Preceptor
support for this curriculum has led us to pilot the
workshop in community pediatric offices, training all
office staff, including providers, social workers,
managerial and clerical staff.
In this workshop participants will: 1) participate in
an interactive demonstration of our general and
office-based workshops; 2) discuss the barriers to
teaching about sexuality in an office setting, and how
to address them; and 3) develop a "Safe Office
Kit" for their own practices that will allow them
to train their own faculty and staff.
S. Sack, E. Ferrara, S. Starr, D. M. Keller, and E.
Perrin, University of Massachusetts Medical School,
Worcester, MA, and Tufts University School of Medicine,
Boston, MA
6102 Clinical
Forensic Medicine: Bridging the Gap Between Medicine and
Law
Medical practitioners who work in
acute care settings are likely to encounter forensic
issues, such as child abuse, assault or unexpected
death. However, few training programs prepare physicians
to adequately manage these issues.
Objective: This workshop is designed to increase
participant awareness of their pediatric patients’
forensic medical needs, and to review techniques for the
acute evaluation of such patients.
Methods: Experts in the fields of Pediatric Emergency
Medicine, Child Abuse and Neglect, Toxicology and
Forensic Medicine will work directly with participants
to teach them how to evaluate pediatric patients from a
forensic perspective. Workshop participants will receive
hands-on instruction in the following skills: the
detection, collection and preservation of evidence,
documentation of injuries (including medical
photography), pattern injury recognition and
interpretation of injuries, preparation for court
testimony, and reporting requirements and regulations.
During one of the segments, participants will rotate
through stations where they will utilize these skills
using state-of-the-art equipment. All registrants will
also receive a comprehensive syllabus containing
relevant information and recent references related to
the practice of Clinical Forensic Medicine that is
designed to be used as a teaching aid.
K. Bechtel, K. Santucci, L. Arnold, C. Baum J. Klig
and M. D. Baker, Section of Pediatric Emergency
Medicine, Yale-New Haven Children’s Hospital, New
Haven, CT
6103 Culture,
Spirituality, and Complementary and Alternative
Pediatrics: An Applied Integrative Model
Growing attention in medical
literature has been dedicated to an increasingly
multicultural patient population, to intersections
between spirituality and medicine, and to the wide use
of complementary and alternative therapies in the United
States. Frequently, however, these three topics are
presented as unrelated to one another. Yet in practice,
they often represent intersecting fields of experience.
This workshop will introduce a model that integrates the
three topics and will present illustrative examples from
different areas of the United States.
Workshop participants will next apply this model to
their own family culture through a guided exercise. By
learning to work with a conceptual framework in direct
relation to their own experience, they will learn how an
otherwise abstract model looks in practice. They will
then engage in small group discussion of what they
observed through the exercise. During the third section
of the workshop, participants will engage in a role-play
of history-taking. They will apply the model both as a
family caretaker who has brought a child in for a
consultation, and as the pediatrician. Each role-play
will be followed by group discussion.
Through this workshop, participants will learn to
utilize a conceptual model that integrates
standard-of-care biomedical treatment, culture,
spirituality, and CAM and will recognize the importance
and rationale for adopting an integrative approach of
this kind in pediatric practice. They will also learn
tools with which to teach others this model.
L. Barnes and K. Fox, Department of Pediatrics,
Boston Medical Center, Boston, MA
6104 Design
and Implementation of a Domestic Violence Education
Program for Pediatric Faculty and Residents
Domestic violence is an important
public health problem in this country. The lack of
domestic violence training in medical schools and
residency programs hampers the ability of pediatricians
to provide quality comprehensive health supervision. In
order to address this problem, our multidisciplinary
collaborative group on domestic violence planned and
implemented a domestic violence educational program at
the Children's Hospital of Pittsburgh. This program for
residents and faculty was designed to increase
awareness, improve knowledge, and hone skills in
assessing and assisting families dealing with domestic
violence. A pre- and post-intervention survey was used
to assess change and pinpoint areas of further
educational need. The goal of this workshop is to help
others produce a similar educational program in their
own academic or community setting. The workshop will
involve a discussion of how the collaborative group
evolved, how hospital interest was generated, and how
the course was designed and implemented. Attendees will
participate in the key portion of the educational
program, a two-hour mini course, which includes video
and didactic presentations and small group role-playing.
Participants will have the opportunity to develop their
own plan for creating a similar educational program in
their own clinical settings.
R. Berger, S. C. Hamel, T. Syed, K. DeAntonis, J.
Williams, B. Williams, D. Ploof, J. Syphan, Children's
Hospital of Pittsburgh, Pittsburgh, PA
6105 Early
Identification and Assessment of Children with an Autism
Spectrum Disorder
Pediatricians play a crucial role
in identifying infants and toddlers who may have
significant developmental needs. Recently, there has
been a growing concern about possible increases in the
numbers of children with an autism spectrum disorder (ASD).
Early identification and intervention can significantly
improve the long-term outcome for these children and
their families. Unfortunately, although symptoms of the
ASDs are generally present before 3 years of age, the
average diagnosis is not made until 4.5 years of age.
Given the unusual patterns of development shown by
children with autism in communication, social, and
behavioral skills, parents often report frustration
associated with trying to identify the nature of their
child’s needs and with accessing appropriate services.
Pediatricians can provide helpful screening and
diagnostic referral information. The aim of this
workshop is to provide information about the early signs
of children with an ASD, to identify screening
instruments for the ASDs and to describe the referral
process in case further assessment and intervention are
warranted. Workshop activities will include presentation
and discussion, video observation of children with and
without ASDs and small group evaluations of clinical
vignettes profiling a child in need of more detailed
developmental assessment. The goal is to help
pediatricians implement guidelines recently established
for identifying children with an ASD by the American
Academy of Pediatrics.
C. E. Rice, O. Y. Ousley*, and M. Yeargin-Allsopp,
National Center on Birth Defects and Developmental
Disabilities, Centers for Disease Control and Prevention
and *Emory University Department of Psychiatry, Atlanta,
GA
6106 Integrating
Genetics Teaching into Daily Pediatric Practice: Do I
Really Need To Be Doing That?
Daily headlines flash new genetic
discoveries revolutionizing the practice of medicine!
What really has changed and what do we need to know? The
goals of this workshop are to emphasize the relevancy of
integrating genetics into every patient encounter,
enthuse participants about the impact of rapidly
exploding genetic knowledge/technology on patient care
and physician responsibility and discuss the core
genetic competencies our students need to acquire.
During this workshop participants will have the
opportunity to review new advances in the field,
including ethical, legal and social implications. All
attendees will acquire the necessary tools and resources
to enhance their comfort in teaching genetics through
small sub-groups which will focus on stimulating
interest in this area by: 1) working through at least
two educational methods/materials that could be used at
the participant's own site; 2) discussing cases where
"missed opportunities" in genetics impacted
the physician and family in an ethical, legal or social
manner; and 3) locating at least three internet
user-friendly sites as resources for current genetic
information. The workshop, using a series of teaching
exercises, role-playing and short didactic sessions will
focus on our important role as generalists utilizing
genetics as a unifying thread in patient care.
T. Turner, M. Dumont-Driscoll, J. Gigante, and B.
Siegel
6107 Medical
Homes for Children with Special Health Care Needs:
Partnership for Community-Based Care
The AAP and the MCH Bureau
advocate that community-based pediatric offices should
be designed as Medical Homes for Children with Special
Health Care Needs (CSHCN). Primary care physicians
should meet the health promotion and standard medical
care needs of children with a wide variety of medical
and developmental needs (e.g., cerebral palsy, Down
syndrome, inborn errors of metabolism, autism, HIV). Our
team (of physicians, parent coordinator and project
manager) will describe a partnership between the
Children’s Hospital, Boston and six pediatric
practices, focusing on components that have supported
and enhanced Medical Homes in the community. We will
discuss the following topics: 1) creating meaningful
coordination between primary and tertiary care through
electronic linkages, active referral networks,
Individualized Health Planning; 2) provision of relevant
continuing medical education programming for physicians
and nurse practitioners who care for CSHCN; 3) training
future physicians to practice using the medical home
model; 4) conducting research on epidemiology, systems
of care, condition specific issues, etc. that provide
necessary data for improving the health and functional
status of children with special health care needs; and
5) sponsoring consortia of physicians, parents and
others interested in improving services for CSHCN.
T. Silva, E. Davidson, L. Freeman, L. Sofis, and J.
Palfrey, Children’s Hospital, Boston and the East
Boston Neighborhood Health Center, Boston, MA
6108 Orchestrating
Death in the Neonatal Intensive Care Unit
Approximately 10% of newborn
infants admitted to the Neonatal Intensive Care Unit
will die. Many care providers may feel ill prepared to
deal with the ethical and psychosocial aspects as well
as the practical aspects of managing death.
This workshop will use a problem-based learning
approach to analyze a complex neonatal case. A brief
didactic lecture will review the following four aspects
of care: 1) ethical aspects (withdrawal of life support,
resolving decisional conflicts); 2) social aspects
(cultural diversity, conflict resolution, obtaining
autopsy requests); 3) palliative care aspects (pain
management, managing other physical discomforts); and 4)
emotional aspects (enhancing team communications,
developing parent partnerships, addressing emotional
needs of family/staff, creating supportive
environments). Following the didactic session,
participants will be divided into groups, with each
group addressing one aspect of care. Groups will use
decision-making models to analyze the case over
sequential time periods. Following group activities, the
four groups will reconvene. The workshop facilitator
will orchestrate an integrative, collaborative plan
based on input from the four groups.
The goal of this workshop is to provide participants
with an overall model by which they can more effectively
advocate for integrative health services at end of life.
C. Berseth, J. Garcia-Prats, B. Brody, and M. Walden,
Baylor College of Medicine, Department of Pediatrics,
Newborn and Intensive Care Sections, Houston, TX
6109 Program
Evaluation for Advocacy Interventions in Residency
Programs
Many residency programs are
implementing interventions to expose residents to
advocacy activities, enhance residency training with
regard to advocacy, and better meet the needs of
families within the communities in which they live. As
part of these activities, programs face challenges
designing and implementing appropriate evaluations to
determine whether their objectives are being met. The
purpose of this workshop is to highlight local
evaluations being conducted at 6 pediatric residency
programs as part of the Anne E. Dyson Community
Pediatrics Training Initiative and engage participants
in considering multiple aspects of program evaluations.
Using interactive breakout groups, participants will
propose possible methods and challenges of evaluating
hypothetical advocacy interventions. The workshop will:
articulate the usefulness and constraints of evaluating
advocacy interventions; describe fundamental steps to
designing and implementing successful evaluations; and
highlight purposes and creative approaches for
conducting program evaluations. Funded by The Dyson
Foundation.
C. Minkovitz, Johns Hopkins University, Baltimore,
MD, M. Aten, University of Rochester, Rochester, NY, D.
Bragg, Medical College of Wisconsin, Milwaukee, WI, A.
Duggan, H. Grason, Johns Hopkins University, Baltimore,
MD, V. LeBlanc, Columbia University, New York, NY, K.
Minot, Children’s Hospital of Philadelphia,
Philadelphia, PA, M. Zuniga de Nuncio, UCSD, San Diego,
CA
6110 Open
Access Appointment Scheduling: The Cure for the Ailing
Pediatric Practice?
Same day appointment scheduling
systems, commonly referred to as Open Access Scheduling
(OAS), is offered as the solution to poor pediatric
office efficiency. Long waits, poor access to services,
malfunctioning telephone systems, disorganized patient
flow, miscommunication and strained finances are
reported symptoms of some ailing pediatric ambulatory
practices. OAS advocates in academic pediatric
continuity clinics, public sector neighborhood health
centers or in private pediatric practices heartily
endorse this novel appointment system as the cure for
these chronic problems. OAS purports to optimize access
to care while allowing the practitioner/practice to
track patients who do not re-appoint in a timely manner.
OAS relies on the themes of access, interaction,
reliability, and vitality. In its purest form, OAS
offers every patient an appointment on the day that an
appointment is requested. The motto for OAS is, "Do
today’s work today." During this workshop, OAS
experts will provide background information and specific
OAS examples from different pediatric practice settings.
A point–counterpoint debate involving workshop
participants will delineate and discuss the pros and
cons of this model. Is your ambulatory pediatric
practice in need of resuscitation? Come to this workshop
to see if OAS is the cure!
J. Brown, D. Laraque, J. Cox and G. Randolph,
Department of Pediatrics, Colorado School of Medicine,
Denver, CO, Dept. of Pediatrics, Mt. Sinai School of
Medicine, New York, NY, Dept. of Pediatrics, Harvard
Medical School, Boston, MA and Dept. of Pediatrics, U of
N. Carolina School of Medicine, Chapel Hill, NC and the
HCD Committee
6111 Qualitative
Research in Pediatrics
Qualitative research has steadily
acquired greater popularity and respect in medical and
health services research over the past two decades.
Increasingly, this set of methods is viewed as
complementary to traditional quantitative research
approaches. Qualitative research techniques represent a
diverse set of research methods featuring the collection
and analysis of narrative data to capture a subject’s
unfiltered view of a situation or topic. Qualitative
methods hold particular promise in certain research
activities such as medical education, ethics, quality of
care, cultural perspectives, survey research and patient–doctor
communication.
This workshop will introduce participants to
qualitative methodology and its application to research
questions in pediatrics by addressing two of the most
commonly employed methods: focus groups and ethnographic
interviewing. Participants will learn to: (1) identify
research topics appropriate for the use of qualitative
methods; (2) design a qualitative study using the two
highlighted methods; (3) organize a paper for
publication. Methodological issues such as sampling,
data collection, coding, data analysis, and validity and
reliability will be reviewed using examples from
published literature and from participants’ own
research questions.
C. Feudtner, D. C. Grossman, J. I. Takayama,
Department of Pediatrics, University of Washington,
Seattle, WA, and Department of Pediatrics, UCSF, San
Francisco, CA
9:00am – 12:00pm
Special Interest Groups
6112 Faculty
Development
The Faculty Development SIG is a
forum for ongoing exchange in the area of medical
education and faculty development The SIG is open to
anyone interested in these areas. The SIG will use its
List-serve to brainstorm ideas for the upcoming meeting.
Please check for detailed information on this SIG at
www.pas-meeting.org in early 2002. The SIG is cochaired
by Franklin Trimm, Charlie Gaebler-Uhing and Ronald V.
Marino. The List-serve is maintained by Michelle Barratt.
To join the List-serve contact Michelle at
Michelle.S.Barratt@uth.tmc.edu or 713-500-5810.
Cochairs: Charlie Geabler, clgaebler@aol.com,
Ron Marino, rmarino@winthrop.org,
and Franklin Trimm, ftrimm@jaguar1.usouthal.edu
6113 Health
Services Research
Chair: Lawrence Kleinman, lawrence.kleinman@lvh.com
6114 Literacy
Development Programs in Primary Care
This SIG supports primary care
based programs which promote reading aloud and train
clinicians to encourage early literacy development,
based on the Reach Out and Read (ROR) model. In this
year's 3-hour meeting, there will be an invited talk by
an educational specialist on early literacy development,
as well as a focused discussion of quality improvement
and implementation/outcome measures currently being used
or developed to assess and improve program quality.
There will also be presentations and updates on a
variety of research projects in progress around the
country to look at language and literacy effects of
pediatric literacy interventions. The SIG is coordinated
by Robert Needlman, MD (Case Western Reserve School of
Medicine and drspock.com) and Perri Klass, MD (Boston
University School of Medicine and Reach Out and Read).
Cochairs: Perri Klass, perri.klass@bmc.org,
and Robert Needlman, Rneedlman@drspock.com
10:00am – 12:00pm
ASPN Symposium
6120A Molecular
Basis of Renal Development and Disease
Chairs: Ellis D. Avner, Rainbow
Babies & Children's Hospital, Cleveland, OH, and
Paul R. Goodyer, McGill University, Montreal Canada
Renal Development: A
Molecular Overview
Christopher R. Burrow, Mt. Sinai School of Medicine,
New York, NY
Pax 2 in Renal Maldevelopment
Paul R. Goodyer, McGill University, Montreal, Canada
Developmental Interactions of the Renin-Angiotensin
System with Cyclooxygenase-2
Victoria F. Norwood, University of Virginia,
Charlottesville, VA
Polycystin: Kidney Development and PKD
Patricia D. Wilson, Mt. Sinai School of Medicine,
New York, NY
10:15am
– 12:00pm
Award
6150 SPR
Presidential Plenary Session and Awards
SPR Presidential Plenary
Alan M. Krensky, Stanford University, Stanford, CA
Young Investigator Award
Andrew M. Scharenberg
David G. Nathan Award in Hematology–Oncology:
Evaluation of IL-7 Signaling as a Therapeutic Target in
a Transgenic Mouse Model: Effect of Rapamycin on
Progenitor B Cell Malignancies
Valerie I. Brown
E. Mead Johnson Award for Research in Pediatrics
Nancy C. Andrews
Markus Grompe
Supported by an educational grant from Mead
Johnson Nutritionals
10:15am – 12:15pm
Platform Session
6200 Emergency
Medicine/Respiratory Disorders
Chairs: Louis M. Bell and Halim
Hennes
10:15am – 12:15pm
Platform Session
6201 Emergency
Medicine—Psychiatric/General
Chairs: Jane F. Knapp and Linda
Quan
10:15am – 12:15pm
Platform Session
6202 General
Pediatrics II
Chairs: Thomas M. Ball and Mary
Ottolini
10:15am – 12:15pm
Platform Session
6203 Neurodevelopmental
Disabilities I: Prenatal and Postnatal Influences on
Developmental Outcome
Chairs: Herbert J. Cohen and
Philip S. Zeskind
10:15am – 12:15pm
Platform Session
6204 Underserved
Populations II
Chairs: Paul L. McCarthy and
Ronald C. Samuels
10:30am – 12:30pm
LWPES Plenary Session
6250A LWPES
Plenary Session III - Mini Symposium
Breaking the Obesity–Type 2 Diabetes Link
Opening Remarks
Desmond A. Schatz, University
of Florida, Gainesville, FL
Metformin Therapy in Obesity
Michael S. Freemark
Dietary Glycemic Index in the Treatment of Obesity
and Related Complications
David S. Ludwig
New Advances: Adiponectin in Diabeter and Obesity
Philipp Scherer
11:30am
– 2:30pm
Commercial Exhibits Open and Posters Available for
Viewing
Available
for Viewing: 11:30am – 2:30 pm & 4:00pm – 6:45pm
Author Attendance: 4:30pm – 6:30pm
11:45am – 1:15pm
Alliance Club
6300A The
29th Annual Audrey K. Brown Kernicterus Symposium
Chairs: David K. Stevenson and
William J. Cashore
From Mangos to Meconium.
The Ongoing Saga of Bilirubin Conjugation
Antony F. McDonagh
Hyperbilirubinemia in the Northern California Kaiser
Permanente Medical Care Program
Thomas B. Newman, University of California, San
Francisco, CA
The 2002 Symposium will honor the memory of Dr.
Audrey Brown
Supported by an educational grant from the Natus
Medical Inc.
12:00pm – 1:00pm
Alliance Club
6310A Bioethics
Interest Group
Chair: Susan Albersheim
Is It Quality Improvement
OR Is It Research?
Henry L. Halliday, Belfast, Ireland
Jon E. Tyson, Houston, TX
Barbara McGillivray
12:30pm – 2:30 PM
Award
6400 March
of Dimes Prize in Developmental Biology Lectures
Presented by the March of Dimes
Birth Defects Foundation
The year 2002 marks the seventh annual March of Dimes
Prize in Developmental Biology.
The March of Dimes Prize in Developmental Biology is
awarded annually to investigators whose research has
profoundly advanced the science that underlies our
understanding of birth defects.
From the Gene to the Organism
Seymour Benzer, Division of Biology, California
Institute of Technology, Pasadena, California
Sydney Brenner, The Salk Institute, La Jolla, California
Come hear a rare shared lecture by these two
prominent and imaginative scientists whose last joint
speaking engagement (in 1965) is still being talked
about.
Seymour Benzer and Sydney Brenner were chosen to
receive the 2002 March of Dimes Prize for their
tremendously influential bodies of work that have helped
to revolutionize and open up productive new fields of
study in molecular biology and genetics. Their work has
been essential to our understanding of the human
organism and to the design of new treatments for human
birth defects and diseases.
Dr. Benzer has made many highly original
contributions to developmental biology using the
fruitfly as a model organism. His work has revealed
basic genetic mechanisms regulating the early steps of
eye formation, the internal "biological
clock," as well as the first genes that control
behavior, memory, and learning. He is the subject of the
1999 book Time, Love, Memory: A Great Biologist and His
Quest for the Origins of Behavior. With his latest work
on the nervous system, Dr. Benzer is studying the
molecular basis of pain.
In the 1950s, Dr. Brenner helped establish the
existence of messenger RNA, the "working tape"
copy of DNA from which cells make proteins. His
pioneering work with the worm Caenorhabditis elegans in
the 1960s established it as a model system that made it
possible to learn how genes control development,
including programmed cell death (apoptosis), and the
assembly of cells into complex structures. Most
recently, he has been studying vertebrate genome
evolution using the Japanese puffer fish (fugu).
1:00pm – 3:00pm
ASPN Symposium
6420A ESRD
— Long Term Issues
Chairs: Frederick J. Kaskel,
Albert Einstein College of Medicine, New York, NY, and
Craig Wong, Children's Hospital of New Mexico,
Albuquerque, NM
Cardiovascular Risk Factors in ESRD
Rulan Parekh, Johns Hopkins University, Baltimore,
MD
Modifications of Cardiovascular Risk Factors
Ronald J. Portman, University of Texas, Houston, TX
Update on Bone Disease in ESRD
Mary Beth Leonard, The Children's Hospital of
Philadelphia, Philadelphia, PA
Advances in Dialytic Therapies
Stuart Goldstein, Texas Children's Hospital,
Houston, TX
1:30pm
– 5:30pm
APA Presidential Plenary
6450 APA
Presidential Plenary and Armstrong Lecture
Chair: Steve Ludwig
International Health Award: Clinical Presentation,
Immediate Outcome and Prognostic Factors of Cerebral
Malaria in Children Admitted to Mulago Hospital
Richard Idro
Ray E. Helfer Award for Innovation in Pediatric
Education: Measuring Medical Knowledge Competencies
Using Web-Enhanced
Instruction During a Pediatric Resident Ambulatory Block
Month
Larry C. Hurtubise
Carl E. Johnson
Distinguished Career Award
Barbara Starfield
The George Armstrong Lecture
Steven A. Schroeder
2:45pm
– 4:45pm
Topic Symposium
6500 Antibiotic
Resistance: The Race Is On (PIDS Symposium)
Chairs: Joseph W. St. Geme III,
Washington University, St. Louis, MO and Richard F.
Jacobs, University of Arkansas, Arkansas Children's
Hospital, Little Rock, AR
In recent years there has been
an explosion in the prevalence of antibiotic resistance.
As a consequence, treatment decisions now are often
complicated, and treatment is more and more commonly
unsuccessful. In this symposium, speakers will review
the epidemiology of antibiotic resistance, the current
state in treating resistant Staphylococcus aureus and
resistant gram-negative bacteria, and new approaches to
antibiotic discovery.
The Evolving Epidemiology of Antibiotic Resistance
Daniel Sahm, Focus Technologies, Inc., Herndon, VA
The Challenge of Antimicrobial Therapy for the
Staphylococci: Our Backs to the Wall
Robert S. Daum, The University of Chicago, Chicago,
IL
Increasing Resistance in Gram-Negative Bacteria: The
Role of Extended Spectrum Beta Lactamases
David L. Paterson, University of Pittsburgh Medical
Center, Pittsburgh, PA
Genomic Approaches to Antibiotic Discovery
Molly B. Schmid, Integrative Proteomics, Inc.,
Toronto, Canada
Sponsored Jointly with the Pediatric Infectious
Diseases Society
2:45pm – 4:45pm
Topic Symposium
6501 Gene
Nutrient Interaction
Chairs: Sherin Devaskar, Mattel
Children's Hospital, University of California, Los
Angeles, CA and William Hay, Jr., University of Colorado
School of Medicine, Denver, CO
Recent exciting advances in
defining the human genome have provided new
opportunities in research for understanding the
regulation of gene expression. One important focus of
this area of science is the role of the metabolic milieu
on gene expression and function during critical periods
of development. This session will address the effect of
nutrients and metabolic conditions on three aspects of
metabolic gene regulation. William Heird will discuss
how essential fatty acids regulate the expression and
activity of genes and gene products that in turn are
essential for regulation of fatty acid metabolism. These
processes are fundamental during fetal and neonatal life
when essential fatty acids are particularly important
for structural development of the central nervous system
and for the provision of key intermediary substrates
that coordinate the development and activity of such
diverse functions as vascular tone, inflammation, and
nutrient metabolism. Christopher Newgard will discuss
how aspects of the metabolic milieu affect pancreatic
beta cell development and function, and then will
explore molecular engineering approaches to modifying
pancreatic beta cell/islet gene expression of genes that
regulate insulin production and secretion. Barbara Kahn
will discuss the molecular mechanisms involved in
causing substrate-induced insulin resistance, reflecting
on conditional gene knockout models of insulin
resistance in adipose tissue and skeletal muscle.
Together these talks will provide valuable information
about mechanisms responsible for the effect of nutrients
and nutrient metabolic products on key regulatory genes
involved in growth and metabolism, leading to increased
insight into exciting research opportunities in
potential therapeutic manipulations of gene activity.
Fatty Acid Regulation of Fatty Acid Metabolism
William C. Heird, Baylor College of Medicine,
Houston, TX
Molecular Mechanisms for Insulin Resistance in
Obesity and Diabetes
Barbara Kahn, Beth Israel Deaconess Medical Center,
Harvard Medical School, Boston, MA
Metabolic Control Mechanisms in the Pancreatic Beta
Cell Studied By Genetic Engineering
Christopher B. Newgard, University of Texas
Southwestern Medical Center, Dallas, TX
2:45pm
– 4:45pm
Poster Symposium
6550 Bilirubin:
Bench to Bedside
Chairs: Vinod K. Bhutani and
Jon F. Watchko
Supported by an educational grant from Natus Medical,
Inc.
2:45pm – 4:45pm
Platform Session
6551 Cardiology
I
Chairs: Michael Artman and
Scott H. Baldwin
Includes Richard D.
Rowe Award Lecture:
Subclinical Cardiomyopathy in the Mouse Model of the
Very-Long-Chain-Acyl CoA Dehydrogenase Deficiency
Vernat J. Exil
2:45pm – 4:45pm
Platform Session
6552 Clinical
Bioethics
Chairs: Susan Hintz and Jon E.
Tyson
2:45pm – 4:45pm
Platform Session
6553 Developmental
Biology II
Chairs: Michael E. Fant and
Lewis P. Rubin
2:45pm – 4:45pm
Platform Session
6554 Gastroenterology
Chairs: Kathleen B. Schwarz and
Barry K. Wershil
2:45pm – 4:45pm
Poster Symposium
6555 Gut
Integrity–Necrotizing Enterocolitis
Chairs: Robert H. Lane and
Philip T. Nowicki
2:45pm – 4:45pm
Platform Session
6556 Mechanisms
of Brain Injury
Chair: John D. E. Barksd
2:45pm – 4:45pm
Platform Session
6557 Mechanisms
of Tissue Injury: Apoptosis
Chairs: Sandra E. Juul and
Seetha Shankaran
2:45pm – 4:45pm
Platform Session
6558 Nitric
Oxide/Carbon Monoxide
Chair: Francis R. Poulain
2:45pm – 4:45pm
Platform Session
6559 Novel
Approaches to Neonatal Diseases
Chairs: Phyllis A. Dennery and
Sherin U. Devaskar
2:45pm – 4:45pm
Poster Symposium
6560 Perinatal
Lung Growth and Function
Chairs: Lucky Jain and A. Keith
Tanswell
2:45pm – 4:45pm
Platform Session
6561 The
Lula O. Lubchenco Symposium on Neonatal Epidemiology and
Follow-Up
Chairs: Virginia Delaney-Black
and T. Michael O'Shea
FEATURED SPEAKER: Virginia
Delaney-Black
2:45pm – 4:45pm
Poster Symposium
6562 Ventilator
Strategies: Benefits and Limitations
Chairs: James Cummings and Rita
Ryan
2:45pm – 4:45pm
Alliance Club
6580A Milk
Club
Breastfeeding: Global Advances. Environmental Concerns
Chair: Ardythe L. Morrow
Achieving Population-Level
Increases in Optimal Breastfeeding: Evaluation of
Demonstration Projects in Developing Countries
Nadra Franklin, Academy for Educational Development,
Director of Monitoring and Evaluation, LINKAGES Project
Environmental Chemicals in Human Milk
Cheston M. Berlin
4:00pm – 6:45pm
Commercial Exhibits Open and Posters Available for
Viewing
Available
for Viewing: 4:00 PM – 6:45 PM
Author Attendance: 4:45 PM – 6:30 PM
4:45pm
– 6:30pm
Poster Session III
Allergy, Immunology and
Rheumatology
– Allergy, Immunology and
Rheumatology
Cardiology
– AIDS Cardiomyopathy
– Cardiovascular Development
– Hypothermia
– Myocardial Performance and Reflexes
Critical Care
– Critical Care
– Mechanisms of Brain Injury
Developmental Biology
– Brain Development and Injury
– Cardiac and Pulmonary Development
– Developmental Biology
Dysmorphology and Teratology
– Dysmorphology/Teratology
Gastroenterology
– Gastroenterology
– Gut Motility
– Inflammatory and Infectious Diseases
Genetics/Inborn Errors of Metabolism
– Genetics/Inborn Errors
Neonatology
– Bilirubin
– Bronchopulmonary Dysplasia
– Central Nervous System
– Chronic Lung Disease
– Maternal Substance Exposure
– Materno-Neonatal Medicine
– Neonatal Lung Injury:
Oxidants/Antioxidants/Signaling
– NICU Care
– Pain
– Pharmacology
– Respiratory Distress Syndrome/Surfactants
– Retinopathy of Prematurity
– Steroids
Neurology
– Brain Imaging and Function
– Brain Injury and Protection
– Mechanisms of Brain Injury
– Premature Brain Injury
Pharmacology
– Cardiovascular Pharmacology
– Central Nervous System Pharmacology
6:45pm – 8:15pm
Alliance Club
6700A Lung
Club
Surfactant Proteins:
Multifunctional Defenders of the Alveolus
Samuel Hawgood
Supported by an educational grant from Ross
Pediatrics
6:45pm – 9:45pm
Alliance Society
6710A Society
for Developmental Pediatrics
Developmental Outcomes After
Reproductive Technologies: Relevance to Fetal Origins of
Disease
Germaine Buck
Advances in Neuroprotection: From Animal Models to
Clinical Trials
Rebecca Ichord
Special
Report—New Training Initiatives in Neurodevelopmental
Pediatrics: Opportunities and Challenges
Professors of Developmental
Disabilities Committee, SDP
Evening
APA Board/Awardees Dinner
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