Saturday, May 4

Sunday, May 5

TUESDAY, MAY 7

8:00am – 10:00am
Topic Symposium
7000 Advances in Autism: Etiology, Imaging and Treatment
Chair: Daniel Coury, Children's Hospital, Columbus, OH
The autistic spectrum disorders have received increased attention from the public and research communities over the past decade. Theories regarding the possible etiology of the disorder, techniques for better evaluating and diagnosing persons displaying symptoms, and evidence-based treatment options have all received attention. Panel members will present the latest thinking regarding these issues and discuss controversial findings that have confused clinicians and families.

8:00am – 10:00am
Topic Symposium
7001 Neonatal Cholestasis
Chairs: Frederick Suchy, Mount Sinai School of Medicine, New York, NY and William Berquist, Stanford University School of Medicine, Palo Alto, CA
This symposium will highlight the significant recent progress made in defining the etiology of neonatal cholestasis. The advances in this area over the past few years have been breathtaking. For example, the genetic basis of a number of important pediatric liver diseases has been defined, including mutations in transporters that result in several forms of progressive familial intrahepatic cholestasis. The viral etiology and genetic causes of some forms of biliary atresia have also been elucidated. Insight into liver development has also come form the identification of the gene responsible for Allagile’s Syndrome. Advances in these areas of research have been important in elucidating the pathophysiology of these disorders and have provided new insights into the molecular and cellular physiology of the normal hepatocyte.

8:00am – 10:00am
Platform Session
7050 Cardiology II
Chairs: Ronald M. Payne and Jeffrey A. Towbin

8:00am – 10:00am
Platform Session
7051 Clinical Trials: Perinatal and Neonatal
Chairs: David P. Carlton and Robin K. Ohls

8:00am – 10:00am
Platform Session
7052 Developmental Pharmacology
Chairs: Sylvain Chemtob and Deborah G. McCarver

8:00am – 10:00am
Platform Session
7053 Education: Medical Students
Chairs: Bruce Z. Morgenstern and David M. Keller

8:00am – 10:00am
Platform Session
7054 General Pediatrics III
Chairs: Carol D. Berkowitz and Janet Serwint

8:00am – 10:00am
Platform Session
7055 Health Services Research: The Practice and the Patient
Chairs: Paul M. Darden II and Modena Wilson

8:00am – 10:00am
Poster Symposium
7056 Inflammation in Lung Injury and Remodelling
Chairs: Carl T. D'Angio and David Warburton

8:00am – 10:00am
Platform Session
7057 Injury: Motor Vehicle
Chair: Flaura Koplin Winston

8:00am – 10:00am
Poster Symposium
7058 Modeling To Detect Bioterrorism and Other Threats to Public Health
Chairs: Stephen M. Downs and Sarah S. Long

8:00am – 10:00am
Platform Session
7059 Neonatology—Patient-Oriented Research III: Metabolism and Nutrition
Chairs: Pamela J. Kling and Linda J. Van Marter

8:00am – 10:00am
Poster Symposium
7060 Neuro-Protection and Apoptosis
Chairs: Sidhartha Tan and

8:00am – 10:00am
Platform Session
7061 Underserved Populations III
Chairs: Jay H. Mayefsky and John I. Takayama

8:45am – 11:45am
Mini Course
7090 Controlling Asthma in the New Millennium
Chair: James S. Seidel, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance, CA
Although we have an understanding of the pathophysiology and treatment of asthma, the incidence, severity, and mortality from the disease is increasing. Twice in the past 10 years the National Heart Lung and Blood Institute has issued Guidelines for Diagnosis and Management of Asthma. These have not been widely adopted nor used. This mini course will explore the management of asthma in the emergency department and office setting and explore new methods to form care partnerships between practitioners, families and children to improve the care of asthma.

8:45am – 11:45am
Workshops

7100 BaFá BaFá™: A Cross-Cultural Simulation Experience for Medical Educators and Preceptors
Cultural sensitivity and cultural competence have become increasingly salient topics in medical education and practice in recent years. Though no consisently agreed-upon definitions have yet been formulated for either of these terms, there is widespread consensus about many of their key elements. Among these are self-awareness; an ability to empathize with others; a willingness to try to "see through others' eyes" when differences in values and expectations make interactions challenging and understanding difficult to achieve; and a capacity to act upon all of these qualities in formulating workable action plans. Originally designed as a training tool for U.S. servicemen being stationed abroad, the cross-cultural simulation game BaFá BaFá™ (Shirts, 1974) provides an immersion experience in cross cultural interaction and its challenges and rewards. Participants are assigned membership in one of two fictitious cultures and move into separate rooms to learn the basic values framework and interaction rules of their new cultures (a roughly 15-minute process). Following this brief "enculturation," the two groups exchange smaller subgroups of visitors and observers, who interact in their host cultures and attempt to describe to their co-culturists their experiences with and interpretations of the "others." When all participants have had a chance to visit, the exchange ends and the groups reunite to discuss and analyze their experiences and insights. Successfully used in a wide variety of settings, the insights produced through participation in BaFá BaFá™ about the pervasiveness and influence of cultural norms and worldviews will here be applied to cross-cultural challenges in clinical practice and medical education.
B. O'Connor and A. Alario, Division of Pediatric Ambulatory Medicine, Rhode Island Hospital/Brown Medical School, Providence, RI

7101 Cardiac Auscultation in Pediatrics: Interactive Workshop To Improve Diagnostic Accuracy and Teaching
Despite advances in sophisticated imaging tools, cardiac auscultation using a simple stethoscope remains a powerful and fundamental skill used by both the generalist and specialist to discriminate disease from health. However, recent studies have shown that proficiency among residents in training is declining, pointing out the need for improvements in the teaching and assessment of this clinical skill.

7102 Constructing and Presenting Workshops That Work
Workshops are a popular and versatile method of teaching adults. From teaching a procedure to teaching how to teach, from local retreats to national meetings, from precepting students to developing the skills of colleagues, workshops are widely used in medical education. This workshop will give participants the tools/framework necessary to construct and lead their own effective workshops. Facilitators of this workshop are from a variety of institutions and are participants in the APA National Pediatric Faculty Development Scholars Program. We will draw from our participation in this program, our previous experience with this workshop and current literature to review concepts of adult learning theory and techniques for working with small groups. Through participatory and interactive segments, the group will address how to conduct a needs assessment of the target audience and use the results to plan an effective workshop. Techniques for effective communication, stimulating audience participation and interaction, and evaluation will be demonstrated and practiced. During interactive breakout sessions, participants can choose to focus on the logistics of new workshop development or on refining their previously developed workshops. A listing of faculty development scholars by region will be provided to facilitate further networking and long-range access to workshop development expertise.
E. Zenni, J. Andrake, L. Pasquinelli, J. Christner, S. Wong and T. Shope, Department of Pediatrics, University of Florida Health Science Center, Jacksonville, FL

7103 Implementing Medical School Curricular Innovations for a Changing Health Care Environment: Challenges and Opportunities
While integrated health care systems where patient care is intensely managed are becoming more common, young physicians are not being taught how to provide high quality health care within these systems. Therefore, the Health Resources and Services Administration (HRSA) has funded a national medical education program (1997–2002), Undergraduate Medical Education for the 21st Century (UME-21). It is administered by the American Association of Colleges of Osteopathic Medicine. UME-21 funds 18 allopathic medical schools to develop, implement, and evaluate innovative educational strategies in the clinical years of medical school. The goal of the curricular innovations is to provide future physicians with the knowledge, skills, values and attitudes necessary to provide high quality, population-based, cost-effective medical care to their patients within integrated health care systems. This project aims to foster effective primary care teaching in ambulatory and community-based settings.

7104 Introduction to Molecular Techniques in Pediatric Research Training: Basic Principles of Gene Regulation and Expression Analyses
Recent advances in cell and molecular biology have revolutionized our understanding of the molecular mechanisms underlying human disease. Subspecialty training in pediatrics requires a comprehensive understanding of the molecular methodologies involved in the current diagnosis and treatment of human disease as well as the future design of therapeutic interventions. This workshop is designed to provide the pediatric physician in training with an overview of some basic molecular principles relevant to understanding normal gene expression as well as aberrant gene expression resulting in human disease. Workshop modules will focus on participant identification of several common laboratory methodologies for DNA cloning, analyses of gene regulation and expression, and histological tissue analyses. Upon completion of this workshop, participants will be able to (a) describe three fundamental steps of gene cloning and analysis, (b) define two processes that regulate transcriptional control of gene expression, (c) identify two methods for analysis of gene expression in vitro and (d) identify two histological techniques for the subcellular localization of gene expression products in vivo.
Patricia L. Ramsay, Assistant Professor of Pediatrics, Departments of Perinatal-Neonatal Medicine and Cellular and Molecular Biology, Baylor College of Medicine, Houston, TX

7105 Medical–Legal Collaboration: Advocacy in the Clinical Setting
Lawyers have become an essential part of the multidisciplinary healthcare team that low-income communities rely on to protect the health of their children. No longer is a doctor’s letter enough. Poor families navigating the bureaucratic barriers to government benefits such as food stamps or subsidized housing need both a doctor and a lawyer by their side. The goal of this workshop is to underline the importance of making local social resource networks more accessible to the patient population, while simultaneously teaching health care providers how to do so. The workshop will:

7106 Quality Improvement Research—A How To Session
Quality improvement activities are intended to close the gap between desired evidence-based structures and processes of health care and what is actually delivered. The Agency for Healthcare Research and Quality (AHRQ) continues to encourage and support rigorous research so that quality improvement efforts can themselves be evidence-based. In this workshop, AHRQ awardees will explain how they successfully applied for grants for quality improvement research, and how they are conducting quality improvement research in real world settings. The grantees will discuss the theoretical and conceptual QI frameworks that informed their approaches, the interventions they designed and implemented, the tools they used and developed, the practicalities of collaborations with health systems and the barriers and opportunities they encountered, including IRB issues. The workshop will include substantial opportunities to address participants' questions about individual research projects and the overall QI theme.
D. M. Dougherty and M. Miller (co-chairs), Agency for Healthcare Research and Quality, Rockville, MD; Charles Irwin, MD, University of California-San Francisco; MaryAnn Shafer, MD, University of California-San Francisco, and two other awardees of AHRQ quality improvement grants.

7107 The Management Skills You Need When Asked To Be the "Medical Director"
Physicians are frequently asked to shoulder administrative responsibilities in addition to their more traditional clinical and teaching duties. Balancing these new responsibilities can be a challenge. Often time does not permit formal preparation and training for these duties. This workshop provides a "hands-on" practical overview of basic skills needed for effective administrative leadership.

7108 Understanding Multivariate Regression: A Case-Based Approach
Objective: To enable clinicians to evaluate and interpret results of studies which utilize multivariate regression analytic techniques.

7109 Community-Based Physicians
The following is the agenda for the Community-Based Physicians SIG which will be meeting on Tuesday morning May 6 in the Baltimore Convention Center:

7110 Continuity Clinic
The Continuity Directors SIG was organized by Jan Drutz 12 years ago and continues to be a very active network for preceptors in resident continuity settings. We’re very pleased that over the years, the group has grown and completed projects that none of us individually could have accomplished. The annual SIG meeting, workshops, directories with clearing house information, newsletters and research have blossomed by the involvement of countless individuals committed to enhancing resident education. Our group has remained consistently enthusiastic and highly motivated because of all the Continuity Directors’ and preceptors’ attendance and active participation!

7111 Pediatric Emergency Medicine Program Directors
The program for Baltimore will continue the theme of development of programs to mentor young faculty in their career paths of becoming scholars and excellent clinical educators. There will be discussion on goal setting and issues to improve professional growth. The second part of the program will discuss the initial data entered in the ED benchmarking data that is currently being collected with your assistance. This includes characteristics of PEDs and descriptions/demographics of our programs and faculty. We look forward to a strong contingent at the meeting. For information contact Richard Ruddy, MD Cincinnati, Ohio 513-636-7973 or richard.ruddy@chmcc.org
Chair: Richard Ruddy, richard.ruddy@chmcc.org

7112 Pediatric Tobacco Issues
This inaugural meeting of the "Cig SIG" will include an introductory session during which members will briefly present their interests and work in pediatric tobacco issues, a presentation by members of the AAP's Center for Child Health Research and presentation of a proposed APA tobacco policy. A presentation by a potential funder is being pursued. Other presentations will be considered. if you are interested in suggesting a topic for discussion or in making a presentation, please contact either Dana Best, MD, MPH (dbbest@cnmc.org) or Deborah Moss, MD, MPH (mossd@pitt.edu).
Cochairs: Dana Best, dbbest@cnmc.org, and Deborah Moss, mossd@chplink.chp.edu

7113 Pediatrics for Family Practice
Iam looking forward to our May meeting. Tentative plans are to discuss:

7114 Race in Medicine
This year's meeting will be the first gathering of the Race in Medicine SIG. Our SIG is being formed to address three areas related to race:

7115 Serving the Underserved
We have invited local health department experts to describe the innovative data collection system used in Baltimore across several different city departments. This should be a fascinating discussion about the capacity of local government to provide comprehensive population-based data that would be important for health monitoring, tracking, etc. Next, we have invited faculty from the Dyson Initiatives funded sites to discuss their successes and failures in getting residents involved in community based projects. We will spend time during the SIG meeting to update members about innovative approaches, lessons learned, etc. that have come about as a result of the APA National Pediatric Faculty Development Scholars Program. Finally, we will present for the first time some of the data from the curriculum development project.

Cochairs: Jeff Brown, jbrown@dhha.org, and Ron Samuels, samuels@tch.harvard.edu

10:00am – 11:45am
State of the Art Plenary
7200 Pediatric Pain
Chairs: K. J. S. Anand, Arkansas Children's Hospital, Little Rock, AR and R. Whit Hall, University of Arkansas for Medical Sciences, Little Rock, AR
Critical periods for early brain development are associated with neurogenesis, neuronal migration, exuberant synaptogenesis, and developmental regulation of cell differentiation and apoptosis. Exposure to repetitive or prolonged pain during critical windows in development can permanently alter the neural substrates associated with pain processing as well as other behavioral domains. This symposium will describe age related changes in pain processing, recent advances in analgesic pharmacology for pediatric patients, and the long-term effects of neonatal pain on subsequent cognition and behavior. Translational research applied to pain processing and analgesic management will be emphasized, to provide the practicing pediatrician with the scientific rationale for current clinical practice.

10:00am – 11:45am
State of the Art Plenary
7201 Regenerative Medicine—From Stem Cells to Tissues
Chair: Clifford W. Bogue, Yale University School of Medicine, New Haven, CT
The potential to repair tissues and organs from stem cells has generated great excitement over the past year. Many diseases and pathological conditions, such as liver failure, spinal cord injury, Alzheimer’s disease and myocardial infarction, are now being viewed as potentially curable conditions through the use of stem cells. This session will focus on the developmental biology of stem cells and their amazing ability to give rise to many different fully-differentiated cell types. Investigators in the field of stem cell biology will discuss the potential advantages and limitations of using human embryonic stem cells, the plasticity of bone marrow-derived stem cells, and the therapeutic use of stem cells to regenerate damaged organs.

10:00am – 11:45am
State of the Art Plenary
7202 Pharmacogenomics: Clinical and Therapeutic Implications
Chair: James Padbury, Women & Infant's Hospital of Rhode Island, Brown University, Providence, RI
The availability of high density sequence databases for large segments of the human genome has lead to the identification of single nucleotide polymorphisms (SNPs) in many important genes. If these SNPs occur in regulatory regions of important catalytic proteins, occur in binding domains of transmembrane signaling molecules or occur in the regulatory region of a gene, they can profoundly affect the function of that gene and on an individual patient basis. It has become clear these mechanisms account for some of the highly variable, once considered "idiosyncratic", responses to drug therapy. Pharmacogenomics is the study of how genetics affects responses to drugs. Pharmacogenomics holds the promise that drugs might one day be tailor-made for and adapted to each person's own genetic makeup. In this symposium speakers will present prominent examples of how pharmacogenomic implications affect the biology of disease and therapy from the fields of behavioral genetics and sychotherapeutics, cancer chemotherapy and the treatment of asthma. The perspectives presented will help the attendee understand a pathobiological and clinically sound approach to these disorders. The discussion will include basic science, clinical research and an industry perspective on this rapidly emerging area of importance.

12:00pm – 1:30pm
Poster Session IV
Available for Viewing:  10:00 AM – 1:30 PM
Author Attendance:  12:00 PM – 1:30 PM

Behavioral Pediatrics
– Adolescence
– Literacy Promotion
– Neonatal–Patient Oriented
– Neurodevelopmental Disabilities
– Nutrition
– Sexual Development
Cardiology
– Cardiology Outcomes
– Clinical Research in Cardiology
– Single Ventricle: Physiology and Outcomes
General Pediatrics and Preventive Pediatrics
– Behavior/Development
– Breast Feeding
– Children with Special Health Care Needs
– Nutrition
– Obesity
– Smoking
Neonatology
– Cardiovascular Disease and Physiology
– Control of Breathing
– General Pulmonology
– Liquid Ventilator
– Neonatal Pulmonary Hypertension and Therapy
– Neonatal Pulmonology
– Nitric Oxide
– Persistent Pulmonary Hypertension of the Newborn/Meconium
– Ventilator Strategies/Pulmonary Function Testing
Pulmonology
– In Vitro Investigation
– In Vivo Investigation
– Patient-Oriented Investigation

1:45pm – 3:45pm
Hot Topic
7700 Models for Building Mental Health Capacity in Pediatric Primary Care
Chair: Anne M. Gadomski, The Mary Imogene Bassett Research Institute, Cooperstown, NY
This session will describe three models presently under study for building the capacity of pediatric primary care sites to manage children’s mental health problems. Two models are based on enhancements or extra resources for primary care providers, and the third is based on primary providers' skills.

1:45pm – 3:45pm
Hot Topic
7701 The Cytokine Controversy
Chair: William Keenan, St. Louis University, St Louis, MO
Recent evidence suggests that the inflammatory response of the fetus can result in brain and lung injury pre and postnatally. Are cytokines the mediators of injury or mere bystanders? What therapeutic interventions can protect the neonate? Is it already too late by birth? The speakers will present both the pros and cons of the inflammatory response and a panel discussion will attempt to summarize available information and suggest questions and potential strategies for future research.

1:45pm – 3:45pm
Hot Topic
7702 Disaster Preparedness: Beyond 9/11
Chairs: Tina L. Cheng, Johns Hopkins University School of Medicine, Baltimore, MD; Danelle Laraque, Mount Sinai School of Medicine, New York, NY; and Benard Dreyer, New York, NY
The impact of 9/11 and the public health aftermath have affected us personally and professionally. This session will address what the child health professional needs to know regarding disaster planning and preparedness. Speakers will review and provide updates on national and regional systems for emergency management and how those systems interact with local public health agencies, the pediatrician's role in the community's preparedness including what the school system, the pediatric office and the patient should be doing to prepare and respond, recognition and management of chemical and biologic agents of terrorism, and the psychological reactions to disaster and stress.

Disaster Planning and Preparedness for Child Health Professionals
George L. Foltin, New York University School of Medicine and Bellevue Hospital Center, New York, NY
Biologic Agents of Terrorism
Anne Fine, New York City Department of Health, New York, NY
Chemical Agents of Terrorism
Fred Henretig, University of Pennsylvania School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA
Helping Children Cope With Terrorism and Disasters
David J. Schonfeld, Yale University School of Medicine, New Haven, CT
Discussion

1:45pm – 3:45pm
Platform Session
7800 Asthma
Chairs: Ellen F. Crain and Richard M. Ruddy
Includes Ludwig–Seidel Award Lecture:
Does End-Tidal Capnography Predict the Need for Hospitalization in Acute Childhood Asthma?
Sergey Kunkov

1:45pm – 3:45pm
Platform Session
7801 Critical Care
Chairs: Clifford W. Bogue and David N. Cornfield

1:45pm – 3:45pm
Platform Session
7802 General Pediatrics IV
Chairs: Jeffrey M. Devries and Susan Feigelman

1:45pm – 3:45pm
Platform Session
7803 Health Services Research
Chairs: Denise M. Dougherty and Thomas B. Newman

1:45pm – 3:45pm
Platform Session
7804 Neurodevelopmental Disabilities II: Autism, ADHD and Neuroimaging
Chairs: Ronald L. Lindsay and Nancy J. Roizen

1:45pm – 3:45pm
Platform Session
7805 Underserved Populations IV
Chairs: Thomas G. DeWitt and Victoria Meguid