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CARDIOLOGY

12:00pm-3:00pm
Mini Course
4103 Sports Participation by Chronically Ill Children and Adolescents: Let the Games Begin!
Chair: Dilip Patel, Michigan State University, Kalamazoo Center for Medical Studies, Kalamazoo, MI
This mini course will focus on helping children and adolescents with chronic illness take full part in sports play (competitive and non-competitive). The role of sports in the lives of our children has become increasingly important in the enhancement of their development. A variety of illnesses will be reviewed in this perspective, with emphasis on diabetes mellitus, asthma and developmental disabilities. Questions from the audience will be sought. The course will be taught by a sports medicine pediatrician, a pediatric endocrinologist and a neurodevelopmental specialist.

12:00pm-3:00pm
Mini Course
4104 The New Pediatrics in the Genomic Era
Chairs: Isaac Kohane, Lyle Palmer and Scott Pomeroy, Children's Hospital, Boston, MA
The sequencing of the human genome and the availability of large-scale genomic measurement technologies will change the manner in which clinical care and pediatric research is conducted. We will address how these genomic technologies, bioinformatics and genetic epidemiology can be applied in these endeavors.

1:00pm-3:00pm
Poster Symposium
4182 Historical Perspectives
Chairs: Thor Willy Hansen and James Kendig

3:15pm-5:15pm
Topic Symposium
4200 Cloning and Embryonic Stem Cells
Chair: Judith Hall, University of British Columbia, Vancouver, Canada
There is enormous public interest in cloning and embryonic stem cells. This symposium will update the pediatric community on recent developments and raises a variety of policy and ethical issues.

3:15pm-5:15pm
Platform Session
4258 Pulmonary Vascular Biology
Chairs: Jeffrey R. Fineman and Robin L. Steinhorn

8:00am-10:00am
Topic Symposium
5000 Inflammatory Disorders of the Cardiovascular System
Chair: James Bristow, University of California, San Francisco, CA

1:45pm-2:30pm
State of the Art Plenary
5590 Children as Victims of Bioterrorism: Protecting the Fragile Host
Chairs: Phyllis Dennery, Stanford University School of Medicine, Palo Alto, CA and Tina Lee Cheng, Johns Hopkins University School of Medicine, Baltimore, MD
With the recent world events and new threats of biowarfare, what should pediatricians know? Due to their size and physiology, children are at higher risk of injury from bioterrorism. This session will address the biology, clinical manifestations, and possible preventive strategies for likely biowarfare agents. The unique vulnerability of the child will be addressed.

2:00pm-4:00pm
State of the Art Plenary
5701 Children as Research Subjects: Ethical and Regulatory Issues
Chair: Myron Genel, Yale University School of Medicine, New Haven, CT
A number of highly publicized adverse events, including the death of two volunteers participating in non-therapeutic research, and the federal shutdown of research at many well-recognized academic institutions because of inadequate compliance with regulatory requirements have intensified scrutiny of the protection afforded to human subjects participating in research, including children. Furthermore a Maryland court has recently decreed that children cannot participate in research without the potential for direct benefit. As a consequence there has been increasing media attention and Congressional concern regarding the adequacy of institutional oversight and investigator attentiveness to established standards and regulations. In addition, new regulations issued under the Health Insurance Portability and Accountability Act of l996(HIPAA) threaten the capacity to conduct health services and outcomes research. These issues will be addressed in the 9th annual Public Policy Plenary Symposium in an interactive format intended to stimulate dialogue among the members of the panel and with the audience.

2:30pm-4:00pm
State of the Art Plenary
5702 Developmental Biology and Pediatrics
Chair: David H. Rowitch, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA
Basic studies of developmental biology can have profound implications for child health and disease. In this State of the Art Plenary Plenary, pediatric investigators at the forefront of basic science will describe recent advances in our understanding of development of the central nervous system, heart and blood with implications for the pathophysiology of congenital malformations, acquired disease and pediatric cancer.

2:30pm-4:00pm
State of the Art Plenary
5703 Insulin Resistance Syndromes
Chairs: Alan Rogol, Insmed Pharmaceuticals, Inc., Glen Allen, VA and Charlotte Boney, Rhode Island Hospital, Providence, RI
Insulin resistance is the underlying factor in many of the consequences of obesity in childhood and adolescence, including ovarian hyperandrogenism, hypertension, hyperlipidemia, and Type 2 diabetes. Obesity, dyslipidemia, and Type 2 diabetes are components of SyndromeX in adults, a serious public health issue. In addition, insulin has a role in the regulation of leptin, the major signal of adiposity to the brain. Dr. Arslanian will discuss insulin resistance in polycystic ovary disease and Type 2 diabetes. Dr. Freedman will review the cardiac risk factors related to insulin resistance, and Dr. Roemmich will discuss the insulin-leptin axis in obesity and puberty.

4:15pm-6:15pm
Platform Session
5902 Cardiopulmonary Development
Chairs: James Bristow and Bruce D. Gelb

8:00am-10:00am
Topic Symposium
6001 New Strategies in Pediatric Heart Failure: Basic Science to Clinical Practice
Chair: Daniel Bernstein, Stanford University Medical Center, Palo Alto, CA
Recent advances in molecular cardiology have dramatically improved our understanding of the pathophysiology of heart failure. These advances have led to the development of new pharmacologic tools for more effectively managing heart failure and avoiding or postponing transplantation. However, the benefits of these new approaches have not always been shared by pediatric-age patients. This session will review two major areas of recent research breakthroughs in myocardial damage and remodeling, discuss the issues involved in translating adult clinical trials into pediatric practice, and introduce an initiative by pediatricians in the Heart Failure Society to develop pediatric heart failure management guidelines.

8:00am-10:00am
Platform Session
6052 Developmental Biology I
Chairs: Emese Pinter and Rashmin C. Savani

12:30pm-2:30pm
Award
6400 March of Dimes Prize in Developmental Biology Lectures
Presented by the March of Dimes Birth Defects Foundation

2:45pm-4:45pm
Platform Session
6551 Cardiology I
Chairs: Michael Artman and Scott H. Baldwin
Includes Richard D. Rowe Award Lecture:
Subclinical Cardiomyopathy in the Mouse Model of the Very-Long-Chain-Acyl CoA Dehydrogenase Deficiency
Vernat J. Exil

2:45pm-4:45pm
Platform Session
6553 Developmental Biology II
Chairs: Michael E. Fant and Lewis P. Rubin

– Cardiology
– Developmental Biology
– Pharmacology

Tuesday, May 7, 2002

8:00am-10:00am
Platform Session
7050 Cardiology II
Chairs: Ronald M. Payne and Jeffrey A. Towbin

8:00am-10:00am
Platform Session
7052 Developmental Pharmacology
Chairs: Sylvain Chemtob and Deborah G. McCarver

7101 Cardiac Auscultation in Pediatrics: Interactive Workshop To Improve Diagnostic Accuracy and Teaching
Despite advances in sophisticated imaging tools, cardiac auscultation using a simple stethoscope remains a powerful and fundamental skill used by both the generalist and specialist to discriminate disease from health. However, recent studies have shown that proficiency among residents in training is declining, pointing out the need for improvements in the teaching and assessment of this clinical skill.

7104 Introduction to Molecular Techniques in Pediatric Research Training: Basic Principles of Gene Regulation and Expression Analyses
Recent advances in cell and molecular biology have revolutionized our understanding of the molecular mechanisms underlying human disease. Subspecialty training in pediatrics requires a comprehensive understanding of the molecular methodologies involved in the current diagnosis and treatment of human disease as well as the future design of therapeutic interventions. This workshop is designed to provide the pediatric physician in training with an overview of some basic molecular principles relevant to understanding normal gene expression as well as aberrant gene expression resulting in human disease. Workshop modules will focus on participant identification of several common laboratory methodologies for DNA cloning, analyses of gene regulation and expression, and histological tissue analyses. Upon completion of this workshop, participants will be able to (a) describe three fundamental steps of gene cloning and analysis, (b) define two processes that regulate transcriptional control of gene expression, (c) identify two methods for analysis of gene expression in vitro and (d) identify two histological techniques for the subcellular localization of gene expression products in vivo.
Patricia L. Ramsay, Assistant Professor of Pediatrics, Departments of Perinatal-Neonatal Medicine and Cellular and Molecular Biology, Baylor College of Medicine, Houston, TX

10:00am-11:45am
State of the Art Plenary
7201 Regenerative Medicine—From Stem Cells to Tissues
Chair: Clifford W. Bogue, Yale University School of Medicine, New Haven, CT
The potential to repair tissues and organs from stem cells has generated great excitement over the past year. Many diseases and pathological conditions, such as liver failure, spinal cord injury, Alzheimer’s disease and myocardial infarction, are now being viewed as potentially curable conditions through the use of stem cells. This session will focus on the developmental biology of stem cells and their amazing ability to give rise to many different fully-differentiated cell types. Investigators in the field of stem cell biology will discuss the potential advantages and limitations of using human embryonic stem cells, the plasticity of bone marrow-derived stem cells, and the therapeutic use of stem cells to regenerate damaged organs.

– Cardiology
– Neonatology

1:45pm-3:45pm
Hot Topic
7702 Disaster Preparedness: Beyond 9/11
Chairs: Tina L. Cheng, Johns Hopkins University School of Medicine, Baltimore, MD; Danelle Laraque, Mount Sinai School of Medicine, New York, NY; and Benard Dreyer, New York, NY
The impact of 9/11 and the public health aftermath have affected us personally and professionally. This session will address what the child health professional needs to know regarding disaster planning and preparedness. Speakers will review and provide updates on national and regional systems for emergency management and how those systems interact with local public health agencies, the pediatrician's role in the community's preparedness including what the school system, the pediatric office and the patient should be doing to prepare and respond, recognition and management of chemical and biologic agents of terrorism, and the psychological reactions to disaster and stress.

Disaster Planning and Preparedness for Child Health Professionals
George L. Foltin, New York University School of Medicine and Bellevue Hospital Center, New York, NY
Biologic Agents of Terrorism
Anne Fine, New York City Department of Health, New York, NY
Chemical Agents of Terrorism
Fred Henretig, University of Pennsylvania School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA
Helping Children Cope with Terrorism and Disasters
David J. Schonfeld, Yale University School of Medicine, New Haven, CT
Discussion