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GASTROENTEROLOGY
AND NUTRITION
Saturday, May 4, 2002
8:30am-11:30am
Special Interest Group
4008
Nutrition
We are developing a
"Teacher's Guide to Clinical Pediatric
Nutrition". Our objectives are to:
1. provide the essential vocabulary and knowledge of
pediatric nutrition and
2. enable use of that vocabulary and knowledge in
clinical settings.
We have already prepared a 42 page monograph,
"Pediatric Nutrition Notes" written for 3rd
year medical students. These Notes accomplish our first
objective. In the SIG session in Baltimore, Saturday
morning of May 4th, we will develop the matrix for the
second part of the project -- "A Case Book of
Clinical Pediatric Nutrition." The Case Book will
enable pediatric residents to apply basic principles of
nutrition in clinical practice -- our second objective.
Those interested in participating can obtain a full
prospectus for the project by contacting one of the
organizers:
Robert Karp - Rkarp@downstate.edu
Sandra Hassink - shassink@NEMOURS.ORG
Steven Bachrach - sbachrac@NEMOURS.ORG
Elizabeth Shepard - Shepardwe@aol.com
Chair: Sandy Hassink, Shassink@nemours.org
1:00pm-3:00pm
Poster Symposium
4182
Historical Perspectives
Chairs: Thor Willy Hansen
and James Kendig
3:15pm-5:15pm
Topic Symposium
4200
Cloning and Embryonic Stem Cells
Chair: Judith Hall,
University of British Columbia, Vancouver, Canada
There is enormous public interest in cloning and
embryonic stem cells. This symposium will update the
pediatric community on recent developments and raises a
variety of policy and ethical issues.
Overview
Judith G. Hall, University of British Columbia,
Vancouver, Canada
Imprinting and Reprogramming
Arthur L. Beaudet, Baylor College of Medicine,
Houston, TX
Cloning
Brigid Hogan, Vanderbilt University Medical Center
and the Howard Hughes Medical Institute, Nashville, TN
Embryonic Stem Cells
Janet Rossant, Samuel Lunenfeld Research Institute,
Mount Sinai Hospital ON, Canada
3:15pm-5:15pm
Poster Symposium
4256
Neonatal and Fetal Nutrition and Metabolism I
Chairs: Dennis Bier and
Patti Thureen
5:15pm-7:15pm
Poster Session I (Author Attended)
and Opening Reception
– Endocrinology
7:15pm-9:30pm
Alliance Club
4500A
Perinatal Nutrition and Metabolism Club
Long-Term Developmental
Consequences of Perinatal Malnutrition
Janina Galler, Boston
University School of Medicine, Boston, MA
Supported by an educational grant from the Ross
Pediatrics
Sunday, May 5, 2002
8:00am-10:00am
Platform Session
5054
Neonatal and Fetal Nutrition and Metabolism II
Chairs: Michael K.
Georgieff and Satish C. Kalhan
8:00am-11:00am
Mini Course
5090
Adolescent Medicine - Part II—Eating Disorders
Chair: Donald E. Greydanus,
Michigan State University, Kalamazoo, MI
This presentation will present
an overview of the research on the diagnosis,
assessment, and treatment (therapy: including
psychological and pharmacological; settings: inpatient,
day treatment, and outpatient) of adolescents with
eating disorders. A brief comparison of the diagnostic
criteria used by the American Psychiatric Association
and the World Health Organization will be presented and
discussed regarding the relevance to research design and
diagnosis. Special issues (such as research design,
subject selection, research settings, geographical
location, definitions, terminology, race and culture,
managed care, and reimbursement) and their impact on our
current knowledge base and on treatment choices will be
addressed. Recommendations for future directions in
assessment, treatment, and research will be offered.
Overview
Donald E. Greydanus, Michigan State University
College of Human Medicine, Kalamazoo, MI
Diagnostic Criteria: American Psychiatric
Association, World Health Organization, Implications for
Diagnosing Adolescents
Helen D. Pratt, Michigan State University, Center
for Medical Studies, Kalamazoo, MI
Special Issues: Subject Selection: Gender, Race,
Ethnicity, Sexual Orientation
Helen D. Pratt, Michigan State University, Center
for Medical Studies, Kalamazoo, MI
Research Design: Research/Treatment Settings,
Inpatient, Day Treatment, Outpatient, Hospital, Clinic,
Community, Geographical Location, Definitions,
Disorders, Recovery
Helen D. Pratt, Michigan State University, Center
for Medical Studies, Kalamazoo, MI
Break
Treatment Interventions: Psychological, Psycho-pharmacologic
Helen D. Pratt, Michigan State University, Center
for Medical Studies, Kalamazoo, MI
Treatment Outcomes
Helen D. Pratt, Michigan State University, Center
for Medical Studies, Kalamazoo, MI
Recommendations for Future Research
Helen D. Pratt, Michigan State University, Center
for Medical Studies, Kalamazoo, MI
Discussion
11:45am-1:45pm
Poster Session II (Author Attended)
– Neonatology
1:45pm-2:30pm
State of the Art Plenary
5590
Children as Victims of Bioterrorism: Protecting the
Fragile Host
Chairs: Phyllis Dennery,
Stanford University School of Medicine, Palo Alto, CA
and Tina Lee Cheng, Johns Hopkins University School of
Medicine, Baltimore, MD
With the recent world events
and new threats of biowarfare, what should pediatricians
know? Due to their size and physiology, children are at
higher risk of injury from bioterrorism. This session
will address the biology, clinical manifestations, and
possible preventive strategies for likely biowarfare
agents. The unique vulnerability of the child will be
addressed.
Overview
Phyllis A. Dennery, Stanford University School of
Medicine, Palo Alto, CA
Children as Victims of Bioterrorism: Protecting the
Fragile Host
Ralph D. Feigin, Baylor College of Medicine,
Houston, TX
Discussion
2:00pm-4:00pm
State of the Art Plenary
5701
Children as Research Subjects: Ethical and Regulatory
Issues
Chair: Myron Genel, Yale
University School of Medicine, New Haven, CT
A number of highly publicized adverse events,
including the death of two volunteers participating in
non-therapeutic research, and the federal shutdown of
research at many well-recognized academic institutions
because of inadequate compliance with regulatory
requirements have intensified scrutiny of the protection
afforded to human subjects participating in research,
including children. Furthermore a Maryland court has
recently decreed that children cannot participate in
research without the potential for direct benefit. As a
consequence there has been increasing media attention
and Congressional concern regarding the adequacy of
institutional oversight and investigator attentiveness
to established standards and regulations. In addition,
new regulations issued under the Health Insurance
Portability and Accountability Act of l996(HIPAA)
threaten the capacity to conduct health services and
outcomes research. These issues will be addressed in the
9th annual Public Policy Plenary Symposium in an
interactive format intended to stimulate dialogue among
the members of the panel and with the audience.
Overview
Myron Genel, Yale University School of Medicine, New
Haven, CT
Overseeing Research in Children: New Concerns and New
Regulations
Alan R. Fleischman, The New York Academy of
Medicine, New York, NY
International Health Research: Where Bioethics,
Politics and Economics Converge
Eric M. Meslin, Indiana University Center for
Bioethics, Indianapolis, IN
Compliance: What You and Your Institution Need to
Know (and Do)
Pearl O'Rourke, Partners HealthCare System, Inc.,
Boston, MA
HIPAA, Privacy & Confidentiality and Research In
Children?
Brian Kamoie, The George Washington University,
Washington, DC
Discussion
Sponsored jointly with the Public Policy Council
of the APS, AMSPDC, SPR and the Public Policy Committee
of the APA
Partially supported by an educational grant from
Columbus Children's Hospital
2:30pm-4:00pm
State of the Art Plenary
5703
Insulin Resistance Syndromes
Chairs: Alan Rogol, Insmed
Pharmaceuticals, Inc., Glen Allen, VA and Charlotte
Boney, Rhode Island Hospital, Providence, RI
Insulin resistance is the
underlying factor in many of the consequences of obesity
in childhood and adolescence, including ovarian
hyperandrogenism, hypertension, hyperlipidemia, and Type
2 diabetes. Obesity, dyslipidemia, and Type 2 diabetes
are components of SyndromeX in adults, a serious public
health issue. In addition, insulin has a role in the
regulation of leptin, the major signal of adiposity to
the brain. Dr. Arslanian will discuss insulin resistance
in polycystic ovary disease and Type 2 diabetes. Dr.
Freedman will review the cardiac risk factors related to
insulin resistance, and Dr. Roemmich will discuss the
insulin-leptin axis in obesity and puberty.
Insulin Resistance: It's Not for Adults Only
Silva A. Arslanian, Children's Hospital of
Pittsburgh, Pittsburgh, PA
Clustering of Coronary Heart Disease Risk Factors in
Obese Children
David Freedman, Division of Nutrition and Physical
Activity, Centers for Disease Control, Atlanta, GA
The Insulin-Leptin Axis in Puberty
James Roemmich, School of Medicine and Biomedical
Sciences, University of Buffalo, Buffalo, NY
Sponsored jointly with the Lawson Wilkins Pediatric
Endocrine Society and the American Academy of Pediatrics
2:30pm-4:00pm
State of the Art Plenary
5704
Pediatric Research and the Human DNA Sequence:
Approaching Defects of Host Defenses in the Genomic Era
Chairs: Jennifer M. Puck,
National Human Genome Research Institute, National
Institutes of Health, Bethesda, MD and Stephen J.
Chanock, National Cancer Institute, National Institutes
of Health, Bethesda, MD
This session will provide a
framework for understanding how genetics and genomics
can accelerate progress in understanding defects in
immunity and host defenses. Host defenses are used to
demonstrate the general power of these technologies to
elucidate pathogenetic mechanisms and predict disease
susceptibility. This program will address classical and
novel approaches to discovering genes underlying primary
immunodeficiencies as well as characterization of
modifier genes. A brief overview of the human genome,
its structure, contents and relationship to genomes of
other species will be presented in order to discuss
current and future potential for understanding pediatric
diseases and treatments. Emphasis will be placed on the
continued prime importance of careful clinical
observation, as well as the ethical and practical issues
that genome science presents to society.
Finding a Multitude of Disease Genes for Primary
Immune Disorders
Jennifer M. Puck, National Human Genome Research
Institute/National Institutes of Health, Bethesda, MD
The Role of Vairation in the Human Genome: Single
Nucleotide Polymorphisms and Disease Modifiers
Stephen J. Chanock, National Cancer Institute,
National Institutes of Health, Bethesda, MD
Applications of Genomic Technology to Understanding
Human Phenotypes
Aravinda Chakravarti, Johns Hopkins University
School of Medicine, Baltimore, MD
Sponsored jointly with the Pediatric Infectious
Diseases Society
4:15pm-6:15pm
Topic Symposium
5801
IUGR—Recent Advances
Chair: David Carlton,
University of Wisconsin, Madison, WI
Intra-uterine growth restriction leads to various
adaptive changes in blood flow and metabolism which
leads to fetal survival in an adverse environment. This
session will address these adaptive changes which occur
in-utero and the long-term impact secondary to these
changes in the adult IUGR progeny. Dr. Battaglia will
present information related to blood flow and hepatic
metabolism in the human fetus/infant, Dr. Devaskar and
Dr. Hill will present work in animal models that sets
the IUGR fetus towards developing diabetes as an adult.
Dr. Devaskar will present changes in various organs,
while Dr. Hill will focus on changes that occur in the
beta-islets of the pancreas.
Clinical Studies of the Fetal Circulation and
Placental Transport
Frederick C. Battaglia, University of Colorado
School of Medicine, Denver, CO
Animal Studies - Adult Outcome of the IUGR Fetus
Sherin U. Devaskar, University of California, Los
Angeles, CA
The Impact of IUGR on the Development and Postnatal
Function of the Endocrine Pancreas
David Hill, University of Western Ontario, Canada
4:15pm-6:15pm
Platform Session
5911
Pediatric Nutrition and Metabolism
Chair: Michael R. Narkewicz
Monday, May 6, 2002
8:00am-10:00am
Poster Symposium
6050
Advances in Clinical Nutrition
Chairs: Michael R.
Narkewicz and David K. Rassin
10:15am-12:15pm
Platform Session
6202
General Pediatrics II
Chairs: Thomas M. Ball and
Mary Ottolini
12:30pm-2:30pm
Award
6400
March of Dimes Prize in Developmental Biology Lectures
Presented by the March of
Dimes Birth Defects Foundation
The year 2002 marks the seventh annual March of Dimes
Prize in Developmental Biology.
The March of Dimes Prize in Developmental Bilogy is
awarded annually to investigators whose research has
profoundly advanced the science that underlies our
understanding of birth defects.
From the Gene to the Organism
Seymour Benzer, Division of Biology, California
Institute of Technology, Pasadena, California
Sydney Brenner, The Salk Institute, La Jolla, California
Come hear a rare shared lecture by these two
prominent and imaginative scientists whose last joint
speaking engagement (in 1965) is still being talked
about.
Seymour Benzer and Sydney Brenner were chosen to
receive the 2002 March of Dimes Prize for their
tremendously influential bodies of work that have helped
to revolutionize and open up productive new fields of
study in molecular biology and genetics. Their work has
been essential to our understanding of the human
organism and to the design of new treatments for human
birth defects and diseases.
Dr. Benzer has made many highly original
contributions to developmental biology using the
fruitfly as a model organism. His work has revealed
basic genetic mechanisms regulating the early steps of
eye formation, the internal "biological
clock," as well as the first genes that control
behavior, memory, and learning. He is the subject of the
1999 book Time, Love, Memory: A Great Biologist and His
Quest for the Origins of Behavior. With his latest work
on the nervous system, Dr. Benzer is studying the
molecular basis of pain.
In the 1950s, Dr. Brenner helped establish the
existence of messenger RNA, the "working tape"
copy of DNA from which cells make proteins. His
pioneering work with the worm Caenorhabditis elegans in
the 1960s established it as a model system that made it
possible to learn how genes control development,
including programmed cell death (apoptosis), and the
assembly of cells into complex structures. Most
recently, he has been studying vertebrate genome
evolution using the Japanese puffer fish (fugu).
2:45pm-4:45pm
Topic Symposium
6501
Gene Nutrient Interaction
Chairs: Sherin Devaskar,
Mattel Children's Hospital, University of California,
Los Angeles, CA and William Hay, Jr., University of
Colorado School of Medicine, Denver, CO
Recent exciting advances in
defining the human genome have provided new
opportunities in research for understanding the
regulation of gene expression. One important focus of
this area of science is the role of the metabolic milieu
on gene expression and function during critical periods
of development. This session will address the effect of
nutrients and metabolic conditions on three aspects of
metabolic gene regulation. William Heird will discuss
how essential fatty acids regulate the expression and
activity of genes and gene products that in turn are
essential for regulation of fatty acid metabolism. These
processes are fundamental during fetal and neonatal life
when essential fatty acids are particularly important
for structural development of the central nervous system
and for the provision of key intermediary substrates
that coordinate the development and activity of such
diverse functions as vascular tone, inflammation, and
nutrient metabolism. Christopher Newgard will discuss
how aspects of the metabolic milieu affect pancreatic
beta cell development and function, and then will
explore molecular engineering approaches to modifying
pancreatic beta cell/islet gene expression of genes that
regulate insulin production and secretion. Barbara Kahn
will discuss the molecular mechanisms involved in
causing substrate-induced insulin resistance, reflecting
on conditional gene knockout models of insulin
resistance in adipose tissue and skeletal muscle.
Together these talks will provide valuable information
about mechanisms responsible for the effect of nutrients
and nutrient metabolic products on key regulatory genes
involved in growth and metabolism, leading to increased
insight into exciting research opportunities in
potential therapeutic manipulations of gene activity.
Fatty Acid Regulation of Fatty Acid Metabolism
William C. Heird, Baylor College of Medicine,
Houston, TX
Molecular Mechanisms for Insulin Resistance in
Obesity and Diabetes
Barbara Kahn, Beth Israel Deaconess Medical Center,
Harvard Medical School, Boston, MA
Metabolic Control Mechanisms in the Pancreatic Beta
Cell Studied By Genetic Engineering
Christopher B. Newgard, University of Texas
Southwestern Medical Center, Dallas, TX
2:45pm-4:45pm
Platform Session
6554
Gastroenterology
Chairs: Kathleen B. Schwarz
and Barry K. Wershil
2:45pm-4:45pm
Poster Symposium
6555
Gut Integrity–Necrotizing Enterocolitis
Chairs: Robert H. Lane and
Philip T. Nowicki
2:45pm-4:45pm
Platform Session
6557
Mechanisms of Tissue Injury: Apoptosis
Chairs: Sandra E. Juul and
Seetha Shankaran
2:45pm-4:45pm
Platform Session
6561
The Lula O. Lubchenco Symposium on Neonatal Epidemiology
and Follow-Up
Chairs: Virginia
Delaney-Black and T. Michael O'Shea
FEATURED SPEAKER:
Virginia Delaney-Black
2:45pm-4:45pm
Alliance Club
6580A
Milk Club
Breastfeeding: Global Advances. Environmental Concerns
Achieving Population-Level
Increases in Optimal Breastfeeding: Evaluation of
Demonstration Projects in Developing Countries
Nadra Franklin, Academy for
Educational Development, Director of Monitoring and
Evaluation, LINKAGES Project
Environmental Chemicals in Human Milk
Cheston M. Berlin
4:45pm-6:30pm
Poster Session III (Author Attended)
– Gastroenterology
Tuesday, May 7, 2002
8:00am-10:00am
Topic Symposium
7001
Neonatal Cholestasis
Chairs: Frederick Suchy,
Mount Sinai School of Medicine, New York, NY and William
Berquist, Stanford University School of Medicine, Palo
Alto, CA
This symposium will highlight
the significant recent progress made in defining the
etiology of neonatal cholestasis. The advances in this
area over the past few years have been breathtaking. For
example, the genetic basis of a number of important
pediatric liver diseases has been defined, including
mutations in transporters that result in several forms
of progressive familial intrahepatic cholestasis. The
viral etiology and genetic causes of some forms of
biliary atresia have also been elucidated. Insight into
liver development has also come form the identification
of the gene responsible for Allagile’s Syndrome.
Advances in these areas of research have been important
in elucidating the pathophysiology of these disorders
and have provided new insights into the molecular and
cellular physiology of the normal hepatocyte.
Overview: Where We Have Come in Last Two Decades
William F. Balistreri, Children's Hospital Medical
Center, Cincinnati, OH
The Pathogenesis of Biliary Atresia: The Importance
of Novel Genes and Infections
Ronald J. Sokol, University of Colorado Health
Science Center, The Children's Hospital, Denver, CO
Progressive Familial Intrahepatic Cholestasis
Frederick J. Suchy, Mount Sinai School of Medicine,
New York
Alagille Syndrome: Insights From Identification of
the Underlying Genetic Defect
David A. Piccoli, The Children's Hospital of
Philadelphia and University of Pennsylvania School of
Medicine, Philadelphia, PA
Sponsored jointly with the North American Society for
Pediatric Gastroenterology, Hepatology and Nutrition
10:00am-11:45am
State of the Art Plenary
7201
Regenerative Medicine—From Stem Cells to Tissues
Chair: Clifford W. Bogue,
Yale University School of Medicine, New Haven, CT
The potential to repair
tissues and organs from stem cells has generated great
excitement over the past year. Many diseases and
pathological conditions, such as liver failure, spinal
cord injury, Alzheimer’s disease and myocardial
infarction, are now being viewed as potentially curable
conditions through the use of stem cells. This session
will focus on the developmental biology of stem cells
and their amazing ability to give rise to many different
fully-differentiated cell types. Investigators in the
field of stem cell biology will discuss the potential
advantages and limitations of using human embryonic stem
cells, the plasticity of bone marrow-derived stem cells,
and the therapeutic use of stem cells to regenerate
damaged organs.
Overview
Clifford W. Bogue, Yale University School of
Medicine, New Haven, CT
Human Pluripotent Stem Cells: Differentiation and
Transplantation
John Gearhart, Johns Hopkins School of Medicine,
Johns Hopkins Hospital, Baltimore, MD
Plasticity of Bone Marrow Derived Stem Cells
Diane Krause, Yale University School of Medicine,
New Haven, CT
Potential Use of Stem Cells to Repair Infarcted
Myocardium
Donald Orlic, National Human Genome Research
Institute, National Institutes of Health, Bethesda, MD
Discussion
12:00pm-1:30pm
Poster Session IV (Author Attended)
– Behavioral Pediatrics
– General Pediatrics and Preventive Pediatrics
1:45pm-3:45pm
Hot Topic
7701
The Cytokine Controversy
Chair: William Keenan, St.
Louis University, St Louis, MO
Recent evidence suggests that
the inflammatory response of the fetus can result in
brain and lung injury pre and postnatally. Are cytokines
the mediators of injury or mere bystanders? What
therapeutic interventions can protect the neonate? Is it
already too late by birth? The speakers will present
both the pros and cons of the inflammatory response and
a panel discussion will attempt to summarize available
information and suggest questions and potential
strategies for future research.
Overview
William J. Keenan, St. Louis University, St Louis,
MO
The Fetal Inflammatory Response and Preterm Brain
Injury
Olaf Dammann, Harvard Medical School, Children's
Hospital, Boston, MA
Cytokines and Lung Injury: The Bad
Steven R. Seidner, University of Texas Health
Sciences Center, San Antonio, TX
Cytokines and Injury: The Good
Phyllis A. Dennery, Stanford University School of
Medicine, Palo Alto, CA
Discussion
1:45pm-3:45pm
Hot Topic
7702
Disaster Preparedness: Beyond 9/11
Chairs: Tina L. Cheng,
Johns Hopkins University School of Medicine, Baltimore,
MD; Danelle Laraque, Mount Sinai School of Medicine, New
York, NY; and Benard Dreyer, New York, NY
The impact of 9/11 and the
public health aftermath have affected us personally and
professionally. This session will address what the child
health professional needs to know regarding disaster
planning and preparedness. Speakers will review and
provide updates on national and regional systems for
emergency management and how those systems interact with
local public health agencies, the pediatrician's role in
the community's preparedness including what the school
system, the pediatric office and the patient should be
doing to prepare and respond, recognition and management
of chemical and biologic agents of terrorism, and the
psychological reactions to disaster and stress.
Disaster Planning and Preparedness for Child Health
Professionals
George L. Foltin, New York University School of
Medicine and Bellevue Hospital Center, New York, NY
Biologic Agents of Terrorism
Anne Fine, New York City Department of Health, New
York, NY
Chemical Agents of Terrorism
Fred Henretig, University of Pennsylvania School of
Medicine and Children's Hospital of Philadelphia,
Philadelphia, PA
Helping Children Cope with Terrorism and Disasters
David J. Schonfeld, Yale University School of
Medicine, New Haven, CT
Discussion
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Last Updated: September 27, 2006
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