INFECTIOUS
DISEASES*
*See
also the Pediatric
Infectious Diseases Society
INFECTIOUS DISEASES*
Saturday,
May 4, 2002
8:30am-11:30am
Special Interest Group
4007
Newborn Nursery
The newborn nursery SIG will
discuss Group B Streptococcus prevention and evaluation
for newborn sepsis with the goal of developing a
multicentered study of asymptomatic babies at risk.
Current practice and protocols for the SIG study will be
discussed and a plan established to answer the
questions. Teaching our students and residents in the
nursery a competency based curriculum presents a
challenge. Each participant will bring their program’s
needs, challenges and curriculum to discuss in small
groups for "hands- on" experience in
critiquing the existing curricula, developing a model
curriculum and generating creative ideas for
implementation. An update on screening for
hyperbilirubinemia and treatment will be discussed in
light of the JACO Kernicterus alert. Other topics will
include circumcision, breastfeeding solutions and pain
management.
Chair: Linda Meloy, Lmeloy@hsc.vcu.edu
Supported by an educational grant from the Natus
Medical Inc.
12:00pm-3:00pm
Mini Course
4102
Shifting Paradigms of Neonatal Sepsis
Chair: Pablo J. Sánchez,
University of Texas Southwestern Medical Center, Dallas,
TX
The changing epidemiology of
neonatal sepsis in the neonatal intensive care unit (NICU)
will be discussed, including antibiotic utilization for
both early- and late-onset sepsis and benchmarking ideas
for reducing nosocomial infections.
Neonatal Sepsis in the GBS Chemoprophylaxis Era
Barbara J. Stoll, Emory University School of
Medicine, Atlanta, GA
Fungal Infections in the NICU: New Strategies for Old
Bugs
Judith L. Rowen, University of Texas Medical Branch
at Galveston, Galveston, TX
Break
Antimicrobial Utilization in the NICU: Strategies to
Reduce Resistance
Pablo J. Sánchez, University of Texas Southwestern
Medical Center, Dallas, TX
Preventive Strategies: Where Do We Go From Here?
Roger G. Faix, University of Utah, Salt Lake City,
UT
Discussion
Sponsored jointly with the Pediatric Infectious
Diseases Society
3:15pm-5:15pm
Topic Symposium
4201
Innate Immunity
Chairs: Robert Modlin,
University of California, Los Angeles, CA and David B.
Lewis, Stanford University Medical Center, Stanford, CA
Most microorganisms
encountered in daily life by normal, healthy children
fail to cause disease. Rather, they are destroyed within
minutes or hours by defense mechanisms that do not
require priming or pre-existing experience. This
symposium will highlight advances in our understanding
of such innate immunity. Pattern recognition by
Toll-like receptors, a novel antimicrobial protein and
the role of natural killer cells in resistance to viral
infection will be discussed.
Role of Mammalian Toll-like Receptors in Microbial
Infection
Robert L. Modlin, University of California, Los
Angeles, CA
Granulysin: A Novel Antimicrobial Peptide of CTL and
NK Cells
Carol Clayberger, Stanford University School of
Medicine, Stanford, CA
Role of Natural Killer Cells in Resistance to Viral
Infections
Wayne M. Yokoyama, Howard Hughes Medical Institute
and Washington University, St Louis, MO
Sponsored jointly with the Pediatric Infectious
Diseases Society
3:15pm-5:15pm
Platform Session
4253
Infectious Diseases: Understanding Microbial Targets of
Virulence and Pathogenesis
Chair: David B. Haslam and
Terrence L. Stull
5:15pm-7:15pm
Poster Session I (Author Attended)
& Opening Reception
–
Neonatology
Sunday,
May 5, 2002
8:00am-10:00am
Topic Symposium
5000
Inflammatory Disorders of the Cardiovascular System
Chair: James Bristow,
University of California, San Francisco, CA
Inflammatory diseases of the
cardiovascular system remain an important cause of
morbidity and mortality in infants and children. While
we do not think of these as genetic diseases, the
application of powerful molecular genetic tools to these
diseases has begun bear fruit. This session will provide
an update on the pathogenesis of Kawasaki syndrome, the
importance of viral infection and persistence of viral
genomes in dilated cardiomyopathy and transplant
rejection, and the mechanism of autoimmunity in
congenital complete heart block.
Viral Myocarditis
Jeffrey A. Towbin, Baylor College of Medicine,
Houston, TX
The Immunopathogenesis of Cardiac Inflammation in
Kawasaki Disease
Anne H. Rowley, Northwestern University Medical
School, The Children's Memorial Hospital, Chicago, IL
Inflammatory Diseases of the Heart: Viruses and
Transplant Rejection
Neil E. Bowles, Baylor College of Medicine, Houston,
TX
Complete Congenital Heart Block: Functional and
Molecular Aspects
Mohamed Boutjdir, SUNY Health Science Center and VA
Medical Center at Brooklyn, NY
Sponsored jointly with the Pediatric Infectious
Diseases Society
8:00am-10:00am
Poster Symposia
5055
New Topics in Childhood Immunization Delivery
Chair: Lance Rodewald and
Judith S. Shaw
8:00am-10:00am
Poster Symposia
5056
Perinatal and Neonatal Infectious Diseases
Chairs: F. Sessions Cole
and Roger G. Faid
8:00am-11:00am
Special Interest Group
5109
AIDS/HIV
Chair: Nancy Hutton, nhutton@welchlink.welch.jhu.edu
10:15am-11:45am
APS Presidential Plenary, Howland Award & (11:15am)
St. Geme Award
11:45am-1:45pm
Poster Session II
–
General Pediatrics and Preventive Pediatrics
– Infectious Diseases
1:45pm-2:30pm
State of the Art Plenary
5590
Children as Victims of Bioterrorism: Protecting the
Fragile Host
Chairs: Phyllis Dennery,
Stanford University School of Medicine, Palo Alto, CA
and Tina Lee Cheng, Johns Hopkins University School of
Medicine, Baltimore, MD
With the recent world events
and new threats of biowarfare, what should pediatricians
know? Due to their size and physiology, children are at
higher risk of injury from bioterrorism. This session
will address the biology, clinical manifestations, and
possible preventive strategies for likely biowarfare
agents. The unique vulnerability of the child will be
addressed.
Overview
Phyllis A. Dennery, Stanford University School of
Medicine, Palo Alto, CA
Children as Victims of Bioterrorism: Protecting the
Fragile Host
Ralph D. Feigin, Baylor College of Medicine,
Houston, TX
Discussion
2:30pm-4:00pm
State of the Art Plenary
5702
Developmental Biology and Pediatrics
Chair: David H. Rowitch,
Harvard Medical School, Dana-Farber Cancer Institute,
Boston, MA
Basic studies of developmental
biology can have profound implications for child health
and disease. In this State of the Art Plenary Plenary,
pediatric investigators at the forefront of basic
science will describe recent advances in our
understanding of development of the central nervous
system, heart and blood with implications for the
pathophysiology of congenital malformations, acquired
disease and pediatric cancer.
Hedgehog Signaling in CNS Development and
Tumorigenesis
David H. Rowitch, Harvard Medical School,
Dana-Farber Cancer Institute, Boston, MA
Molecular Pathways of Cardiac Development and
Congenital Heart Disease
Deepak Srivastava, The University of Texas
Southwestern Medical Center, Dallas, TX
Molecular Control of Hematopoietic Cell Lineage
Stuart H. Orkin, Dana Farber Cancer Institute,
Boston, MA
2:30pm-4:00pm
State of the Art Plenary
5704
Pediatric Research and the Human DNA Sequence:
Approaching Defects of Host Defenses in the Genomic Era
Chairs: Jennifer M. Puck,
National Human Genome Research Institute, National
Institutes of Health, Bethesda, MD and Stephen J.
Chanock, National Cancer Institute, National Institutes
of Health, Bethesda, MD
This session will provide a
framework for understanding how genetics and genomics
can accelerate progress in understanding defects in
immunity and host defenses. Host defenses are used to
demonstrate the general power of these technologies to
elucidate pathogenetic mechanisms and predict disease
susceptibility. This program will address classical and
novel approaches to discovering genes underlying primary
immunodeficiencies as well as characterization of
modifier genes. A brief overview of the human genome,
its structure, contents and relationship to genomes of
other species will be presented in order to discuss
current and future potential for understanding pediatric
diseases and treatments. Emphasis will be placed on the
continued prime importance of careful clinical
observation, as well as the ethical and practical issues
that genome science presents to society.
Finding a Multitude of Disease Genes for Primary
Immune Disorders
Jennifer M. Puck, National Human Genome Research
Institute/National Institutes of Health, Bethesda, MD
The Role of Vairation in the Human Genome: Single
Nucleotide Polymorphisms and Disease Modifiers
Stephen J. Chanock, National Cancer Institute,
National Institutes of Health, Bethesda, MD
Applications of Genomic Technology to Understanding
Human Phenotypes
Aravinda Chakravarti, Johns Hopkins University
School of Medicine, Baltimore, MD
Sponsored jointly with the Pediatric Infectious
Diseases Society
4:15pm-6:15pm
Topic Symposium
5802
The Molecular Basis of Clinical Manifestations of
Infection
Chair: Philip Brunell,
NIAID, National Institutes of Health, Bethesda, MD
This symposium will explore
the molecular basis of the clinical expression of
infectious diseases. The effect of a variety of
different agents on the different organ systems of the
human body will be presented by experts in their fields.
Mycobacterial Susceptibility: What We Get and Why
Steven M. Holland, National Institute of Allergy and
Infectious Disease/NIH, Bethesda, MD
Cryptosporidium
Anthony R. Hayward, National Institute of Health,
National Center for Research Resources, Bethesda, MD
Cellular Genes That Modulate the Outcome of EBV
Infection
Jeffrey I. Cohen, National Institutes of Health,
Bethesda, MD
Host–Pathogen Interactions in Candida Infections
Margaret K. Hostetter, Yale University School of
Medicine, New Haven, CT
Sponsored jointly with the Pediatric Infectious
Diseases Society
4:15pm-6:15pm
Platform Session
5904
Emergency Medicine/Infectious Diseases
Chairs: David M. Jaffe and
Kathy N. Shaw
4:15pm-6:15pm
Platform Session
5912
Pulmonology
Chair: Marie M. Egan
Monday, May 6, 2002
8:00am-10:00am
Platform Session
6055
Infectious Diseases: Focus on Future Vaccines
Chair: W. Paul Glezen and
Neal A. Halsey
10:15am-12:15pm
Platform Session
6200
Emergency Medicine/Respiratory Disorders
Chair: Louis M. Bell and
Halim Hennes
10:15am-12:00pm
SPR Presidential Plenary, Awards and E. Mead Johnson
Awards
2:45pm-4:45pm
Topic Symposium
6500
Antibiotic Resistance: The Race Is On (PIDS
Symposium)
Chairs: Joseph W. St. Geme
III, Washington University, St. Louis, MO and Richard F.
Jacobs, University of Arkansas, Arkansas Children's
Hospital, Little Rock, AR
In recent years there has been
an explosion in the prevalence of antibiotic resistance.
As a consequence, treatment decisions now are often
complicated, and treatment is more and more commonly
unsuccessful. In this symposium, speakers will review
the epidemiology of antibiotic resistance, the current
state in treating resistant Staphylococcus aureus
and resistant gram-negative bacteria, and new approaches
to antibiotic discovery.
The Evolving Epidemiology of Antibiotic Resistance
Daniel Sahm, Focus Technologies, Inc., Herndon, VA
The Challenge of Antimicrobial Therapy for the
Staphylococci: Our Backs to the Wall
Robert S. Daum, The University of Chicago, Chicago,
IL
Increasing Resistance in Gram-Negative Bacteria: The
Role of Extended Spectrum Beta Lactamases
David L. Paterson, University of Pittsburgh Medical
Center, Pittsburgh, PA
Genomic Approaches to Antibiotic Discovery
Molly B. Schmid, Integrative Proteomics, Inc.,
Toronto, Canada
Sponsored jointly with the Pediatric Infectious
Diseases Society
2:45pm-4:45pm
Poster Symposium
6555
Gut Integrity–Necrotizing Enterocolitis
Chairs: Robert H. Lane and
Philip T. Nowicki
2:45pm-4:45pm
Club
6580
Milk Club
4:45pm-6:30pm
Poster Session III
–
Gastroenterology
5:00pm-6:00pm
PIDS Business Meeting
6:00pm
PIDS Annual Dinner and Awards Banquest
Tuesday,
May 7, 2002
8:00am-10:00am
Poster Symposium
7056
Inflammation in Lung Injury and Remodelling
Chairs: Carl T. D'Angio and
David Warburton
8:00am-10:00am
Poster Symposium
7058
Modeling To Detect Bioterrorism and Other Threats to
Public Health
Chairs: Stephen M. Downs
and Sarah S. Long
1:45pm-3:45pm
Hot Topic
7701
The Cytokine Controversy
Chair: William Keenan, St.
Louis University, St Louis, MO
Recent evidence suggests that
the inflammatory response of the fetus can result in
brain and lung injury pre and postnatally. Are cytokines
the mediators of injury or mere bystanders? What
therapeutic interventions can protect the neonate? Is it
already too late by birth? The speakers will present
both the pros and cons of the inflammatory response and
a panel discussion will attempt to summarize available
information and suggest questions and potential
strategies for future research.
Overview
William J. Keenan, St. Louis University, St Louis,
MO
The Fetal Inflammatory Response and Preterm Brain
Injury
Olaf Dammann, Harvard Medical School, Children's
Hospital, Boston, MA
Cytokines and Lung Injury: The Bad
Steven R. Seidner, University of Texas Health
Sciences Center, San Antonio, TX
Cytokines and Injury: The Good
Phyllis A. Dennery, Stanford University School of
Medicine, Palo Alto, CA
Discussion
7702
Disaster Preparedness: Beyond 9/11
Chairs: Tina L. Cheng,
Johns Hopkins University School of Medicine, Baltimore,
MD; Danelle Laraque, Mount Sinai School of Medicine, New
York, NY; and Benard Dreyer, New York, NY
The impact of 9/11 and the public health aftermath
have affected us personally and professionally. This
session will address what the child health professional
needs to know regarding disaster planning and
preparedness. Speakers will review and provide updates
on national and regional systems for emergency
management and how those systems interact with local
public health agencies, the pediatrician's role in the
community's preparedness including what the school
system, the pediatric office and the patient should be
doing to prepare and respond, recognition and management
of chemical and biologic agents of terrorism, and the
psychological reactions to disaster and stress.
Disaster Planning and Preparedness for Child Health
Professionals
George L. Foltin, New York University School of
Medicine and Bellevue Hospital Center, New York, NY
Biologic Agents of Terrorism
Anne Fine, New York City Department of Health, New
York, NY
Chemical Agents of Terrorism
Fred Henretig, University of Pennsylvania School of
Medicine and Children's Hospital of Philadelphia,
Philadelphia, PA
Psychological Reactions to Stress
David J. Schonfeld, Yale University School of
Medicine, New Haven, CT
Discussion
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