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NEUROLOGY*

*See also the Society for Developmental Pediatrics Program

12:00pm – 3:00pm
Mini Course
4103 Sports Participation by Chronically Ill Children and Adolescents: Let the Games Begin!
Chair: Dilip Patel, Michigan State University, Kalamazoo Center for Medical Studies, Kalamazoo, MI
This mini course will focus on helping children and adolescents with chronic illness take full part in sports play (competitive and non-competitive). The role of sports in the lives of our children has become increasingly important in the enhancement of their development. A variety of illnesses will be reviewed in this perspective, with emphasis on diabetes mellitus, asthma and developmental disabilities. Questions from the audience will be sought. The course will be taught by a sports medicine pediatrician, a pediatric endocrinologist and a neurodevelopmental specialist.

3:15pm – 5:15pm
Topic Symposium
4200 Cloning and Embryonic Stem Cells
Chair: Judith Hall, University of British Columbia, Vancouver, Canada
There is enormous public interest in cloning and embryonic stem cells. This symposium will update the pediatric community on recent developments and raises a variety of policy and ethical issues.

3:15pm – 5:15pm
Topic Symposium
4202 Stroke in Childhood
Chair: Donna Ferriero, University of California, San Francisco, CA
This session will update physicians on epidemiology and risk factors for perinatal and childhood stroke. Emphasis will be placed on identifying risk factors, increasing recognition, and providing possibilities for treatment.

5:15pm – 7:15pm
Poster Session I (Author Attended)
and Opening Reception
– Neurology

12:00pm – 1:30pm
Alliance Club
5300A Perinatal Brain Club
The Use of Cranial Ultrasound and Advanced Magnetic Resonance Imaging Techniques in the Understanding and Detection of Neonatal Brain Injury
Linda S. de Vries, Wilhelmina Children's Hospital, UMCU, The Netherlands
Petra S. Huppi, Children's Hospital, University of Geneva, Geneva, Switzerland
Terrie E. Inder

1:45pm – 2:30pm
State of the Art Plenary
5590 Children as Victims of Bioterrorism: Protecting the Fragile Host
Chairs: Phyllis Dennery, Stanford University School of Medicine, Palo Alto, CA and Tina Lee Cheng, Johns Hopkins University School of Medicine, Baltimore, MD
With the recent world events and new threats of biowarfare, what should pediatricians know? Due to their size and physiology, children are at higher risk of injury from bioterrorism. This session will address the biology, clinical manifestations, and possible preventive strategies for likely biowarfare agents. The unique vulnerability of the child will be addressed.

2:00pm – 4:00pm
State of the Art Plenary
5701 Children as Research Subjects: Ethical and Regulatory Issues
Chair: Myron Genel, Yale University School of Medicine, New Haven, CT
A number of highly publicized adverse events, including the death of two volunteers participating in non-therapeutic research, and the federal shutdown of research at many well-recognized academic institutions because of inadequate compliance with regulatory requirements have intensified scrutiny of the protection afforded to human subjects participating in research, including children. Furthermore a Maryland court has recently decreed that children cannot participate in research without the potential for direct benefit. As a consequence there has been increasing media attention and Congressional concern regarding the adequacy of institutional oversight and investigator attentiveness to established standards and regulations. In addition, new regulations issued under the Health Insurance Portability and Accountability Act of l996(HIPAA) threaten the capacity to conduct health services and outcomes research. These issues will be addressed in the 9th annual Public Policy Plenary Symposium in an interactive format intended to stimulate dialogue among the members of the panel and with the audience.

2:30pm – 4:00pm
State of the Art Plenary
5702 Developmental Biology and Pediatrics
Chair: David H. Rowitch, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA
Basic studies of developmental biology can have profound implications for child health and disease. In this State of the Art Plenary Plenary, pediatric investigators at the forefront of basic science will describe recent advances in our understanding of development of the central nervous system, heart and blood with implications for the pathophysiology of congenital malformations, acquired disease and pediatric cancer.

4:15pm – 6:15pm
Platform Session
5901 Brain Imaging
Chair: William D. Gaillard

4:15pm – 6:15pm
Poster Symposium
5906 Neonatal Epidemiology and Follow-Up
Chairs: Mark A. Klebanoff and Saroj Saigal

8:00am – 10:00am
Topic Symposium
6000 Human Brain Imaging: Insights into Development and Plasticity
Chairs: Sherin U. Devaskar, University of California, Los Angeles, CA and Joseph J. Volpe, Boston Children's Hospital, Harvard Medical School, Boston, MA

10:15am – 12:15pm
Platform Session
6203 Neurodevelopmental Disabilities I: Prenatal and Postnatal Influences on Developmental Outcome
Chairs: Herbert J. Cohen and Philip S. Zeskind

12:30pm – 2:30pm
Award
6400 March of Dimes Prize in Developmental Biology Lectures
Presented by the March of Dimes Birth Defects Foundation

2:45pm – 4:45pm
Platform Session
6556 Mechanisms of Brain Injury
Chair: John D. E. Barks

4:45pm – 6:30pm
Poster Session III (Author Attended)
– Critical Care
– Developmental Biology
– Neonatology
– Neurology
– Pharmacology

8:00am – 10:00am
Topic Symposium
7000 Advances in Autism: Etiology, Imaging and Treatment
Chair: Daniel Coury, Children's Hospital, Columbus, OH
The autistic spectrum disorders have received increased attention from the public and research communities over the past decade. Theories regarding the possible etiology of the disorder, techniques for better evaluating and diagnosing persons displaying symptoms, and evidence-based treatment options have all received attention. Panel members will present the latest thinking regarding these issues and discuss controversial findings that have confused clinicians and families.

8:00am – 10:00am
Poster Symposium
7060 Neuro Protection and Apoptosis
Chair: Sidhartha Tan

10:00am – 11:45am
State of the Art Plenary
7201 Regenerative Medicine—From Stem Cells to Tissues
Chair: Clifford W. Bogue, Yale University School of Medicine, New Haven, CT
The potential to repair tissues and organs from stem cells has generated great excitement over the past year. Many diseases and pathological conditions, such as liver failure, spinal cord injury, Alzheimer’s disease and myocardial infarction, are now being viewed as potentially curable conditions through the use of stem cells. This session will focus on the developmental biology of stem cells and their amazing ability to give rise to many different fully-differentiated cell types. Investigators in the field of stem cell biology will discuss the potential advantages and limitations of using human embryonic stem cells, the plasticity of bone marrow-derived stem cells, and the therapeutic use of stem cells to regenerate damaged organs.

12:00pm – 1:30pm
Poster Session IV (Author Attended)
– Behavioral Pediatrics

1:45pm – 3:30pm
Platform Session
7804 Neurodevelopmental Disabilities II: Autism, ADHD and Neuroimaging
Chairs: Ronald L. Lindsay and Nancy J. Roizen

1:45pm – 3:45pm
Hot Topic
7701 The Cytokine Controversy
Chair: William Keenan, St. Louis University, St Louis, MO
Recent evidence suggests that the inflammatory response of the fetus can result in brain and lung injury pre and postnatally. Are cytokines the mediators of injury or mere bystanders? What therapeutic interventions can protect the neonate? Is it already too late by birth? The speakers will present both the pros and cons of the inflammatory response and a panel discussion will attempt to summarize available information and suggest questions and potential strategies for future research.

1:45pm – 3:45pm
Hot Topic
7702 Disaster Preparedness: Beyond 9/11
Chairs: Tina L. Cheng, Johns Hopkins University School of Medicine, Baltimore, MD; Danielle Laraque, Mount Sinai School of Medicine, New York, NY; and Benard Dreyer, New York, NY
The impact of 9/11 and the public health aftermath have affected us personally and professionally. This session will address what the child health professional needs to know regarding disaster planning and preparedness. Speakers will review and provide updates on national and regional systems for emergency management and how those systems interact with local public health agencies, the pediatrician's role in the community's preparedness including what the school system, the pediatric office and the patient should be doing to prepare and respond, recognition and management of chemical and biologic agents of terrorism, and the psychological reactions to disaster and stress.

Disaster Planning and Preparedness for Child Health Professionals
George L. Foltin, New York University School of Medicine and Bellevue Hospital Center, New York, NY
Biologic Agents of Terrorism
Anne Fine, New York City Department of Health, New York, NY
Chemical Agents of Terrorism
Fred Henretig, University of Pennsylvania School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA
Helping Children Cope with Terrorism and Disasters
David J. Schonfeld, Yale University School of Medicine, New Haven, CT
Discussion