3100      Cellular Basis of Ischemia-Reperfusion Injury in Children
PAS/ASPN Topic Symposium ~ Room 608/609
Chairs: Sharon P. Andreoli, Indiana University School of Medicine, Indianapolis, IN and Mark Payne, Wake Forest University School of Medicine, Winston-Salem, NC

The focus of this symposia is on ischemia-reperfusion injury in children. There are many settings during infancy and childhood where damage may occur from an ischemic, or hypoxic, event and include birth asphyxia, cardiovascular collapse or even organ transplantation. This multidisciplinary symposium will examine the molecular and cellular events underlying cell injury following such events.
 

Ischemia-Reperfusion in the Developing Brain-Role of Oxidative Stress
Donna M. Ferriero, University of California, San Francisco, CA
 

The Cellular Biology of Renal Ischemia-Reperfusion Injury
Bruce Molitoris, Indiana University School of Medicine, Indianapolis, IN
 

Endogenous Inhibitors and Promoters of Cell Survival in the Ischemic Heart
Michael T. Crow, Johns Hopkins University, Baltimore, MD
 

Inflammatory Mechanisms of Ischemia-Reperfusion Injury in the Brain
Faye S. Silverstein, University of Michigan, Ann Arbor, MI
 

3675A Hot Topics in Renal Genetic Diseases
ASPN Symposium ~ Room 4C2
Chairs: Friedhelm Hildebrandt, University of Michigan, Ann Arbor, MI and Lisa Satlin, Mount Sinai School of Medicine, New York, NY

This session will highlight recent progress that has been made in the identification of genes that are mutated in several hereditary diseases associated with high morbidity in the pediatric population. The objective is to understand the molecular mechanisms underlying the genesis of each of these diseases. Discussion will focus on the identity of the responsible gene, its localization within the kidney and physiology.
 

ARPKD: Identification of the Gene and Analysis of the Protein
Peter C. Harris, Mayo Clinic, Rochester, MN
 

Discovering Novel Disease Mechanisms by Positional Cloning of Genes Causing Nephronophthisis
Friedhelm Hildebrandt, University of Michigan, Ann Arbor, MI
 

The Genetics of Primary Hyperoxalurias
Craig B. Langman, Feinberg School of Medicine, Northwestern University, Chicago, IL
 

Cystinuria
Paul R. Goodyer, McGill University, Montreal, Canada
 

The Roles of Podocin and Nephrin in Podocyte Biology
William E. Smoyer, University of Michigan, Ann Arbor, MI
 

3805      Nephrology I
ASPN/PAS Platform Session ~ Room 4C2
 

3900      Nephrology Posters I & Exhibits
ASPN/PAS Poster Session I ~ Exhibit Hall E
 

ASPN Social Event
Columbia Tower Club, Bank of American Tower, 701Fifth Avenue

* Shuttle service leaves from the Grand Hyatt starting at 7:45pm, and runs continuously until 10:15pm.
 

4370A      Nutrition and Growth in Pediatric Kidney Disease
ASPN Symposium ~ Room 611/612
Chairs: Bradley Warady, The Children's Mercy Hospital, Kansas City, MO and Vimal Chadha, Virginia Commonwealth University, Richmond, VA

Growth failure is one of the onerous clinical manifestations of chronic renal insufficiency in infants, children and adolescents and is multifactorial in origin.  Malnutrition can have a profound impact on growth and overall paatient outcome and neuropeptides such as alpha melanocyte-stimulating hormone and neuropeptide Y may play a role.  The bone status is influential and control of secondary hyperparathyroidism and prevention of adynamic bone are needed to maximize growth velocity.  Finally, new approaches to individualizing recombinant growth hormone therapy to address the pertubations of the GH/IGF axis may result in superior outcomes. 
 

Nutrition, Growth and Development in Children with Chronic Renal Insufficiency  
Bradley A. Warady, The Children's Mercy Hospital, Kansas City, MO
 

The Impact of Neuropeptide Signaling on Nutrition in Chronic Renal Disease
Robert H. K. Mak, Oregon Health & Science University, Portland, OR
 

Renal Osteodystrophy and Growth
Isidro B. Salusky, UCLA School of Medicine, Los Angeles, CA
 

Optimization of Growth Hormone Therapy
Ron G. Rosenfeld, Lucile Packard Foundation for Children's Health, Palo Alto, CA
 

4515      Nephrology Posters II & Exhibits
ASPN/PAS Poster Session II ~ Exhibit Hall E 
 

4600      Pediatric Solid Organ Transplantation in the 21st Century
PAS/ASPN/AST/LWPES/NASPGHAN Topic Symposium ~ Room 4C2
Chairs: Ellis D. Avner, President, ASPN, Mitchell B. Cohen, President, NASPGHAN and Mark A. Sperling, President, LWPES

Organ transplantation remains the final therapeutic option for many patients with chronic diseases of many organ systems. Extraordinary advances in molecular and cellular biology have led to new immunological approaches which should make the holy grail of immune tolerance a reality for the 21st century. This symposium will focus on the exciting advances in four areas       of pediatric solid organ transplantation: pancreatic organ and islet transplantation as a cure for diabetes, hepatic transplantation for chronic hepatic and metabolic disease, renal transplantation for end stage renal disease and small bowel transplantation for previously untreatable catastrophic bowel injury. This symposium is proudly sponsored by the American Society of Pediatric Nephrology (ASPN), the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), and the Lawson Wilkins Pediatric , and supported by funding from the American Society of Transplantation and the Juvenile Diabetes Research Foundation International.
 

Evolving Therapeutic Role of Transplant Therapies for T1DM
David M. Harlan, National Institutes of Health, Bethesda, MD
 

Hepatic Transplantation-Controversies and Challenges
Suzanne V. McDiarmid, University of California, Los Angeles, CA
 

Renal Transplantation-Approaching the Holy Grail
William E. Harmon, Harvard Medical School, Children's Hospital, Boston, MA
 

Small Bowel Transplantation-Ready for Prime Time
Simon P. Horslen, University of Nebraska Medical Center, Omaha, NE
 

Sponsored jointly with the American Society of Pediatric Nephrology, American Society of Transplantation, North American Society of Pediatric Gastroenterology, Hepatology and Nutrition and Lawson Wilkins Pediatric Endocrine Society and the Pediatric Academic Societies

Supported by an educational grant from the American Society of Transplantation and the Juvenile Diabetes Research Foundation International
 

5080A ASPN Breakfast and Awards
Grand Hyatt ~ Leonesa I & II
     

Awards Presentations & Presidential Address

Research Training Awards
Lisa M. Satlin, M.D., Mt. Sinai School of Medicine, New York, NY, Presenter
Recipients:
Gina-Marie Barletta, M.D., Fellow, University of Michigan Health Systems, Mott Children's Hospital
Michael Riordan, M.D., Fellow, Yale University School of Medicine
Robert Woroniecki, M.D., Fellow, Albert Einstein College of Medicine, Children's Hospital at Montefiore

American Academy of Pediatrics Section on Nephrology  - Henry L. Barnett Award
Steven Wassner, M.D. Hershey Medical Center, Hershey, PA, Presenter
Recipient:
Richard N. Fine, M.D., Professor and Chairman, Department of Pediatrics, Stonybrook University School of Medicine, Stonybrook, NY

Founder's Award
Ira Greifer, M.D., Montefiore Medical Center, Bronx, NY, Presenter
Recipient:
Alan B. Gruskin, M.D., Professor, Department of Pediatrics, Wayne State University School of Medicine

ASPN Presidential Address
Ellis D. Avner, M.D., Chief Medical Officer, Rainbow Babies and Children's Hospital, Cleveland, OH
 

5270A Primer on Renal Coding and Billing
ASPN Workshop ~ Room 3AB
Chair: Sandra Watkins, University of Washington/Children's Hospital, Seattle, WA and Watson Arnold, Cook Children's Medical Center, Fort Worth, TX

This workshop will help the practicing pediatric nephrologists to understand the basis for various renal-specific CPT codes, code and bill properly for clinical care, document appropriately and build a fiscally sound dialysis program.
 

E&M Codes, Dialysis Codes and MCP
Chester Amedia, Renal Disease Management, Boardman, OH
 

Facility Billing, Composite Rate
Mark W. Joseph, Phoenix Children's Hospital, Phoenix, AZ
 

Documentation
Jordan M. Symons, University of Washington/Children's Hospital, Seattle, WA
 

11:30

Exception for Dialysis Facility
Stuart Goldstein, Baylor College of Medicine/Texas Children's Hospital, Houston, TX
 

5570A      Hypertension-Related Target Organ Damage in Children
ASPN Symposium ~ Room 608/609
Chairs: Joseph Flynn, Montefiore Medical Center, Bronx, NY and Jonathan Sorof, UT-Houston Medical School, Houston, TX

Hypertension is known to cause target-organ damage in adults, but the adverse effects of hypertension in children are less well-described.  In this session, issues related to the detection and manifestations of hypertension-mediated target organ damage will be discussed, as well as possible strategies for reversal of such injury.
 

Hypertension-Induced Vascular Injury
Samuel S. Gidding, A.I. DuPont Institute, Wilmington, DE
 

Detection of Target Organ Damage
Stephen R. Daniels, University of Cincinnati College of Medicine, Cincinnati, OH
 

What Is the Blood Pressure Threshold for Development of Target Organ Damage in Children
Jonathan M. Sorof, UT-Houston Medical School, Houston, TX
 

Pathophysiology of Microalbuminuria in Hypertension and Reversibility with Treatment
George Bakris, St. Luke's Medical Center, Chicago, IL
 

Co-sponsored by the American Society of Pediatric Nephrology and the International Pediatric Hypertension Association

Supported by an educational grant from the International Pediatric Hypertension Association (IPHA) and King Pharmaceuticals
 

5750A      Genomics and Proteomics in Renal Development and Disease
ASPN Symposium ~ Room 608/609
Chairs: Lisa M. Guay-Woodford, University of Alabama at Birmingham, Birmingham, AL and Robert H.K. Mak, Oregon Health & Science University, Portland, OR

The success of the Human Genome Project has created unparallelled opportunities for global analyses of gene expression.  This approach has the potential to explain the molecular basis of development and differentiation and to identify both diagnostic and therapeutic targets for  a wide array of human diseases.  Furthermore, since the number of functional genes estimated from the Human Genome Project is less than expected and may not account for the complexity of biological pertubations, protein profiling may be even more informative than gene or mRNA profiling.  In this symposium, we will present examples of how advances in both functional genomics and proteomics have impacted research in pediatric nephrology.
 

Biomarker Discovery: Integration of Genomic and Proteomic Approaches
Srinivasa R. Nagalla, Oregon Health & Science University, Portland, OR
 

Global Changes in Gene Expression During Renal Development
Sanjay Nigam, University of California, San Diego, La Jolla, CA
 

Arrays Amaze: The Many Faces of Allograft Dysfunction
Minnie Sarwal, Stanford University, Stanford, CA
 

Gene Expression in Ischemia
Prasad Devarajan, Cinncinnati Children's Hospital Medical Center, Cincinnati, OH
 

The National Institute of Diabetes, Digestive and Kidney Diseases is sponsoring a prospective trial of treatments for children and young adults with focal segmental glomerulosclerosis (FSGS).  Clinical Centers have been chosen for the study, and a treatment protocol is being developed.  However, little is known about the pathogenesis of FSGS.  The clinical study will provide the opportunity to collect patient samples for concurrent or future analysis. The Open Workshop is planned to provide an opportunity for all pediatricians, not only nephrologists, to provide input regarding what additional samples should be stored and how they might be tested.  It is anticipated that collaborations will develop to study various aspects of FSGS, including epidemiology, genetics, endocrinology, cardiology, immunology or physiology.  Potential availability of additional funding  also will be considered.
 

H. William Schnaper, Northwestern University, Chicago, IL
Marva M. Moxey-Mims, NIH/NIDDK/DKUH, Bethesda, MD