Lawson Wilkins Pediatric Endocrine Society
May 2 – 6, 2003
Grand Hyatt Seattle & Washington State Convention and Trade Center

Register by March 7th for substantial savings.  

• Pre-Registration has closed.
  Onsite Registration will be available.

• Housing has closed—If you need assistance obtaining housing, please contact the Seattle Housing Bureau, 8:30am–5:00pm (Pacific Time), Monday–Friday, at: 888-877-0255 (toll free) or 206-461-5881 (international).

Contact for LWPES information:

Raymond Hintz, MD
Department of Pediatrics 
Stanford University Medical Center 
Rm. S-302  
Stanford CA 94305    
Phone:  650-723-5791    Fax:  650-725-8375 
Email: hintz@stanford.edu 
URL: www.lwpes.org

Contact for housing, registration and general information:
PAS Program Office
3400 Research Forest Dr.   
The Woodlands, TX  77381
Phone:  281-419-0052     Fax: 281-419-0082
Email:  info@pas-meeting.org

URL:  www.pas-meeting.org

Conference 
Objectives

At the conclusion of this educational activity the participant should be better able to:

• Comprehend new information and skills in various areas of basic and clinical pediatric research.

• Apply knowledge gained in all areas of pediatric investigation and practice.

• Understand new tools for teaching and practicing of medicine related to pediatrics.

Continuing 
Education

Continuing Education is through the PAS, as follows:

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Tulane University Health Sciences Center and the Pediatric Academic Societies. Tulane University Health Sciences Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Tulane University Health Sciences Center designates this educational activity for a maximum of 36.50 hours in category 1 credit toward the AMA Physician’s Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the educational activity.

Tulane University Health Sciences Center presents this activity for educational purposes only. Participants are expected to utilize their own expertise and judgment while engaged in the practice of medicine. The content of the presentations is provided solely by presenters who have been selected because of their recognized expertise.
 

LWPES Program Schedule 
(as of March 26, 2003)

THURSDAY, MAY 1

LWPES Executive Board Meeting
Sheraton ~ Suite 418-420
 

LWPES Committees 
Sheraton 

• Program Committee ~ Poplar

• Drug & Therapeutics Committee ~ Suite 416

• Intersex Committee ~ Suite 430

• Professional & Clinical Affairs Committee ~ Suite 418-420
   

LWPES Executive Committee 
Sheraton ~ Suite 422-424
 

LWPES Reception
Sheraton ~ Metropolitan Ballroom
 

3270A LWPES Plenary Session I
Room 6B
 

Lawson Wilkins Lecture 
Lessons from Tissue-Specific lgfl Knockout Mice
Derek LeRoith, National Institutes of Health, Bethesda, MD
 

Robert Blizzard Lecture
Autoimmune Polyglandular Syndrome Type I: Clinical Insights from Molecular Discoveries
Diane Mathis, Joslin Diabetes Center, Boston, MA
 

Coffee Break
 

Esoterix Lecture
Defective Signaling in Endocrine Disorders
Allen Spiegel, National Institutes of Health, Bethesda, MD
 

Lunch Break
 

3740A      Diabetes Symposium
Room 6B
Chair: Nicole Glaser, University of California, Davis, Sacramento, CA

Significant advances in both the understanding of the underlying causes, as well as in pragmatic aspects of clinical management of diabetes, are highlighted. Work at three levels: 1) biology of islet cell function and survival, 2) analysis of informative monogenic forms of diabetes, and 3) new methods of diabetes monitoring, will be discussed.
 

Common Threads in Types I and II Diabetes
Morris White, Joslin Diabetes Center, Boston, MA
 

New Monogenic Forms of Diabetes: Insights and Puzzles
Constantine Polychronakos, McGill University, Montreal, Canada
 

New Monitoring Methods in Diabetes
Denis Daneman, Hospital for Sick Children, Toronto, Canada
 

Clinical Management Controversies Workshops
LWPES Workshops

Controversial issues in the management of patients will be discussed in the context of patient presentations.
 

3875A

Workshop I-Adrenal
Room 3A
Chairs: Walter Miller, University of California at San Francisco, San Francisco, CA and Phyllis Speiser, New York University, Manhasset, NY

• Surgical Treatment for Ambiguous Genitalia- Who Are We Treating and When?

• Prenatal Treatment of CAH-Should All Fetuses Be Treated and By Whom?
   

3876A

Workshop II-Thyroid
Room 2A
Chairs: Thomas Foley, University of Pittsburgh, Pittsburgh, PA and Stephen LaFranchi, Oregon Health & Science University, Portland, OR

• The Preterm Infant with Hypothyroxinemia

• Thyroid Nodules-The Initial Approach

• Thyroid Cancer Treatment of Children: Role and Extent of Surgery, Radioactive Iodine Therapy, Follow up
   

3877A

Workshop III-Hypoglycemia in Infants and Children (Ketotic and Nonketotic)
Room 3B
Chairs: Charles Stanley, Children's Hospital of Philadelphia, Philadelphia, PA and Joseph Wolfsdorf, Children's Hospital Boston, Boston, MA

• Diagnostic Workup, Role of Genetic Testing

• Medical and Surgical Therapies
   

3878A

Workshop IV-Private Practice Issues in Pediatric Endocrinology
Room 2B
Chairs: Jay Cohen, The Endocrine Clinic P.C., Memphis, TN, Henry Anhalt, Maimonides Medical Center, Brooklyn, NY and Naomi Neufeld, Neufeld Medical Group, Los Angeles, CA

• Common Issues in the Private Practice of Pediatric Endocrinology
   

3925      Endocrinology Posters I, PAS Opening Reception & Exhibits
(Exhibit Hours:  4:00pm-7:30pm)
Poster Session I ~ Exhibit Hall E

• Available for Viewing ~ 4:00pm-7:00pm

• Author Attendance ~ 5:15pm-7:15pm

SUNDAY, MAY 4

4360A LWPES Presidential Lecture 
Room  6B

Diversity Amidst Unity
Mark A. Sperling, President, LWPES,  University of Pittsburgh, Children's Hospital, Pittsburgh, PA
 

4531      Endocrinology Posters II & Exhibits
(Exhibit Hours:  11:00am-3:00pm)          
PAS/LWPES Original Science Abstracts ~ Exhibit Hall E

• Available for Veiwing ~ 11:00am-3:00pm

• Author Attendance ~ 11:45am-1:45pm

4600      Pediatric Solid Organ Transplantation in the 21st Century
PAS/ASPN/AST/LWPES/NASPGHAN Topic Symposium ~ Room 4C2
Chairs: Ellis D. Avner, President, ASPN, Mitchell B. Cohen, President, NASPGHAN and Mark A. Sperling, President, LWPES

Organ transplantation remains the final therapeutic option for many patients with chronic diseases of many organ systems. Extraordinary advances in molecular and cellular biology have led to new immunological approaches which should make the holy grail of immune tolerance a reality for the 21st century. This symposium will focus on the exciting advances in four areas of pediatric solid organ transplantation: pancreatic organ and islet transplantation as a cure for diabetes, hepatic transplantation for chronic hepatic and metabolic disease, renal transplantation for end stage renal disease and small bowel transplantation for previously untreatable catastrophic bowel injury. This symposium is proudly sponsored by the American Society of Pediatric Nephrology (ASPN), the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), and the Lawson Wilkins Pediatric, and supported by funding from the American Society of Transplantation and the Juvenile Diabetes Research Foundation International.
 

Evolving Therapeutic Role of Transplant Therapies for T1DM
David M. Harlan, National Institutes of Health, Bethesda, MD
 

Hepatic Transplantation-Controversies and Challenges
Suzanne V. McDiarmid, University of California, Los Angeles, CA
 

Renal Transplantation-Approaching the Holy Grail
William E. Harmon, Harvard Medical School, Children's Hospital, Boston, MA
 

Small Bowel Transplantation-Ready for Prime Time
Simon P. Horslen, University of Nebraska Medical Center, Omaha, NE
 

Sponsored jointly with the American Society of Pediatric Nephrology, American Society of Transplantation, North American Society of Pediatric Gastroenterology, Hepatology and Nutrition and Lawson Wilkins Pediatric Endocrine Society and the Pediatric Academic Societies 
Supported in part by an educational grant from the American Society of Transplantation and Juvenile Diabetes Research Foundation International
 

4780  Sex and the Pediatrician
PAS/LWPES State of the Art ~ Room 6B
Chair: David Geller, UCLA School of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA

The processes of gonadal differentiation, X-inactivation and the proper imprinting of selected genes are all required for the correct development of gonadal and phenotypic sex. Recent advances in these three areas will be presented.
 

4800      Getting the Fat Out: A Practical Approach to Pediatric Lipid Disorders
PAS/LWPES Mini Course ~ Room 611/612
Chairs: Brian W. McCrindle, The Hospital for Sick Children, Toronto, Ontario, Canada and Charlotte M. Boney, Rhode Island Hospital, Providence, RI

This course will review the evaluation and treatment of lipid disorders in children. Although diet and obesity are the most common causes of lipid disorders in children, the practitioner needs to be able to distinguish familial from acquired hyperlipidemias. The format will include four speakers who will present 1) lipoprotein biosynthesis and metabolism, primary (familial) versus secondary (acquired) disorders and selective screening; 2) dyslipidemia of obesity and insulin resistance; 3) non-pharmacologic treatments of managing dietary changes and obesity; and 4) the pharmacologic treatment of primary hyperlipidemias. Each session will include examples of the practical application of the material. The course will conclude with a panel discussion of the speakers with plenty of time for questions.
 

4852  "Home from War" - Follow Up Post Hematopoietic Stem Cell Transplant
PAS/ASPHO Topic Symposium ~ Room 602/604
Chair: Nancy Bunin, The Children's Hospital of Philadelphia, Philadelphia, PA

Children return to their referring hematologists/oncologists or pediatricians for follow up post hematopoietic stem cell transplant (HSCT). This session will discuss some of the issues, both immediate and long term, that these children face. Many patients may require special care due to chronic graft vs. host disease, and the current treatment, challenges and particular infectious concerns of these patients will be discussed. Immune reconstitution post HSCT will be described, with presentation of newer therapies to accelerate reconstitution. Finally, survivors of HSCT are at risk for multiple endocrinologic abnormalities, including growth failure, hypogonadism and hypothyroidism. The endocrinologic follow-up of these patients and current intervention will be discussed.
 

Panel Discussion
 

Sponsored jointly with the American Society of Pediatric Hematology/Oncology and the Pediatric Academic Societies
 

5350  Bone Health
PAS/LWPES Topic Symposium ~ Room 6B
Chair: Catherine Gordon, Children's Hospital, Boston, MA

Healthy bones in childhood are of vital importance, for they determine future bone health or disease in adulthood. In this symposium, recent advances in the understanding of the biology of bone formation and turnover will be discussed. Clinical disorders affecting pediatric bone health, and the assessment of their impact, will be presented. The controversial issue of whether breast-fed babies should be given supplemental vitamin D will be considered next. Finally, recent advances in the use of new anti-resorptive agents in the treatment of metabolic bone diseases of children will be presented.
 

Disorders Affecting Pediatric Bone Health and Their Assessment
Laura K. Bachrach, Stanford University Medical Center, Stanford, CA
 

5550  The March of Dimes Prize in Developmental Biology Lectures
Room 6E

Come hear lectures by two distinguished scientists whose studies revealing the structure and function of nuclear hormone receptors has earned them the 2003 March of Dimes Prize in Developmental Biology.

Nuclear hormone receptors are molecules of DNA that help regulate genes located in the nuclei of cells.  These receptors act as go-betweens for hormones, which need their cooperation to send instructions to targeted genes - telling these genes when to be active, how much product they should make, and which specific tissue or organs to affect.  It is through interaction with these receptors that hormones exercise control of many functions essential to life and health, including metabolism, reproduction, growth, and cell differentiation. 

The pioneering research of Prof. Chambon and Dr. Evans has laid the foundation for our understanding of the roles of nuclear receptors in metabolic diseases and their treatment.  Their work has opened up productive new areas in endocrinology and physiology and led directly to the development of dozens of new drugs to treat birth defects, pediatric disorders, endocrine-related cancers, and other serious illnesses.

More recently, Dr. Chambon has focused on the crucial importance of the vitamin A derivative retinoic acid as a hormone signal during the early stages of development.  His studies suggest that genetic modifications in the process of retinoic acid synthesis could be responsible for early embryonic death and spontaneous abortion in humans.

Dr. Evans' recent studies have led to a new hormone that appears to be the molecular trigger controlling the formation of fat cells.  This hormone and its chemical derivatives represent one of the newest and most important advances in understanding problems arising from excess weight and obesity and the potential treatment of adult onset diabetes (Type II diabetes).
 

Genetic Dissection of Retinoid Signaling in Development and Homeostasis
Pierre Chambon, Professor and Director of the Institute for Genetics and Cellular and Molecular Biology, CNRS/INSERM/Université Lous Pasteur , Strasbourg, France
 

Nuclear Receptor: The Complex Journey to Obesity
Ronald M. Evans, Professor, Gene Expression Laboratory and March of Dimes Chair in Molecular & Developmental Biology, The Salk Institute for Biological Studies, La Jolla, CA
 

5652      Newborn Screening: Challenges and Controversies
PAS/LWPES Topic Symposium ~ Room 6B
Chair: Edward R. B. McCabe, David Geffen School of Medicine at UCLA, Mattel Children's Hospital, Los Angeles, CA

Newborn screening programs, which have been in place for more than 40 years, are facing major challenges. Technological advances permit the addition of an increasing number of diseases, including many for which the benefits are not as clear-cut as for PKU, congenital hyperthyroidism or sickle cell disease. As pilot projects evaluate the addition of new tests, the importance of involving parents in decision-making is being actively discussed. Originally established with a "public health imperative," the predominant state model has been one of "informed dissent." Various models for informing and involving parents will be discussed, as well as their feasibility and cost. There are a number of legislative developments under consideration locally and nationally, and these will be presented and analyzed. As new diseases are considered for addition to screening batteries, it is possible to screen for disorders that have no effective interventions defined. It is clear that if we do not screen for these diseases, no improvements in care will advance. We will discuss whether such arguments justify screening. In summary, technological advances are forcing policy decisions. We will discuss the impacts of these challenges.
 

5653      Nutrient Signaling
PAS/LWPES Topic Symposium ~ Room 611/612
Chair: Philip A. Gruppuso, Rhode Island Hospital and Brown University, Providence, RI

In the past several years, considerable progress has been made in understanding the mechanisms by which nutrient availability controls cell growth and proliferation. While hormonal mechanisms have been carefully studied and are well established, the signal transduction mechanisms that account for nutrient responsiveness at the cellular level have only recently come under intense scrutiny. This symposium will focus on these cellular mechanisms. Topics will include the nutrient regulation of cell proliferation, nutritional control of mRNA translation and the developmental modulation of nutrient signaling. In particular, speakers will focus on the molecular nature and regulation of cell signaling mechanisms that are nutrient-responsive, the integration of these signaling pathways and their developmental modulation. A goal of the symposium is to provide a physiological context for these signaling mechanisms, thereby establishing their relationship to a critical area in pediatrics, the nutritional control of growth.
 

Sponsored jointly with the Lawson Wilkins Pediatric Endocrine Society and the Pediatric Academic Societies
 

6300  Early Origins of Later Life Disease
PAS/LWPES State of the Art ~ Room 6C
Chair: Sherin U. Devaskar, University of California, Los Angeles, CA

This session will address the topic of "perinatal origins of adult disease." The three speakers will address different aspects related to the early origins of adult disease. Dr. Kent Thornburg will address the issues related to the fetal origins of adult-onset cardiovascular disease, Dr. Guiseppe Colasurdo will discuss the impact on adult-onset reactive airway disease due to postnatal exposure to environmental stimulants, and Dr. Pinchas Cohen will cover the influence of postnatal insulin-like growth factor on the development of carcinogenesis. All three speakers will shed light on the mechanisms underlying the phenomenon of "Perinatal Origins of Adult Disease" in three different disease states using various animal models. This session will provide cutting edge information that will help set the stage for future interventions targeted at the mechanisms outlined.