The focus of this symposia is on ischemia–reperfusion injury in children. There are many settings during infancy and childhood where damage may occur from an ischemic, or hypoxic, event and include birth asphyxia, cardiovascular collapse or even organ transplantation. This multidisciplinary symposium will examine the molecular and cellular events underlying cell injury following such events.

The use of handheld computers in medicine has grown dramatically. This session is intended for those who have a handheld computer (Palm or Pocket PC), or are considering purchasing one, but who have not yet learned how to use it. The goal of the session is to help the beginner achieve a working familiarity with handheld computing such that they will leave the session ready, able and eager to use their own device in their daily life and clinical practice. Ideally, all participants should bring their own handheld. The session will include an overview of the devices and their desktop software; mastery of the basic (built-in) functions: datebook/calendar, address book, memo pad, to-do lists; and add-on applications: where to find them, how to install them and what applications are available specific to clinical pediatrics. Participants should be familiar with the use of personal computers and the Internet, but no prior knowledge of handheld computing is assumed.

Introductions and Overview of Mini Course

Lecture (with Audience Participation)—PDA Basics, Hardware and Software, the Palm OS and Its Functions

Palm OS Functions, Continued; PPC OS

Medical and Pediatric Applications for the PDA
 

In the current climate of funding opportunities, the ability to successfully obtain extramural support involves applying for grants that are appropriate for an investigator's career stage and drafting a clear and focused application. In this session, we will discuss career-stage-appropriate funding opportunities from the NIH. We will also address how to write a grant application, focusing on strategies with proven success. The working of NIH study sections will be reviewed along with how to best address the concerns of review panels. We will also focus on how to obtain funding for fellowship postdoctoral training and early stages of an academic career.
 

Background: Observational research studies have become increasingly complex. The results of observational research studies can be driven by properties other than chance or causation. While these factors may drive the p values of the results, they also change the appropriate interpretation.

Workshop Methods: In the first half of this workshop, we will formally define confounding, effect modification, restriction vs. heterogeneity of exposure, intermediate variables, selection bias and differential vs. nondifferential information bias. In the second half, we will use a case-based approach to illustrate examples of studies in which the results are driven by these factors and compare differences in the appropriate interpretation in the presence and absence of these factors. Minimal math skills will be needed, however, familiarity with basic concepts of study design and data analysis (case control vs. cohort study, interpretation of Ors, etc.) is recommended. We will specifically illustrate examples of effect modification vs. confounding, intermediate variables vs. confounding, selection bias, underpowered studies, and the role of measurement error in determining effect estimates.
 

Based upon our SIG meeting discussion, a number of newborn nursery topics will be addressed. A response by our group B streptococcous work group, headed by John Olsson, to the CDC guidelines will challenge us to prevention in our nurseries of sepsis and concepts for studies. We will discuss jaundice guidelines, screening, treatment and breastfeeding. Hypoglycemia detection and treatment will be surveyed and presented. Current screening with meconium and treatment of substance-exposed infants will be described. We will explore pain control in nurseries and circumcision.

During the session, Latha Chandran will distribute and discuss the results of the survey of our members needs and current practices. We will update our E-mail lists for our members and discuss new teaching ideas.
 

The field of medicine is replete with examples of ways that handheld computers may be used to educate, organize and inform clinicians. There are also examples of how researchers may benefit from this technology. During this more advanced session, we will discuss some of these uses of handheld computers. We will provide examples of software in a variety of domains and discuss their historical, current and future use. We also will demonstrate some future technology and discuss its implications. At the conclusion of this session, participants will have increased familiarity with state-of-the-art applications, techniques to install them and the future of handheld computers and wireless networking.

Introductions and Overview of Mini Course

Lecture with Audience Participation: The Top 10 Novel Uses of PDAs in Health Care

Exercises and Demonstrations
 

Cell and molecular biology have revolutionized our understanding of the aberrant physiology underlying the mechanisms of human disease. Subspecialty training in pediatrics requires a comprehensive understanding of the molecular methodologies involved in the current diagnosis and treatment of human disease, as well as the future design of therapeutic interventions. This workshop is designed to provide the pediatric physician in training with an overview of some basic molecular principles relevant to understanding normal gene expression, as well as an understanding of the methodologies utilized in current diagnostic and experimental designs. Workshop modules will focus on participant identification of several common laboratory methodologies for DNA sub-cloning, generation of reporter gene constructs and reporter gene system analyses. Upon completion of this workshop, participants will be able to (a) describe two critical components for gene sub-cloning and analysis, (b) design a tissue-specific reporter gene construct for both in vitro and/or in vivo analysis and (c) identify two methods for the analysis of genetically altered gene expression in vitro and/or in vivo.
 

This interactive session will provide the attendee with basic information on publication of a manuscript, as derived from the perspective of an editor. Issues (with data provided when possible) to be discussed are:

A. View From the Inside

1. Characters involved
2. Manuscript flow
3. Peer review process
4. Working with the author

B. View From the Outside

1. How to choose the right journal for your paper
2. How to prepare the cover letter
3. How to prepare the abstract
4. How to prepare the body of the manuscript
5. How to prepare the references

C. Conflict of Interest and Ethics
 

The 21st century heralds a paradigm shift in medical education with a focus turned to competence and outcomes. The Accreditation Council for Graduate Medical Education (ACGME) is spearheading a competency-based system of graduate medical education coincident with the American Board of Pediatrics’ (ABP) initiative to transition from periodic "recertification" to "maintenance of certification." Our greatest challenge as educators lies in developing tools to evaluate competence during training and to equip all trainees with the skills necessary to achieve quality continuous professional development in order to maintain their certification in pediatrics.

The overarching goal of this workshop is to explore the value of using technology as a tool for promoting self-assessment and lifelong learning in continuous professional development. We will demonstrate how physicians can use an innovative web-centered tool to document competence in practice-based learning and improvement. Participants will discover how to create and manage a personal list of educational needs based on their professional experiences, develop individualized learning plans to address these needs and then document the impact of learning on their practice.

The outcome of implementing this web-based technology will be the ability to demonstrate competence of our trainees in the domain of practice-based learning and improvement to the ACGME and the preparation of tomorrow’s physicians to demonstrate evidence of continuous professional development in maintaining their certification.
 

What should you do when parents want you to continue burdensome treatments, which you think are futile? What should you do when parents want you to stop intensive care treatment, the continuation of which you think is in the best interests of the child? Who ought to make decisions for the not yet competent? Is it the parents, the doctors, the ethics committee, society or some other disinterested third party? The goal of this seminar is to consider the complexity of these difficult decisions, looking at factual and evaluative considerations. Through interactive case discussion we will identify the problems and potential pitfalls in decision-making for the pediatric population.
 

• Surgical Treatment for Ambiguous Genitalia— Who Are We Treating and When?
• Prenatal Treatment of CAH—Should All Fetuses Be Treated and By Whom?
   

Supported by an educational grant from Ross Pediatrics

Contact for information:
Rebecca Simmons, M.D.
Children’s Hospital, Philadelphia, Abramson Research Center
Room 416, 34th & Civic Center Blvd.
Philadelphia, PA 19104-4318
Phone: (215)590-2895 Fax: (215)590-4267
Email: rsimmons@mail.med.upenn.edu
 

5:15pm–7:15pm
Poster Session I
Original Science Abstracts – Poster Session

• Neonatal Infectious Diseases
• Multi-Organ Ischemia-Reperfusion
• Hematology/Oncology
• Skin
• Bilirubin
• Neonatal Pulmonary and Ventilation
• Epidemiology
• Breast Feeding/Well Child
   

While most of medicine must deal primarily with injury and aging, neonatology deals with the newborn and developing systems. The new biology is being applied to how the infant develops and how injury can be avoided. Wonderful research opportunities span the range from basic research to translational studies to clinical research. The challenge is to get the training necessary to answer the multiple questions for which we need answers.

An informal, friendly discussion on how to succeed in academic neonatology.

Avroy A. Fanaroff, Case Western Reserve University School of Medicine, Cleveland, OH

Pulmonary edema remains a significant problem in acute and chronic lung diseases of the newborn. This session will review our current understanding of the importance of lung fluid balance and respiratory health and provide new insights about this relationship. Dr. Jain will review the role of Na reabsorption and fluid clearance across the respiratory epithelium of the alveolar space with a focus on molecular regulation. Dr. Barker will provide an overview of our understanding of the importance of the airway epithelium in regulating fluid and ion transport. Dr. Bland will discuss new insights on lung fluid balance in evolving and established bronchopulmonary dysplasia.

This program will give a "pediatric perspective" to smallpox bioterrorism preparedness planning efforts now under way within federal, state and local public health agencies. It will include a review of smallpox epidemiology, clinical disease, smallpox (vaccinia) vaccine and lessons learned from the WHO Smallpox Eradication Program. The nature of the current threat and responses to that threat will be discussed.

• Adolescent Follow Up
• Respiratory
• Infection
• Infectious Diseases
• Gastroenterology
• Resuscitation
• Inflammation Markers
• Metabolism
• Population-Based Issues
• Respiratory
   

Organ transplantation remains the final therapeutic option for many patients with chronic diseases of many organ systems. Extraordinary advances in molecular and cellular biology have led to new immunological approaches which should make the holy grail of immune tolerance a reality for the 21st century. This symposium will focus on the exciting advances in four areas of pediatric solid organ transplantation: pancreatic organ and islet transplantation as a cure for diabetes, hepatic transplantation for chronic hepatic and metabolic disease, renal transplantation for end stage renal disease and small bowel transplantation for previously untreatable catastrophic bowel injury. This symposium is proudly sponsored by the American Society of Pediatric Nephrology (ASPN), the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), and the Lawson Wilkins Pediatric , and supported by funding from the American Society of Transplantation and the Juvenile Diabetes Research Foundation International

Receive helpful pointers to make your talks memorable and useful. This session will introduce methods of planning and organizing presentations, preparing and designing visual aids, handouts and clear delivery.
 

The 2001 World Trade Center and anthrax attacks established terrorism as a reality in this country. In addition to anthrax, critical biological agents include smallpox, plague, tularemia, botulinum toxin, and viral hemorrhagic fever. Release of sarin nerve gas in the Tokyo subway system by the Aum Shinrikyo cult in 1995 resulted in some 5,000 casualties, including 12 deaths, and the threat of a radiation incident perpetrated by terrorists is also real. Pediatricians have a key role in the management of illness after a terrorist incident, including biological, chemical or nuclear releases. Effective preparedness requires an increased index of suspicion for unusual diseases or clusters of illness, with prompt reporting to public health authorities to facilitate recognition of an outbreak and subsequent intervention. Psychological effects of a domestic terrorist disaster on children will also need to be managed appropriately. This workshop will address the epidemiologic, clinical, preparedness and response issues relevant to biological, chemical and nuclear threats to children, who are especially vulnerable. Specific and detailed diagnostic and management information will be provided, as well as emergency contact and educational resource information.
 

Increasingly, extremely and very low birth weight preterm infants appear to have marked nutritional deficiencies that are associated with abnormal development. This symposium will focus on three nutrients—amino acids/protein, PUFAs, and iron—reviewing evidence for deficiencies in preterm infants, roles and requirements, and the potential for improving outcome by a more aggressive approach to feeding preterm infants with greater amounts of these nutrients. Scott Denne will discuss the important benefits and potential risks of more aggressive IV amino acid and enteral protein nutrition in preterm infants, focusing on studies of protein and nitrogen balance and growth. Shelia Innis will discuss the role of polyunsaturated essential fatty acids in neural development and neurodevelopmental outcome. Michael Georgieff will discuss the role of iron nutrition in brain development and present results of studies that have addressed neurodevelopmental and cognitive outcome.

This state of the art symposium will be of interest to practitioners, generalists, neonatologists and infectious diseases specialists and will explore current controversies in the diagnosis and management of neonatal HSV infection. Speakers will present maternal factors that may allow interruption of maternal–fetal transmission of the virus, the latest strategies for diagnosis and treatment of newborns and the potential prevention of neonatal HSV by use of pre-emptive antiviral therapy and vaccines.

Discussion

In the face of dramatic alterations in health care delivery during the 1990s, the roles of pediatric generalists and subspecialists have changed. This has led to national debate as to how general pediatricians and subspecialists should be trained, how they should interact and what final product or solution is desired. Both the United States and Canada are affected by these changes. In this session three experts will cover important aspects of this emerging problem.

The processes of gonadal differentiation, X-inactivation and the proper imprinting of selected genes are all required for the correct development of gonadal and phenotypic sex. Recent advances in these three areas will be presented.

This session reviews current research principles in selected sexually transmitted diseases. First, clinical epidemiology and prevention issues for Chlamydia trachomatis are considered, emphasizing rescreening (delayed retesting of infected persons), novel strategies for ensuring partner treatment, and the role of male screening in disease control. Then, new directions in public health and prevention aspects of genital herpes are outlined. An update of the HSV vaccine is presented. Finally, human papillomavirus (HPV) is considered, including new recommendations in human papillomavirus testing, triage of abnormal Pap smears and the current status of HPV vaccines. Questions are encouraged from the audience.

This symposium highlights how a variety of approaches have led to understanding how mutations in specific genes cause abnormalities in cardiopulmonary development. Our focus is on reproducing, in a transgenic animal, a genotype relevant to human disease, observing the fidelity of the phenotype and then establishing the downstream pathobiology. For example, in the case of a transcription factor mutation, the pathobiology should be evident based upon the target genes involved. When an extracellular matrix component is mutated, strategies are designed to define how this alters cellular events that cause disease.

This 2-hour symposium will review two current topics in developmental neurogenetics using both mouse and human malformations to elucidate the molecular basis of normal and abnormal brain development. The two areas covered will be midbrain–hindbrain (brainstem and cerebellum) development and nonradial migration in the forebrain. For both topics, speakers will review existing mouse models and genes known to be involved in key developmental steps, review relevant human malformations and present the results of ongoing research.

In low- and middle-income countries where more than 80% of the world’s population lives, birth defects and other perinatal problems cause more loss of healthy years of life to early mortality and disability than almost any other condition. Yet, development of strategies for the prevention and care of birth defects has received insufficient international attention to date. The reasons for this include: a general lack of knowledge of the problem and of the considerable social and economic toll it imposes; a lack of awareness of the potential for prevention; and, as important, the absence of an international framework of mechanisms for promoting cooperative actions and solutions.

This session will present statistics on the global toll of birth defects and discuss a recent report of the U.S. Institute of Medicine commissioned to identify cost-effective opportunities for care and prevention of birth defects in developing countries. Specific recommendations for priority research, capacity building and institutional efforts to reduce adverse birth outcomes will also be discussed. The session will explore the applicability of the report’s findings to developing countries. It will also suggest what actions are required to implement appropriate public health strategies. It will conclude with a presentation on research directions for care and prevention.

Attendees of this topic symposium will learn of the exciting new advancements in understanding the genetic contributions to a variety of gastrointestinal diseases such as intractable diarrhea, Hirschsprung’s Disease and inflammatory bowel disease.

New information is emerging that attests to the importance of the intrauterine environment on subsequent neonatal and child health. Although premature labor is one of the most acute outcomes that result from alterations in the normal intrauterine environment, more subtle outcomes include those affecting the respiratory and central nervous systems. Dr. Alan Jobe will discuss the exciting new insights that he and his colleagues have made concerning lung function and intrauterine inflammation. Dr. Van Marter will examine the epidemiological information available that highlights the role of intrauterine inflammation and subsequent neurological development.

Family presence for procedures is a relatively new concept in pediatric medicine. Studies have shown that many parents prefer to be with their children when they undergo painful or invasive procedures. Some physicians are reluctant to accept this break with tradition and refuse to allow parents in the room. The purpose of this workshop is to develop an approach to successful procedures with parental presence. Workshop leaders (including physicians, social work, housestaff) will address critical issues such as:

• Review of the literature—what do parents/families want?
• What is best for the children?
• What rights do the parents have? How about the physicians?
• Are some situations/procedures (i.e., resuscitations) "off-limits"?
• How can we instill confidence in trainees when the family is watching?
• Can we preserve teaching opportunities?
• Are there safety risks? Legal issues?
• Enlisting the help of others: the role of liaisons, social workers, therapists

Using case scenarios and role-playing, workshop leaders will address the pros and cons of family presence for procedures. Participants will be expected to share their experiences and ideas to move forward with this "unconventional" approach to medical care. It is expected that through discussion and debate we will implement a system for success.
 

The incidence of lawsuits in the United States continues to rise. Within this environment, pediatricians are vulnerable to litigation yet often have limited experience and information about the legal process and relevant principles of law. Legal dilemmas are particularly common in acute care settings and frequently are managed without the immediate advice of counsel. In this workshop, participants will explore basic legal issues that impact on medical practitioners, gain familiarity with the litigation process and examine strategies for testifying in court. A team of specialists in pediatric emergency medicine, malpractice issues, court testimony and forensic medicine will begin the workshop with an interactive presentation of case scenarios that highlight common statutory dilemmas, malpractice issues and the litigation process (civil and criminal). Participants will then view videotapes of court testimony and discuss strategies for testifying as a fact or expert witness. Workshop leaders and participants will conclude the session with small group discussions of individual experiences with civil or criminal proceedings and legal testimony. A complete syllabus will be provided for the workshop that is designed for use as a teaching manual.
 

Healthy bones in childhood are of vital importance, for they determine future bone health or disease in adulthood. In this symposium, recent advances in the understanding of the biology of bone formation and turnover will be discussed. Clinical disorders affecting pediatric bone health, and the assessment of their impact, will be presented. The controversial issue of whether breast-fed babies should be given supplemental vitamin D will be considered next. Finally, recent advances in the use of new anti-resorptive agents in the treatment of metabolic bone diseases of children will be presented.

Contact for information:
David K. Stevenson, M.D.
Neonatal & Developmental Medicine
Stanford University School of Medicine
750 Welch Road, Suite 315, Palo Alto, CA 94305
Phone: (650)723-5711 Fax: (650)725-8351
EMail: dstevenson@stanford.edu

Al Aynsley-Green, National Clinical Director for Children, Department of Health, Her Majesty's Government, Nuffield Professor of Child Health, The Institute of Child Health, University College London
University of London, Director of Clinical Research & Development, Great Ormond Street Hospital for Children and The Institute of Child Health, London

What happens when there is a public national concern about excessive poor outcomes at a Children's Medical Center? This was the scenario in Bristol, England, where a crisis in the outcome of children after cardiac surgery developed even when well–trained, committed, concerned clinicians and subspecialists were intimately involved. Because of this, Professor Al Aynsley-Green, President of the Academic Paediatricians, was appointed to the new post of National Clinical Director for Children by Parliament and to Chair a Children's Taskforce to answer the question of how can such a negative experience like this be turned into positive outcomes for children? He is charged to secure the health and well-being of all children throughout childhood into adult life by developing a National Service Framework for children's services across health, social care and education.

Lessons he has learned and experiences he has lived will be shared to help pediatricians around the world with our quest to improve the lives and health of children. The goals, activities and experiences of the Children's Taskforce, as well as six external working groups, are exportable, practical and logical. Strategies used for developing opportunities not only to improve child health at a local level but also at a national level will be discussed.

Opportunities for questions and discussion will be provided so attendees can share effective techniques to improve child life and health.

Newborn screening programs, which have been in place for more than 40 years, are facing major challenges. Technological advances permit the addition of an increasing number of diseases, including many for which the benefits are not as clear-cut as for PKU, congenital hyperthyroidism or sickle cell disease. As pilot projects evaluate the addition of new tests, the importance of involving parents in decision-making is being actively discussed. Originally established with a "public health imperative," the predominant state model has been one of "informed dissent." Various models for informing and involving parents will be discussed, as well as their feasibility and cost. There are a number of legislative developments under consideration locally and nationally, and these will be presented and analyzed. As new diseases are considered for addition to screening batteries, it is possible to screen for disorders that have no effective interventions defined. It is clear that if we do not screen for these diseases, no improvements in care will advance. We will discuss whether such arguments justify screening. In summary, technological advances are forcing policy decisions. We will discuss the impacts of these challenges.

In the past several years, considerable progress has been made in understanding the mechanisms by which nutrient availability controls cell growth and proliferation. While hormonal mechanisms have been carefully studied and are well established, the signal transduction mechanisms that account for nutrient responsiveness at the cellular level have only recently come under intense scrutiny. This symposium will focus on these cellular mechanisms. Topics will include the nutrient regulation of cell proliferation, nutritional control of mRNA translation and the developmental modulation of nutrient signaling. In particular, speakers will focus on the molecular nature and regulation of cell signaling mechanisms that are nutrient-responsive, the integration of these signaling pathways and their developmental modulation. A goal of the symposium is to provide a physiological context for these signaling mechanisms, thereby establishing their relationship to a critical area in pediatrics, the nutritional control of growth.

This symposium covers four issues in vaccination. The American Academy of Pediatrics and CDC currently are moving toward a recommendation for universal annual vaccination of infants with killed or live influenza vaccine. Why is this? Now that Rotashield is off the market, a new rotavirus vaccine is needed and may be on the way. Despite good protection of children by vaccination, pertussis infections are rising in adolescents and adults. Can they be controlled? Recent disruptions in vaccine supply have caused pediatricians significant problems. What are the causes and solutions?