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2005 PAS Annual Meeting s May 14 –17 s Washington, DC |
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Last Updated: April 12, 2005 8:00am–10:00am Much remains unknown about the physiology involved in
transition from intra-uterine to extra-uterine life in
the premature or full-term infant. Many strategies
have been employed to manipulate the hormonal milieu
of some of our sickest patients. Assuming adrenal
insufficiency in a critically ill neonate has become
fairly routine, despite precious few data. This
symposium draws on the expertise of endocrinologists
and neonatologists and will enlighten the attendees to
some of the practical clinical controversies that
exist in these patients. Target Audience: Neonatologists, critical care
doctors and endocrinologists. Impact of Postnatal Glucocorticoids on L-HPA Stress
in Axis Development Sick Euthyroid—Should It Be Treated? Adrenal Insufficiency in the PICU/NICU Discussion Sponsored jointly by the Lawson Wilkins
Pediatric Endocrine Society and the Pediatric Academic
Societies 8:00am–10:00am Introduction NCICAIS Intervention: Differences Between Research
and Clinical Settings Asthma Risk Factor Assessment: What Are the Needs of
Inner-City Families? The Asthma Counselor Speaks: Barriers and Successes Aligning Incentives For Optimal Asthma Care Discussion 8:00am–10:00am Transitions are a part of everyone's life experience.
Most young people with special health care needs and
disabilities (SHCN/D) become independent members of
adult society, but some need deliberate guidance and
support. With increasing success in reducing the
mortality of once devastating pediatric diseases, the
latter group is growing in number. A new consensus
statement from the American Academy of Pediatrics and
the U.S. Federal Government (Healthy People 2010) has
focused attention on the need to assist young people
with SHCN/D in attaining their potential in adulthood.
This symposium will discuss the growing number of
young people with SHCN/D and present approaches for
effecting these transitions. Specific disease-related examples will be used to highlight
the issues, the barriers and the key elements of
successful programs that transition patients from
pediatric care to the adult system. All Grown Up and Wondering What To Do: Transitioning
Complex Pediatric Patients to Adult Care Transition Best Practices Transition to Adult Care in the Nephrology
Population–Renal Failure or Success Training and Workforce Issues for Successful
Transition Discussion Sponsored jointly by the American Society
of Pediatric Nephrology, Lawson Wilkins Pediatric
Endocrine Society and the Pediatric Academic Societies 8:00am–10:00am 8:00am–10:00am 8:00am–10:00am 8:00am–10:00am 8:00am–10:00am 8:00am–10:00am 8:00am–10:00am 8:00am–10:00am 8:00am–10:00am 8:00am–10:00am 8:00am–10:00am 8:00am–10:00am The Programme for Global Paediatric Research (“PGPR”)
is an international union of paediatric scientists and
societies. It has been formed to address the disparity
between the scientific resources available in
high-income countries and the quantity of scientific
research aimed at child health problems in mid- and
low-income countries. PGPR brings together scientists
from throughout the world for the purposes of
education, collaborative research, and ultimately the
maintenance of child health and the cure of childhood
diseases. This three-part symposium will focus on the
serious problem of birth asphyxia in developing
countries. Part 1 will provide a review of the
clinical problem. Part 2 will feature platform
presentations from selected abstracts on issues
surrounding birth asphyxia. Part 3 will be comprised
of region-specific presentations. At the follow up
workshop on May 18 colleagues from high-, mid- and
low-income regions, who are working in fields related
to birth asphyxia, will meet in order to examine the
issues surrounding birth asphyxia and establish clear
plans for collaborative study and other action. One of
the expected outcomes of the workshop will be the
development of a preliminary statement and plan for
action concerning birth asphyxia in developing
countries. Target Audience: Researchers and clinicians
interested and/or involved in all aspects of the study
of birth asphyxia, in any setting. Introduction and Overview Pathophysiology of Birth Asphyxia Prevention and Treatment of Birth Asphyxia Outcome Studies on Birth Asphyxia 8:45am–11:45am Promoting cultural competency in resident training
prepares residents to meet the needs of our diverse
population. The focus of this workshop is to introduce
a process of planning, implementing and evaluating a
comprehensive curriculum designed to help residents
develop interpersonal and communication skills that
will facilitate delivery of culturally effective
health care. The competencies for 'Delivery of
Culturally Effective Care' proposed by The Anne E.
Dyson Community Pediatrics Training Initiative
Curriculum Committee will be discussed in the context
of this curriculum. Participants will be introduced to
different models and methodologies to promote cultural
competency in health care delivery and then will
generate a systematic approach to fit their own
program needs. Objectives:
Method of Instruction: Short didactic presentations,
group discussion, and small group problem solving
sessions. Target Audience: Junior faculty, mid-level faculty. 8:45am–11:45am Ten residency-training programs across the country,
recognized as the Anne E. Dyson Community Pediatrics
Training Initiative, have investigated how to enhance
graduate medical education for pediatricians to
directly improve the health of children. These diverse
programs have partnered with community-based
organizations (CBOs) to develop innovative service
learning experiences for pediatric residents. This
workshop will engage participants and facilitators in
sharing examples of effective community–academic
partnerships that contribute to the knowledge, skills
and attitudes of pediatric residents for community and
public health improvement. Objectives:
Method of Instruction: An interactive format of
question and answer, with use of specific case
studies/examples from the five residency sites
represented to highlight challenges and solutions
experienced. Target Audience: Trainee, junior faculty, mid-level
faculty, senior faculty. 8:45am–11:45am This workshop will teach participants to recognize
existing or create new resident educational
experiences that meet the Practice-Based Learning and
Improvement (PBL & I) competency. We will also
explore methods for evaluating the PBL & I
competency. Participants will have an opportunity to
design PBL & I tools for their own residency
educational settings. Participants will also be given
examples and ready-to-use tools that can be applied to
a variety of settings. A mini-didactic session will be
followed by interactive small and large group
sessions. Objectives:
Method of Instruction: Short didactic session,
followed by interactive participant small and large
group discussions. Target Audience: Junior faculty, mid-level faculty,
senior faculty. 8:45am–11:45am In order to "prepare residents for the role of
advocate for children," as required by the RRC,
program directors must break advocacy in a set of
competencies and establish appropriate degrees of
mastery for trainees at different levels of residency
training. In this workshop, participants will:
Participants will experience and review a variety of
teaching methodologies and will receive sample
curricula, which may be modified for use at their home
institutions. Objectives:
Method of Instruction: Interactive didactic lecture,
small group discussion and guided synthesis. Target Audience: Junior faculty, mid-level faculty,
senior faculty. 8:45am–11:45am In this interactive workshop, participants will
explore the importance of direct observation of
residents, discuss barriers to initiating a program
for direct observation and review existing tools that
have been generated to aid in structured observation
of patient encounters. "SCORE"—Structured Clinical Observations
for Resident Education—will be introduced as a
program to institute direct observation of residents
in new settings and to address assessment and
documentation of competency. Participants will learn
the basics of SCORE and practice the use of this tool
through illustrative case scenarios, including video,
and develop plans for implementing constructive
feedback for trainees. Participants will receive a
CD-ROM, which will include the video practice-case
scenarios and SCORE forms, for implementation of a
direct observation program in their own practice
settings. Objectives:
Method of Instruction: Interactive discussion, case
scenarios, use of handouts, slides and video. Target Audience: Trainee, junior faculty, mid-level
faculty. 8:45am–11:45am Measurement and feedback are critical components of
quality improvement (QI) initiatives. This workshop
will provide participants with proven methods for
creating measurement and feedback strategies that
support QI initiatives in ambulatory settings (primary
and specialty care). Objectives:
This workshop will include brief presentations based
on recent research findings as well as lessons learned
from several groups involved in national QI
initiatives in ambulatory settings. Using tools
presented during the workshop, participants will work
independently and in small groups to create a balanced
set of measures and an overall measurement strategy
for a potential or existing QI initiative in their own
setting. Method of Instruction: Brief presentations, question
and answer, and small groups. Target Audience: Junior faculty, mid-level faculty,
senior faculty. 8:45am–11:45am Using collaborative learning methods and brief
didactic presentations, this workshop defines chronic
condition management as the "third leg" of
the primary care stool (with health promotion and
acute illness management). Participants will see the
medical home concept in the context of a chronic care
model through which to target specific practice
improvements. Small audience groupings will identify
simple improvement projects, and participants will
commit to implementing two simple improvement projects
in their practice settings. Using an email address
list, participants and faculty will maintain follow-up
conversations and collaborative support for on-going
improvement. Objectives:
Method of Instruction: Problem solving using
collaborative learning and quality improvement methods
with brief didactic presentations targeting audience
interests. Target Audience: Trainee, junior faculty, mid-level
faculty. 8:45am–11:45am With the growth of attention on patient safety and
the expansion of baseline knowledge about patient
safety via research, multiple national level efforts
have been started to focus on pediatric patient
safety. This workshop will have brief presentations
from several of these groups to describe their efforts
to date and plans for the future. Workshop
participants will gain knowledge, attitudes and skills
to help them bring patient safety and quality to
real-time implementation in their daily practice by
learning about these efforts and how they can join.
The workshop will include 1 hour of presentations from
the workshop leaders and then rotating 30-minute
roundtables with individual leaders for workshop
participants to share ideas and inputs on national
efforts. Objectives:
Method of Instruction: Presentation and roundtable
discussions. Target Audience: Trainee, junior faculty, mid-level
faculty. 8:45am–11:45am All pediatricians and subspecialists should be
proficient in using evidence-based medicine in
clinical practice. In this workshop, learners will
participate in interactive, facilitated small group
discussions and a practical exercise to learn the
skills of practicing evidence-based medicine:
The concepts and tools promulgated by the Center for
Evidence-Based Medicine at Oxford will be used during
this workshop. Objectives:
Method of Instruction: Small group discussions with
strong interactive methods. The workshop leaders will
facilitate discussions using real-life example of
important questions and relevant articles from
clinical pediatrics. Target Audience: Trainee, junior faculty, mid-level
faculty. 8:45am–11:45am Parents seek advice from the pediatrician concerning
child behavior management. This past year, Boston
Floating Hospital (BFH) residency implemented a
comprehensive approach to address resident learning
concerning parent education. This workshop will help
participants to develop residency programs by
describing the BFH model. Participants will be
provided with sample materials to support resident
education, including the new AAP Connected Kids
program, to be launched in 2005. The BFH parenting
education series began with a Positive Parenting Week
and continued with monthly lunch conferences. Each
conference began with a case. A variety of techniques
were used to encourage residents to explore their own
values and experiences and to relate these to the
available research and to the case under discussion. Objectives:
Method of Instruction: Brief didactic session, a
reproduction of a sample resident teaching conference
(small group followed by large group), and group
discussion. Participants will be able to take home
Connected Kids pilot kits for use in their clinics. Target Audience: Trainee, junior faculty, mid-level
faculty. 8:45am–11:45am Appropriate medical consultations are critical to
effective patient care. Perhaps outwardly
straightforward, the process leaves physicians and
patients often feeling frustrated and confused.
Physicians in training are also caught in the
consultation crossfire. They generally receive little
guidance or feedback about communicating with
colleagues and caring for patients as a team. These
skills are essential to each of the ACGME
competencies. The faculty presenters will enact a role
play, briefly summarize the literature on
consultations and facilitate small group sessions
where learners will be able to critique and adapt
methods to improve and teach consultation practices in
their own institutions. Learners will be provided a
sample consultation behavioral checklist based on the
ACGME competencies and materials for teaching
residents consultations at their institution. Objectives:
Method of Instruction: Large group facilitation based
on a role play and medical, educational, and business
literature; roundtable discussion aimed at helping
learners solve real problems; and networking. Target Audience: Trainee, junior faculty, mid-level
faculty. 8:45am–11:45am To overcome barriers to the identification and
treatment of obesity in children, we have developed a
program directed at primary care providers and
families of overweight 8–12 year olds. This program,
successful in a research setting, was adapted and
applied in the primary care setting. The program
consists of a module for primary care providers and a
module to train health educators from among the office
staff to deliver a behaviorally based group
intervention focusing on a modification of dietary and
physical activity habits. This interactive workshop
will demonstrate all the components of the program
through role play. Objectives:
Method of Instruction: Brief didactic session
followed by interactive demonstrations of provider and
parent modules. Target Audience: Trainee, junior faculty, mid-level
faculty. 8:45am–11:45am Many pediatric residency training programs offer an
experience in a hospital-based setting or satellite
office. Often times, resident clinics are operated
conjointly with a faculty pediatric practice. This can
lead to confusion for staff and families, poor
productivity and difficulty marketing the practice. During this workshop, two models of successful,
combined resident and faculty practices will be
presented by physician, administrator and nurse
leaders. Both models originated as typical
hospital-based resident clinics that emerged into
productive academic general practices. Participants
will use case studies, large and small group
discussion and problem-solving activities to explore
issues including: (1) understanding productivity
standards and financial reports; (2) teaching billing
and compliance to learners; (3) managing staffing
needs, determining the appropriate provider-to-nurse
ratio, optimizing room utilization, maintaining morale
and addressing reporting structure; (4) providing
continuity of care in an academic practice, including
managing schedules of 30+ providers; (5) educating
learners in this environment; and (6) ensuring quality
improvement and marketing efforts. Workshop
participants will be asked to share and learn from
each other by presenting challenges encountered in
their own practices. Objectives:
Method of Instruction: Large and small group
discussions and problem solving. Target Audience: Mid-level faculty, senior faculty. 8:45am–11:45am This workshop will use a case-based approach to walk
participants through a series of multivariate
regression analyses. Interpretation of the results
before and after each independent variable is added
will illustrate the interpretation and the underlying
concept of statistical adjustment. Graphical
illustration of multivariate regression will further
illustrate these concepts. Emphasis is on
understanding the interpretation of the results rather
than on the mathematical concepts of multivariate
regression, and minimal math skill will be needed for
participation. Objectives:
Method of Instruction: Case-based learning. Target Audience: Trainee, junior faculty, mid-level
faculty. 8:45am–11:45am Since developing an extended-hours service, members
of the University of Michigan Pediatric Hospitalist
Program have been using evening and night-time
admissions to observe house staff "in
action," as they admit pediatric patients to the
ward service. Through videotaped clinical vignettes
and role playing, workshop participants will learn and
practice techniques used to observe, give feedback and
evaluate competency in interview skills, examination
skills and problem-solving skills. In small groups,
participants can focus on one of the following areas:
(1) Developing faculty in techniques of observation
and feedback, (2) developing an evening hospitalist
program with time and support for education and (3)
evaluating the competency assessment
process—research questions and opportunities for
clinical scholar-educators. Objectives:
Method of Instruction: Videotaped and role-played
clinical encounters, small and large group
discussions. Target Audience: Trainee, junior faculty, mid-level
faculty. 8:45am–11:45am Qualitative research methods provide an opportunity
to explore complex questions in medical research. In
this workshop, participants will receive an overview
of commonly used qualitative methods, how qualitative
research is different than quantitative research and
explore some examples of research questions that are
best approached using qualitative methods. They will
then practice using the qualitative research tools on
sample data and discuss the strengths and weaknesses
of the different methodologies in small groups. Each
participant will then identify methods that can be
applied to projects they are currently working on.
Finally, participants will review examples of articles
using qualitative methods to better understand how
data analysis can be translated into scholarly work. Objectives:
Method of Instruction: Large group discussion of
qualitative research methods followed by small group
work in which participants will use a number of
qualitative research tools. Target Audience: Trainee, junior faculty, mid-level
faculty. This workshop is sponsored by the APA
Faculty Development Program in the domain of Research. 8:45am–11:45am From past experience, we realize that our SIG is
well-attended by both residents and faculty.
Therefore, we are striving to put together a SIG
meeting that will meet the needs of both groups. We will continue our well-received Resident Advocacy
Poster Session and give residents the opportunity to
present their work. A new activity this year will be
the opportunity for several residents to give an oral
presentation about their projects. News will be
forthcoming about how and when to submit abstracts
from your housestaff. We are planning an interactive
session with small groups focusing on certain themes,
such as “how to evaluate your advocacy
curriculum,” “how to develop advocacy curricular
experiences with no money” or “what innovative
curricular experiences are out there.” These small
groups will allow more faculty and residents to
participate and share their experiences with others
who are facing similar challenges or opportunities at
their institutions. Finally, we plan to end the SIG
meeting with a moderated Open Forum for both residents
and faculty to address issues raised in the small
groups and next steps for the SIG for the following
year. We look forward to working together, as always, to
improve the training of our housestaff and
consequently the lives of the children in our
communities. 8:45am–11:45am The Medical Student Education SIG welcomes those
interested in any aspect of medical student education.
The SIG is dedicated to collaboration, innovation and
addressing current issues in medical student
education. This year we will continue our work on
competency-based education in the clerkship year by
examining self-identified core competencies. We will
also spend some time addressing the LCME requirements
for the types and numbers of different patients that
medical students are expected to see during the
clerkship experience. Working in both large and small
groups, we hope to develop a list of symptoms, signs
or clinical conditions that would be important for a
medical student to see or evaluate whether in patient,
computer or simulated encounters. We will also discuss
ways to track these experiences or assess competency.
By the end of the SIG meeting we hope to be able to
develop an approach to the LCME requirement within the
confines of self-identified core competencies using
both live and simulated educational materials. The
meeting is always lively, and we welcome those who
have attended in the past as well as those who have
not. 8:45am–11:45am The School and Community Health SIG is planning an
exciting workshop for the May meeting in Washington,
DC. Last year the SIG focused on the topic of obesity,
and we had several speakers that discussed research as
well as service-oriented programs in school and
community settings. Attendees last year enjoyed the
topical focus, so this coming year we will be focusing
on innovative mental health programs being implemented
in community- and school-based settings. In addition,
we will be bringing back abstract and poster
presentations of fellows, residents and students on
this topical area to support and promote the work of
this critical group of meeting attendees. As usual,
our workshop is interactive and allows for networking
and discussion, so please join us for a great session. 10:15am–11:45am Elias A. Zerhouni, the Director of the NIH and Vice
Admiral Richard H. Carmona, the Surgeon General of the
United States, will provide PAS attendees with their
views of the critical issues related to pediatric
research and the health of our nation's children. Target Audience: All attendees Introduction The NIH Roadmap for Medical Research Promoting Health for U.S. Children and Their Families Discussion 10:15am–11:45am Improved survival of newborn infants with lung
disease has unmasked distinct genetic mechanisms that
contribute to acute, chronic and lethal pulmonary
insufficiency. Mutations in the surfactant protein
genes B and C and a lamellar body transporter gene
(ATP-binding cassette transporter A3 or ABCA3) may
disrupt pulmonary surfactant function and alveolar
type 2 pneumocyte metabolism. After discussing the
clinical aspects of the surfactant protein
deficiencies, we will discuss how more common
polymorphisms in the surfactant protein genes may be
related to respiratory distress and our current
understanding of the pathogenetic contribution of
mutations in the ABCA3 gene to both acute neonatal and
chronic interstitial lung disease in children. Target Audience: Neonatologists, pulmonologists and
geneticists. Introduction Clinical Aspects of Surfactant Protein Deficiencies Polymorphisms in the Surfactant Protein Genes ABCA3 and the Genetic Basis of Interstitial Lung
Disease Summary Supported in part by an unrestricted
educational grant from Dey, LP 10:15am–11:45am There is growing recognition that developmental
outcomes in minority children are influenced by
factors that are either unique to minority children or
that have differing effects among minority and
nonminority children. This topic symposium will
consist of presentations on the effects of different
contextual variables on minority child behavioral and
developmental competencies. A conceptual model
describing the inter-relationship among these factors
and minority child developmental competencies will be
presented, followed by research that explores the
differing effects of individual, family and community
level contexts on the health and development of
minority children. Target Audience: Researchers, clinicians and
educators involved with primary care and
behavioral/developmental services to minority
families. Introduction Minority Child Development: An Integrative Model The Six Primary Tasks of Parenting Ethnic Gaps in Early Health and Development: Causes,
Consequences and Prevention Closing Remarks 10:30am–12:30pm The Programme for Global Paediatric Research (“PGPR”)
is an international union of paediatric scientists and
societies. It has been formed to address the disparity
between the scientific resources available in
high-income countries and the quantity of scientific
research aimed at child health problems in mid- and
low-income countries. PGPR brings together scientists
from throughout the world for the purposes of
education, collaborative research, and ultimately the
maintenance of child health and the cure of childhood
diseases. This three-part symposium will focus on the
serious problem of birth asphyxia in developing
countries. Part 1 (“Birth Asphyxia: A Review of the
Clinical Problem”) will provide a review of the
clinical problem. Part 2 will feature platform
presentations from selected abstracts on issues
surrounding birth asphyxia. Part 3 (“A Global View
on Birth Asphyxia”) will be comprised of
region-specific presentations. At the follow up
workshop on May 18 colleagues from high-, mid- and
low-income regions, who are working in fields related
to birth asphyxia, will meet in order to examine the
issues surrounding birth asphyxia and establish clear
plans for collaborative study and other action. One of
the expected outcomes of the workshop will be the
development of a preliminary statement and plan for
action concerning birth asphyxia in developing
countries. Target Audience: Target Audience: Researchers and
clinicians interested and/or involved in all aspects
of the study of birth asphyxia, in any setting. 12:00pm–1:30pm Addressing the medical and public health consequences
of an emerging infection, a naturally occurring
outbreak or a bioterrorist attack requires
well-developed capabilities for detection, analysis
and response. In the context of national preparedness
there has been heavy investment to develop these
capabilities, but only limited attention has been paid
to the unique needs of the pediatric population.
Further, the use of these systems for every day
problems as well as disasters is critical if the
efforts are to be sustainable. A multidisciplinary faculty from the Center for
Biopreparedness at Children’s Hospital Boston will
present leading-edge research on (1) public health
informatics for the real-time epidemiology of
outbreaks of infectious disease among children, (2)
approaches to development and dissemination of
principles of pediatric bioterrorism response and (3)
the dual use of biopreparedness technology. Target Audience: Scientists and clinicians involved
in bioterrorism preparedness efforts, emergency
medicine, public health and epidemiology.
Approaches to Development and Dissemination of
Principles of Pediatric Bioterrorism Real Time Epidemiology of Outbreaks of Infectious
Disease Among Children Dual Use of Real-Time Outbreak Detection Technology Discussion 12:00pm–1:30pm Author Poster Set Up:
7:00am–9:00am (Hall E Entrance) Critical
Care: Cardiology: Neonatal
Pulmonology: Neonatology: Neonatal
Neurology: Neurology: Behavioral
and Developmental Pediatrics: General
Pediatrics and Preventive Pediatrics: Emergency Medicine: 1:30pm–3:30pm The Programme for Global Paediatric Research (“PGPR”)
is an international union of paediatric scientists and
societies. It has been formed to address the disparity
between the scientific resources available in
high-income countries and the quantity of scientific
research aimed at child health problems in mid- and
low-income countries. PGPR brings together scientists
from throughout the world for the purposes of
education, collaborative research, and ultimately the
maintenance of child health and the cure of childhood
diseases. This three-part symposium will focus on the
serious problem of birth asphyxia in developing
countries. Part 1 (“Birth Asphyxia: A Review of the
Clinical Problem”) will provide a review of the
clinical problem. Part 2 will feature platform
presentations from selected abstracts on issues
surrounding birth asphyxia. Part 3 (“A Global View
on Birth Asphyxia”) will be comprised of
region-specific presentations. At the follow up
workshop on May 18 colleagues from high-, mid- and
low-income regions, who are working in fields related
to birth asphyxia, will meet in order to examine the
issues surrounding birth asphyxia and establish clear
plans for collaborative study and other action. One of
the expected outcomes of the workshop will be the
development of a preliminary statement and plan for
action concerning birth asphyxia in developing
countries. Target Audience: Target Audience: Researchers and
clinicians interested and/or involved in all aspects
of the study of birth asphyxia, in any setting. Introduction and Overview Africa China Central and South America India Concluding Comments 1:45pm–3:45pm Changes in medicine domestically and globally are
transforming primary care in the United States. Many
have suggested that primary care is in crisis or at
least at a crossroads in the United States. Primary
care pediatrics has been grappling with its identity
and responding to significant changes in medical
systems (e.g., managed care, nonphysician providers,
specialization), science (e.g., genomics) and family
needs (e.g., coordinated care, cultural competence).
The pace and scope of these changes are such that
primary care pediatricians of the future will not be
performing the same role as today. This session will
focus on the future of pediatric primary care and
identifies potential roles and new models for primary
care pediatrics. Target Audience: Academicians and practitioners of
primary or specialty care. Introduction—Primary Care: Steering the Future Patients and Populations: The Challenge to Pediatric
Practice Pediatric Primary Care and Informatics Pediatric Primary Care and Genetics New and Emerging Models for Pediatric Primary Care Primary Care Pediatrics Summary Discussion 1:45pm–3:45pm The pathogenesis of numerous single-gene disorders
has been effectively delineated. However, the
application of this knowledge to patient care has
lagged far behind. This symposium will present recent
progress made in the development of therapeutic
strategies for four classical pediatric disorders.
First, novel genetic therapies for hematologic
diseases will be discussed. Second, interventions that
reverse the key abnormalities in signal transduction
underlying autosomal dominant polycystic kidney
disease, a leading cause of end-stage renal disease,
will be presented. Third, we will discuss a treatment
strategy that normalizes the intracellular processing
and function of the mutated cystic fibrosis
transmembrane conductance regulator (CFTR), which
underlies the majority of cases of CF. Fourth,
pharmacologic strategies against muscular dystrophy
will be presented. These four innovative approaches
provide great hope for patients suffering from these
disorders, and they serve as exciting examples of
potential means to combat other devastating pediatric
conditions. Target Audience: Scientists and clinicians involved
with the development of new therapeutic strategies for
a variety of childhood disorders. Embryonic Globins as Therapeutic Agents for
Hemoglobinopathies and Thalassemias Novel Therapies for Renal Cystic Diseases Curcumin and Cystic Fibrosis Pharmacologic Strategies Against Muscular Dystrophy 1:45pm–3:45pm Pulmonary hypertension contributes significantly to
high morbidity and mortality in diverse clinical
settings, including term or near-term newborns with
hypoxemic respiratory failure, premature infants with
RDS, congenital heart disease, idiopathic or primary
pulmonary hypertension and other diseases. Recent
advances in molecular biology, genetics and physiology
have led to novel therapeutic strategies that are now
available for the treatment of severe pulmonary
hypertension. This symposium will present novel
mechanisms in the pathogenesis of pulmonary
hypertension, as well as critical appraisal of
treatment options for neonates, infants and children
with pulmonary hypertension. First, basic molecular
and cellular mechanisms that underlie the development
of pulmonary hypertension will be presented. This will
be followed by a discussion of the physiologic basis
for current therapeutic approaches to persistent
pulmonary hypertension of the newborn and ongoing
controversies in patient management. The next speaker
will discuss the use of inhaled nitric oxide (iNO) in
premature infants. Although approved for use in the
term or near-term neonate with hypoxemic respiratory
failure, the potential role for iNO in premature
newborns for the treatment of acute lung disease or
the prevention of bronchopulmonary dysplasia has been
highly controversial. Finally, we will learn of novel
treatment strategies for children with chronic
pulmonary hypertension, including clinical approaches
that utilize separate or combined therapies, such as
prostacyclin analogues, endothelin receptor
antagonists and PDE5 inhibitors. Target Audience: Scientists and clinicians from
diverse clinical backgrounds, including neonatology,
cardiology, pulmonary medicine and critical care who
are involved with newborns and children with acute and
chronic pulmonary hypertension. This symposium will
describe recent advances in the basic science and
clinical management strategies of pulmonary
hypertension. Novel Mechanisms in the Pathogenesis of Pulmonary
Hypertension New Insights in the Pathophysiology and Treatment of
PPHN Controversies in the Use of Inhaled NO in Premature
Newborns Novel Therapeutic Strategies for the Treatment of
Pulmonary Hypertension Supported by an unrestricted educational
grant from INO Therapeutics 1:45pm–3:45pm |
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Last Updated: September 26, 2006