The March of Dimes Prize
in Developmental Biology Lectures

Many Little Things
Oliver Smithies
Excellence Professor of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC

Dr. Capecchi and Dr. Smithies were chosen to receive the Prize for pioneering the development of gene targeting in mice as a means of determining how genes function. Their seminal work on "knockouts" revolutionized not only the use of the mouse as a model system, but the study of human disease and development as well. Gene targeting is now practiced routinely by thousands of scientists all over the world, enabling them to address the most complex and critical biological problems, including the causes and treatment of birth defects and many other disorders.

Presented by the March of Dimes Birth Defects Foundation