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Last
updated February 4, 2005
Saturday, MAY 14
8:00am–11:00am
4103—Neonatal
Immunology—Relevance to the Clinician
PAS Mini Course
Chair:
E. Richard Stiehm, Mattel Children's Hospital at UCLA, Los
Angeles, CA
Developmental immunology, immunotherapy for the
neonate with infection, diagnosis of immunodeficiency and
relevance to the development of allergy will be discussed.
Target Audience: Pediatricians who care for newborns,
including neonatologists dealing with premature, high-risk
newborns.
Overview
E.
Richard Stiehm, Mattel Children's Hospital at UCLA, Los
Angeles, CA
Transient and Congenital Immunodeficiencies of the
Newborn: Recognition and Management
David
B. Lewis, Stanford University Medical Center, Stanford, CA
Newborn Immunity as a Predictor for the Development
of Wheezing and Allergy
James
E. Gern, University of Wisconsin, Madison, WI
Immunologic Intervention in the Newborn: Relevance to
Newborn Infections
Harry
R. Hill, University of Utah School of Medicine, Salt Lake
City, UT
11:45am–2:45pm
4505—Rheumatic
Diseases in Children: Frontiers in Research and Clinical
Care
PAS/SAM Mini Course
Chair:
James Jarvis, University of Oklahoma College of Medicine,
Oklahoma City, OK
Once considered rare, it is now known that rheumatic
diseases are among the most common chronic conditions
affecting children. In the past decade we have witnessed
unparalleled progress in our understanding of rheumatic
disease in children. Advances in basic immunology,
genetics and clinical care have revolutionized our
capacity to care for children with these complex, often
life-threatening illnesses. Indeed, rheumatic diseases
are, arguably, the model for investigation for complex
diseases characterized by genetic/environmental
interactions. Thus, research approaches developed to
advance our understanding of these illnesses are likely to
be applicable to many vexing childhood diseases, such as
type 2 diabetes, prematurity and attention
deficit-hyperactivity disorder.
This symposium will cover some of the most recent
advances that have been made in our understanding of the
genetics and pathogenesis of juvenile rheumatoid arthritis
(JRA), the most common of the rheumatic diseases of
children. These first two talks will cover JRA as a
complex trait and demonstrate how approaches used to
investigate this disorder might also be used to approach
other complex genetic traits of childhood such as obesity
or type 2 diabetes. Next, we will examine some of the
exciting new treatments now in use or emerging in JRA and
will discuss how those same treatments might be used in
other chronic or acute inflammatory states. Finally, we
will present a discussion on the recently formed
Children’s Arthritis and Rheumatology Research Alliance
(CARRA), with a focus on how multi-institutional studies
can extend beyond clinical trials to address complex
issues such as pathogenesis and the biology of response to
therapy.
Target Audience: Aacademic physicians and scientists
looking for an update on the rapidly changing field of
rheumatic diseases in children; clinicians and scientists
with an interest in complex genetic traits (e.g., obesity,
type 2 diabetes, ADHD), gene expression profiling and/or
immunomodulatory therapies (e.g., for septic shock);
clinicians involved in (or planning) multi-center clinical
trials and/or multi-center investigations.
Pediatric Rheumatology: The Future Is Here
James
N. Jarvis, University of Oklahoma College of Medicine,
Oklahoma City, OK
Genetic Analysis of JRA: Approaches to Complex Traits
Sampath
Prahalad, University of Utah School of Medicine, Salt Lake
City, UT
Gene Expression Studies in JRA: Promises and Pitfalls
James
N. Jarvis, University of Oklahoma College of Medicine,
Oklahoma City, OK
Emerging Concepts of Therapy in JRA: Biologics and
Beyond
Murray
H. Passo, Children's Hospital Medical Center, Cincinnati,
OH
The Future of Rheumatology Research: The Children's
Arthritis and Rheumatology Research Alliance (CARRA)
Christy
Sandborg, Stanford University Medical Center, Stanford, CA
Sponsored jointly by the American Academy
of Pediatrics Section on Rheumatology, the Society for
Adolescent Medicine and the Pediatric Academic Societies
1:00pm–3:00pm
4652—Neonatal
Infectious Disease and Inflammation
PAS Original Science Abstracts -
Platform Session
1:00pm–3:00pm
4654—Pulmonary
Vascular Biology
PAS Original Science Abstracts -
Poster Symposium
3:15pm–5:15pm
4848—Neonatal
Hematology–Immunology
PAS Original Science Abstracts -
Poster Symposium
Sunday, MAY 15
2:00pm–4:00pm
5522—Update
on Human Milk Immunobiology and Infectious Disease: New
Insights and Current Controversies
PAS/PIDS/Milk Club Topic
Symposium
Chairs:
Mark R. Schleiss, University of Minnesota Medical School,
Minneapolis, MN; and Lawrence M. Gartner, Professor
Emeritus, University of Chicago, Chicago, IL
The importance of human milk feeding to reduce risk
of infectious disease in infants is undisputed among
pediatricians. Nevertheless, more data are needed about
the basic biology of human milk, particularly in relation
to specific health and developmental effects on term and
premature infants. There have recently been significant
advances in the understanding of the immunobiology of
breast milk, particularly with respect to the role of
oligosaccharides in protection against diarrheal disease,
and new insights into interrelationships between breast
milk and gut immune responses. In addition to presenting
these new research data, this session will also review
clinical controversies in breast feeding practice,
including issues of milk storage and the potential for
transmission of infectious pathogens, in particular
cytomegalovirus, via human milk. Areas of need for future
clinical and basic research will be emphasized.
Target Audience: Clinicians responsible for the care
of newborn infants, particularly premature infants;
neonatologists, gastroenterologists, infectious diseases
physicians and general pediatricians; and basic scientists
conducting research on human milk, secretory immunity or
gut immunity.
The Future of Breast Milk Research: What Do We Need
To Learn?
Lawrence
M. Gartner, Professor Emeritus, University of Chicago,
Chicago, IL
Human Milk Oligosaccharides and Their Role in
Protection Against Gastroenteritis
Ardythe
L. Morrow, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
Infectious Diseases and Human Milk: Does
Cytomegalovirus Pose a Risk to the Breast-fed Infant?
Mark
R. Schleiss, University of Minnesota Medical School,
Minneapolis, MN
Human Milk as a Carrier of Biochemical Responses to
the Newborn
W.
Allan Walker, Harvard Medical School, Boston, MA
Mother's Milk, Milk Banks and Preemies: Effects of
Pasteurization and Storage on Milk Nutrition and Biology
Richard
J. Schanler, Schneider Children's Hospital at North Shore,
North Shore University Hospital, Manhasset, NY
Human Milk Immunology: The Whole Is Greater Than the
Sum of Its Parts
Charles
Isaacs, New York State Institute for Basic Research,
Staten Island, NY
Discussion
Sponsored jointly by the Pediatric
Infectious Diseases Society, the Milk Club and the
Pediatric Academic Societies
2:00pm–4:00pm
5539—Rheumatology
PAS Original Science Abstracts -
Poster Symposium
4:15pm–5:45pm
5702—Identification
of Asthma-Susceptibility Genes and Implications for New
Pharmaceutical Development
PAS State of the Art Plenary
Chair:
Clifford W. Bogue, Yale University School of Medicine, New
Haven, CT
Asthma is rapidly emerging as a major public health
disorder in childhood. Innovative strategies combining
genetic mapping and gene expression profiling are
providing the tools to identify genes that underpin asthma
predisposition. This presentation not only has relevance
for an important pediatric medical topic, but also
establishes a paradigm that can be used for other complex
genetic disorders that affect children.
Target Audience: This session will be of interest to
a broad audience including practicing pediatricians,
geneticists, pulmonologists, pharmacologists, critical
care specialists and allergist/immunologists
Marsha Wills-Karp, Children's Hospital Medical
Center, Cincinnati, OH
4:15pm–5:45pm
5703—Stem
Cell Therapies: What's On the Horizon for Pediatrics and
Pediatric Diseases
PAS State of the Art Plenary
Chair:
Stuart Orkin, Dana Farber Cancer Institute, Boston, MA
Stem cell-based approaches hold great promise for
treating many of the tissue degenerative disorders that
afflict our aging population. This symposium will explore
the role of stem cell therapies in pediatric disorders due
to inborn errors of metabolism and other single-gene
defects. Furthermore, the symposium will discuss the
implications of new data indicating that fetal cells in
the maternal circulation can participate in maternal wound
repair, implying that the fetus may be able to “treat”
its mother.
Target Audience: Broad appeal for scientists and
clinicians interested in new therapeutic approaches based
on stem cell biology.
Stem Cell Therapy in Lysosomal Storage Disorders
Susan
L. Staba, University of Florida, Gainesville, FL
Liver Repopulation with Stem Cells
Markus
Grompe, Oregon Health & Science University, Portland,
OR
Pregnancy-Associated Stem Cells: Does the Fetus
"Treat" Its Mother?
Diana
W. Bianchi, Tufts University School of Medicine, Floating
Hospital for Children, Boston, MA
Summation and Perspectives
Stuart
H. Orkin, Dana Farber Cancer Institute, Boston, MA
Monday, MAY 16
8:00am–10:00am
6130—Allergy
and Immunology
PAS Original Science Abstracts -
Platform Session
2:00pm–4:00pm
6600—Virus–Host
Interactions: Mechanisms Underlying Persistent Viral
Infections
PAS/PIDS Topic Symposium
Chairs:
Kenneth A. Alexander, Duke University Medical Center,
Durham, NC; and John Vanchiere, Baylor College of
Medicine, Houston, TX
In recent years it has become clear that traditional
concepts about immune response to and clearance of
pathogenic viruses are only part of the whole story.
Increasing numbers of viruses are now recognized to cause
persistent, low-level replication in the host, with
long-term adverse health consequences in both normal and
immune compromised hosts. These include viruses known to
establish latency, such as the herpes viruses, and viruses
that can cause persistent infection without a latent
state, such as hepatitis C virus and polyomaviruses. This
symposium will focus on virus–host interactions that
allow for establishment of latent or persistent infection
and the opportunities to exploit these interactions to
facilitate gene therapy.
Target Audience: Scientists and clinicians from the
following disciplines: pediatric infectious diseases,
general pediatricians, pediatric gastroenterologists,
pediatric hematology/oncology physicians.
Viral Persistence: Surveillance of the Iceberg from
Its Surface
John
A. Vanchiere, Baylor College of Medicine, Houston, TX
Unraveling the Molecular Mechanisms of Herpes Simplex
Virus Latency and Reactivation in the Nervous System
Nancy
M. Sawtell, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
Hepatitis C: Mechanisms Contributing to Chronic
Infection and Immune Evasion
Stanley
Lemon, University of Texas Medical Branch, Galveston, TX
Adenovirus Based Vectors as Tools to Understand Viral
Persistence
Andrea
Amalfitano, Duke University Medical Center, Durham, NC
Sponsored jointly by the Pediatric
Infectious Diseases Society and the Pediatric Academic
Societies
3:00pm–5:00pm
6700—Disorders
of Leukocyte Movement
PAS Topic Symposium
Chair:
Richard E. Stiehm, Mattel Children's Hospital at UCLA, Los
Angeles, CA
This symposium will focus on the importance of
leukocyte movement in infection and inflammation,
including basic mechanisms and abnormalities in several
rheumatic and immunodeficiency syndromes, including the
WHIM syndrome, the first described disorder of a chemokine
receptor mutation.
Target Audience: Immunologists, hematologists,
rheumatologists and basic scientists.
Introduction
E.
Richard Stiehm, Mattel Children's Hospital at UCLA, Los
Angeles, CA
Introduction to Cell Movement and Abnormalities in
Rheumatic Syndromes
Anna
Huttenlocher, University of Wisconsin, Madison, WI
Chemokines, Chemokine Receptors and the Defect in the
Warts-Hypogammaglobulinemia-Infection-Myelokathexis (WHIM)
Syndrome
Virginia
Gulino, National Cancer Institute/NIH, Bethesda, MD
Leukocyte Adhesion Defects: Clinical and Laboratory
Correlates
Steven
M. Holland, National Institute of Allergy and Infectious
Disease/NIH, Bethesda, MD
Tuesday, MAY 17
8:00am–10:00am
7101—Inner-City
Asthma Intervention Program: Research to Practice
PAS Topic Symposium
Chair:
Pamela R. Wood, University of Texas Health Sciences Center
at San Antonio, San Antonio, TX
The National Cooperative Inner City Asthma
Intervention (NCICAIS) is an asthma counselor (AC),
social-worker-driven intervention for inner-city children
with persistent asthma. Although the AC intervention was
shown to decrease symptom days in a randomized, controlled
trial, there were no data on implementation of this
intervention outside the research setting. In 2001, the
Centers for Disease Control and Prevention funded a 4-year
program to implement the asthma counselor model in 22
sites. This “research to practice” session will
explore lessons learned through the implementation process
and the implications for researchers, clinicians and
policy makers.
Target Audience: General pediatricians,
pulmonologists, allergists and other health professionals
who care for children with asthma; health services
researchers; and program planners.
Introduction
Pamela
R. Wood, University of Texas Health Sciences Center at San
Antonio, San Antonio, TX
NCICAIS Intervention: Differences Between Research
and Clinical Settings
Meyer
Kattan, Mount Sinai School of Medicine, New York, NY
Asthma Risk Factor Assessment: What Are the Needs of
Inner-City Families?
Karen
Warman, Children's Hospital at Montefiore, Albert Einstein
College of Medicine, Bronx, NY
The Asthma Counselor Speaks: Barriers and Successes
Laudy
Rodriguez, Mount Sinai Medical Center, New York, NY
Aligning Incentives For Optimal Asthma Care
Cathy
Carroll, Children's Mercy Hospitals and Clinics, Kansas
City, MO
Discussion
8:00am–10:00am
7158—Mechanisms
of Childhood Lung Disease
PAS Original Science Abstracts -
Platform Session
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