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Last
updated February 16, 2005
Saturday, MAY 14
8:00am–11:00am
4102—Imaging
of the Developing Organism: Tools for the Developmental
Biologist
PAS Mini Course
Chair:
Colin K.L. Phoon, New York University School of Medicine,
New York, NY
Rapid advances in developmental genetics over the
past decade have led to the generation of myriad animal
models of abnormal development and the elucidation of many
genes involved in development. Phenotypic analysis has
traditionally been limited to histological or in vitro
techniques. Innovations in sophisticated imaging
modalities now allow investigators to see the results of
genetic manipulation in striking detail, including in vivo
imaging of the embryo, three-dimensional reconstruction of
embryonic structures and functional analysis of the
cardiovascular system. Such imaging tools will prove
invaluable in linking genomic processes with their
phenotypic manifestations. Multi-modality, non-redundant
imaging can help investigators answer key biological
questions. This state of the art mini course is designed
to provide investigators specializing in developmental
processes with an overview of several current innovative
imaging approaches for the study of the embryonic and
early postnatal organism and to stimulate collaboration as
well as advances in phenotypic analyses.
Target Audience: Scientists involved in basic
developmental biology research from various fields,
including cardiology, neurology, cell biology,
developmental biology (patterning, etc.) and genetics.
Introduction: What Can Advanced Imaging Do for the
Developmental Biologist?
Colin
K.L. Phoon, New York University School of Medicine, New
York, NY
In Vivo Ultrasound and MR Microimaging of Mouse Brain
Development
Daniel
H. Turnbull, Skirball Institute of Biomolecular Medicine,
New York University School of Medicine, New York, NY
Optical Projection Tomography: A New Approach for 3D
Microscopy and Gene Expression
James
Sharpe, MRC Human Genetics Unit, Western General Hospital,
Edinburgh, United Kingdom
Quantifying Developmental Dynamics Using DPIV
Jay
R. Hove, Genome Research Institute, University of
Cincinnati, Cincinnati, OH
Break
Dynamic Imaging of Fluid Forces and Heart Motions in
Developing Embryos
Mary
E. Dickinson, California Institute of Technology, Beckman
Institute, Pasadena, CA
Mapping Cardiac Excitation in Embryonic and Adult
Hearts
Gregory
E. Morley, New York University School of Medicine, New
York, NY
Panel Discussion and Question & Answer
11:45am–2:45pm
4501—Fish,
Worms and Flies
PAS Mini Course
Chair:
Edward R.B. McCabe, Mattel Children's Hospital at UCLA,
Los Angeles, CA
One of the most important lessons of the Human Genome
Project is how similar we are to the organisms that
surround us. The similarities between our biology and
theirs means that they truly are models from which we
learn more about ourselves and our diseases. In this mini
course, we will see how the fruit fly, Drosophila
melanogaster, can be used to identify drugs for human
diseases. We will learn how the nematode worm,
Caenorhabditis elegans, can be used to investigate
signaling pathways that are preserved from worms to humans
and are critical to committing undifferentiated cells to
differentiate correctly. The zebrafish, Danio rerio,
provides us with a vertebrate model for studying organ
systems similar to our own. The presenters will provide a
general overview of their organism and then an in-depth
description of their research.
Target Audience: Investigators involved with or
interested in learning about research involving model
organisms. Appeal will be the strengths of these
non-mammalian models for investigations ranging from
developmental biology to high-throughput drug screens.
Overview of Non-mammalian Model Organisms
Edward
R.B. McCabe, Mattel Children's Hospital at UCLA, Los
Angeles, CA
Flies: Identifying New Drugs for Human Diseases
Juan
Botas, Baylor College of Medicine, Houston, TX
Worms: Signal Transduction and Cellular
Differentiation
David
M. Eisenmann, University of Maryland, Baltimore, MD
Fish: Developmental Genetics of the Heart
Didier
Stainier, University of California, San Francisco, CA
Discussion
Sponsored jointly by the AAP Section on
Cardiology and the Pediatric Academic Societies
1:00pm–3:00pm
4652—Neonatal
Infectious Disease and Inflammation
PAS Original Science Abstracts -
Platform Session
1:00pm–3:00pm
4654—Pulmonary
Vascular Biology
PAS Original Science Abstracts -
Poster Symposium
3:15pm–5:15pm
4843—Gastroenterology
PAS Original Science Abstracts -
Platform Session
3:15pm–5:15pm
4844—Genetic
Basis of Disease
PAS Original Science Abstracts -
Platform Session
3:15pm–5:15pm
4851—Pathogenesis
of Bronchopulmonary Dysplasia
PAS Original Science Abstracts -
Platform Session
Sunday, MAY 15
8:00am–10:00am
5146—Neonatal
CNS Injury
PAS Original Science Abstracts -
Platform Session
8:00am–10:00am
5150—Vascular
Mediators in Persistent Pulmonary Hypertension
PAS Original Science Abstracts -
Platform Session
12:00pm–1:30pm
5491A—Directors
of Research in Pediatrics
Club
Developmental and Pediatric Initiatives at NIH
Institutes Other than NICHD
Carl
E. Hunt
Story Landis
Charles Peterson, National Institutes of Health, National
Heart, Lung and Blood Institute, Bethesda, MD
Leaders from several other NIH Institutes will speak
and lead a discussion on this topic. A box lunch will be
provided. No reservation is necessary.
Contact:
Nina F. Schor, M.D., Ph.D.
Children's Hospital of Pittsburgh
Phone: 412-692-6182
Email: nfschor@pitt.edu
2:00pm–4:00pm
5521—Regulation
of Alveolar Epithelial Repair—or, How Do We Put It All
Back Together Again
PAS Topic Symposium
Chairs:
Rita Ryan, State University of New York at Buffalo, Women
and Children's Hospital of Buffalo, Buffalo, NY; and Heber
Nielsen, Tufts University School of Medicine, Tufts-New
England Medical Center, Boston, MA
Regulation of alveolar epithelial repair after many
forms of lung injury remains incompletely understood. The
type II cell is an important source of growth factors and
there are autocrine and paracrine mediators that are
altered during the repair process. Type I cells are the
primary covering of the alveolar epithelium, and their
restoration is critical to recapitulate normal repair.
This symposium will focus on the fundamental mechanisms of
epithelial repair after injury and examine connections
with lung development. Finally, relevance to current
clinical disease will be discussed.
Target Audience: Physician and basic scientists
interested in how the alveolar epithelium repairs itself
after injury and the relationship of lung repair with lung
development.
Introduction
Rita
M. Ryan, State University of New York at Buffalo, Women
and Children's Hospital of Buffalo, Buffalo, NY
Heber C. Nielsen, Tufts New England Medical Center,
Boston, MA
Type II Cell Mitogens
Timothy
D. Le Cras, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
Type II Cell Proliferation During Lung Injury and
Repair
Michael
A. O'Reilly, University of Rochester, Rochester, NY
Type I Cells in Alveolar Repair
Susan
H. Guttentag, Children's Hospital of Philadelphia,
Philadelphia, PA
Apoptosis in Alveolar Epithelial Repair
Lin
L. Mantell, Institute for Medical Research at North
Shore-Long Island Jewish, New York University School of
Medicine, Manhasset, NY
Translating Alveolar Epithelial Repair Fundamentals
to the Bedside
John
S. Torday, Los Angeles Biomedical Research Institute at
Harbor-UCLA Medical Center, Torrance, CA
2:00pm–4:00pm
5522—Update
on Human Milk Immunobiology and Infectious Disease: New
Insights and Current Controversies
PAS/PIDS/Milk Club Topic
Symposium
Chairs:
Mark R. Schleiss, University of Minnesota Medical School,
Minneapolis, MN; and Lawrence M. Gartner, Professor
Emeritus, University of Chicago, Chicago, IL
The importance of human milk feeding to reduce risk
of infectious disease in infants is undisputed among
pediatricians. Nevertheless, more data are needed about
the basic biology of human milk, particularly in relation
to specific health and developmental effects on term and
premature infants. There have recently been significant
advances in the understanding of the immunobiology of
breast milk, particularly with respect to the role of
oligosaccharides in protection against diarrheal disease,
and new insights into interrelationships between breast
milk and gut immune responses. In addition to presenting
these new research data, this session will also review
clinical controversies in breast feeding practice,
including issues of milk storage and the potential for
transmission of infectious pathogens, in particular
cytomegalovirus, via human milk. Areas of need for future
clinical and basic research will be emphasized.
Target Audience: Clinicians responsible for the care
of newborn infants, particularly premature infants;
neonatologists, gastroenterologists, infectious diseases
physicians and general pediatricians; and basic scientists
conducting research on human milk, secretory immunity or
gut immunity.
The Future of Breast Milk Research: What Do We Need
To Learn?
Lawrence
M. Gartner, Professor Emeritus, University of Chicago,
Chicago, IL
Human Milk Oligosaccharides and Their Role in
Protection Against Gastroenteritis
Ardythe
L. Morrow, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
Infectious Diseases and Human Milk: Does
Cytomegalovirus Pose a Risk to the Breast-fed Infant?
Mark
R. Schleiss, University of Minnesota Medical School,
Minneapolis, MN
Human Milk as a Carrier of Biochemical Responses to
the Newborn
W.
Allan Walker, Harvard Medical School, Boston, MA
Mother's Milk, Milk Banks and Preemies: Effects of
Pasteurization and Storage on Milk Nutrition and Biology
Richard
J. Schanler, Schneider Children's Hospital at North Shore,
North Shore University Hospital, Manhasset, NY
Human Milk Immunology: The Whole Is Greater Than the
Sum of Its Parts
Charles
Isaacs, New York State Institute for Basic Research,
Staten Island, NY
Discussion
Sponsored jointly by the Pediatric
Infectious Diseases Society, the Milk Club and the
Pediatric Academic Societies
4:15pm–6:15pm
5743—Pediatric
Nutrition and Metabolism
PAS Original Science Abstracts -
Platform Session
Monday, MAY 16
8:00am–10:00am
6131—Brain
Metabolism and Injury
PAS Original Science Abstracts -
Platform Session
8:00am–10:00am
6133—Development
Biology
PAS Original Science Abstracts -
Platform Session
1:00pm–2:45pm
6500—The
March of Dimes Prize in Developmental Biology Lectures
PAS Award
Mario Capecchi, University of Utah, Salt Lake City
Oliver Smithies, University of North Carolina at Chapel
Hill.
Dr. Capecchi and Dr. Smithies were chosen to receive
the Prize for pioneering the development of gene targeting
in mice as a means of determining how genes function.
Their seminal work on "knockouts" revolutionized
not only the use of the mouse as a model system, but the
study of human disease and development as well. Gene
targeting is now practiced routinely by thousands of
scientists all over the world, enabling them to address
the most complex and critical biological problems,
including the causes and treatment of birth defects and
many other disorders.
Presented by the March of Dimes Birth
Defects Foundation
3:00pm–5:00pm
6700—Disorders
of Leukocyte Movement
PAS Topic Symposium
Chair:
Richard E. Stiehm, Mattel Children's Hospital at UCLA, Los
Angeles, CA
This symposium will focus on the importance of
leukocyte movement in infection and inflammation,
including basic mechanisms and abnormalities in several
rheumatic and immunodeficiency syndromes, including the
WHIM syndrome, the first described disorder of a chemokine
receptor mutation.
Introduction
E.
Richard Stiehm, Mattel Children's Hospital at UCLA, Los
Angeles, CA
Introduction to Cell Movement and Abnormalities in
Rheumatic Syndromes
Anna
Huttenlocher, University of Wisconsin, Madison, WI
Chemokines, Chemokine Receptors and the Defect in the
Warts-Hypogammaglobulinemia-Infection-Myelokathexis (WHIM)
Syndrome
Virginia
Gulino, National Cancer Institute/NIH, Bethesda, MD
Leukocyte Adhesion Defects: Clinical and Laboratory
Correlates
Steven
M. Holland, National Institute of Allergy and Infectious
Disease/NIH, Bethesda, MD
3:00pm–5:00pm
6730—Cardiac
and Pulmonary Development
PAS Original Science Abstracts -
Platform Session
3:00pm–5:00pm
6732—Neonatal
Hyperoxia and the Lung
PAS Original Science Abstracts -
Platform Session
3:00pm–5:00pm
6733—Neonatal
Neurology—Neuroinflammation
PAS Original Science Abstracts -
Poster Symposium
5:15pm–6:45pm
Poster
Session III
PAS Original Science Abstracts -
Poster Session
Developmental Biology:
6850—Brain
6851—General
6852—Lung
Neonatology:
6872—Steroids
and Lung Development
Tuesday, MAY 17
8:00am–10:00am
7156—Genetic
Basis of Cardiopulmonary Disease
PAS Original Science Abstracts -
Platform Session
8:00am–10:00am
7157—Lung
Maturation, Septation and Growth
PAS Original Science Abstracts -
Platform Session
8:00am–10:00am
7158—Mechanisms
of Childhood Lung Disease
PAS Original Science Abstracts -
Platform Session
8:00am–10:00am
7159—Neonatal
Neurology—Experimental Models
PAS Original Science Abstracts -
Poster Symposium
10:15am–11:45am
7300—Children's
Health and the Federal Government: Research and Public
Health Policy
PAS State of the Art Plenary
Chairs:
Lisa Guay-Woodford, President, Society for Pediatric
Research; and Paul Young, Chair, PAS Program Committee
Elias A. Zerhouni, the Director of the NIH and Vice
Admiral Richard H. Carmona, the Surgeon General of the
United States, will provide PAS attendees with their views
of the critical issues related to pediatric research and
the health of our nation's children.
Target Audience: All attendees
Introduction
Paul
C. Young, University of Utah School of Medicine, Salt Lake
City, UT
Lisa M. Guay-Woodford, University of Alabama at
Birmingham, Birmingham, AL
The NIH Roadmap for Medical Research
Elias
A. Zerhouni, Director, National Institutes of Health,
Bethesda, MD
Promoting Health for U.S. Children and Their Families
Vice
Admiral Richard H. Carmona, Surgeon General of the United
States, Washington, DC
Discussion
10:15am–11:45am
7301—Genetic
Mechanisms of Respiratory Distress in the Newborn Infant
PAS State of the Art Plenary
Chair:
F. Sessions Cole, Washington University School of
Medicine, St. Louis Children's Hospital, St. Louis, MO
Improved survival of newborn infants with lung
disease has unmasked distinct genetic mechanisms that
contribute to acute, chronic and lethal pulmonary
insufficiency. Mutations in the surfactant protein genes B
and C and a lamellar body transporter gene (ATP-binding
cassette transporter A3 or ABCA3) may disrupt pulmonary
surfactant function and alveolar type 2 pneumocyte
metabolism. After discussing the clinical aspects of the
surfactant protein deficiencies, we will discuss how more
common polymorphisms in the surfactant protein genes may
be related to respiratory distress and our current
understanding of the pathogenetic contribution of
mutations in the ABCA3 gene to both acute neonatal and
chronic interstitial lung disease in children.
Target Audience: Neonatologists, pulmonologists and
geneticists.
Introduction
F.
Sessions Cole, Washington University School of Medicine,
St. Louis Children's Hospital, St. Louis, MO
Clinical Aspects of Surfactant Protein Deficiencies
Aaron
Hamvas, Washington University School of Medicine, St.
Louis Children's Hospital, St. Louis, MO
Polymorphisms in the Surfactant Protein Genes
Mikko
Hallman, University of Oulu, Oulu, Finland
ABCA3 and the Genetic Basis of Interstitial Lung
Disease
Lawrence
M. Nogee, Johns Hopkins School of Medicine, Baltimore, MD
Summary
F.
Sessions Cole, Washington University School of Medicine,
St. Louis Children's Hospital, St. Louis, MO
Supported in part by an unrestricted
educational grant from Dey, LP
1:45pm–3:45pm
7601—New
Therapeutic Strategies for Classical Pediatric Diseases
PAS Hot Topic
Chairs:
David Cornfield, University of Minnesota School of
Medicine, Minneapolis, MN; and Nina F. Schor, Children's
Hospital of Pittsburgh, Pittsburgh, PA
The pathogenesis of numerous single-gene disorders
has been effectively delineated. However, the application
of this knowledge to patient care has lagged far behind.
This symposium will present recent progress made in the
development of therapeutic strategies for four classical
pediatric disorders. First, novel genetic therapies for
hematologic diseases will be discussed. Second,
interventions that reverse the key abnormalities in signal
transduction underlying autosomal dominant polycystic
kidney disease, a leading cause of end-stage renal
disease, will be presented. Third, we will discuss a
treatment strategy that normalizes the intracellular
processing and function of the mutated cystic fibrosis
transmembrane conductance regulator (CFTR), which
underlies the majority of cases of CF. Fourth,
pharmacologic strategies against muscular dystrophy will
be presented. These four innovative approaches provide
great hope for patients suffering from these disorders,
and they serve as exciting examples of potential means to
combat other devastating pediatric conditions.
Target Audience: Scientists and clinicians involved
with the development of new therapeutic strategies for a
variety of childhood disorders.
Embryonic Globins as Therapeutic Agents for
Hemoglobinopathies and Thalassemias
J.
Eric Russell, The Children's Hospital of Philadelphia,
Philadelphia, PA
Novel Therapies for Renal Cystic Diseases
Vicente
E. Torres, Mayo Clinic, Rochester, MN
Curcumin and Cystic Fibrosis
Marie
E. Egan, Yale University School of Medicine, New Haven, CT
Pharmacologic Strategies Against Muscular Dystrophy
Tejvir
S. Khurana, University of Pennsylvania School of Medicine,
Philadelphia, PA
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