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Last
updated February 10, 2005
Saturday, MAY 14
11:45am–2:45pm
4501—Fish,
Worms and Flies
PAS Mini Course
Chair:
Edward R.B. McCabe, Mattel Children's Hospital at UCLA,
Los Angeles, CA
One of the most important lessons of the Human Genome
Project is how similar we are to the organisms that
surround us. The similarities between our biology and
theirs means that they truly are models from which we
learn more about ourselves and our diseases. In this mini
course, we will see how the fruit fly, Drosophila
melanogaster, can be used to identify drugs for human
diseases. We will learn how the nematode worm,
Caenorhabditis elegans, can be used to investigate
signaling pathways that are preserved from worms to humans
and are critical to committing undifferentiated cells to
differentiate correctly. The zebrafish, Danio rerio,
provides us with a vertebrate model for studying organ
systems similar to our own. The presenters will provide a
general overview of their organism and then an in-depth
description of their research.
Target Audience: Investigators involved with or
interested in learning about research involving model
organisms. Appeal will be the strengths of these
non-mammalian models for investigations ranging from
developmental biology to high-throughput drug screens.
Overview of Non-mammalian Model Organisms
Edward
R.B. McCabe, Mattel Children's Hospital at UCLA, Los
Angeles, CA
Flies: Identifying New Drugs for Human Diseases
Juan
Botas, Baylor College of Medicine, Houston, TX
Worms: Signal Transduction and Cellular
Differentiation
David
M. Eisenmann, University of Maryland, Baltimore, MD
Fish: Developmental Genetics of the Heart
Didier
Stainier, University of California, San Francisco, CA
Discussion
Sponsored jointly by the AAP Section on
Cardiology and the Pediatric Academic Societies
11:45am–2:45pm
4504—Nonendocrine
Causes of Short Stature and Their Management
PAS/LWPES Mini Course
Chairs:
Craig A. Alter, Children's Hospital of Philadelphia,
Philadelphia, PA; and Alan Rogol, University of Virginia,
Charlottesville, VA
Short stature is the most common cause of referral to
the pediatric endocrinologist. This symposium will draw on
the expertise of geneticists, orthopedic surgeons and
radiologists and promises to be instructive to all
attendees regardless of their background. It will also
help generalists identify clinically those patients in
their practice who may benefit from further evaluation for
growth and adolescent development.
Target Audience: Any clinician who encounters short
stature in his practice will benefit from this mini
course. Imparted by nationally recognized leaders in
genetics/dysmorphology, radiology and orthopedics, this
mini course will help generalists, geneticists and
endocrinologists identify which patients may benefit from
further evaluation and work up.
The Clinical Approach to Nonendocrine Short
Stature—The Pediatrician's Nightmare
Judith
G. Hall, The University of British Columbia, British
Columbia's Children's Hospital, Vancouver, Canada
The Radiographic Approach to Short Stature
Bruce
R. Parker, Texas Children's Hospital, Houston, TX
The Orthopedic Approach to the Child with Congenital
Deformity and Short Stature
David
Feldman, Hospital for Joint Diseases, NYU Medical Center,
New York, NY
Discussion
Sponsored jointly by the Lawson Wilkins
Pediatric Endocrine Society and the Pediatric Academic
Societies
1:00pm–3:00pm
4600A—Urolithiasis
and Mineral Metabolism
ASPN Symposium
Chairs:
Uri S. Alon, Children's Mercy Hospital, Kansas City, MO;
and Dawn S. Milliner, Mayo Clinic, Rochester, MN
The symposium will address new findings and
developments in our understanding of phosphate homeostasis
in health and disease. Genetic, environmental and
idopathic etiologies of pediatric urolithiasis will be
discussed, as well as medical means and urological
techniques utilized in the management of kidney stone
disease.
Target Audience: Scientists and clinicians involved
with pediatric mineral metabolism and kidney stone
disease.
New Insights into the Regulation of Phosphate
Metabolism
Anthony
A. Portale, University of California, San Francisco, CA
Pediatric Clinical Trials with Intravenous Vitamin D
Analogs
Laurence
Greenbaum, Medical College of Wisconsin, Milwaukee, WI
Genetic Basis of Stone Forming Disease
Dawn
S. Milliner, Mayo Clinic, Rochester, MN
Idiopathic Calcium Stones
Uri
S. Alon, Children's Mercy Hospital, Kansas City, MO
Urologic Intervention in Children with Urolithiasis
Jeffrey
S. Palmer, Rainbow Babies and Children's Hospital,
Cleveland, OH
Discussion
3:15pm–5:15pm
4801—The
Pediatric Generalist and Pediatric Subspecialists in the
21st Century: Who Will Take Care of Children with
Subspecialty Disorders?
PAS Topic Symposium
Chair:
Robert P. Schwartz, Wake Forest University School of
Medicine, Winston-Salem, NC
The demand for pediatric subspecialty service is
increasing, and waiting times for appointments get longer.
Workforce and reimbursement issues contribute to the
problem. In this symposium we will discuss the
relationship of the pediatric generalist and subspecialist
in the care of the children with common uncomplicated, as
well as complex, subspecialty disorders in the 21st
century.
Target Audience: Pediatric medical and surgical
subspecialists, academic and private practice
pediatricians.
Introduction and Opening Remarks
Robert
P. Schwartz, Wake Forest University School of Medicine,
Winston-Salem, NC
Role of the Pediatric Generalist in Management of
Diabetes in the 21st Century
Francine
R. Kaufman, University of Southern California Keck School
of Medicine, Children's Hospital of Los Angeles, Los
Angeles, CA
Role of the General Pediatrician in Management of
Neurodevelopmental Disorders
Fan
Tait, Utah Department of Health, Salt Lake City, UT
Role of the General Pediatrician in Management of
Chronic Subspecialty Disorders
Gordon
B. Glade, Utah Valley Pediatrics, American Fork, UT
Creating a Generalist-Specialist Team
Christopher
J. Stille, University of Massachusetts Medical School,
Worcester, MA
Discussion
Summary
Robert
P. Schwartz, Wake Forest University School of Medicine,
Winston-Salem, NC
Sponsored jointly by the American Academy
of Pediatrics: Pediatrics for the 21st Century Symposium
Series and the Pediatric Academic Societies
3:15pm–5:15pm
4852—Type
I Diabetes—Clinical/Basic
PAS Original Science Abstracts -
Poster Symposium
5:15pm–7:15pm
Poster
Session I
PAS Original Science Abstracts -
Poster Session
Endocrinology:
4930—McCune-Albright/Calcium/Bone
4931—Diabetes
Sunday, MAY 15
8:00am–10:00am
5144—Endocrinology:
Clinical
PAS/LWPES Original Science
Abstracts - Poster Symposium
11:45am–1:45pm
Poster
Session II
PAS Original Science Abstracts -
Poster Session
General Pediatrics and Preventive
Pediatrics:
5405—Bone/Metabolic Disease
Endocrinology:
5425—Obesity/Insulin Resistance
5426—Thyroid
5427—Potpourri
2:00pm–4:00pm
5520—Consequences
of Metabolic Syndrome in Children: Hypertension, Diabetes
and Renal Disease
PAS/ASPN/IPHA/LWPES Topic
Symposium
Chairs:
Joseph Flynn, Montefiore Medical Center, Bronx, NY; and
Henry Anhalt, Saint Barnabas Medical Center, Livingston,
NJ
The incidence of the metabolic syndrome and of type 2
diabetes mellitus (T2DM) is now exploding in children as a
consequence of the obesity epidemic. These children may be
at significant risk of target-organ damage, including
hypertension, atherosclerosis and diabetic nephropathy.
This symposium will examine key aspects of this epidemic,
with special focus on the pathogenesis of the target-organ
effects of the metabolic syndrome in the young.
Target Audience: Any physician who cares for children
with obesity, diabetes or their
consequences—pediatricians, pediatric cardiologists,
pediatric endocrinologists, pediatric nephrologists.
Can We Agree on a Definition of the Metabolic
Syndrome in Children?
Sonia
K. Caprio, Yale University School of Medicine, New Haven,
CT
Pathogenesis of Structural Vascular Changes in
Patients with Hypertension and the Metabolic Syndrome
Albert
P. Rocchini, University of Michigan Health Center, Ann
Arbor, MI
Diabetic Nephropathy in Patients with Type 1 and Type
2 Diabetes
Kumar
Sharma, Jefferson Medical College, Philadelphia, PA
Mechanisms of Diabetic Nephropathy: Insights from
Genomics/Proteomics
Erwin
Bottinger, Mount Sinai School of Medicine, New York, NY
Sponsored jointly by the American Society
of Pediatric Nephrology, International Pediatric
Hypertension Association, Lawson Wilkins Pediatric
Endocrine Society and the Pediatric Academic Societies
4:15pm–6:15pm
5700—Clinical
Trial Registries: Challenges and Opportunities
PAS/PPC State of the Art Plenary
Chair:
Myron Genel, Chair, Public Policy Council and Professor
Emeritus of Pediatrics, Yale University School of
Medicine, New Haven, CT
Over the past year there has been a great deal of
attention in the medical literature and lay press to the
availability of data conducted by pharmaceutical firms,
particularly when that data reveals potential side effects
or fails to demonstrate significant benefit. The American
Medical Association's Council on Scientific Affairs has
recommended that the Department of Health and Human
Services establish a comprehensive registry for all
clinical trials and that results from these trials be
publicly available. The Council as well as the
International Committee of Medical Journal Editors(ICMJE)
has also recommended that institutional review boards
require registration of clinical trials and the ICMJE will
soon require registration as a precondition for
publication. Finally legislation has been introduced—The
Fair Access to Clinical Trials(FACT) Act—that would
codify these recommendations for all clinical trials
irrespective of sponsorship, perhaps through expansion on
the National Library of Medicine's ClinicalTrials.gov
website. This symposium, the 12th Annual Public Policy
Plenary organized by the Public Policy Council and the
Public Policy and Advocacy Committee of the Ambulatory
Pediatric Association, will explore the implications of
these proposals, particularly for pediatric investigation
and clinical practice, with a panel of international
authorities. Time has been set aside to allow meaningful
discussion involving the panel and audience.
Target Audience: Pediatric clinicians and clinical
investigators
Overview
Myron
Genel, Chair, Public Policy Council and Professor Emeritus
of Pediatrics, Yale University School of Medicine, New
Haven, CT
Why We Need a Global, Unified System for Clinical
Trial Registration
Kay
Dickersin, Director, U.S. Cochrane Center and Professor
Community Health, Brown University, Providence, RI
Registering Clinical Trials—The Response from
Medical Journals
Christine
Laine, Deputy Editor, Annals of Internal Medicine and
Executive Secretary, International Committee of Medical
Journal Editors, Philadelphia, PA
ClinicalTrials.gov–For All and Open To All
Donald
Lindberg, Director, National Library of Medicine, NIH,
Bethesda, MD
Implications for Pediatric Research
David
J. Schonfeld, Chair, American Academy of Pediatrics
Committee on Research, Yale University School of Medicine,
New Haven, CT
Discussion. Panel & Audience.
Sponsored jointly by the Public Policy
Council, the Public Policy Advocacy Committee of the
Ambulatory Pediatric Association and the Pediatric
Academic Societies
4:15pm–6:15pm
5741—Corticosteroids
and Premature Neonates
PAS Original Science Abstracts -
Platform Session
Monday, MAY 16
8:00am–10:00am
6132—Clinical
Trials in Perinatal and Neonatal Medicine I
PAS Original Science Abstracts -
Platform Session
8:00am–10:00am
6142—Obesity
and Metabolism I
PAS Original Science Abstracts -
Platform Session
10:15am–12:00pm
6300—SPR
Presidential Plenary and Awards
SPR Presidential Plenary
Introduction
Lisa
M. Guay-Woodford, University of Alabama at Birmingham,
Birmingham, AL
Maureen Andrew Mentor Awardee
Edward
R.B. McCabe, Mattel Children's Hospital at UCLA, Los
Angeles, CA
Richard D. Rowe Awardee
Vidu
Garg, University of Texas Southwestern Medical School,
Dallas, TX
Richard D. Rowe Award Honorable Mention
Conrad
L. Epting, University of California, San Francisco
Stephanie Marie Ware, Cincinnati Children's Hospital
Medical Center, Cincinnati, OH
David G. Nathan Awardee
Mwe
Mwe Chao
Douglas K. Richardson Awardee
Maureen
Hack, Case Western Reserve University, Cleveland, OH
Young Investigator Awardee
Anne
Marguerite Moon, University of Utah Health Sciences Center
SPR Distinguished Service Award
Samuel
Hawgood, University of California Medical Center, San
Francisco, CA
E. Mead Johnson Awardees
Elizabeth C. Engle, Children's Hospital, Boston, MA
Gene Therapy for Inherited Lung Disease
Terence
R. Flotte, University of Florida, Gainesville, FL
SPR Presidential Address
Lisa
M. Guay-Woodford, University of Alabama at Birmingham,
Birmingham, AL
*The E. Mead Johnson Awards are supported
by an educational grant from Mead Johnson Nutritionals
1:00pm–2:45pm
6500—The
March of Dimes Prize in Developmental Biology Lectures
PAS Award
Mario Capecchi, University of Utah, Salt Lake City;
Oliver Smithies, University of North Carolina at Chapel
Hill.
Dr. Capecchi and Dr. Smithies were chosen to receive
the Prize for pioneering the development of gene targeting
in mice as a means of determining how genes function.
Their seminal work on "knockouts" revolutionized
not only the use of the mouse as a model system, but the
study of human disease and development as well. Gene
targeting is now practiced routinely by thousands of
scientists all over the world, enabling them to address
the most complex and critical biological problems,
including the causes and treatment of birth defects and
many other disorders.
Presented by the March of Dimes Birth
Defects Foundation
3:00pm–5:00pm
6701—Endocrine
Complications of Cancer Therapy
PAS/ASPHO/LWPES Topic Symposium
Chairs:
H. Stacy Nicholson, Oregon Health & Science
University, Portland, OR; and Charles A. Sklar, Memorial
Sloan-Kettering Cancer Center, New York, NY
The primary objective of this session is to review
common endocrine sequelae of anti-cancer therapies,
focusing particularly on fertility outcomes. In addition
to discussing sequelae, interventions will also be a
particular focus, in particular assisted fertility
(present and future options).
Target Audience: Oncologists and endocrinologists who
must counsel patients and families regarding fertility
outcomes and options following treatment for childhood
cancer.
Reproductive Challenges After Childhood Cancer
Henry
Stacy Nicholson,
Fertility Deficits in Survivors of Childhood Cancer
Charles
A. Sklar, Memorial Sloan-Kettering Cancer Center, New
York, NY
The Promise of Ovarian Cryopreservation
David
Lee, Oregon Health & Science University, Portland, OR
Fertility Preservation Options for Males
Paul
Turek, University of California, San Francisco, CA
Sponsored jointly by the American Society
of Pediatric Hematology/Oncology, the Lawson Wilkins
Pediatric Endocrine Society and the Pediatric Academic
Societies
3:00pm–5:00pm
6734—Obesity
and Metabolism II
PAS Original Science Abstracts -
Poster Symposium
Tuesday, MAY 17
8:00am–10:00am
7100—Endocrine
Controversies and the Role of Hormone
Replacement/Treatment in the NICU/PICU
PAS/LWPES Topic Symposium
Chairs:
Ram Menon, University of Michigan, Ann Arbor, MI; and
Mitchell Geffner, Children's Hospital of Los Angeles, Los
Angeles, CA
Much remains unknown about the physiology involved in
transition from intra-uterine to extra-uterine life in the
premature or full-term infant. Many strategies have been
employed to manipulate the hormonal milieu of some of our
sickest patients. Assuming adrenal insufficiency in a
critically ill neonate has become fairly routine, despite
precious few data. This symposium draws on the expertise
of endocrinologists and neonatologists and will enlighten
the attendees to some of the practical clinical
controversies that exist in these patients.
Target Audience: Neonatologists, critical care
doctors and endocrinologists.
Impact of Postnatal Glucocorticoids on L-HPA Stress
in Axis Development
Charles
R. Macías Neal, University of Hawaii, John A. Burns
School of Medicine, Honolulu, HI
Sick Euthyroid—Should It Be Treated?
Edmund
F. La Gamma, New York Medical College, Westchester Medical
Center, Valhalla, NY
Adrenal Insufficiency in the PICU/NICU
Delia
M. Vazquez, University of Michigan Medical School, Ann
Arbor, MI
Discussion
Sponsored jointly by the Lawson Wilkins
Pediatric Endocrine Society and the Pediatric Academic
Societies
8:00am–10:00am
7102—Transitioning
Complex Pediatric Patients to Adult Care
PAS/ASPN/LWPES Hot Topic
Chair:
Sandra L. Watkins, University of Washington, Seattle, WA
Transitions are a part of everyone's life experience.
Most young people with special health care needs and
disabilities (SHCN/D) become independent members of adult
society, but some need deliberate guidance and support.
With increasing success in reducing the mortality of once
devastating pediatric diseases, the latter group is
growing in number. A new consensus statement from the
American Academy of Pediatrics and the U.S. Federal
Government (Healthy People 2010) has focused attention on
the need to assist young people with SHCN/D in attaining
their potential in adulthood. This symposium will discuss
the growing number of young people with SHCN/D and present
approaches for effecting these transitions. Specific disease-related examples will be used to highlight
the issues, the barriers and the key elements of
successful programs that transition patients from
pediatric care to the adult system.
All Grown Up and Wondering What To Do: Transitioning
Complex Pediatric Patients to Adult Care
Patience
H. White, George Washington University School of Medicine,
Washington, DC
Transition Best Practices
Cecily
L. Betz, University Center For Excellence in Development
Disabilities, Children's Hospital Los Angeles, CA
Transition to Adult Care in the Nephrology
Population–Renal Failure or Success
Maria
Ferris, University of North Carolina-Chapel Hill, NC
Training and Workforce Issues for Successful
Transition
Roberta
G. Williams, University of Southern California, Los
Angeles, CA
Discussion
Sponsored jointly by the American Society
of Pediatric Nephrology, Lawson Wilkins Pediatric
Endocrine Society and the Pediatric Academic Societies
8:00am–10:00am
7152—Clinical
Trials in Perinatal and Neonatal Medicine II
PAS Original Science Abstracts -
Platform Session
10:15am–11:45am
7300—Children's
Health and the Federal Government: Research and Public
Health Policy
PAS State of the Art Plenary
Chairs:
Lisa Guay-Woodford, President, Society for Pediatric
Research; and Paul Young, Chair, PAS Program Committee
Elias A. Zerhouni, the Director of the NIH and Vice
Admiral Richard H. Carmona, the Surgeon General of the
United States, will provide PAS attendees with their views
of the critical issues related to pediatric research and
the health of our nation's children.
Introduction
Paul
C. Young, University of Utah School of Medicine, Salt Lake
City, UT
Lisa M. Guay-Woodford, University of Alabama at
Birmingham, Birmingham, AL
The NIH Roadmap for Medical Research
Elias
A. Zerhouni, Director, National Institutes of Health,
Bethesda, MD
Promoting Health for U.S. Children and Their Families
Vice
Admiral Richard H. Carmona, Surgeon General of the United
States, Washington, DC
Discussion
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