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Last
updated February 10, 2005
Saturday, MAY 14
8:00am–11:00am
4102—Imaging
of the Developing Organism: Tools for the Developmental
Biologist
PAS Mini Course
Chair:
Colin K.L. Phoon, New York University School of Medicine,
New York, NY
Rapid advances in developmental genetics over the
past decade have led to the generation of myriad animal
models of abnormal development and the elucidation of many
genes involved in development. Phenotypic analysis has
traditionally been limited to histological or in vitro
techniques. Innovations in sophisticated imaging
modalities now allow investigators to see the results of
genetic manipulation in striking detail, including in vivo
imaging of the embryo, three-dimensional reconstruction of
embryonic structures and functional analysis of the
cardiovascular system. Such imaging tools will prove
invaluable in linking genomic processes with their
phenotypic manifestations. Multi-modality, non-redundant
imaging can help investigators answer key biological
questions. This state of the art mini course is designed
to provide investigators specializing in developmental
processes with an overview of several current innovative
imaging approaches for the study of the embryonic and
early postnatal organism and to stimulate collaboration as
well as advances in phenotypic analyses.
Target Audience: Scientists involved in basic
developmental biology research from various fields,
including cardiology, neurology, cell biology,
developmental biology (patterning, etc.) and genetics.
Introduction: What Can Advanced Imaging Do for the
Developmental Biologist?
Colin
K.L. Phoon, New York University School of Medicine, New
York, NY
In Vivo Ultrasound and MR Microimaging of Mouse Brain
Development
Daniel
H. Turnbull, Skirball Institute of Biomolecular Medicine,
New York University School of Medicine, New York, NY
Optical Projection Tomography: A New Approach for 3D
Microscopy and Gene Expression
James
Sharpe, MRC Human Genetics Unit, Western General Hospital,
Edinburgh, United Kingdom
Quantifying Developmental Dynamics Using DPIV
Jay
R. Hove, Genome Research Institute, University of
Cincinnati, Cincinnati, OH
Break
Dynamic Imaging of Fluid Forces and Heart Motions in
Developing Embryos
Mary
E. Dickinson, California Institute of Technology, Beckman
Institute, Pasadena, CA
Mapping Cardiac Excitation in Embryonic and Adult
Hearts
Gregory
E. Morley, New York University School of Medicine, New
York, NY
Panel Discussion and Question & Answer
11:45am–2:45pm
4501—Fish,
Worms and Flies
PAS Mini Course
Chair:
Edward R.B. McCabe, Mattel Children's Hospital at UCLA,
Los Angeles, CA
One of the most important lessons of the Human Genome
Project is how similar we are to the organisms that
surround us. The similarities between our biology and
theirs means that they truly are models from which we
learn more about ourselves and our diseases. In this mini
course, we will see how the fruit fly, Drosophila
melanogaster, can be used to identify drugs for human
diseases. We will learn how the nematode worm,
Caenorhabditis elegans, can be used to investigate
signaling pathways that are preserved from worms to humans
and are critical to committing undifferentiated cells to
differentiate correctly. The zebrafish, Danio rerio,
provides us with a vertebrate model for studying organ
systems similar to our own. The presenters will provide a
general overview of their organism and then an in-depth
description of their research.
Target Audience: Investigators involved with or
interested in learning about research involving model
organisms. Appeal will be the strengths of these
non-mammalian models for investigations ranging from
developmental biology to high-throughput drug screens.
Overview of Non-mammalian Model Organisms
Edward
R.B. McCabe, Mattel Children's Hospital at UCLA, Los
Angeles, CA
Flies: Identifying New Drugs for Human Diseases
Juan
Botas, Baylor College of Medicine, Houston, TX
Worms: Signal Transduction and Cellular
Differentiation
David
M. Eisenmann, University of Maryland, Baltimore, MD
Sponsored jointly by the AAP Section on
Cardiology and the Pediatric Academic Societies
Fish: Developmental Genetics of the Heart
Didier
Stainier, University of California, San Francisco, CA
Discussion
Sponsored jointly by the AAP Section on
Cardiology and the Pediatric Academic Societies
11:45am–2:45pm
4504—Nonendocrine
Causes of Short Stature and Their Management
PAS/LWPES Mini Course
Chairs:
Craig A. Alter, Children's Hospital of Philadelphia,
Philadelphia, PA; and Alan Rogol, University of Virginia,
Charlottesville, VA
Short stature is the most common cause of referral to
the pediatric endocrinologist. This symposium will draw on
the expertise of geneticists, orthopedic surgeons and
radiologists and promises to be instructive to all
attendees regardless of their background. It will also
help generalists identify clinically those patients in
their practice who may benefit from further evaluation for
growth and adolescent development.
Target Audience: Any clinician who encounters short
stature in his practice will benefit from this mini
course. Imparted by nationally recognized leaders in
genetics/dysmorphology, radiology and orthopedics, this
mini course will help generalists, geneticists and
endocrinologists identify which patients may benefit from
further evaluation and work up.
The Clinical Approach to Nonendocrine Short
Stature—The Pediatrician's Nightmare
Judith
G. Hall, The University of British Columbia, British
Columbia's Children's Hospital, Vancouver, Canada
The Radiographic Approach to Short Stature
Bruce
R. Parker, Texas Children's Hospital, Houston, TX
The Orthopedic Approach to the Child with Congenital
Deformity and Short Stature
David
Feldman, Hospital for Joint Diseases, NYU Medical Center,
New York, NY
Discussion
Sponsored jointly by the Lawson Wilkins
Pediatric Endocrine Society and the Pediatric Academic
Societies
11:45am–2:45pm
4505—Rheumatic
Diseases in Children: Frontiers in Research and Clinical
Care
PAS/SAM Mini Course
Chair:
James Jarvis, University of Oklahoma College of Medicine,
Oklahoma City, OK
Once considered rare, it is now known that rheumatic
diseases are among the most common chronic conditions
affecting children. In the past decade we have witnessed
unparalleled progress in our understanding of rheumatic
disease in children. Advances in basic immunology,
genetics and clinical care have revolutionized our
capacity to care for children with these complex, often
life-threatening illnesses. Indeed, rheumatic diseases
are, arguably, the model for investigation for complex
diseases characterized by genetic/environmental
interactions. Thus, research approaches developed to
advance our understanding of these illnesses are likely to
be applicable to many vexing childhood diseases, such as
type 2 diabetes, prematurity and attention
deficit-hyperactivity disorder.
This symposium will cover some of the most recent
advances that have been made in our understanding of the
genetics and pathogenesis of juvenile rheumatoid arthritis
(JRA), the most common of the rheumatic diseases of
children. These first two talks will cover JRA as a
complex trait and demonstrate how approaches used to
investigate this disorder might also be used to approach
other complex genetic traits of childhood such as obesity
or type 2 diabetes. Next, we will examine some of the
exciting new treatments now in use or emerging in JRA and
will discuss how those same treatments might be used in
other chronic or acute inflammatory states. Finally, we
will present a discussion on the recently formed
Children’s Arthritis and Rheumatology Research Alliance
(CARRA), with a focus on how multi-institutional studies
can extend beyond clinical trials to address complex
issues such as pathogenesis and the biology of response to
therapy.
Target Audience: Aacademic physicians and scientists
looking for an update on the rapidly changing field of
rheumatic diseases in children; clinicians and scientists
with an interest in complex genetic traits (e.g., obesity,
type 2 diabetes, ADHD), gene expression profiling and/or
immunomodulatory therapies (e.g., for septic shock);
clinicians involved in (or planning) multi-center clinical
trials and/or multi-center investigations.
Pediatric Rheumatology: The Future Is Here
James
N. Jarvis, University of Oklahoma College of Medicine,
Oklahoma City, OK
Genetic Analysis of JRA: Approaches to Complex Traits
Sampath
Prahalad, University of Utah School of Medicine, Salt Lake
City, UT
Gene Expression Studies in JRA: Promises and Pitfalls
James
N. Jarvis, University of Oklahoma College of Medicine,
Oklahoma City, OK
Emerging Concepts of Therapy in JRA: Biologics and
Beyond
Murray
H. Passo, Children's Hospital Medical Center, Cincinnati,
OH
The Future of Rheumatology Research: The Children's
Arthritis and Rheumatology Research Alliance (CARRA)
Christy
Sandborg, Stanford University Medical Center, Stanford, CA
Sponsored jointly by the American Academy
of Pediatrics Section on Rheumatology, the Society for
Adolescent Medicine and the Pediatric Academic Societies
3:15pm–5:15pm
4844—Genetic
Basis of Disease
PAS Original Science Abstracts -
Platform Session
7:00am–8:00am
5051—Academic
Genetics
PAS Meet the Professor Breakfast
William A. Gahl, National Human Genome Research Institute, NIH,
Bethesda, MD
This session should provide trainees and junior
faculty with insight into the pediatrics and inborn errors
of metabolism communities. Topics will include
establishing genetics training programs, choosing an area
of clinical or basic research and the future of genetics
as a specialty.
Target Audience: Trainee, junior faculty
Sunday, MAY 15
8:00am–10:00am
5100—Advances
in Understanding the Molecular Basis of Cardiac
Electrophysiologic Diseases of Childhood
PAS Topic Symposium
Chair:
Steve A.N. Goldstein, University of Chicago and Pritzker
School of Medicine, Chicago, IL
This topic symposium is directed toward educating
interested members about the state of the art in
electrophysiological disorders of the heart, with a focus
on the channelopathies (long QT syndrome including SIDS,
Brugada syndrome). The discussion will range from insights
gained from animal models of these disorders to the impact
of gene discovery on clinical practice today.
Target Audience: Physicians, scientists and trainees
with interest in pediatric cardiology, ion channels and/or
the epidemiology of sudden death in infants and children.
Introduction
Steve
A.N. Goldstein, University of Chicago, Pritzker School of
Medicine, Chicago, IL
Animal Models of Electrophysiologic Disease
Charles
I. Berul, Children's Hospital Boston, Havard Medical
School, Boston, MA
Channelopathies and Sudden Death
Jeffrey
A. Towbin, Baylor College of Medicine, Houston, TX
Genetic Testing for Cardiac Channelopathies
Michael
J. Ackerman, Mayo Clinic College of Medicine, Rochester,
MN
Discussion
8:00am–10:00am
5104—Whole
Genome Investigation To Identify Susceptibility Genes
PAS Topic Symposium
Chairs:
Diana W. Bianchi, Tufts-New England Medical Center,
Boston, MA and Eric P. Hoffman, Children's National
Medical Center, Washington, DC
With the completion of the human genome, new tools
are now available to identify the genetic determinants for
complex pediatric disorders. This symposium will introduce
these new tools and discuss how they are being applied to
three critically important clinical issues in pediatrics.
First, the use of the HapMap and other recent advances in
whole genome association studies will be reviewed. Second,
the pursuit of susceptibility genes relevant to drug
responsiveness will be presented in the realm of pediatric
organ transplantation. Third, the identification of
susceptibility genes for reading disability will be
discussed.
Finally, the genetics of neurodevelopmental disorders
will be highlighted. The next layer of fundamental
understanding of complex disorders in pediatrics will
depend heavily on such strategies, and this symposium will
relay the matching high levels of excitement and rigor
with which these pursuits should go forth.
Target Audience: Scientists and clinicians involved
in investigations of the genetic basis of pediatric
diseases.
Whole Genome Association Studies for Complex Traits
and Diseases: Role of the HapMap and Other Recent Advances
Joel
N. Hirschhorn, Children's Hospital / Harvard Medical
School, Boston, MA; Broad Institute of MIT and Harvard,
Cambridge, MA
Genetic Contribution to Graft and Patient Outcomes
After Solid Organ Transplantation
Steven
A. Webber, University of Pittsburgh School of Medicine,
Pittsburgh, PA
Identifying Susceptibility Genes for Reading
Disability
Jeffrey
R. Gruen, Yale University School of Medicine, New Haven,
CT
The Genetics of Neurodevelopmental Disorders
Anthony
P. Monaco, University of Oxford, Oxford, England
8:00am–11:00am
5239—Transgenic
and Gene Knockout Methods in Mice
PAS Educational Workshop
Leader:
Louis Muglia, St. Louis, MO; Co-leader: Scott Saunders
Genetic analyses in mice provide a powerful approach
to understanding fundamental areas of interest in
pediatrics. Transgenic and gene knockout model systems in
mice have advanced our understanding of developmental,
physiological and cognitive processes difficult to dissect
mechanistically in either lower organisms or humans. In
this workshop, a practical framework for the design and
production of genetically altered mice will be presented.
Discussion will begin with availability of resources for
DNA analysis and clone acquisition and progress through
consideration of construct production for pronuclear
injection or introduction into embryonic stem cells.
Limitations in interpretation of findings obtained in
conventional transgenic or knockout animals will be
reviewed, and methods to overcome these limitations with
conditional knockouts or inducible transgenes will be
presented.
10:15am–11:45am
5350—APS
Presidential Plenary and Awards
APS Presidential Plenary
2005 APS Presidential Address
Elizabeth
R. McAnarney, University of Rochester Medical Center,
Rochester, NY
53rd Annual John Howland Award*
Mary
Ellen Avery, Thomas Morgan Rotch Distinguished Professor
of Pediatrics, Harvard Medical School; Physician-in-Chief,
Emerita, Children's Hospital, Boston, MA
Introduction
Margaret
K. Hostetter, Jean McLean Wallace Professor and Chair,
Department of Pediatrics, Yale University School of
Medicine, New Haven, CT
*Presented by the Federation of Pediatric
Organizations on behalf of the Ambulatory Pediatric
Association, American Academy of Pediatrics, American
Board of Pediatrics, American Pediatric Society,
Association of Medical School Pediatric Department
Chairmen, Association of Pediatric Program Directors and
the Society for Pediatric Research
11:45am–1:45pm
Poster
Session II
PAS Original Science Abstracts -
Poster Session
Nephrology:
5434—Renal
Genetics
2:00pm–5:00pm
5560—Innovations
in the Diagnosis of Genetic Diseases
PAS Mini Course
Chair:
Hans C. Andersson, Tulane University Medical School, New
Orleans, LA
Each year novel findings in characterizing genetic
disorders make the diagnosis and care of children with
these diseases more relevant to primary care pediatricians
and pediatric subspecialists. The challenge of staying
informed about clinically applicable innovations in
medical genetic research is daunting. Covering three
diverse areas, this program is designed to summarize a
variety of new findings in genetic disease research that
are directly applicable for clinicians. The mandate for
hearing screening in all newborns has revealed a
complexity of hearing genes that are becoming available
for clinical analysis in the diagnosis of hearing-impaired
children. An overview of hearing-impairment physiology
will lead into a molecular description of genes now known
to be involved in hearing impairment, many of which are
available for clinical diagnosis. Disorders of
intracellular vesicle trafficking, which result in
oculocutaneous albinism and bleeding disorders due to
defects in melanosomes and platelet dense body function,
will be described along with molecular studies of
causative genetic mutations. Disorders of cholesterol
biosynthesis that result in multiple congenital anomalies
have revealed unexpected actions of cholesterol and its
precursor sterols in the unfolding of the embryonic body
plan. An overview of the most common of these disorders,
Smith-Lemli-Opitz syndrome, will characterize our
understanding of the function of cholesterol in
neurological development and suggest that these functions
may have important public health implications beyond our
diagnosis and treatment of the sterol diseases themselves.
Target Audience: Clinician scientists and academic
pediatricians involved in the care of newborns and
multispecialty disorders.
Approaches to Diagnosis of Genetic Disorders: Which
Is the Right Test?
Hans
C. Andersson, Tulane University Medical School, New
Orleans, LA
Diagnosing and Managing Hearing Loss from Birth
Charles
I. Berlin, Louisiana State University Health Sciences
Center, New Orleans, LA
Advances in Genetic Diagnosis of Hearing Loss
Bronya
J.B. Keats, Louisiana State University Health Sciences
Center, New Orleans, LA
Disorders of Intracellular Vesicles Presenting with
Albinism and Platelet Dysfunction
William
A. Gahl, National Human Genome Research Institute, NIH,
Bethesda, MD
The Clinical and Biochemical Spectrum of Inborn
Errors of Cholesterol Biosynthesis
Richard
I. Kelley, Kennedy Krieger Institute, Baltimore, MD
4:15pm–5:45pm
5702—Identification
of Asthma-Susceptibility Genes and Implications for New
Pharmaceutical Development
PAS State of the Art Plenary
Chair:
Clifford W. Bogue, Yale University School of Medicine, New
Haven, CT
Asthma is rapidly emerging as a major public health
disorder in childhood. Innovative strategies combining
genetic mapping and gene expression profiling are
providing the tools to identify genes that underpin asthma
predisposition. This presentation not only has relevance
for an important pediatric medical topic, but also
establishes a paradigm that can be used for other complex
genetic disorders that affect children.
Target Audience: This session will be of interest to
a broad audience including practicing pediatricians,
geneticists, pulmonologists, pharmacologists, critical
care specialists and allergist/immunologists
Marsha Wills-Karp, Children's Hospital Medical
Center, Cincinnati, OH
Monday, MAY 16
8:00am–10:00am
6136—Genetics
PAS Original Science Abstracts -
Platform Session
8:15am–10:15am
6150A—Gene
Therapy—A Primer for the Clinician
ASPHO Symposium
Chair:
Jakub Tolar, University of Minnesota, Minneapolis, MN
Viral and non-viral vectors have been utilized to
ferry novel DNA into target cells and raise the potential
of altering congenital gene lesions in a therapeutic
manner. Work in this intensely exciting field must come
with caution, however, as these approaches carry some
nontrivial dangers for the patients, such as insertional
mutagenesis and immune deregulation. The program will
begin with a review of gene therapy approaches and a
summary of gene therapy clinical trials to date, including
the severe combined immunodeficiency (SCID) clinical
trial. The program will follow with a presentation of the
most recent data on gene therapy for hemophilia. The
symposium will conclude with an overview of immune
implications when inserting foreign genes in the human
genome and rationale for the upcoming clinical trial of
gene therapy for Fanconi Anemia. While gene therapy has
yielded some notable successes and holds considerable
promise, one should walk away from the session with a
realistic overview of the possibilities and limitations of
gene therapy for childhood diseases.
Introduction
Jakub
Tolar, Chair (and Overview )
Review of Gene Therapy Clinical Trials, Including
SCID
Christof
von Kalle, Speaker
Gene Therapy for Hemophilia
Katherine
A. High, Speaker
Immunology of Gene Transfer and Gene Therapy for
Fanconi Anemia
Patrick
F. Kelly, Speaker
9:00am–12:00pm
6205—Developmental
and Molecular Imaging
PAS Educational Workshop
Leader:
Colin K.L. Phoon, New York, NY; Co-leader: Christopher
Contag
Advances in imaging now allow characterization of
many developmental processes, particularly in the in vivo
organism. This workshop is designed to introduce the
audience to two such techniques: ultrasound biomicroscopy
and biophotonic imaging, in detail. The emphasis is on
practical aspects of imaging, with the opportunity for
hands-on imaging and use of representative systems.
10:15am–12:00pm
6300—SPR
Presidential Plenary and Awards
SPR Presidential Plenary
Introduction
Lisa
M. Guay-Woodford, University of Alabama at Birmingham,
Birmingham, AL
Maureen Andrew Mentor Awardee
Edward
R.B. McCabe, Mattel Children's Hospital at UCLA, Los
Angeles, CA
David G. Nathan Awardee
Mwe
Mwe Chao
Douglas K. Richardson Awardee
Maureen
Hack, Case Western Reserve University, Cleveland, OH
Richard D. Rowe Awardee
Vidu
Garg, University of Texas Southwestern Medical School,
Dallas, TX
Richard D. Rowe Award Honorable Mention
Conrad
L. Epting, University of California, San Francisco
Stephanie
Marie Ware, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
Young Investigator Awardee
Anne
Marguerite Moon, University of Utah Health Sciences Center
SPR Distinguished Service Award
Samuel
Hawgood, University of California Medical Center, San
Francisco, CA
E. Mead
Johnson Awardees
Elizabeth C. Engle, Children's Hospital, Boston, MA
Gene Therapy for Inherited Lung Disease
Terence
R. Flotte, University of Florida, Gainesville, FL
SPR Presidential Address
Lisa
M. Guay-Woodford, University of Alabama at Birmingham,
Birmingham, AL
*The E. Mead Johnson Awards are supported
by an educational grant from Mead Johnson Nutritionals
1:00pm–2:45pm
6500—The
March of Dimes Prize in Developmental Biology Lectures
PAS Award
Mario Capecchi, University of Utah, Salt Lake City
Oliver Smithies, University of North Carolina at Chapel
Hill.
Dr. Capecchi and Dr. Smithies were chosen to receive
the Prize for pioneering the development of gene targeting
in mice as a means of determining how genes function.
Their seminal work on "knockouts" revolutionized
not only the use of the mouse as a model system, but the
study of human disease and development as well. Gene
targeting is now practiced routinely by thousands of
scientists all over the world, enabling them to address
the most complex and critical biological problems,
including the causes and treatment of birth defects and
many other disorders.
3:00pm–5:00pm
6700—Disorders
of Leukocyte Movement
PAS Topic Symposium
Chair:
Richard E. Stiehm, Mattel Children's Hospital at UCLA, Los
Angeles, CA
This symposium will focus on the importance of
leukocyte movement in infection and inflammation,
including basic mechanisms and abnormalities in several
rheumatic and immunodeficiency syndromes, including the
WHIM syndrome, the first described disorder of a chemokine
receptor mutation.
Target Audience: Immunologists, hematologists,
rheumatologists and basic scientists.
Introduction
E.
Richard Stiehm, Mattel Children's Hospital at UCLA, Los
Angeles, CA
Introduction to Cell Movement and Abnormalities in
Rheumatic Syndromes
Anna
Huttenlocher, University of Wisconsin, Madison, WI
Chemokines, Chemokine Receptors and the Defect in the
Warts-Hypogammaglobulinemia-Infection-Myelokathexis (WHIM)
Syndrome
Virginia
Gulino, National Cancer Institute/NIH, Bethesda, MD
Leukocyte Adhesion Defects: Clinical and Laboratory
Correlates
Steven
M. Holland, National Institute of Allergy and Infectious
Disease/NIH, Bethesda, MD
3:00pm–5:00pm
6760—Functional
Genomics
PAS Educational Workshop
Leader:
Clifford W. Bogue, New Haven, CT; Co-leaders: James D.
Bristow and Cecilia Lo
Understanding the function of genes and other parts
of the genome is known as functional genomics. The Human
Genome Project is just the first step in understanding
humans at the molecular level. Now that the sequencing
phase of the human and mouse genomes is complete, many
questions remain unanswered, including the function and
regulation of most of the estimated 30,000-35,000 mouse
and human genes. The mouse has a long and rich history in
biological research and many consider it a model organism
for the study of human development and disease. Over the
past few years, exciting progress has been made in
developing techniques for chromosome engineering,
mutagenesis, mapping and maintenance of mutations and
identification of mutant genes in the mouse. Additionally,
whole genome sequence analysis of many different species
is proving to be incredibly fruitful in identifying
critical gene regulatory motifs. In this workshop, we will
present some of the techniques that are being applied to
the daunting yet exciting task of functional genomic
analysis in the mouse.
Objectives:
-
To learn about contemporary scientific techniques
currently in use to determine the function of the
genome.
-
To learn how the genomic sequence of various
organisms can be used to determine gene function.
Method of Instruction: Three lectures with
question-and-answer sessions.
Target Audience: Trainee, junior faculty, mid-level
faculty, senior faculty.
5:15pm–6:45pm
Poster
Session III
PAS Original Science Abstracts -
Poster Session
6890–Genetics
Tuesday, MAY 17
8:00am–10:00am
7156—Genetic
Basis of Cardiopulmonary Disease
PAS Original Science Abstracts -
Platform Session
10:15am–11:45am
7301—Genetic
Mechanisms of Respiratory Distress in the Newborn Infant
PAS State of the Art Plenary
Chair:
F. Sessions Cole, Washington University School of
Medicine, St. Louis Children's Hospital, St. Louis, MO
Improved survival of newborn infants with lung
disease has unmasked distinct genetic mechanisms that
contribute to acute, chronic and lethal pulmonary
insufficiency. Mutations in the surfactant protein genes B
and C and a lamellar body transporter gene (ATP-binding
cassette transporter A3 or ABCA3) may disrupt pulmonary
surfactant function and alveolar type 2 pneumocyte
metabolism. After discussing the clinical aspects of the
surfactant protein deficiencies, we will discuss how more
common polymorphisms in the surfactant protein genes may
be related to respiratory distress and our current
understanding of the pathogenetic contribution of
mutations in the ABCA3 gene to both acute neonatal and
chronic interstitial lung disease in children.
Target Audience: Neonatologists, pulmonologists and
geneticists.
Introduction
F.
Sessions Cole, Washington University School of Medicine,
St. Louis Children's Hospital, St. Louis, MO
Clinical Aspects of Surfactant Protein Deficiencies
Aaron
Hamvas, Washington University School of Medicine, St.
Louis Children's Hospital, St. Louis, MO
Polymorphisms in the Surfactant Protein Genes
Mikko
Hallman, University of Oulu, Oulu, Finland
ABCA3 and the Genetic Basis of Interstitial Lung
Disease
Lawrence
M. Nogee, Johns Hopkins School of Medicine, Baltimore, MD
Summary
F.
Sessions Cole, Washington University School of Medicine,
St. Louis Children's Hospital, St. Louis, MO
Supported in part by an unrestricted
educational grant from Dey, LP
12:00pm–1:30pm
7411—Poster
Session IV: Cardiology: Genetic Basis of Cardiovascular
Disease
PAS Original Science Abstracts -
Poster Session
Cardiology
7411—Genetic
Basis of Cardiovascular Disease
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