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Mail Address:
Suite B-7
3400 Research Forest Drive
The Woodlands, TX  77381 USA
Telephone:  281-419-0052
Facsimile:  281-419-0082

2005 PAS Annual Meeting
May 14 – 17
Washington, DC 
 

Infectious Diseases

Back to Track Index
Daily Expanded Schedule
Alliance Programs
 

  

Last updated February 10, 2005


Saturday, MAY 14

8:00am–11:00am
4103—Neonatal Immunology—Relevance to the Clinician
PAS Mini Course
Chair: E. Richard Stiehm, Mattel Children's Hospital at UCLA, Los Angeles, CA

Developmental immunology, immunotherapy for the neonate with infection, diagnosis of immunodeficiency and relevance to the development of allergy will be discussed.

Target Audience: Pediatricians who care for newborns, including neonatologists dealing with premature, high-risk newborns.

Overview
E. Richard Stiehm, Mattel Children's Hospital at UCLA, Los Angeles, CA

Transient and Congenital Immunodeficiencies of the Newborn: Recognition and Management
David B. Lewis, Stanford University Medical Center, Stanford, CA

Newborn Immunity as a Predictor for the Development of Wheezing and Allergy
James E. Gern, University of Wisconsin, Madison, WI

Immunologic Intervention in the Newborn: Relevance to Newborn Infections
Harry R. Hill, University of Utah School of Medicine, Salt Lake City, UT
 

1:00pm–3:00pm
4652—Neonatal Infectious Disease and Inflammation
PAS Original Science Abstracts - Platform Session

3:15pm–5:15pm
4849—Neonatal Infectious Disease
PAS Original Science Abstracts - Platform Session

3:15pm–5:15pm
4890—AIDS/HIV
APA Special Interest Group
Chairs: Nancy Hutton, nhutton@jhmi.edu; and Lois Chandler Howland, lois.howland@umassmed.edu

HIV/AIDS is becoming increasingly prevalent among the U.S. adolescent population due to “aging up” of perinatally infected children and to adolescents becoming infected through high-risk behaviors. Providing effective health education to reduce HIV transmission risk, offering accessible and confidential HIV counseling and screening and identifying effective strategies to improve HIV treatment adherence among adolescents are the key issues to be addressed in the AIDS/HIV Special Interest Group meeting this year. An interactive format will bring clinicians and researchers together to provide the most recent information and to discuss the most effective approaches to these issues.
 

5:15pm–7:15pm
Poster Session I
PAS Original Science Abstracts - Poster Session

Neonatal Infectious Diseases:
4970—Coagulase Negative Staph
4971—Central Venous Catheters
4972—Antibiotic Usage
4973—Gram Negatives
4974—Candida
4975—Neonatal Sepsis and Pneumonia
4976—Neonatal Sepsis, Diagnosis
4977—Cytokines, Immunomodulation, Pathogenesis

Infectious Diseases:
4980—Herpesviruses
4981—Human Papillomavirus
4982—Respiratory Syncytial Virus (RSV)
4983—Human Metapneumovirus
4984—Influenza
4985—Miscellaneous Respiratory Viruses
4986—Miscellaneous Viruses
4987—HIV
 

Sunday, MAY 15

7:00am–8:00am
5053—Infectious Diseases
PAS Meet the Professor Breakfast

Sarah S. Long, MCP Hahnemann University School of Medicine, St. Christopher's Hospital for Children, Philadelphia, PA

This interactive session is designed to provide trainees and junior faculty with insight and advice concerning the pursuit of an academic career in pediatric infectious diseases. Infectious diseases includes a wide variety of career goals. Specific attention will be given to describing approaches to obtaining the best possible training to match individual goals—in clinical infectious diseases, epidemiology, as well as in basic and applied research. The discussion also will include perspectives especially useful for junior faculty on getting known, getting published and getting promoted.

Target Audience: Trainee, junior faculty.

 

8:00am–10:00am
5101—ARDS: New Pathways and Treatments
PAS Topic Symposium
Chairs: Steven H. Abman, University of Colorado School of Medicine, Denver, CO; and Alan Jobe, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Acute respiratory distress syndrome (ARDS) remains a leading cause of morbidity and death in critically ill neonates, infants and children. ARDS is associated with diverse clinical disorders, including sepsis, trauma, aspiration and infection and is characterized by lung inflammation, non-hydrostatic pulmonary edema and poor lung compliance. Recent advances in the basic pathobiology of lung injury have led to new insights into the etiology and potential therapeutic approaches toward ARDS. In addition, recent clinical studies have examined differences between adult and pediatric ARDS, genetic susceptibility factors that may increase the risk for ARDS, interactive cellular and physiologic mechanisms that cause progressive lung injury and the role of different strategies of mechanical ventilation that can adversely or favorably determine the clinical outcomes of patients with ARDS. This symposium includes leading experts in the field of lung biology and critical care who will present state of the art information on basic pathophysiologic mechanisms of ARDS and new therapeutic approaches. These integrated topics are of marked interest to intensivists, neonatologists, pulmonologists, infectious disease and basic scientists in the field of lung biology.

Target Audience: Scientists and clinicians interested in basic mechanisms underlying the pathophysiology of acute lung injury and clinical strategies in the management of acute hypoxemic respiratory failure in neonates, infants and children.

New Insights into ARDS
Michael Matthay, University of California San Francisco Medical School, San Francisco, CA

Mechanisms of Tissue Injury in Sepsis/ARDS
Hector R. Wong, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Role of Permissive Hypercapnea in Acute Lung Injury
Brian Kavanagh, Hospital for Sick Children, Toronto, ON, Canada

Novel Ventilator Strategies in ARDS
John H. Arnold, Children's Hospital, Boston, MA
 

8:00am–10:00am
5102—Community-Acquired Staphylococcal Disease: New Twists for a Traditional Pediatric Pathogen
PAS/PIDS Hot Topic
Chairs: Stephen I. Pelton, Boston University School of Medicine, Boston, MA; and Sheldon L. Kaplan, Baylor College of Medicine, Houston, TX

Community-acquired, methicillin-resistant Staphylococcal disease has been reported with increasing frequency from multiple geographic locations in the United States over the past several years. This symposium will present current data on the epidemiology, molecular genetics and clinical aspects of these evolving pathogens, as well as on infection control practices that may be useful for prevention.

Target Audience: Scientists and clinicians from the following disciplines: pediatric infectious disease, community pediatricians, pediatric ER and public health.

Community-Acquired Staphylococcal Disease: New Twists for a Traditional Pediatric Pathogen
Stephen I. Pelton, Boston University School of Medicine, Boston, MA

Epidemiology of Community-Acquired, Methicillin-Resistant Staphylococcus aureus
Daniel B. Jernigan, Centers for Disease Control and Prevention, Atlanta, GA

The Molecular Basis For Epidemic Community-Onset MRSA
Robert S. Daum, The University of Chicago, Chicago, IL

Clinical Implications of Community-Acquired, Methicillin-Resistant Staphylocccus aureus
Sheldon L. Kaplan, Baylor College of Medicine, Houston, TX

Prevention and Control of Methicillin-Resistant Staphylococcus aureus
Donald A. Goldmann, Children's Hospital Boston, Boston, MA

Sponsored jointly by the Pediatric Infectious Diseases Society and the Pediatric Academic Societies
 

11:45am–1:45pm
Poster Session II
PAS Original Science Abstracts - Poster Session

Infectious Diseases:
5470—Inflammatory Mediators
5471—Fungal Infections
5472—Borrelia, Rickettsia, Ehrlichia
5473—Group A Streptococcus
5474—Meningitis
5475—Miscellaneous
5476—Staphylococcus aureus
5477—Pneumococcus
5478—Pertussis
5479—Tuberculosis
5480—Vaccines

2:00pm–4:00pm
5522—Update on Human Milk Immunobiology and Infectious Disease: New Insights and Current Controversies
PAS/PIDS/Milk Club Topic Symposium
Chairs: Mark R. Schleiss, University of Minnesota Medical School, Minneapolis, MN; and Lawrence M. Gartner, Professor Emeritus, University of Chicago, Chicago, IL

The importance of human milk feeding to reduce risk of infectious disease in infants is undisputed among pediatricians. Nevertheless, more data are needed about the basic biology of human milk, particularly in relation to specific health and developmental effects on term and premature infants. There have recently been significant advances in the understanding of the immunobiology of breast milk, particularly with respect to the role of oligosaccharides in protection against diarrheal disease, and new insights into interrelationships between breast milk and gut immune responses. In addition to presenting these new research data, this session will also review clinical controversies in breast feeding practice, including issues of milk storage and the potential for transmission of infectious pathogens, in particular cytomegalovirus, via human milk. Areas of need for future clinical and basic research will be emphasized.

Target Audience: Clinicians responsible for the care of newborn infants, particularly premature infants; neonatologists, gastroenterologists, infectious diseases physicians and general pediatricians; and basic scientists conducting research on human milk, secretory immunity or gut immunity.

The Future of Breast Milk Research: What Do We Need To Learn?
Lawrence M. Gartner, Professor Emeritus, University of Chicago, Chicago, IL

Human Milk Oligosaccharides and Their Role in Protection Against Gastroenteritis
Ardythe L. Morrow, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Infectious Diseases and Human Milk: Does Cytomegalovirus Pose a Risk to the Breast-fed Infant?
Mark R. Schleiss, University of Minnesota Medical School, Minneapolis, MN

Human Milk as a Carrier of Biochemical Responses to the Newborn
W. Allan Walker, Harvard Medical School, Boston, MA

Mother's Milk, Milk Banks and Preemies: Effects of Pasteurization and Storage on Milk Nutrition and Biology
Richard J. Schanler, Schneider Children's Hospital at North Shore, North Shore University Hospital, Manhasset, NY

Human Milk Immunology: The Whole Is Greater Than the Sum of Its Parts
Charles Isaacs, New York State Institute for Basic Research, Staten Island, NY

Discussion

Sponsored jointly by the Pediatric Infectious Diseases Society, the Milk Club and the Pediatric Academic Societies
 

2:00pm–4:00pm
5532—Epidemiology Research II
PAS Original Science Abstracts - Platform Session

2:00pm–4:00pm
5538—Pathogenesis, Prevention and Treatment of Necrotizing Enterocolitis
PAS Original Science Abstracts - Poster Symposium

4:15pm–6:15pm
5700—Clinical Trial Registries: Challenges and Opportunities
PAS/PPC State of the Art Plenary
Chair: Myron Genel, Chair, Public Policy Council and Professor Emeritus of Pediatrics, Yale University School of Medicine, New Haven, CT

Over the past year there has been a great deal of attention in the medical literature and lay press to the availability of data conducted by pharmaceutical firms, particularly when that data reveals potential side effects or fails to demonstrate significant benefit. The American Medical Association's Council on Scientific Affairs has recommended that the Department of Health and Human Services establish a comprehensive registry for all clinical trials and that results from these trials be publicly available. The Council as well as the International Committee of Medical Journal Editors(ICMJE) has also recommended that institutional review boards require registration of clinical trials and the ICMJE will soon require registration as a precondition for publication. Finally legislation has been introduced—The Fair Access to Clinical Trials(FACT) Act—that would codify these recommendations for all clinical trials irrespective of sponsorship, perhaps through expansion on the National Library of Medicine's ClinicalTrials.gov website. This symposium, the 12th Annual Public Policy Plenary organized by the Public Policy Council and the Public Policy and Advocacy Committee of the Ambulatory Pediatric Association, will explore the implications of these proposals, particularly for pediatric investigation and clinical practice, with a panel of international authorities. Time has been set aside to allow meaningful discussion involving the panel and audience.

Target Audience: Pediatric clinicians and clinical investigators.

Overview
Myron Genel, Chair, Public Policy Council and Professor Emeritus of Pediatrics, Yale University School of Medicine, New Haven, CT

Why We Need a Global, Unified System for Clinical Trial Registration
Kay Dickersin, Director, U.S. Cochrane Center and Professor Community Health, Brown University, Providence, RI

Registering Clinical Trials—The Response from Medical Journals
Christine Laine, Deputy Editor, Annals of Internal Medicine and Executive Secretary, International Committee of Medical Journal Editors, Philadelphia, PA

ClinicalTrials.gov–For All and Open To All
Donald Lindberg, Director, National Library of Medicine, NIH, Bethesda, MD

Implications for Pediatric Research
David J. Schonfeld, Chair, American Academy of Pediatrics Committee on Research, Yale University School of Medicine, New Haven, CT

Discussion. Panel & Audience

Sponsored jointly by the Public Policy Council, the Public Policy Advocacy Committee of the Ambulatory Pediatric Association and the Pediatric Academic Societies
 

4:15pm–5:45pm
5701—Crossing the Pediatric Quality Chasm
PAS State of the Art Plenary
Chair: Thomas F. Boat, University of Cincinnati College of Medicine, Cincinnati, OH

This state of the art plenary addresses the pediatric dimension of the national movement in quality improvement accelerated by the 2001 Institute of Medicine report, "Crossing the Quality Chasm, A New Health System for the 21st Century." The ability to understand, adopt and determine the impact of quality improvement processes is critical to academic pediatric health centers. To sustain viability in the coming health care crisis, they will have to demonstrate that their care is of the highest quality, safety and reliability. The Plenary addresses quality improvement: (1) as it relates to academic pediatrics; (2) its current state of science and practice in pediatrics; (3) how it is practically being applied in an academic setting in the context of the missions of patient care, research and education; and (4) training implications. Presenters are recognized leaders in the field.

Target Audience: Anyone involved in patient care in an academic setting, particularly individuals with administrative responsibilities (clinic/service heads, division chiefs, chairs, etc.) or with research/teaching interest in the area of quality improvement.

The Important Role of Quality Improvement in Academic Pediatrics
Thomas F. Boat, University of Cincinnati College of Medicine, Cincinnati, OH

What Is the State of Quality Improvement in Pediatrics?
Carole M. Lannon, North Carolina Center for Children's Health Care Improvement, Chapel Hill, NC

How To Integrate Research, Teaching and Quality of Care Missions
Uma R. Kotagal, University of Cincinnati College of Medicine, Cincinnati, OH

Training and Maintaining the Pediatricians of the 21st Century—The Role of Quality Improvement
Paul Miles, American Board of Pediatrics, Chapel Hill, NC

Discussion
 

4:15pm–5:45pm
5703—Stem Cell Therapies: What's On the Horizon for Pediatrics and Pediatric Diseases
PAS State of the Art Plenary
Chair: Stuart Orkin, Dana Farber Cancer Institute, Boston, MA

Stem cell-based approaches hold great promise for treating many of the tissue degenerative disorders that afflict our aging population. This symposium will explore the role of stem cell therapies in pediatric disorders due to inborn errors of metabolism and other single-gene defects. Furthermore, the symposium will discuss the implications of new data indicating that fetal cells in the maternal circulation can participate in maternal wound repair, implying that the fetus may be able to “treat” its mother.

Target Audience: Broad appeal for scientists and clinicians interested in new therapeutic approaches based on stem cell biology.

Stem Cell Therapy in Lysosomal Storage Disorders
Susan L. Staba, University of Florida, Gainesville, FL

Liver Repopulation with Stem Cells
Markus Grompe, Oregon Health & Science University, Portland, OR

Summation and Perspectives
Stuart H. Orkin, Dana Farber Cancer Institute, Boston, MA

Pregnancy-Associated Stem Cells: Does the Fetus "Treat" Its Mother?
Diana W. Bianchi, Tufts University School of Medicine, Floating Hospital for Children, Boston, MA
 

6:15pm–7:15pm
5875A—Neonatal Sepsis Club
 Club

Hot Topics in Neonatal Meningitis
George H. McCracken

Contact:
David Kaufman, M.D.
University of Virginia Children's Medical Center
Phone: 434-924-9114
Email: davidkaufman@virginia.edu
 

Monday, MAY 16

8:00am–10:00am
6137—Infectious Diseases
PAS Original Science Abstracts - Platform Session

10:15am–12:00pm
6300—SPR Presidential Plenary and Awards
SPR Presidential Plenary

Introduction
Lisa M. Guay-Woodford, University of Alabama at Birmingham, Birmingham, AL

Maureen Andrew Mentor Awardee
Edward R.B. McCabe, Mattel Children's Hospital at UCLA, Los Angeles, CA

Richard D. Rowe Awardee
Vidu Garg, University of Texas Southwestern Medical School, Dallas, TX

Richard D. Rowe Award Honorable Mention
Conrad L. Epting, University of California, San Francisco
Stephanie Marie Ware, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

David G. Nathan Awardee
Mwe Mwe Chao,

Douglas K. Richardson Awardee
Maureen Hack, Case Western Reserve University, Cleveland, OH

Young Investigator Awardee
Anne Marguerite Moon, University of Utah Health Sciences Center

SPR Distinguished Service Award
Samuel Hawgood, University of California Medical Center, San Francisco, CA

E. Mead Johnson Awardees
Elizabeth C. Engle, Children's Hospital, Boston, MA

Gene Therapy for Inherited Lung Disease
Terence R. Flotte, University of Florida, Gainesville, FL

SPR Presidential Address
Lisa M. Guay-Woodford, University of Alabama at Birmingham, Birmingham, AL

*The E. Mead Johnson Awards are supported by an educational grant from Mead Johnson Nutritionals
 

10:15am–12:15pm
6355—Immunizations Delivery
PAS Original Science Abstracts - Poster Symposium

 

2:00pm–4:00pm
6600—Virus–Host Interactions: Mechanisms Underlying Persistent Viral Infections
PAS/PIDS Topic Symposium
Chairs: Kenneth A. Alexander, Duke University Medical Center, Durham, NC; and John Vanchiere, Baylor College of Medicine, Houston, TX

In recent years it has become clear that traditional concepts about immune response to and clearance of pathogenic viruses are only part of the whole story. Increasing numbers of viruses are now recognized to cause persistent, low-level replication in the host, with long-term adverse health consequences in both normal and immune compromised hosts. These include viruses known to establish latency, such as the herpes viruses, and viruses that can cause persistent infection without a latent state, such as hepatitis C virus and polyomaviruses. This symposium will focus on virus–host interactions that allow for establishment of latent or persistent infection and the opportunities to exploit these interactions to facilitate gene therapy.

Target Audience: Scientists and clinicians from the following disciplines: pediatric infectious diseases, general pediatricians, pediatric gastroenterologists, pediatric hematology/oncology physicians.

Viral Persistence: Surveillance of the Iceberg from Its Surface
John A. Vanchiere, Baylor College of Medicine, Houston, TX

Unraveling the Molecular Mechanisms of Herpes Simplex Virus Latency and Reactivation in the Nervous System
Nancy M. Sawtell, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Hepatitis C: Mechanisms Contributing to Chronic Infection and Immune Evasion
Stanley Lemon, University of Texas Medical Branch, Galveston, TX

Adenovirus Based Vectors as Tools to Understand Viral Persistence
Andrea Amalfitano, Duke University Medical Center, Durham, NC

Sponsored jointly by the Pediatric Infectious Diseases Society and the Pediatric Academic Societies
 

3:00pm–5:00pm
6700—Disorders of Leukocyte Movement
PAS Topic Symposium
Chair: Richard E. Stiehm, Mattel Children's Hospital at UCLA, Los Angeles, CA

This symposium will focus on the importance of leukocyte movement in infection and inflammation, including basic mechanisms and abnormalities in several rheumatic and immunodeficiency syndromes, including the WHIM syndrome, the first described disorder of a chemokine receptor mutation.

Target Audience: Immunologists, hematologists, rheumatologists and basic scientists.

Introduction
E. Richard Stiehm, Mattel Children's Hospital at UCLA, Los Angeles, CA

Introduction to Cell Movement and Abnormalities in Rheumatic Syndromes
Anna Huttenlocher, University of Wisconsin, Madison, WI

Chemokines, Chemokine Receptors and the Defect in the Warts-Hypogammaglobulinemia-Infection-Myelokathexis (WHIM) Syndrome
Virginia Gulino, National Cancer Institute/NIH, Bethesda, MD

Leukocyte Adhesion Defects: Clinical and Laboratory Correlates
Steven M. Holland, National Institute of Allergy and Infectious Disease/NIH, Bethesda, MD
 

3:00pm–5:00pm
6736—Placental Biology
PAS Original Science Abstracts - Poster Symposium

4:00pm–5:00pm
6790A—PIDS Plotkin Award Lectureship
PIDS Award

The Pediatric Infectious Diseases Society (PIDS) has established the Stanley A. Plotkin Lectureship in Vaccinology to honor Dr. Plotkin, the Society's "Founding Father." The lecture, which takes place at the annual PIDS meeting, is sponsored by Sanofi Pasteur. Dr. Plotkin was medical director at Sanofi Pasteur and remains a medical and scientific advisor. Dr. Plotkin was awarded with the inaugural lectureship in 2004.

Introduction
Ross E. McKinney, Duke University Medical Center, Durham, NC

Smallpox, Polio, Can Measles be Far Behind?
Samuel L. Katz, Duke University Medical Center, Durham, NC

Supported by an educational grant from Sanofi Pasteur
 

5:00pm–6:00pm
6795A—PIDS Business Meeting
PIDS Business Meeting

5:15pm–6:45pm
Poster Session III
PAS Original Science Abstracts - Poster Session

Adolescent Medicine:
6803—Sexually Transmitted Infections (STIs) and Reproductive Health

General Pediatrics and Preventive Pediatrics:
6823—Infectious Disease

Global Paediatric Research:
6830—Birth Asphyxia

Neonatology:
6875—Neonatal Infection/Inflammation
 

6:15pm–
6930A—PIDS Annual Dinner and Awards Banquet
PIDS Dinner

 

Tuesday, MAY 17

8:00am–10:00am
7152—Clinical Trials in Perinatal and Neonatal Medicine II
PAS Original Science Abstracts - Platform Session

8:00am–10:00am
7155—General Pediatrics III
PAS Original Science Abstracts - Platform Session

8:00am–10:00am
7158—Mechanisms of Childhood Lung Disease
PAS Original Science Abstracts - Platform Session

10:15am–11:45am
7300—Children's Health and the Federal Government: Research and Public Health Policy
PAS State of the Art Plenary
Chairs: Lisa Guay-Woodford, President, Society for Pediatric Research; and Paul Young, Chair, PAS Program Committee

Elias A. Zerhouni, the Director of the NIH and Vice Admiral Richard H. Carmona, the Surgeon General of the United States, will provide PAS attendees with their views of the critical issues related to pediatric research and the health of our nation's children.

Target Audience: All attendees

Introduction
Paul C. Young, University of Utah School of Medicine, Salt Lake City, UT
Lisa M. Guay-Woodford, University of Alabama at Birmingham, Birmingham, AL

The NIH Roadmap for Medical Research
Elias A. Zerhouni, Director, National Institutes of Health, Bethesda, MD

Promoting Health for U.S. Children and Their Families
Vice Admiral Richard H. Carmona, Surgeon General of the United States, Washington, DC

Discussion
 

7303—Pediatric Biopreparedness: Dual-Use Systems for Everyday and Times of Trouble
PAS State of the Art Plenary
Chairs: Michael W. Shannon, Children's Hospital Boston, Boston, MA; and Kenneth D. Mandl, Children's Hospital Boston, Boston, MA

Addressing the medical and public health consequences of an emerging infection, a naturally occurring outbreak or a bioterrorist attack requires well-developed capabilities for detection, analysis and response. In the context of national preparedness there has been heavy investment to develop these capabilities, but only limited attention has been paid to the unique needs of the pediatric population. Further, the use of these systems for every day problems as well as disasters is critical if the efforts are to be sustainable.

A multidisciplinary faculty from the Center for Biopreparedness at Children’s Hospital Boston will present leading-edge research on (1) public health informatics for the real-time epidemiology of outbreaks of infectious disease among children, (2) approaches to development and dissemination of principles of pediatric bioterrorism response and (3) the dual use of biopreparedness technology.

Target Audience: Scientists and clinicians involved in bioterrorism preparedness efforts, emergency medicine, public health and epidemiology.

Pediatric Biopreparedness
Michael W. Shannon, Children's Hospital Boston, Boston, MA

Approaches to Development and Dissemination of Principles of Pediatric Bioterrorism
Michael W. Shannon, Children's Hospital Boston, Boston, MA

Real Time Epidemiology of Outbreaks of Infectious Disease Among Children
Ben Y. Reis, Children's Hospital Boston, Boston, MA

Dual Use of Real-Time Outbreak Detection Technology
Kenneth D. Mandl, Children's Hospital Boston, Boston, MA

Discussion
 
 
   

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