Neonatology

Last updated February 10, 2005

Saturday, MAY 14

8:00am–11:00am
4102—Imaging of the Developing Organism: Tools for the Developmental Biologist
PAS Mini Course
Chair: Colin K.L. Phoon, New York University School of Medicine, New York, NY

Rapid advances in developmental genetics over the past decade have led to the generation of myriad animal models of abnormal development and the elucidation of many genes involved in development. Phenotypic analysis has traditionally been limited to histological or in vitro techniques. Innovations in sophisticated imaging modalities now allow investigators to see the results of genetic manipulation in striking detail, including in vivo imaging of the embryo, three-dimensional reconstruction of embryonic structures and functional analysis of the cardiovascular system. Such imaging tools will prove invaluable in linking genomic processes with their phenotypic manifestations. Multi-modality, non-redundant imaging can help investigators answer key biological questions. This state of the art mini course is designed to provide investigators specializing in developmental processes with an overview of several current innovative imaging approaches for the study of the embryonic and early postnatal organism and to stimulate collaboration as well as advances in phenotypic analyses.

Target Audience: Scientists involved in basic developmental biology research from various fields, including cardiology, neurology, cell biology, developmental biology (patterning, etc.) and genetics.

Introduction: What Can Advanced Imaging Do for the Developmental Biologist?
Colin K.L. Phoon, New York University School of Medicine, New York, NY

In Vivo Ultrasound and MR Microimaging of Mouse Brain Development
Daniel H. Turnbull, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY

Optical Projection Tomography: A New Approach for 3D Microscopy and Gene Expression
James Sharpe, MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom

Quantifying Developmental Dynamics Using DPIV
Jay R. Hove, Genome Research Institute, University of Cincinnati, Cincinnati, OH

Break

Dynamic Imaging of Fluid Forces and Heart Motions in Developing Embryos
Mary E. Dickinson, California Institute of Technology, Beckman Institute, Pasadena, CA

Mapping Cardiac Excitation in Embryonic and Adult Hearts
Gregory E. Morley, New York University School of Medicine, New York, NY

Panel Discussion and Question & Answer
 

8:00am–11:00am
4103—Neonatal Immunology—Relevance to the Clinician
PAS Mini Course
Chair: E. Richard Stiehm, Mattel Children's Hospital at UCLA, Los Angeles, CA

Developmental immunology, immunotherapy for the neonate with infection, diagnosis of immunodeficiency and relevance to the development of allergy will be discussed.

Target Audience: Pediatricians who care for newborns, including neonatologists dealing with premature, high-risk newborns.

Overview
E. Richard Stiehm, Mattel Children's Hospital at UCLA, Los Angeles, CA

Transient and Congenital Immunodeficiencies of the Newborn: Recognition and Management
David B. Lewis, Stanford University Medical Center, Stanford, CA

Newborn Immunity as a Predictor for the Development of Wheezing and Allergy
James E. Gern, University of Wisconsin, Madison, WI

Immunologic Intervention in the Newborn: Relevance to Newborn Infections
Harry R. Hill, University of Utah School of Medicine, Salt Lake City, UT
 

8:00am–11:00am
4153—Developmental Care (DC) in the Newborn Nursery—An Interactive Workshop
PAS Educational Workshop
Leader: Juzer M. Tyebkhan, Edmonton, AB, Canada; Co-leader: Leonora Hendson

Understand what developmental care (DC) really is, why it is beneficial for preterm infants and how to practically implement it in your nursery. This is an interactive workshop that will answer the frequently asked question, "Exactly what should we do DIFFERENTLY if we use DC to care for preterm infants?" The workshop will include a quiz (informal and entertaining), video demonstrations of DC at the bedside compared with traditional (non-developmental) care, a slide show/video showing how a routine NICU procedure (extubation) can be made family-centered, behaviourally guided and developmentally friendly. Participants will be actively involved and will take home at least three practical points that will help them implement DC in their nurseries.

Objectives:

1. Participants will know the scientific basis for developmental care and the evidence supporting its use.

2. Participants will take back at least three practical points that will allow them to implement developmental care in their nurseries.

Method of Instruction: (1) Introduction; (2) quiz (informal, interactive and entertaining): the scientific background, and current evidence for DC (Powerpoint presentation); (3) "hands-on" practice with behavioural observation, as a framework for implementing DC; (4) video demonstrations of DC at tbe bedside compared with traditional (non-developmental) care, and of infant behavioural responses; (5) Slide show/video, "Family centered, behaviourally guided and developmentally friendly extubation": How to make the change from traditional, procedure-based care to developmental, family-centered care using a practical example—the extubation of a preterm infant; (6) Participant input: How can we really become "Family Centered" in the NICU?; (7) Roundtable discussion: Overcoming the obstacles to implementing DC in the nursery; (8) Summing up. Handouts, summarizing the workshop, with reference list will be provided. A "Developmental Survival Card" will be given to all participants.

Target Audience: Trainee, junior faculty, mid-level faculty, all disciplines that work in neonatal nurseries
 

4300—Development of Hypertension in the Newborn: Translating Theory into Practical Application
PAS/IPHA Topic Symposium
Chairs: Elaine Urbina, Children's Hospital Medical Center, Cincinnati, OH; and Luc Brion, Montefiore Medical Center, Bronx, NY

Hypertension is found in up to 2% of term or preterm neonates. The prevalence is difficult to ascertain precisely since the definition of hypertension in this age group has not been completely standardized. However, recent studies have provided normative data that may be useful in identifying these infants. This symposium will examine key aspects of the diagnosis of hypertension in the neonate including measurement and instrumentation issues and normal values. Pre- and post-natal risk factors for the development of neonatal hypertension will be addressed along with treatment options. Perinatal programming for future cardiovascular disease will also be addressed.

Target Audience: Neonatologists, pediatric nephrologists, pediatric cardiologists, general pediatricians

How Do We Measure BP in the Neonate and What Is Normal?
Alan Zubrow, Drexel University College of Medicine, St. Christopher's Hospital for Children, Philadelphia, PA

How Does “Perinatal Programming” Contribute to the Development of Subsequent Vascular Disease?
Julie R. Ingelfinger, Massachusetts General Hospital, Boston, MA

Perinatal Influences on Blood Pressure In the Newborn
Matthew W. Gillman, Harvard Medical School/Harvard Pilgrim Health Care, Boston, MA

What Non-pharmacologic and Drug Treatment Options Are Available for the Management of Neonatal Hypertension
Douglas L. Blowey, Children's Mercy Hospitals and Clinics, Kansas City, MO

Sponsored jointly by the International Pediatric Hypertension Association and the Pediatric Academic Societies
 

10:30am–12:30pm
4402—Issues in Neonatal Resuscitation
PAS Original Science Abstracts - Poster Symposium

11:45am–2:45pm
4501—Fish, Worms and Flies
PAS Mini Course
Chair: Edward R.B. McCabe, Mattel Children's Hospital at UCLA, Los Angeles, CA

One of the most important lessons of the Human Genome Project is how similar we are to the organisms that surround us. The similarities between our biology and theirs means that they truly are models from which we learn more about ourselves and our diseases. In this mini course, we will see how the fruit fly, Drosophila melanogaster, can be used to identify drugs for human diseases. We will learn how the nematode worm, Caenorhabditis elegans, can be used to investigate signaling pathways that are preserved from worms to humans and are critical to committing undifferentiated cells to differentiate correctly. The zebrafish, Danio rerio, provides us with a vertebrate model for studying organ systems similar to our own. The presenters will provide a general overview of their organism and then an in-depth description of their research.

Target Audience: Investigators involved with or interested in learning about research involving model organisms. Appeal will be the strengths of these non-mammalian models for investigations ranging from developmental biology to high-throughput drug screens.

Overview of Non-mammalian Model Organisms
Edward R.B. McCabe, Mattel Children's Hospital at UCLA, Los Angeles, CA

Flies: Identifying New Drugs for Human Diseases
Juan Botas, Baylor College of Medicine, Houston, TX

Worms: Signal Transduction and Cellular Differentiation
David M. Eisenmann, University of Maryland, Baltimore, MD

Fish: Developmental Genetics of the Heart
Didier Stainier, University of California, San Francisco, CA

Discussion

Sponsored jointly by the AAP Section on Cardiology and the Pediatric Academic Societies
 

11:45am–2:45pm
4503—Neonatal Follow-Up: A Global Perspective
PAS Mini Course
Chair: Maureen Hack, Case Western Reserve University, Cleveland, OH

The increase in survival of extremely immature infants, together with the institution of randomized clinical trials to assess the efficacy and safety of the many technologic and pharmacologic advances in perinatal care, has led to a renewed interest in current outcomes and the methodologic issues related to high-risk follow-up. Questions include the practicality of actual assessment of children versus the reliability of parental reports and age of follow-up. Traditional measures of outcome have included mainly cognitive and neurosensory function, but there is increasing interest in the overall functioning of the child, as well as other measures of health including health status and quality of life. This session will review epidemiologic principles and state of the art measures of cognitive and neuropsychologic assessment, neurologic impairment, including cerebral palsy, health status, growth and quality of life. The presentations will be illustrated with examples of recent outcome studies. Audience participation will be encouraged.

Target Audience: Scientists and clinicians involved with clinical care and research pertaining to the results of neonatal intensive care.

Historical Overview and Introduction
Maureen Hack, Case Western Reserve University, Cleveland, OH

Epidemiology Principles in Designing, Executing and Analyzing Newborn Follow-Up Studies
Nigel Paneth, Michigan State University College of Human Medicine, East Lansing, MI

Cognitive and Neurophysiologic Outcomes
Glen Aylward, Southern Illinois University School of Medicine, Springfield, IL

Cerebral Palsy and Other Neurologic Outcomes
Betty R. Vohr, Women and Infant's Hospital, Providence, RI

Health Status and Growth
Maureen Hack, Case Western Reserve University, Cleveland, OH

Issues in Measuring Quality of Life in Children
Saroj Saigal, McMaster University, Hamilton, Ontario, Canada

Discussion
 

11:45am–2:45pm
4506—Update in Neonatal/Pediatric Nutrition Support
PAS Mini Course
Chair: Michael Narkewicz, Children's Hospital, Denver, CO; and Mark Corkins, Riley Hospital for Children and Indiana University, Indianapolis, IN

Nutrition is critical to the normal growth and development of children. Our ability to supply nutrition to ill infants has increased dramatically in the last half of the twentieth century with the development of parenteral nutrition (TPN) and commercially prepared formulas. This advanced technology has also presented us with new knowledge as new nutritional deficiencies were discovered in patients on long-term TPN. The new technology has also created new risks associated with the supply of this nutrition. This session will explore some of the micronutrients necessary in infant TPN and some of the potential toxicities. The potential risks and new information concerning enteral formulas for use in infants will be presented.

Target Audience: Clinicians involved in the care of ill infants that require nutrition support beyond standard feedings.

Introduction
Michael R. Narkewicz, University of Colorado Health Sciences Center, Denver, CO

Cysteine, Choline and Carnitine: Are These Cs Important to the Neonate?
Sandeep K. Gupta, Riley Hospital for Children and Indiana University, Indianapolis, IN

Aluminum Toxicity in TPN
Gordon L. Klein, University of Texas Medical Branch, Galveston, TX

TPN-Associated Liver Disease in the Neonate
Beth Anne Carter, Baylor College of Medicine, Houston, TX

Fat Soluble Vitamin Requirements in the Neonate
Frank R. Greer, University of Wisconsin and Meriter Hospital, Madison, WI

Enteral Formula Safety
Mark R. Corkins, Riley Hospital for Children, Indiana University, Indianapolis, IN

Recent Advances in Neonatal Formulas
Jane D. Carver, University of South Florida College of Medicine, Tampa, FL

Discussion
 Saturday, MAY 14

1:00pm–3:00pm
4652—Neonatal Infectious Disease and Inflammation
PAS Original Science Abstracts - Platform Session

1:00pm–3:00pm
4654—Pulmonary Vascular Biology
PAS Original Science Abstracts - Poster Symposium

3:15pm–5:15pm
4843—Gastroenterology
PAS Original Science Abstracts - Platform Session

3:15pm–5:15pm
4847—Human Milk or Breastfeeding
PAS Original Science Abstracts - Poster Symposium

3:15pm–5:15pm
4848—Neonatal Hematology–Immunology
PAS Original Science Abstracts - Poster Symposium

3:15pm–5:15pm
4849—Neonatal Infectious Disease
PAS Original Science Abstracts - Platform Session

3:15pm–5:15pm
4851—Pathogenesis of Bronchopulmonary Dysplasia
PAS Original Science Abstracts - Platform Session

5:15pm–7:15pm
Poster Session I
PAS Original Science Abstracts - Poster Session

Neonatology:
4960—Resuscitation/Hypoxemia
4961—Ophthalmology/Retinopathy of Prematurity
4962—Pain and Pain Management
4963—Cardiovascular—CHD, Blood Pressure
4964—Pregnancy

Neonatal Infectious Diseases:
4970—Coagulase Negative Staph
4971—Central Venous Catheters
4972—Antibiotic Usage
4973—Gram Negatives
4974—Candida
4975—Neonatal Sepsis and Pneumonia
4976—Neonatal Sepsis, Diagnosis
4977—Cytokines, Immunomodulation, Pathogenesis

7:15pm–8:30pm
4991A—Neonatal Hemodynamics Club
 Club

Cerebral Blood Flow in the Neonate: Autoregulation, Pathophysiology and Neurodevelopmental Outcome

Cerebral Autoregulation in the Newborn: Do We Really Have a Clue?
Adre J. du Plessis,

The Impact of Early Hypotension and Low Systemic Perfusion on Neurodevelopment in the Preterm Neonate. Do Our Treatments Help?
David Osborn, Royal Prince Alfred Hospital, Camperdown, Australia

Contact:
Istvan Seri, M.D., Ph.D.
Children's Hospital at Los Angeles and the Women's and Children's Hospital at the LAS/USC Medical Center, University of Southern California
Phone: 323-669-5932
Email: iseri@chla.usc.edu
 

Sunday, MAY 15

7:00am–8:00am
5054—Neonatology I
Academic Career Paths in Neonatology
PAS Meet the Professor Breakfast

Christine A. Gleason, W. Alan Hodson Professor of Pediatrics and Head, Division of Neonatology, University of Washington, Childrens Hospital and Regional Medical Center, Seattle, WA

This session is designed to provide trainees and junior faculty with insights into two different academic career paths in neonatology—the Clinician-Scientist and Clinician-Educator faculty tracks. Training requirements and ongoing educational needs, academic job descriptions and job searches and new fundable areas of scholarship in neonatal-perinatal medicine will be addressed. Special emphasis will be given to seeking and obtaining appropriate career development mentoring and to issues of academic career and personal balance, particularly given the intense clinical demands of our field.

Target Audience: Trainee, junior faculty.
 

7:00am–8:00am
5055—Neonatology II
Foundations for a Successful Career in Academic Neonatology
PAS Meet the Professor Breakfast

Eduardo Bancalari, Professor of Pediatrics, Director, Division of Newborn Medicine, University of Miami School of Medicine, Miami, FL

This session is designed to provide trainees and junior faculty insight and advice concerning the pursuit of an academic career in neonatal-perinatal medicine. Emphasis will be placed on the steps to achieve the best possible training in clinical neonatology as well as in research in newborn medicine and in developmental biology. The main hurdles and opportunities for advancement in academic neonatology will be analyzed. Past and present trends in newborn medicine and their impact on career opportunities in this exciting field of pediatrics will be discussed.

Target Audience: Trainee, junior faculty.
 

8:00am–10:00am
5101—ARDS: New Pathways and Treatments
PAS Topic Symposium
Chairs: Steven H. Abman, University of Colorado School of Medicine, Denver, CO; and Alan Jobe, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Acute respiratory distress syndrome (ARDS) remains a leading cause of morbidity and death in critically ill neonates, infants and children. ARDS is associated with diverse clinical disorders, including sepsis, trauma, aspiration and infection and is characterized by lung inflammation, non-hydrostatic pulmonary edema and poor lung compliance. Recent advances in the basic pathobiology of lung injury have led to new insights into the etiology and potential therapeutic approaches toward ARDS. In addition, recent clinical studies have examined differences between adult and pediatric ARDS, genetic susceptibility factors that may increase the risk for ARDS, interactive cellular and physiologic mechanisms that cause progressive lung injury and the role of different strategies of mechanical ventilation that can adversely or favorably determine the clinical outcomes of patients with ARDS. This symposium includes leading experts in the field of lung biology and critical care who will present state of the art information on basic pathophysiologic mechanisms of ARDS and new therapeutic approaches. These integrated topics are of marked interest to intensivists, neonatologists, pulmonologists, infectious disease and basic scientists in the field of lung biology.

Target Audience: Scientists and clinicians interested in basic mechanisms underlying the pathophysiology of acute lung injury and clinical strategies in the management of acute hypoxemic respiratory failure in neonates, infants and children.

New Insights into ARDS
Michael Matthay, University of California San Francisco Medical School, San Francisco, CA

Mechanisms of Tissue Injury in Sepsis/ARDS
Hector R. Wong, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Role of Permissive Hypercapnea in Acute Lung Injury
Brian Kavanagh, Hospital for Sick Children, Toronto, ON, Canada

Novel Ventilator Strategies in ARDS
John H. Arnold, Children's Hospital, Boston, MA
 

8:00am–10:00am
5103—Gastroesophageal Reflux Disease in Infants and Children
PAS/NASPGHAN Topic Symposium
Chairs: Benny Kerzner, Children's National Medical Center, Washington, DC; and Eric Hassall, British Columbia Children’s Hospital, University of British Columbia, Vancouver, Canada

Moderate-to-severe GERD in the premature infant, newborn and child presents challenging diagnostic and therapeutic issues to a neonatologist, pediatrician, gastroenterologist and surgeon. First, new information on the epidemiology, pathophysiology and genetics will be presented. Second, new modes of diagnostic testing (e.g., impedance monitoring) will be reviewed along with extra-esophageal manifestations of GERD. Third, the pros and cons of medical, endoscopic (e.g., radiofrequency, ablation suturing) and surgical therapy will be discussed.

Target Audience: Scientists and clinicians involved with premature newborns, infants and children with difficult to manage moderate-to-severe reflux, suffering from extra-esophageal complications.

Overview
Eric Hassall, British Columbia Children’s Hospital, University of British Columbia, Vancouver, Canada

Born To Reflux: The Epidemiology, Pathophysiology and Genetic Features of GERD in Infants
Benny Kerzner, Children's National Medical Center, Washington, DC

EERD (Extraesophageal Reflux Disease): Reflux Beyond the Esophageal Box
Victor M. Pineiro, Nemours Children's Clinic-Orlando, FL

Too Many Operations, Too Few Reasons: Why it’s Time to Change Course
Eric Hassall, British Columbia Children’s Hospital, University of British Columbia, Vancouver, Canada

Sponsored jointly by the North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition and the Pediatric Academic Societies
 

8:00am–10:00am
5146—Neonatal CNS Injury
PAS Original Science Abstracts - Platform Session

8:00am–10:00am
5147—Oxidant Signaling Pathways
PAS Original Science Abstracts - Poster Symposium

8:00am–10:00am
5150—Vascular Mediators in Persistent Pulmonary Hypertension
PAS Original Science Abstracts - Platform Session

10:15am–11:45am
5350—APS Presidential Plenary and Awards
APS Presidential Plenary

2005 APS Presidential Address
Elizabeth R. McAnarney, University of Rochester Medical Center, Rochester, NY

53rd Annual John Howland Award*
Mary Ellen Avery, Thomas Morgan Rotch Distinguished Professor of Pediatrics, Harvard Medical School; Physician-in-Chief, Emerita, Children's Hospital, Boston, MA

Introduction
Margaret K. Hostetter, Jean McLean Wallace Professor and Chair, Department of Pediatrics, Yale University School of Medicine, New Haven, CT

*Presented by the Federation of Pediatric Organizations on behalf of the Ambulatory Pediatric Association, American Academy of Pediatrics, American Board of Pediatrics, American Pediatric Society, Association of Medical School Pediatric Department Chairmen, Association of Pediatric Program Directors and the Society for Pediatric Research
 

11:45am–1:45pm
Poster Session II
PAS Original Science Abstracts - Poster Session

Neonatology:
5465—Apnea—Respiratory Control
5466—Control of Breathing
5467—Bilirubin and Phototherapy
5468—Neonatal–Fetal Nutrition and Metabolism

Infectious Diseases:
5480—Vaccines
 

12:00pm–1:30pm
5492A—Milk Club—Advancing Evidence-Based Care of Breastfeeding Mothers and Infants
 Club

Does Maternal Obesity Impede Lactation? Evidence and Clinical Implications
Kathleen M. Rasmussen, Cornell University, Ithaca, NY

Vitamin D Supplementation of Mothers or Infants? The Need for Evidence-Based Care
Carol L. Wagner, Medical University of South Carolina, Charleston, SC

Vitamin D and Breastfeeding Mother-Infant Pairs: An International Perspective
Adekunle H. Dawodu, Cincinnati Children's Hospital, Cincinnati, OH

The Milk Club gives one travel award each year to an outstanding trainee (medical, graduate, resident or post-doctoral student) who submits a first-authored abstract on breastfeeding.

Contact:
Ardythe L. Morrow, Ph.D.
Cincinnati Children's Hospital Medical Center
Phone: 513-636-7626
Email: ardythe.morrow@chmcc.org
 

12:00pm–1:30pm
5494A—Perinatal Brain Club
 Club

Impact of Neonatal Seizures on the Developing Brain

Basic Mechanisms of Epileptogenesis in the Developing Brain
Brenda Porter, Children's Hospital of Philadelphia, Philadelphia, PA

Imaging and Neonatal Seizures—Can We Predict Outcome
Steven P. Miller, University of California at San Francisco, San Francisco, CA

The Role of aEEG in the Detection and Monitoring of Neonatal Seizures
Linda DeVries, Wilhelmina Children's Hospital, Utrecht, The Netherlands

Contact:
Jeff Perlman, M.D.
Weill Medical College of Cornell University
Phone: 212-746-3530
Email: jmp2007@med.cornell.edu
 

2:00pm–4:00pm
5521—Regulation of Alveolar Epithelial Repair—or, How Do We Put It All Back Together Again
PAS Topic Symposium
Chairs: Rita Ryan, State University of New York at Buffalo, Women and Children's Hospital of Buffalo, Buffalo, NY; and Heber Nielsen, Tufts University School of Medicine, Tufts-New England Medical Center, Boston, MA

Regulation of alveolar epithelial repair after many forms of lung injury remains incompletely understood. The type II cell is an important source of growth factors and there are autocrine and paracrine mediators that are altered during the repair process. Type I cells are the primary covering of the alveolar epithelium, and their restoration is critical to recapitulate normal repair. This symposium will focus on the fundamental mechanisms of epithelial repair after injury and examine connections with lung development. Finally, relevance to current clinical disease will be discussed.

Target Audience: Physician and basic scientists interested in how the alveolar epithelium repairs itself after injury and the relationship of lung repair with lung development.

Introduction
Rita M. Ryan, State University of New York at Buffalo, Women and Children's Hospital of Buffalo, Buffalo, NY
Heber C. Nielsen, Tufts New England Medical Center, Boston, MA

Type II Cell Mitogens
Timothy D. Le Cras, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Type II Cell Proliferation During Lung Injury and Repair
Michael A. O'Reilly, University of Rochester, Rochester, NY

Type I Cells in Alveolar Repair
Susan H. Guttentag, Children's Hospital of Philadelphia, Philadelphia, PA

Apoptosis in Alveolar Epithelial Repair
Lin L. Mantell, Institute for Medical Research at North Shore-Long Island Jewish, New York University School of Medicine, Manhasset, NY

Translating Alveolar Epithelial Repair Fundamentals to the Bedside
John S. Torday, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA
 

2:00pm–4:00pm
5522—Update on Human Milk Immunobiology and Infectious Disease: New Insights and Current Controversies
PAS/PIDS/Milk Club Topic Symposium
Chairs: Mark R. Schleiss, University of Minnesota Medical School, Minneapolis, MN; and Lawrence M. Gartner, Professor Emeritus, University of Chicago, Chicago, IL

The importance of human milk feeding to reduce risk of infectious disease in infants is undisputed among pediatricians. Nevertheless, more data are needed about the basic biology of human milk, particularly in relation to specific health and developmental effects on term and premature infants. There have recently been significant advances in the understanding of the immunobiology of breast milk, particularly with respect to the role of oligosaccharides in protection against diarrheal disease, and new insights into interrelationships between breast milk and gut immune responses. In addition to presenting these new research data, this session will also review clinical controversies in breast feeding practice, including issues of milk storage and the potential for transmission of infectious pathogens, in particular cytomegalovirus, via human milk. Areas of need for future clinical and basic research will be emphasized.

Target Audience: Clinicians responsible for the care of newborn infants, particularly premature infants; neonatologists, gastroenterologists, infectious diseases physicians and general pediatricians; and basic scientists conducting research on human milk, secretory immunity or gut immunity.

The Future of Breast Milk Research: What Do We Need To Learn?
Lawrence M. Gartner, Professor Emeritus, University of Chicago, Chicago, IL

Human Milk Oligosaccharides and Their Role in Protection Against Gastroenteritis
Ardythe L. Morrow, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Infectious Diseases and Human Milk: Does Cytomegalovirus Pose a Risk to the Breast-fed Infant?
Mark R. Schleiss, University of Minnesota Medical School, Minneapolis, MN

Human Milk as a Carrier of Biochemical Responses to the Newborn
W. Allan Walker, Harvard Medical School, Boston, MA

Mother's Milk, Milk Banks and Preemies: Effects of Pasteurization and Storage on Milk Nutrition and Biology
Richard J. Schanler, Schneider Children's Hospital at North Shore, North Shore University Hospital, Manhasset, NY

Human Milk Immunology: The Whole Is Greater Than the Sum of Its Parts
Charles Isaacs, New York State Institute for Basic Research, Staten Island, NY

Discussion

Sponsored jointly by the Pediatric Infectious Diseases Society, the Milk Club and the Pediatric Academic Societies
 

2:00pm–4:00pm
5535—Neonatal Epidemiology and Follow-up
PAS Original Science Abstracts - Platform Session

2:00pm–4:00pm
5536—Neonatal–Fetal Nutrition and Metabolism I
PAS Original Science Abstracts - Platform Session

2:00pm–4:00pm
5537—Neurology/Neonatal Neurology
PAS Original Science Abstracts - Platform Session

2:00pm–4:00pm
5538—Pathogenesis, Prevention and Treatment of Necrotizing Enterocolitis
PAS Original Science Abstracts - Poster Symposium

2:00pm–5:00pm
5589—Newborn Nursery
APA Special Interest Group
Chair: Linda Meloy, lmeloy@mail2.vcu.edu

Information not yet available.
 

4:15pm–6:15pm
5741—Corticosteroids and Premature Neonates
PAS Original Science Abstracts - Platform Session

4:15pm–6:15pm
5743—Pediatric Nutrition and Metabolism
PAS Original Science Abstracts - Platform Session

6:15pm–7:15pm
5875A—Neonatal Sepsis Club
 Club

Hot Topics in Neonatal Meningitis
George H. McCracken

Contact:
David Kaufman, M.D.
University of Virginia Children's Medical Center
Phone: 434-924-9114
Email: davidkaufman@virginia.edu
 

Monday, MAY 16

8:00am–10:00am
6131—Brain Metabolism and Injury
PAS Original Science Abstracts - Platform Session

8:00am–10:00am
6132—Clinical Trials in Perinatal and Neonatal Medicine I
PAS Original Science Abstracts - Platform Session

8:00am–10:00am
6133—Development Biology
PAS Original Science Abstracts - Platform Session

8:00am–10:00am
6139—Neonatal Outcomes: Impact of Health Services Utilization and Socioeconomics
PAS Original Science Abstracts - Platform Session

8:00am–10:00am
6140—Neonatal–Fetal Nutrition and Metabolism II
PAS Original Science Abstracts - Poster Symposium

8:00am–10:00am
6141—Neurodevelopmental Disabilities
PAS Original Science Abstracts - Poster Symposium

9:00am–12:00pm
6207—NICHD Neonatal Research Network—How Do I Apply?
PAS Educational Workshop
Leader: Rosemary D. Higgins, Bethesda, MD; Co-leader: Catherine Y. Spong

The purpose of the Neonatal Research Network is to establish and maintain a multi-center research network of neonatal intensive care units with an independent data-coordinating center and NICHD to perform clinical trials, observational research and translational research. The infrastructure is set up for randomized double-blind placebo controlled trials with the ability to follow short-term (clinical effect) and long-term (neurodevelopmental outcome) measures for the high-risk neonatal population. A didactic presentation explaining the NRN's mission, objectives, procedures for application, peer review, funding procedures, capitation of clinical studies, steering committee responsibilities, initiation of clinical trials, data management and manuscript development will be presented by NICHD. Attendees will be given the opportunity to obtain additional information in a question-and-answer session.

Objectives:

1. To familiarize attendees with the Neonatal Research Network.

2. To inform attendees of the application procedure for the NRN.

Method of Instruction: Didactic presentation followed by a question-and-answer session.

Target Audience: Trainee, junior faculty, mid-level faculty.
 

10:15am–12:00pm
6300—SPR Presidential Plenary and Awards
SPR Presidential Plenary

Introduction
Lisa M. Guay-Woodford, University of Alabama at Birmingham, Birmingham, AL

Maureen Andrew Mentor Awardee
Edward R.B. McCabe, Mattel Children's Hospital at UCLA, Los Angeles, CA

Richard D. Rowe Awardee
Vidu Garg, University of Texas Southwestern Medical School, Dallas, TX

Richard D. Rowe Award Honorable Mention
Conrad L. Epting, University of California, San Francisco
Stephanie Marie Ware, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

David G. Nathan Awardee
Mwe Mwe Chao

Douglas K. Richardson Awardee
Maureen Hack, Case Western Reserve University, Cleveland, OH

Young Investigator Awardee
Anne Marguerite Moon, University of Utah Health Sciences Center

SPR Distinguished Service Award
Samuel Hawgood, University of California Medical Center, San Francisco, CA

E. Mead Johnson Awardees

Elizabeth C. Engle, Children's Hospital, Boston, MA

Gene Therapy for Inherited Lung Disease
Terence R. Flotte, University of Florida, Gainesville, FL

SPR Presidential Address
Lisa M. Guay-Woodford, University of Alabama at Birmingham, Birmingham, AL

*The E. Mead Johnson Awards are supported by an educational grant from Mead Johnson Nutritionals

12:00pm–1:00pm
6400A—XXII Annual Audrey K. Brown Kernicterus Symposium
 Club
Chairs: David K. Stevenson, Stanford University School of Medicine, Stanford, CA; William J. Cashore, Wo