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6:00am–8:00am
Respiratory
Viruses in the Development and Exacerbation of Asthma:
Re-examining the Impact of Influenza and the Benefits of
Immunization
PAS
Industry Sponsored Symposium
Yerba
Buena Gardens Salon 7, SF Marriott
Target
Audience: Infectious diseases.
Asthma
is the most common chronic pediatric disorder affecting nearly
6 million U.S. children under age 18. It accounts for over
640,000 annual emergency room visits and is the third leading
cause of hospitalization in children.
The
Centers for Disease Control and Prevention and other major
medical and public health groups recommend influenza
vaccination for all children with asthma. Yet, studies show
even in the best years, only one-third are vaccinated.
Annual
influenza vaccination is vital for all children with asthma,
regardless of severity, to protect them from influenza and its
complications.
The
symposium will highlight the need for routine influenza
vaccination for children with asthma, examine how to define
the asthmatic child and review the importance of increasing
recognition of the impact of influenza in this high-risk
population.
For
registration information please contact:
Dimara
Almeida
Phone: (212) 886-2250
E-mail: rsvp@asthmaflu.com
A
CME Satellite Symposium sponsored by the National Foundation
for Infectious Diseases
Supported
by a grant from Sanofi Pasteur
7:00am–8:00am
4020—Public
Policy Council 20th Annual Legislative Breakfast Symposium
PPC
Breakfast
Room
2002, Moscone West
Chair:
Myron Genel, Yale University School of Medicine, New Haven, CT
Can
Medicaid be "reformed" without adversely impacting
access to care for children and adolescents? As a member of
the Secretary of Health and Human Services' Medicaid
Commission, Carol Berkowitz will provide an overview of the
Commission's activities, the outcome of the ongoing
deliberations of the Medicaid Commission, a preview of the
next steps for the Commission and an outline of the role of
the pediatric community in advocating for the critically
important EPSDT program and opposing cost sharing.
-
Introduction
Myron
Genel, Yale University School of Medicine, New Haven, CT
-
Medicaid
"Reform": Can We Preserve Our Children's Safety
Net?
Carol
D. Berkowitz, Professor of Clinical Pediatrics, David
Geffen School of Medicine at UCLA, Torrance, CA
-
Discussion
7:00am–8:00am
4040A—ASPN
Stone and Bone Club
ASPN
Committee
Sierra
Suite B, SF Marriott
7:00am–8:00am
4050A—Congenital
Thrombotic Thrombocytopenic Purpura (TTP) Registry
ASPHO
Workshop
Golden
Gate Hall A1, SF Marriott
Chair:
David G. Motto, University of Michigan, Ann Arbor, MI
Last
year we established that there was interest in the pediatric
hematology community to establish a registry for patients with
congenital TTP. This year we will describe the formation of
the registry and how individual physicians can access it and
contribute patient information. This registry will contain
descriptive information regarding the presentation, diagnosis,
treatment and outcome of patients with congenital TTP, along
with a database of ADAMTS13 mutations. Information will also
be provided regarding where physicians can obtain clinical and
research laboratory testing for ADAMTS13 activity and mutation
analysis.
7:00am–8:00am
4060A—Pediatric
Cancer—Pharmacogenetics and Pharmacogenomics: Do They Have
Practical Applications?
ASPHO
Workshop
Golden
Gate Hall A2-3, SF Marriott
Chairs:
Brigitta U. Mueller, Baylor College of Medicine, Houston, TX;
and Craig A. Mullen, University of Rochester Medical Center,
Rochester, NY
This
session will review genetic polymorphisms related to drug
metabolism and their relationship to toxicity. Available
pediatric data will be reviewed specifically related to
current recommendations for genetic testing in relationship to
specific agents, as well as dose modifications. This program
will also contain a case review to highlight potential
clinical scenarios in relationship to pharmacogenetic testing.
-
Pharmacogenetics
in Clinical Trials
Lisa
Bomgaars, Texas Children's Cancer Center, Houston, TX
-
Pharmacogenetics
and Toxicity Secondary to Cancer Therapy
Fatih
Okcu, Texas Children's Cancer Center, Baylor College of
Medicine, Houston, TX
-
Case
Discussion
7:00am–8:00am
4070—APA
Regional Breakfasts
APA
Breakfast
SF
Marriott
Region
I . . . . . . Golden Gate Hall B1
Region II . . . . . . Golden Gate Hall B2
Region III . . . . . Golden Gate Hall B3
Region IV . . . . . Golden Gate Hall C1
Region V . . . . . . Golden Gate Hall C2
Region VI. . . . . . Golden Gate Hall C3
Region VII . . . . . Laurel
Region VIII. . . . . Yerba Buena Gardens Salon I
Region IX & X . . Willow
8:00am–9:45am
4134—Neonatal
Pharmacology
PAS
Platform Session
Room
3014, Moscone West
Chairs:
Joyce M. Koenig and Augusto Sola
8:00am–10:00am
4100—Making
Pediatrics Family Friendly
PAS/APPD
Topic Symposium
Room
2003-2007, Moscone West
Chairs:
Carol D. Berkowitz, Harbor-UCLA Medical Center, Torrance, CA;
and Richard E. Behrman, Federation of Pediatric Organizations,
Inc., Menlo Park, CA
Target
Audience: Pediatric clerkship directors, residency program
directors, fellowship directors and division chiefs and
department chairs, as well as those in training or faculty
interested in a family-friendly environment.
The
Federation of Pediatric Organizations (FOPO) released its
Report of the Task Force on Women in Pediatrics in April 2005.
The report recommends structural and functional changes in
academic pediatrics so that family balance is possible during
all stages of training. Specific steps to achieve this goal
were outlined from medical student training up through senior
pediatric faculty. It has been proposed that information
should be collected from medical schools and training programs
so that they can be rated as “family-friendly” in a manner
analogous to Fortune 500 companies. Issues related to a
family-friendly environment include flexible training and work
schedules; provision of sufficient leave for
maternity/paternity and eldercare; resources for childcare,
after-school and lactation facilities; and extension of
timelines for tenure and extramural funding.
-
Overview
Carol
D. Berkowitz, Professor of Clinical Pediatrics, David
Geffen School of Medicine at UCLA, Torrance, CA
Richard E. Behrman, Federation of Pediatric Organizations,
Inc., Menlo Park, CA
-
The
FOPO Report and the View of a Chair
Bonita
F. Stanton, Wayne State University School of Medicine,
Children’s Hospital of Michigan, Detroit, MI
-
Part-Time
Pediatrics: Faculty and Residents
Rebecca
R. S. Socolar, UNC - Chapel Hill, Chapel Hill, NC
-
Parenting
During Medical School, Residency and Fellowship:
Pregnancy, Parental Leave and Lactation
Alison
Volpe Holmes, Dartmouth-New Hampshire Family Practice
Program, Concord, NH
-
The
FOPO Task Force on Women Report and Program Director
Perspectives
Ann
Burke, Wright State University, Dayton, OH
-
Creating
a Great Place to Work™- Lessons from the 100 Best
Companies to Work for in America
Hal
Adler, Great Place to Work Institute™, Inc., San
Francisco, CA
-
Discussion
Sponsored
jointly by the Association of Medical School Pediatric
Department Chairs, the Association of Pediatric Program
Directors and the Pediatric Academic Societies
Supported
in part by an unrestricted educational grant from GATE
Pharmaceuticals
8:00am–10:00am
4105—MRI
of the Brain in Neonates
PAS
Topic Symposium
Room
3022-3024, Moscone West
Chairs:
Terrie E. Inder and Jeff J. Neil, St. Louis Children's
Hospital, St. Louis, MO
Target
Audience: Neonatologists, neurologists, radiologists and
trainees.
Magnetic
resonance (MR) imaging remains a rapidly evolving field,
particularly in its application to newborn infants. This
symposium will first review the basics of MR imaging methods
(including conventional and diffusion MR imaging) and then
highlight clinical applications of these methods to common
neonatal clinical conditions in the term and premature infant.
The talks will be targeted to clinicians and aimed to address
key clinical questions such as:
–
In which infants should I undertake an MR scan in my NICU?
– What are the strengths and weakness of MRI/CT/cranial
ultrasound?
– How can I undertake MR imaging in my institution—safety,
image sequences and interpretation?
– When should I undertake an MR scan in the term or
premature infant?
– What do the abnormalities in the MR scan mean for
long-term neurological outcome?
– How should I use this information in my clinical practice
in the NICU?
– Where is MR imaging taking us in the next 10 years in
newborn medicine?
-
A-B-C
of M-R-I
Jeffrey
J. Neil, Washington University and St. Louis Children's
Hospital, St. Louis, MO
-
Application
of MR Imaging to the Term Infant
Mary
Rutherford, Hammersmith Hospital, London, UK
-
Application
of MR Imaging to the Preterm Infant
Terrie
E. Inder, Washington University and St. Louis Children's
Hospital, St. Louis, MO
-
X-Y-Z-
of M-R-I—The Future with Advanced MR Methods
Petra
S. Huppi, Children's Hospital, University of Geneva,
Geneva, Switzerland
8:00am–10:00am
4110—Pediatric
Fluids and Hyponatremia: Are We Giving Too Much Water?
PAS/ASPN/LWPES
Topic Symposium
Room
3007-3011, Moscone West
Chairs:
John W. Foreman, Duke University Medical Center, Durham, NC;
and D. Michael Foulds, University of Texas Health Science
Center at San Antonio, San Antonio, TX
Target
Audience: Nephrologists, general pediatricians, emergency room
doctors, intensivists, hospitalists, endocrinologists and
anyone who administers IV maintenance fluids.
In
the 1950s, Holiday and Segar devised formulae for calculating
intravenous maintenance fluids for infants and children who
were unable to drink. These formulae have been taught and used
now for over 40 years and have generally stood the test of
time. However, several recent investigators have challenged
these formulae and argued that they put children at risk of
hyponatremia. Since Holiday and Segar devised these formulae,
new information has arisen, such as the concept of non-osmotic
stimulation of ADH release in sick children and our ability to
measure ADH levels in plasma on a routine basis. Arieff and
Ayus were the first to point out that children and women are
at particular risk for developing hyponatremic encephalopathy.
Moritz and Ayus have subsequently argued that hypotonic
parenteral fluid should not be used unless there are ongoing
free water losses or hypernatremia. In addition to this new
clinical data, Verkman’s group has exciting data identifying
molecular mechanisms of cerebral edema, including after water
intoxication. Dr. Arieff will review who is at risk and why.
Dr. Verkman’s group has developed data regarding mechanisms
of cerebral edema in experimental animals. Dr. Moritz will
describe the new concepts of maintenance fluids. Dr. Friedman
will defend the current practice. At the end there will be
time for an exchange between the speakers and the audience on
the right fluid to use in today’s children.
-
Hyponatremic
Encephalopathy: Special Risk Factors for Children and
Women
Allen
I. Arieff, University of California San Francisco, San
Francisco, CA
-
Aquaporin
4 and Cerebral Edema
Alan
S. Verkman, University of California San Francisco, San
Francisco, CA
-
0.9%
Sodium Chloride: The New Approach to Maintenance Fluids in
Pediatrics
Michael
L. Moritz, Children's Hospital of Pittsburgh, Pittsburgh,
PA
-
Maintenance
Therapy: Tried and True
Aaron
L. Friedman, Brown Medical School, Hasbro Children's
Hospital, Providence, RI
Sponsored
jointly by the AAP Section on Nephrology, the American Society
of Pediatric Nephrology, the Lawson Wilkins Pediatric
Endocrine Society and the Pediatric Academic Societies
8:00am–10:00am
4120—Cardiology—Translation
Research and Clinical Studies
PAS
Platform Session
Room
3020, Moscone West
Chairs:
Daniel Bernstein and Bruce Gelb
8:00am–10:00am
4122—Children
with Special Health Care Needs
PAS
Platform Session
Room
2008, Moscone West
Chairs:
Ardis L. Olson and Ruth E.K. Stein
8:00am–10:00am
4124—Genetics
and Dysmorphology
PAS
Platform Session
Room
2006, Moscone West
Chairs:
Suzanne B. Cassidy and Mira Irons
8:00am–10:00am
4126—Health
Services II
PAS
Platform Session
Room
2004, Moscone West
Chairs:
Kevin J. Dombkowski and Stephen M. Downs
8:00am–10:00am
4128—Hospital
Medicine
PAS
Platform Session
Room
2009-2011, Moscone West
Chairs:
Daniel Rauch and John D. Tobin
8:00am–10:00am
4130—Infectious
Diseases II
PAS/PIDS
Platform Session
Room
3001, Moscone West
Chairs:
Kathryn M. Edwards and Michael A. Gerber
8:00am–10:00am
4132—Mechanisms
of Neonatal Lung Injury
PAS
Platform Session
Room
3003-3005, Moscone West
Chairs:
Vineet Bhandari and Vasanth H.S. Kumar
8:00am–10:00am
4136—Nutritional
Disorders—Mechanisms
PAS
Platform Session
Room
3000, Moscone West
Chairs:
Conrad R. Cole and B U.K. Li
8:00am–10:00am
4138—Public
Health and Prevention III
PAS
Platform Session
Room
2002, Moscone West
Chairs:
Chris Feudtner and Rita Mangione-Smith
8:00am–11:00am
4150—The
Skinny on the Adipocyte
PAS/LWPES
Mini Course
Room
3010-3012, Moscone West
Chairs:
Silva A. Arslanian, University of Pittsburgh, Pittsburgh, PA;
and Robert H. Lustig, University of California, San Francisco,
CA
Target
Audience: General pediatricians, gastroenterologists,
endocrinologists, cardiologists, pulmonologists and adolescent
medicine specialists.
Over
the past five years much has been learned about the adipocyte.
The ability of the adipocyte to function as an endocrine
gland, elaborating inflammatory cytokines that result in free
radical formation and premature apoptosis of the beta cell, is
a relatively new concept. This mini course will
comprehensively address many of the newest concepts in
adipocyte function and their impact on health and disease.
Further discussion will include new concepts on the
interactions of IGF-II and other peptides' interactions with
the adipocyte. Lastly, there will be a call for new approaches
to the pediatric obesity epidemic.
-
Adipose
Tissue as an Endocrine Organ
Susan
Fried, University of Maryland School of Medicine,
Baltimore VA Medical Center, Baltimore, MD
-
Obesity
and Inflammation
Christopher
Hug, Whitehead Institute and Children's Hospital,
Cambridge, MA
-
Effects
of GH, IGF-I and Insulin Therapies on Adiposity
Zvi
Laron, Schneider Children's Medical Center of Israel,
Petah Tikva, Isreal
-
Pathology
and Sequelae of Childhood Obesity in Adult Life
Dennis
M. Styne, University of California, Davis Medical Center,
Sacramento, CA
Sponsored
jointly by the Lawson Wilkins Pediatric Endocrine Society and
the Pediatric Academic Societies
8:15am–10:15am
4180A—Chronic
Organ Damage in Sickle Cell Disease: Diagnosis, Prevention and
Treatment
ASPHO
Symposium
Room
3016-3018, Moscone West
Chair:
Russell E. Ware, St. Jude Children’s Hospital, Memphis, TN
Chronic
organ damage is increasingly recognized as an important source
of morbidity and mortality for young persons with sickle cell
disease. This symposium will include descriptions of several
prospective multicenter clinical trials that focus on the
diagnosis, treatment and prevention of organ damage in this
common hematological disorder.
After
attending this session, it is expected that the learner will
be able to:
1.
Discuss ongoing prospective multicenter randomized clinical
trials that focus on brain damage in pediatric patients with
sickle cell anemia.
2. Describe prospective clinical trials that focus on spleen
and kidney damage in very young patients with sickle cell
anemia.
3. Describe new imaging modalities for transfusional iron
overload in the liver and heart, as well as studies using new
oral iron chelating agents for its therapeutic management.
-
Introduction
and Overview
Russell
E. Ware, St. Jude Children's Research Hospital, Memphis,
TN
-
Brain
-
Silent
Infarct Transfusion (SIT) Trial
Michael
R. DeBaun, Washington University School of Medicine,
St. Louis, MO
-
Stroke
with Transfusions Changing to Hydroxyurea (SWiTCH)
Trial
Russell
E. Ware, St. Jude Children's Research Hospital,
Memphis, TN
-
Spleen
and Kidney
-
Splenic
Function in Young Children: Lessons from BABY HUG
Zora
R. Rogers, The University of Texas Southwestern
Medical Center, Dallas, TX
-
Renal
Function in Young Children: BABY HUG, Toddler HUG
Sherri
A. Zimmerman, Duke University Medical Center, Durham,
NC
-
Liver
and Heart
-
New
Imaging Techniques for Transfusional Iron Overload
Thomas
D. Coates, Children's Hospital of Los Angeles, Los
Angeles, CA
-
Oral
Iron Chelators for the Management of Transfusional
Iron Overload
Alan
R. Cohen, Children's Hospital of Philadelphia,
Philadelphia, PA
-
Questions
and Panel Discussion
9:00am–12:00pm
4220—Competency-Based
Evaluation of EBM Skills in Pediatric Residency and Fellowship
Programs
PAS
Educational Workshop
Yerba
Buena Gardens Salon 6, SF Marriott
Leader:
Hans Kersten, Philadelphia, PA; Co-leaders: E. Douglas
Thompson, John Frohna, Robert McGregor, Tahniat Syed, Erin
Giudice, Susan Guralnick, Nancy Spector
Target
Audience: Trainees, fellows, junior faculty, mid-level
faculty, and senior faculty.
This
interactive workshop will provide a framework for evaluation
of EBM skills throughout pediatric educational programs and
three different residency programs' approach to the
development of an evaluation system for their EBM curricula.
Participants will use three validated tools that measure EBM
knowledge and EBM skills (e.g., formulating a question and
searching and critiquing an article) by rotating through
30-minute small group sessions.
Objectives:
–
Participants will learn an EBM evaluation framework.
– Participants will use validated EBM evaluation tools.
– Participants will develop EBM evaluation implementation
strategy for their EBM curricula.
Format:
Small group discussion, videotape, problem solving, and
hands-on experience with tools.
Designed
to meet elements of the core curriculum for pediatric
fellowship subspecialty training.
9:00am–12:00pm
4222—Continuity
Curriculum in the Age of Competencies: Yes We Can!
PAS
Educational Workshop
Yerba
Buena Gardens Salon 1, SF Marriott
Leader:
Wendy Davis, Burlington, VT; Co-leaders: Rebecca Collins,
Paula Algranati, Paul Darden, Jan Drutz, Marilyn
Dumont-Driscoll, Susan Feigelman, Diane Kittredge, John
Olsson, Sharon Riesen, Janet Serwint
Target
Audience: Junior faculty, mid-level faculty, senior faculty,
community practitioners.
Attendees
will acquire skills needed to design a curriculum for use in
the continuity setting, based on the APA Educational
Guidelines and the ACGME Competencies. Workshop leaders will
present a brief review of the Guidelines and Competencies.
Attendees will rotate through small group discussions on
curriculum topic selection, module development,
competency-based evaluation, and overcoming barriers. Leaders
will provide a framework and model tools for each discussion
group.
Objectives:
–
Acquire skills needed to develop a continuity curriculum using
APA Educational Guidelines.
– Gain experience in designing brief, competency-based
evaluation tools.
– Identify solutions to challenges of curriculum planning
(e.g., 80-hour work week).
Format:
Brief didactic introduction, followed by rotation of attendees
through up to four stations for small group discussions.
9:00am–12:00pm
4223—Design
and Conduct of Randomized Clinical Trials
PAS
Educational Workshop
Pacific
Suite B, SF Marriott
Leader:
Mark Klebanoff, Bethesda, MD
Target
Audience: Fellows, junior faculty, mid-level faculty, and
senior faculty.
It
is now almost universally required that randomized trials show
new treatments to be superior to current therapy (or no
therapy) before the new treatments are adopted. In this
workshop we will go through the design and conduct of several
clinical trials, from defining the question to conducting the
final analysis. The format is didactic with extensive
discussion, and we will base as much of the workshop as
possible on real-world trials provided by the participants
themselves.
Objectives:
–
To understand the principles of trial design, conduct and
analysis.
– To improve skills in reading publications of clinical
trial results.
Format:
Didactic sessions with discussion. Real-world examples will be
provided by the participants themselves.
Designed
to meet elements of the core curriculum for pediatric
fellowship subspecialty training.
9:00am–12:00pm
4224—Getting
Your Article Published: The Mysteries of Peer Review and the
Decisions of Journals
PAS
Educational Workshop
Yerba
Buena Gardens Salon 10, SF Marriott
Leader:
Howard Bauchner, Boston, MA
Target
Audience: Fellows, junior faculty, and mid-level faculty.
Understanding
the peer-review process is important for investigators. This
workshop will review the peer-review process and help
investigators prepare manuscripts for publication.
Objectives:
–
To understand the peer-review process
– To improve submissions to peer-review journals
Format:
Didactic presentation, discussion, and vignettes.
Designed
to meet elements of the core curriculum for pediatric
fellowship subspecialty training.
9:00am–12:00pm
4226—Leadership
in the Workplace: A Neglected Competency in Faculty
Development Training
PAS
Educational Workshop
Yerba
Buena Gardens Salon 2, SF Marriott
Leader:
Christiane Corriveau, Washington, DC; Co-leaders: Ira Cohen,
Karen Smith
Target
Audience: Junior and mid-level faculty.
Effective
leadership is essential to facilitating the transformation of
the health care team in the U.S. Physicians have multiple
opportunities to function as leaders in today's health care
environment yet many physicians have not taken on these
leadership roles, often citing lack of formal training in
leadership and management skills. Drawing on their own
personal experiences and leadership theories, participants
will identify effective leadership behaviors, qualities, and
skills. Through interactive exercises and reflective inquiry,
participants will explore personal leadership qualities and
skills needed for professional development and growth.
Objectives:
–
To better understand the complex nature of leadership and its
importance in the delivery of health care today
– To define leadership as a process
– To familiarize the learner with common leadership theories
– To better understand and reflect on one's personal
leadership behaviors through a series of interactive exercises
Format:
Participants will explore leadership theories and practices
through interactive small group processes, video clip
case-based discussions, and reflective inquiry.
9:00am–12:00pm
4228—New
Resources for Teaching Developmental and Behavioral Pediatrics
PAS
Educational Workshop
Yerba
Buena Gardens Salon 11, SF Marriott
Leader:
Steven Parker, Boston, MA
Target
Audience: Fellows, junior faculty, mid-level faculty, senior
faculty, and community practitioners.
The
Division of Developmental and Behavioral Pediatrics at Boston
Medical Center has created two DVDs entitled:
"Developmental and Behavioral Pediatrics: Training
Modules for Clinical Issues in Primary Care."
These
DVDs are intended to enhance the teacher's ability to provide
trainees with engaging and stimulating DBP training
experiences and focus on 24 DBP issues during the first 5
years, including: language delays, social-emotional issues,
temperament, developmental surveillance in primary care,
developmental delays, active children, giving bad news, toilet
training, enuresis, and encopresis, discipline, drugs/alcohol,
cigarettes.
In
this interactive workshop, we will introduce these unique
training tools, and model how they can be used to teach DBP.
At the conclusion of the workshop, each participant will
receive a free set of the DVDs to use in their teaching.
Objective:
–
Become familiarized with the use of new DVD training modules
in Developmental and Behavioral Pediatrics.
Format:
Interactive presentation. Will discuss the intent and format
of the DVDs, and then model their use as a training resource.
9:00am–12:00pm
4230—Recognizing
Common Biostatistical Errors: A Case-Based Approach
PAS
Educational Workshop
Yerba
Buena Gardens Salon 12, SF Marriott
Leader:
Thomas Newman, San Francisco, CA; Co-leader: Susan
Fisher-Owens
Target
Audience: Trainees, fellows, junior faculty, mid-level
faculty, and community practitioners.
This
workshop uses multiple real examples from the pediatric
literature to teach participants how to be more discriminating
consumers of statistics. Topics to be covered include standard
deviation vs. standard error of the mean, commonly violated
assumptions of statistical tests including normality and
independent sampling, between- vs. within-groups comparisons,
"type 3" (dumb or careless) errors, odds ratios vs.
relative risks, relative vs. absolute effect sizes, effect
size exaggeration, and multiple comparisons. In the last part
of the seminar, participants will have the opportunity to test
what they have learned on a set of "unknown"
examples.
Objectives:
–
Choose the correct statistical test.
– Recognize common errors in biostatistics.
– Avoid common errors in biostatistics.
Format:
Case-based question-and-answer period.
Designed
to meet elements of the core curriculum for pediatric
fellowship subspecialty training.
9:00am–12:00pm
4232—Resident
Teachers: Preparing Residents To Be Effective Facilitators of
Learning in the Outpatient Setting
PAS
Educational Workshop
Yerba
Buena Gardens Salon 13, SF Marriott
Leader:
Nathaniel Beers, Washington, DC; Co-leaders: Dale Coddington,
Linda Fu, Patience White
Target
Audience: Trainees, fellows, junior faculty, and mid-level
faculty.
Residents
have been educators in the inpatient setting. As the role of
residents is expanded in the outpatient, there are new skills
required to be effective and efficient facilitators of
learning in the outpatient setting. The workshop will offer an
experience of a curriculum and its evaluation developed by
three graduates of the Master Teacher Program at DC
Children's. The curriculum includes modules on case-based
teaching, precepting, and evaluation/feedback. There will be a
discussion of the theory behind and descriptions of each of
the modules and their evaluation, a chance to experience the
modules and to problem solve around individual institutional
barriers to implementation.
Objectives:
–
To know the skills necessary for residents to be effective
educators in the outpatient setting
– To discuss the lessons learned in developing and
implementing a similar curriculum
– To understand how outpatient teaching can be utilized to
meet ACGME competencies
Format:
Opening presentation with majority of the time spent in small
groups discussions on tools and implementation/barriers.
9:00am–12:00pm
4234—So
You Are an Educator and Want To Be Promoted?: Academic Success
for the Clinician–Educator
PAS
Educational Workshop
Yerba
Buena Gardens Salon 3, SF Marriott
Leader:
Latha Chandran, Stony Brook, NY; Co-leaders: Lucy Osborn,
Virginia Moyer
Target
Audience: Fellows, junior faculty, and mid-level faculty.
This
workshop takes the participants through a promotions committee
decision-making process using real life examples to increase
their understanding of the process as well as factors that
facilitate and impede chances of promotion. The need for
structured documentation using an educator portfolio, in
addition to a standard C.V., will be evidenced and
participants will create an initial version of their
individual portfolios. Workshop leaders will share their own
promotion experiences and institutional experiences in
promotions committees.
Objectives:
–
Enhance participant understanding of the variations in
promotion processes at institutions.
– Demonstrate the usefulness of an educator portfolio for
promotion of clinical educators.
Format:
Interactive seminar, small group problem solving, case based
learning, role-playing and large group discussions.
9:00am–12:00pm
4236—Teach
to Your Strengths and Adapt to Your Learners! Understanding
Individual Teaching and Learning Styles To Maximize Your
Teaching Potential
PAS
Educational Workshop
Yerba
Buena Gardens Salon 4, SF Marriott
Leader:
Heather McPhillips, Seattle, WA; Co-leaders: Richard Shugerman,
Sherilyn Smith and Jordan Symons
Target
Audience: Trainees, fellows, junior faculty, mid-level
faculty, senior faculty, and community practitioners.
Participants
in this highly interactive workshop will work to recognize
their individual teaching strengths and learn to adapt their
teaching style to individual learners' preferences.
Participants will work together to develop a toolbox of
learner-centered strategies for teaching in challenging
situations.
Objectives:
–
Participants will define their individual teaching style.
– Participants will better understand differences in
learning styles.
– Participants will develop strategies to teach to their
individual strengths.
– Participants will develop strategies to teach to learners
with different learning needs.
Format:
This session will be highly interactive with small-group and
larger group discussion, shared problem solving and a small
amount of videotaped examples.
9:00am–12:00pm
4238—Teaching
Decision-Making and Proper Documentation in the Era of
Electronic Medical Records
PAS
Educational Workshop
Yerba
Buena Gardens Salon 14, SF Marriott
Leader:
John Schmidt, Ann Arbor, MI; Co-leaders: Jocelyn Schiller, Amy
Fleming
Target
Audience: fellows, junior faculty, mid-level faculty, and
senior faculty.
Use
of electronic medical records (EMR) promises greater
efficiency and improved communication health-system wide.
Workshop participants will discuss methods for teaching house
staff and students how to take advantage of the efficiency of
an EMR while also writing quality notes. Pediatric
hospitalists from the University of Michigan will discuss the
improvements seen in clarity and thoroughness of notes after
the implementation of a variety of tools. We will demonstrate
templates for medical documentation, including admission
notes, daily progress notes, transfer notes and discharge
summaries. We will discuss other interventions, including the
development of educational sessions for trainees which focus
on proper documenting techniques created with the input of
clinicians, billing, and coding.
Objectives:
–
Learn about attributes of an electronic medical record (EMR)
which impact the quality of documentation.
– Develop strategies to educate trainees on proper
documentation habits within an EMR system.
– Develop strategies to balance the efficiency of the EMR
with billing, coding, and regulatory requirements for students
and residents.
Format:
The workshop will have a brief introduction in a
question-answer format which will identify problems in EMR
documentation. This will be followed by small-groups which
will discuss solutions to these problems.
9:00am–12:00pm
4240—Utilization
of Instructional Alignment for Resident Community-Based
Projects
PAS
Educational Workshop
Yerba
Buena Gardens Salon 5, SF Marriott
Leader:
Quimby McCaskill, Jacksonville, FL; Co-leaders: Colleen
Kalynych, Elisa Zenni, Jeff Goldhagen, David Wood
Target
Audience: Trainees, fellows, junior faculty, mid-level
faculty, senior faculty, and community practitioners.
The
Pediatric RRC requires "structured educational
experiences that prepare residents for the role of advocate
for the health of children within the community." Many
programs are utilizing community-based projects to promote
resident competence in this area. This workshop will introduce
instructional alignment (i.e. aligning objectives with
teaching and evaluation), as it applies to developing a sound
curriculum towards residents achieving competence in community
pediatrics through community-based projects. A videotape
review and analysis will allow participants to become familiar
with the benefits of and the essential components to
instructional alignment. Small work groups will also be used
to apply these concepts.
Objectives:
–
Participants will be able to describe instructional alignment.
– Participants will begin to develop an instructional
alignment protocol in community pediatrics utilizing
community-based projects.
– Participants will describe ways in which to evaluate
residents in national community pediatrics competencies
correlated with ACGME competencies, and explore the value of
electronic portfolios.
Format:
Videotape, roundtable discussions, and small work groups.
9:00am–12:00pm
4242—Well
Child Care for the Premature Infant
PAS
Educational Workshop
Yerba
Buena Gardens Salon 15, SF Marriott
Leader:
Ricki Goldstein, Durham, NC; Co-leader: William Malcolm
Target
Audience: Trainees, fellows, junior faculty, mid-level
faculty, senior faculty, and community practitioners
After
a brief overview of the common problems encountered by
premature infants after discharge, this interactive workshop
will engage the audience in the utilization of a new premature
infant well-child check list being developed for office or
clinic visits during the first 2 years of life. Several videos
of pediatric well-child visits will be viewed which
demonstrate common scenarios involving abnormal motor
development and feeding patterns. After viewing each video,
the workshop participants will complete either a standard
checklist used in a pediatric practice or the one specifically
designed for former premature infants. The key questions or
observations used to detect various problems will be
identified and indications for early intervention will be
discussed.
Objectives:
–
To become familiar with the common medical problems
encountered by premature infants after discharge
– To recognize the red flags for early motor and feeding
problems in premature infants after discharge
– To recognize indications for referring a premature infant
for early intervention services
Format:
(1) Video presentation of well child visit demonstrating
various problems in premature infants; (2) participants to
complete a new check list designed to detect various problems
encountered in the premature infant; and (3) roundtable
discussion of advantages and problems with new check list.
9:00am–12:00pm
4244—Education
in the Digital Age: Designing and Developing Online Teaching
Modules for Medical Learners
PAS
Educational Workshop
Pacific
Suite J, SF Marriott
Leader:
Kadriye Lewis, Cincinnati, OH; Co-leaders: Michael FitzGerald
Target
Audience: Fellows, junior faculty, mid-level faculty, senior
faculty, community practitioners, and all medical educators.
Computer
technology is becoming increasingly central to the area of
teaching in most disciplines, and transformation to online
instructional delivery method represents an exciting new way
to structure teaching and learning. However, many educators,
unfamiliar with the online pedagogy and instructional design
process, simply transfer their courses directly from their
lectures to an online text format. This satisfies the need to
put a course online, but is not the most efficient or
effective way to deliver instructional materials to residents
and medical students. This workshop will provide an essential
grounding for building effective online instructional modules
while preparing medical educators for the digital age
educational approaches.
Objectives:
–
Identify the components of pedagogically effective module
design and development.
– Learn to construct a learning module including assignments
and activities.
– Use templates to guide the development process and rubrics
to assess the strengths and weaknesses of developed modules.
Format:
Showcase demonstration, discussion, and hands-on activities.
9:00am–12:00pm
4250—Emergency
Medicine
APA
Special Interest Group
Golden
Gate Hall A2, SF Marriott
Chairs:
Joan Bothner, bothner.joan@tchden.org;
and Michael Kim, mkim@mcw.edu.
There
has been a significant nationwide increase in the volume of
pediatric patients presenting to emergency departments with
psychiatric and behavioral issues due to a variety of reasons,
which has resulted in a significant challenge to both the
providers of pediatric emergency care and the facilities in
which they work. The emergency medicine SIG meeting during
2006 PAS Annual Meeting will discuss this "psychiatric
crisis in the emergency department." This topic will be
presented in three parts; challenges in clinical evaluation
and interventions, research opportunities and administrative
challenges.
9:00am–12:00pm
4252—Injury
Control
APA
Special Interest Group
Pacific
Suite A, SF Marriott
Chairs:
Shari Barkin, sbarkin@wfubmc.edu;
and Brian Johnston, bdj@u.washington.edu.
The
Injury Control SIG convenes those individuals interested in
the area of injury control at all stages of idea development
and project implementation. During this session you will hear
reports about what your colleagues are doing around the
country in injury control. There will be time for constructive
discussion after each of these brief presentations. We will
also discuss ways to create an active network to stay informed
about our colleagues areas of injury expertise and develop
working collaborations beyond the annual meeting.
9:00am–12:00pm
4254—Integrative
Pediatrics
APA
Special Interest Group
Nob
Hill A, SF Marriott
Chairs:
Sharon Riesen, sriesen@ahs.llumc.edu;
and David Steinhorn, d-steinhorn@northwestern.edu.
The
Integrative Medicine SIG will meet together with the new AAP
provisional Section for Complementary, Holistic and
Integrative Medicine. We will provide a 3-hour multimedia,
experiential presentation for all PAS visitors interested in
finding out more about Complementary and Integrative Medicine
and an opportunity to meet and network with other clinicians,
educators and researchers interested in this topic. Our goal
is to provide a forum to see the current state of
complementary and alternative medicine (CAM) research, an
opportunity to experience a complementary therapy (if they
wish) and to ask about many of the CAM modalities most
commonly used by our patients. Local practitioners from the
San Francisco area will give hands-on demonstrations and
explanations of their specific modality and will answer your
questions, as time permits. Please take advantage of this
unique opportunity to satisfy your curiosity or whet your
appetite to find out about a field which many of our patients
are already exploring.
9:00am–12:00pm
4256—Nutrition
APA
Special Interest Group
Pacific
Suite H, SF Marriott
Chairs:
Sandy Hassink, shassink@nemours.org;
and Robert Karp, robert.karp@downstate.edu.
The
Nutrition SIG will continue with its emphasis on nutrition
education in residency. Our project, "A Teacher's Guide
to Pediatric Nutrition," is readily available at http://downstate.edu/peds/pednutrition.
The model of "stepping stone education" is used with
a primer, "Pediatric Nutrition Notes," as its
foundation. A set of five introductions, Part 2, provide the
tools for usage. Part 3 is a set of eight modules on
pathophysiology, prevention evaluation and treatment of
obesity through childhood. Part 4 contains more than 25
case-based teaching modules on disease processes affected by
nutrition. The Teacher's Guide concludes with a module on
evaluation of teaching applicable to any subject. This
includes use of structured clinical observation for resident
evaluation of taking a diet history and providing guidance.
Faculty
and residents are invited to a 2-hour program with continental
breakfast to explore use of the Teacher's Guide. We will
provide model programs evaluating use of the Teacher's Guide
for achieving basic skills of taking histories and providing
guidance. Participants will join us for presentations,
discussion and continental breakfast. Registration is not
necessary. Queries are welcome by robert.karp@downstate.edu.
9:00am–12:00pm
4258—Practice-Based
Research Networks
APA
Special Interest Group
Pacific
Suite C, SF Marriott
Chair:
Robert Siegel, robertsiegel56@pol.net.
The
Practice-Based Research Network SIG is highlighted by
presentations of recent work done by the SIG members and works
in progress. There will be an open discussion of issues facing
practice-based research as an opportunity to discuss
collaboration on projects and ways of fostering practice-based
research network development.
10:15am–12:15pm
4300—SPR
Presidential Plenary and Awards
SPR
Presidential Plenary
Room
3002-3008, Moscone West
Chair:
Philip W. Shaul, University of Texas Southwestern Medical
Center, Dallas, TX
-
SPR
Award Presentations
-
Student
Research Awards
Allison
Blatz, Case Western Reserve University, Rainbow Babies
& Children's Hospital, Cleveland, OH
Mya
Sendowski, University of California, San Francisco, CA
Karin Batalden, Mayo Medical School, College of
Medicine, Rochester, MN
Prithy
Martis, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
Silvia Gonzaga, Children's Hospital of Philadelphia,
PA
Suzanne Schubbert, University of California, San
Francisco, CA
-
House
Officer Research Award
Keri
Anne Cohn, The Children's Hospital of Philadelphia, PA
Sallie R Permar, Children's Hospital and Boston
Medical Center, Boston, MA
Shrena Patel, University of New Mexico, Albuquerque,
NM
-
Fellow's
Basic Research Award
Camille
Fung, David Geffen School of Medicine at UCLA, Los
Angeles, CA
Michael Hunter, Yale University School of Medicine,
New Haven, CT
Enkhsaikhan
Purevjav, Baylor College of Medicine, Houston, TX
-
Fellow's
Clinical Research Awards
Deepika
Bhatla, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
Maria Miranda, Copenhagen University Hospital,
Hvidovre, Denmark
Joshua D. Schiffman, Stanford University, Palo Alto,
CA
-
David
G. Nathan Award in Hematology/Oncology
Su
Young Kim, National Institutes of Health, Bethesda, MD
-
Japan
Pediatric Society Fellow Awards
Hiroyuki
Ishiguro, Tokai University School of Medicine, Isehara,
Kanagawa, Japan
Kyo Okada, Hino Municipal Hospital, Hino, Tokyo, Japan
Yuka Wada, National Research Institute for Child
Health and Development, Setagaya, Tokyo, Japan
-
Douglas
K. Richardson Award for Perinatal and Pediatric
Healthcare Research
Marie
C. McCormick, Harvard School of Public Health and
Harvard Medical School, Boston, MA
-
Richard
D. Rowe Award in Perinatal Cardiology
Yong
Zhao, Gladstone Institute of Cardiovascular Disease,
University of California San Francisco
-
Young
Investigator Award and Lecture:
Protective
and Non-protective Immune Responses Against
Paramyxoviruses: Understanding Atypical Measles and
Enhanced Respiratory Syncytial Virus Disease
Fernando
Pedro Polack, Johns Hopkins University, Baltimore, MD
-
Maureen
Andrew Mentor Award and Lecture
Donna
M. Ferriero, University of California, San Francisco, CA
-
SPR
Distinguished Service Award
Thomas
A. Hazinski, Vanderbilt University School of Medicine,
Nashville, TN
-
E.
Mead Johnson Awards for Research in Pediatrics and
Lectures:
-
Molecular
Basis for Development of Human B Cell Responses to
Viruses
James
E. Crowe, Professor of Pediatrics, Microbiology and
Immunology, Ingram Professor, Vanderbilt University
Medical Center, Nashville, TN
-
Cell
Division, Genome Stability and Cancer
David
Pellman, The Ted Williams Senior Investigator,
Dana-Farber Cancer Institute and Children’s
Hospital, Boston, MA, Associate Professor of
Pediatrics, Harvard Medical School, Boston, MA
-
Presidential
Address
Philip
W. Shaul, University of Texas Southwestern Medical Center,
Dallas, TX
*The
E. Mead Johnson Awards are supported by an educational grant
from Mead Johnson Nutritionals
10:15am–12:15pm
4320A—New
Frontiers in Reproductive Science
LWPES
Topic Symposium
Room
3001, Moscone West
Chairs:
Ram K. Menon, University of Michigan, Ann Arbor, MI; and Henry
Anhalt, Saint Barnabas Medical Center, Livingston, NJ
Target
Audience: Endocrinologists, geneticists, developmental
biologists and adolescent medicine.
The
regulation of puberty remains one of the greatest mysteries of
medicine. A child is born with all of the necessary components
to undergo puberty at birth but this process is quiescent
until puberty occurs. The attendee will learn the newest
information on the biological regulators of puberty.
In
addition, the attendee will be exposed to newer techniques
available for preservation of fertility in a variety of
different pathological states. Discussion will include the
cryopreservation of the pre-pubertal ovary.
-
Kiss-1
and GPR54 as New Players in Gonadotropin Regulation and
Puberty
Ursula
Kaiser, Brigham and Women's Hospital, Boston, MA
-
Modern
Preservation of Fertility
Kutluk
Oktay, Weill Medical College of Cornell University, New
York, NY
10:15am–12:15pm
4330—Endocrinology:
Growth—Clinical
PAS/LWPES
Platform Session
Room
3007-3011, Moscone West
Chairs:
Jill D. Jacobson and Gadi B. Kletter
10:15am–12:15pm
4335—General
Pediatrics III
PAS
Platform Session
Room
2008, Moscone West
Chairs:
Charles Feild and Lydia M. Furman
10:15am–12:15pm
4340—Hematology/Oncology
III
PAS/ASPHO
Platform Session
Room
3016-3018, Moscone West
Chairs:
Robert Iannone and Mignon Loh
10:15am–12:15pm
4345—Intestinal
Inflammation
PAS
Poster Symposium
Room
3014, Moscone West
Chairs:
Edward J. Hoffenberg and Elizabeth Mannick
10:15am–12:15pm
4347—Late-Breaker
Abstract Session II: General Pediatrics
PAS
Platform Session
Room
2004, Moscone West Convention Center
Chairs:
Yvonne W. Wu and Paul C. Young
The
"Late-Breaker" sessions include reports on clinical
trials and other important and significant pediatric research,
which might not have been ready for reporting at the time of
the winter abstract deadline. Please be sure to review the content
so you don't miss these very special sessions!
10:15am–12:15pm
4350—Mechanisms
of Brain Injury
PAS
Poster Symposium
Room
3020, Moscone West
Chairs:
Maria Delivoria-Papadopoulos and Jeffrey M. Perlman
10:15am–12:15pm
4355—Neurodevelopmental
Outcomes of NICU Graduates
PAS
Poster Symposium
Room
3022-3024, Moscone West
Chairs:
Scott A. Lorch and Michele C. Walsh
10:15am–12:15pm
4360—New
Perspectives on ADHD
PAS
Poster Symposium
Room
2002, Moscone West
Chairs:
Marc A. Lerner and Mark L. Wolraich
10:15am–12:15pm
4365—Nitric
Oxide and Oxygen: A Marriage Made in Heaven or Hell?
PAS
Poster Symposium
Room
3003-3005, Moscone West
Chairs:
Satyan Lakshminrusimha and Leif D. Nelin
12:00pm–1:00pm
4400A—ASPN
Awards Luncheon
ASPN
Luncheon
Yerba
Buena Gardens Salon 7, SF Marriott
12:00pm–1:00pm
4410A—23rd
Annual Audrey K. Brown Kernicterus Symposium
Club
Room
2003-2007, Moscone West
Chairs:
David K. Stevenson, Stanford University School of Medicine,
Stanford, CA; William J. Cashore, Women and Infants Hospital
of Rhode Island, Providence, RI; and Vinod K. Bhutani,
Stanford University School of Medicine, Stanford, CA
-
Organic
Anion Transporter Protein 2 Gene Polymorphisms and
Neonatal Hyperbilirubinemia
Jon F.
Watchko, Division of Newborn Medicine, Department of
Pediatrics, University of Pittsburgh School of Medicine,
Pittsburgh, PA
-
The
Potential Role of Unbound Bilirubin Measurements for the
Management of Jaundiced Newborns
Charles
E. Ahlfors, L.W. Ligand, Vashon, WA
Contact
for information:
David K. Stevenson, M.D.
Stanford University School of Medicine
Phone: 650-723-5711
E-mail: dstevenson@stanford.edu
Supported
in part by an unrestricted educational grant from Natus
Medical, Inc.
12:00pm–1:00pm
4420A—Bioethics
Interest Group
Club
Room
2006, Moscone West
Chair:
Susan Albersheim, British Columbia’s Children’s Hospital,
University of British Columbia, Vancouver, Canada
Panel:
Should All Newborns Be Screened for HIV?
Ram Yogev,
Children's Memorial Hospital, Northwestern University,
Chicago, IL
Ellen Wright Clayton, Vanderbilt University, Nashville, TN
Lainie Friedman Ross, University of Chicago, MacLean Center
for Clinical Medical Ethics, Chicago, IL
Contact
for information:
Susan Albersheim, M.D.
British Columbia's Children's Hospital
Phone: 604-875-2135
Email: salbersheim@ce.bc.ca
12:00pm–1:30pm
4430A—Perinatal
Nutrition and Metabolism Club
Club
Room
2009-2011, Moscone West
-
Probiotics
and Development of Intestinal Host Defense
W.
Allan Walker, Departments of Pediatrics and Nutrition,
Harvard Medical School, Boston, MA
Contact
for information:
Jane McGowan, M.D.
The Johns Hopkins Hospital
Phone: 410-955-4565
Email: jmcgowan@jhmi.edu
Supported
in part by a restricted educational grant from Ross Products
Division, Abbott Laboratories
12:00pm–1:30pm
4440—APA
Luncheons
APA
Luncheon
Golden
Gate Hall B, SF Marriott
–
Region Chairs
– SIG Chairs
– Fellows
12:00pm–6:45pm
Commercial
Exhibits Open and Posters Available for Viewing
PAS
Exhibits
Levels
1 and 2, Moscone West
Posters
Available for Viewing: 12:00pm–6:45pm
Author Attendance: 5:15pm–6:45pm
Level
1:
– Critical Care
– Gastroenterology
– Genetics
– Neonatal Epidemiology and Follow Up
– Neonatal Pulmonology
– Neonatology
– Nephrology
– Pulmonology
Level
2:
– Developmental–Behavioral Pediatrics
– Emergency Medicine
– General Pediatrics
– Medical Education
12:15pm–1:15pm
4470—The
National Children's Study: Status and Future Plans
PAS/PPC
Special Symposium
Room
3010-3012, Moscone West
Chair:
Elena Fuentes-Afflick, University of California, San
Francisco, CA
Target
Audience: Practicing pediatricians, academic child health
professionals, researchers, administrators and policymakers
who are interested in child health across the lifespan.
Professionals interested in the impact of environmental
factors on health outcomes will also be interested.
This
special symposium will present an update on the National
Children's Study,
which recently selected 7 vanguard centers and is prepared to
begin recruitment of subjects. However, the President's budget
proposal allocated no further funding and stated that the
study would be terminated at the end of the current fiscal
year. The panel presenters will discuss the current budgetary
outlook, status of the study, options to implement the study
and respond to questions from the audience.
Panelists
-
Elena
Fuentes-Afflick, University of California, San Francisco,
CA
-
Peter
C. Scheidt, Director, National Children's Study, National
Institute of Child Health and Human Development, National
Institutes of Health, Bethesda, MD
-
Alan
R. Fleischman, Chair, National Children's Study Federal
Advisory Committee, New York Academy of Medicine, New York
and National Institutes of Health, Bethesda, MD
-
David
J. Schonfeld, Member, National Children's Study Federal
Advisory Committee and Chair, AAP Committee on Research,
Cincinnati, OH
Sponsored
jointly by the Public Policy Council and the Pediatric
Academic Societies
12:45pm–2:45pm
4490A—Exploring
Inhibitors: Hemophilia A, Hemophilia B
ASPHO
Industry Sponsored Symposium
Yerba
Buena Gardens Salon 8, SF Marriott
Supported
by a grant from ZLB Behring
1:00pm–2:45pm
4500—March
of Dimes Prize in Developmental Biology Lecture
PAS
Award
Room
3002-3008, Moscone West
Dr.
Varshavsky is a pioneer in the study of ubiquitin, a tiny
protein that has a very big job. Ubiquitin (from the Latin
ubique meaning "everywhere," the source of the word
"ubiquitous") is so named because it is essential to
nearly every major activity in the life cycle of cells,
including cell growth and division during embryo development,
DNA repair, programmed cell death, immune response, and the
nervous system. The ubiquitin system is the housekeeping
mechanism by which the cell maintains a proper and healthy
balance of proteins. Ubiquitin's role was unknown until the
1980s, when Dr. Varshavsky and colleagues elucidated it. This
discovery revolutionized our understanding of the control of
human cells, and ubiquitin quickly became one of the major
areas of study in genetics, developmental biology, cell
biology, and biochemistry. Today ubiquitin is a cornerstone of
medical research into the causes and treatments of birth
defects, neurodegenerative disease, infections, and cancer.
Dr. Varshavsky receives the 2006 March of Dimes Prize for
revealing and characterizing the biological significance of
the ubiquitin system in the regulation of living cells.
-
Regulation
by Proteolysis: The N-End Rule Pathway in Yeast and
Mammals
Alexander
Varshavsky, Smits Professor of Cell Biology, California
Institute of Technology, Pasadena, CA
Presented
by the March of Dimes Birth Defects Foundation
1:45pm–5:15pm
4550—APA
Presidential Plenary and Awards
APA
Presidential Plenary
Room
2003-2007, Moscone West
Claibourne
I. Dungy
Includes
selected original science abstract presentations, as well as
the Presidential Address, APA Outstanding Teaching Award and
APA Research Award.
-
APA
Outstanding Teaching Award
J.
Lindsey Lane
-
APA
Research Award
Neal
Halfon, University of California, Los Angeles, CA
2:00pm–4:00pm
4580—Application
of Translational Science to Vaccinology: Varicella-Zoster
Virus and Human Papillomavirus
PAS/PIDS
State of the Art Plenary
Room
3003-3005, Moscone West
Chairs:
Ann M. Arvin, Stanford University School of Medicine,
Stanford, CA; and Anna-Barbara Moscicki, University of
California, San Francisco, CA
Target
Audience: Infectious disease specialists, primary care
pediatricians, immunologists and adolescent medicine
physicians.
One
of the major goals of infectious diseases research is to
understand the pathogenesis of disease and to use this
knowledge to prevent the illness through vaccination. An
understanding of varicella pathogenesis led to the development
of a successful vaccine, and further insights into long-term
success of the vaccine and the future of varicella
immunization are emerging. A more recent success story is that
of human papillomavirus, in which basic science studies of
pathogenesis led to the development of vaccines based on
virus-like particles. These two examples serve as models of
the success of translational science in combating infectious
diseases.
-
New
Insights into Varicella-Zoster Virus Pathogenesis
Ann M.
Arvin, Stanford University School of Medicine, Stanford,
CA
-
MMRV
and the Future of Immunization Against Varicella-Zoster
Virus
Anne
A. Gershon, Columbia University, New York, NY
-
Pathogenesis
of Human Papillomavirus Infections
Anna-Barbara
Moscicki, University of California, San Francisco, CA
-
Development
of Virus-like Particles for Immunization Against Human
Papillomavirus
John
T. Schiller, National Cancer Institute, National
Institutes of Health, Bethesda, MD
Sponsored
jointly by the Pediatric Infectious Diseases Society and the
Pediatric Academic Societies
3:00pm–4:00pm
4600A—LWPES
Trans-Pacific Lecture
LWPES
Award
Room
3002-3008, Moscone West
Chair:
Mark Sperling, Children's Hospital of Pittsburgh, Pittsburgh,
PA
Target
Audience: Geneticists, endocrinologists and molecular
biologists.
This
new lecture recognizes one outstanding scientist from the
Pacific Rim. This talk will illuminate congenital adrenal
disorders with particular focus on the relationship between
newborn screening and molecular mechanisms.
-
Congenital
Adrenal Disorders: From Newborn Screening to Molecular
Mechanism
Kenji
Fujieda, Asahikawa Medical College, Asahikawa, Japan
3:00pm–5:00pm
4610—Cardiac
Stem Cell Biology and Therapeutics
PAS
Topic Symposium
Room
3001, Moscone West
Chair:
Harold S. Bernstein, University of California, San Francisco,
CA
Target
Audience: Physicians, scientists and trainees with interest in
pediatric cardiology, stem cell biology and reparative
medicine.
This
topic symposium is directed towards educating interested
members about the state of the art in cardiac stem cell
research, both the underlying biology and initial attempts in
animals and humans at cardiac regenerative therapy. The
discussion will range from hematopoietic stem cells to
cardioblasts, as well as to how one assesses the results of
stem cell infusion trials.
-
Recent
History of Secondary Cardiac Myogenesis
Harold
S. Bernstein, University of California, San Francisco, CA
-
Mesenchymal
Stem-Cell-Based Cardiac Regeneration
Andrew
Boyle, Johns Hopins University School of Medicine,
Baltimore, MD
-
Cardioblasts
Kenneth
R. Chien, Mass General Hospital, Harvard Medical School,
Boston, MA
-
Functional
Assessment of Myogenic Stem Cells and Cardiomyocytes for
Cardiac Cell Therapy
Loren
J. Field, Indiana University School of Medicine,
Indianapolis, IN
3:00pm–5:00pm
4620—Hirschsprung’s
Disease and Chronic Constipation: Medical and Surgical
Approaches
PAS/NASPGHAN
Topic Symposium
Room
3014, Moscone West
Chairs:
B U.K. Li, Children's Memorial Hospital, Northwestern
University School of Medicine, Chicago, IL; and Melvin B.
Heyman, University of California San Francisco, San Francisco,
CA
Target
Audience: General pediatricians, pediatric
gastroenterologists, pediatric surgeons and developmental
biologists.
This
symposium will focus on a common yet challenging problem
constipation: the clinical, diagnostic, genetic and surgical
aspects of Hirschsprung’s disease; and diagnostic testing,
medical and surgical treatment of chronic constipation. In
Hirschsprung’s disease, the clinical presentation (red
flags) of, diagnostic testing for and genetic mutations found
will be discussed. Surgical approaches including standard
staged pull-thrus, single stage repairs, laparoscopic
approaches and post-surgical obstructions will be reviewed. In
chronic constipation, the differential diagnosis and
diagnostic testing (findings in anorectal and colonic
manometry, MRI and bead transit studies) will be presented.
Medical and surgical therapeutic approaches will cover
education, behavioral and biofeedback therapy, medical
treatment (disimpaction and maintenance therapy) and antegrade
enemas delivered via cecostomies. The specific approaches
applicable to a general pediatric practice use will be
identified.
-
Clinical
and Genetics Aspects of Hirschsprung's Disease
Cheryl
E. Gariepy, University of Michigan Health System, Ann
Arbor, MI
-
Surgical
Approaches to Hirschsprung's Disease
Daniel
H. Teitelbaum, University of Michigan Hospitals, Ann
Arbor, MI
-
Diagnostic
Approaches to Chronic Constipation
Samuel
Nurko, Children's Hospital and Harvard University, Boston,
MA
-
Therapeutic
Approaches to Chronic Constipation
Warren
P. Bishop, Children's Hospital of Iowa, University of
Iowa, Iowa City, Iowa
Sponsored
jointly by the American Pediatric Surgical Association; the
North American Society for Pediatric Gastroenterology,
Hepatology and Nutrition; and the Pediatric Academic Societies
3:00pm–5:00pm
4625A—Cancer
Etiology
ASPHO
Symposium
Room
3016-3018, Moscone West
Chairs:
Doug K. Graham, University of Colorado at Denver and Health
Sciences Center, Denver, CO; and Julie A. Ross, University of
Minnesota, Minneapolis, MN
This
program will highlight both clinical and basic science
research into the causes of childhood cancer. The program will
begin with an overview of the epidemiology of childhood cancer
including incidence, trends and putative risk factors.
Obstacles to conducting well-designed studies in North America
will be discussed, and the establishment of a North American
Childhood Cancer Research Network will be introduced as a
means to help address some of these challenges. The program
will follow with a discussion of genetic susceptibility to
childhood cancer from single gene disorders with high
individual risk but low population frequency to common
population polymorphisms with low individual risk but high
population frequency. In the final presentation, the role the
family of tyrosine kinases has in the pathogenesis of
childhood cancer will be addressed. Current research on a
novel receptor kinase, Mer, will be presented to suggest a
potential role of this proto-oncogene in the development of
pediatric T cell leukemia and lymphoma.
After
this session, participants should be able to:
1.
Discuss the current state of knowledge regarding the
epidemiology of childhood cancer in the United States.
2. Describe the major activities of the Childhood Cancer
Research Network.
3. Identify the role of genetic susceptibility in the
development of childhood cancer.
4. Describe the role of tyrosine kinases in the pathogenesis
of pediatric cancer, and discuss how these oncogenes are being
targeted in the development of new drugs.
-
Introduction
Doug
K. Graham, University of Colorado at Denver and Health
Sciences Center, Denver, CO
-
Causes
of Childhood Cancer: Where to Next?
Julie
A. Ross, University of Minnesota, Minneapolis, MN
-
Genetic
Susceptibility to Cancer—The Weak and the Strong
Stella
M. Davies, Cincinnati Children’s Hospital Medical
Center, Cincinnati, OH
-
Tyrosine
Kinases as Oncogenes in Pediatric Cancer: The Role of the
Mer Receptor Tyrosine Kinase in Lymphoblastic Leukemia and
Lymphoma
Doug
K. Graham, University of Colorado at Denver and Health
Sciences Center, Denver, CO
-
Question
and Answer Session
3:00pm–5:00pm
4630A—Molecular
Control of the Formation of the Renal Collecting System
ASPN
Symposium
Room
3010-3012, Moscone West
Chairs:
Lisa M. Satlin, Mount Sinai School of Medicine, New York, NY;
and Norman D. Rosenblum, The Hospital for Sick Children,
Toronto, Ontario, Canada
Target
Audience: Clinicians, clinician-scientists and scientists
interested in development, nephrology and human disease
involving the urinary tract.
Kidney
development depends on embryonic processes which pattern the
collecting system consisting of the ureter, renal pelvis and
calyces, and collecting ducts. Disruption of these processes
in humans results in a spectrum of anomalies including
vesicoureteral reflux, malformations of the pelvis and
calyces, a decreased number of collecting ducts and cystic
malformation of these ducts. Presentations in this symposium
will highlight newly elucidated genetic mechanisms that
control different aspects of collecting system formation.
Analyses of genetic mouse models are demonstrating a critical
role for Fibroblast Growth Factor Receptors in controlling
growth and branching of the ureteric buds that give rise to
collecting ducts. Recent evidence reveals a critical role for
HNF1b, a transcription factor, in controlling collecting duct
terminal differentiation and cyst formation via mechanisms
involving PKDH1, the gene mutated in human autosomal recessive
kidney disease. New genetic approaches are being harnessed to
define molecular mechanisms that control formation of the
vesico-ureteric orifice. Together, these discoveries and
approaches are providing novel molecular insights into
developmental nephrology and human disease.
-
Overview
Norman
D. Rosenblum, Professor of Paediatrics and Canada Research
Chair in Developmental Nephrology, Division of Nephrology
& Program in Developmental Biology, The Hospital for
Sick Children, Toronto, Ontario, Canada
-
Role
of Fibroblast Growth Factor Receptors in Kidney
Development
Carlton
M. Bates, Children's Hospital of Columbus, Columbus, OH
-
Transcriptional
Control of the Bradykinin B2 Receptor
Samir
S. El-Dahr, Tulane University School of Medicine, New
Orleans, LA
-
Roles
of HNF-1beta in Kidney Development and Disease
Peter
Igarashi, University of Texas Southwestern School of
Medicine, Dallas, TX
-
Genes
and VUR
Ali
Gharavi, Columbia University, New York, NY
3:00pm–5:00pm
4650—CPCCRN:
The NICHD Collaborative Pediatric Critical Care Research
Network
PAS
Educational Workshop
Room
2004, Moscone West
Leader:
Carol Nicholson, Bethesda, MD; Co-leader: Douglas Willson
Target
Audience: Trainees, fellows, junior faculty, mid-level
faculty, and community practitioners.
There
are 10,500 critically ill and injured children admitted each
year to the PICUs covered in the Network. We would welcome the
opportunity to interact with all of the pediatric
subspecialties in the context of PAS. Our work and our
research are interwoven with each pediatric subspecialty as
well as with pediatric surgery and surgical subspecialties.
Objectives:
–
How cutting edge informatics can be used for collaborative
pediatric research.
– Understand the Network structure, vision and function, in
a multidisciplinary field.
– Learn about new approaches to nosocomial infection during
critical illness.
Format:
An introductory presentation of Network structure and
function, with emphasis on innovation in collaborative
research will begin the workshop. A series of pediatric
critical care scientists will present some of the newer work
being undertaken in the Network in informatics, sedation,
immunology, infectious disease, and outcomes after pediatric
critical illness and injury.
Here
is a specific overview, with each speaker being available for
questions, and audience interaction.
-
The
CPCCRN: Overview
Douglas Willson, MD
-
Functional
Disability Outcomes in Pediatric Critical Care
Murray Pollack, MD
-
Toward
Science-Based Guidelines for Sedation and Mechanical
Ventilation in Pediatric Critical Care
Christopher Newth and/or Sunny Anand
-
Nosocomial
Sepsis and Lymphocytic Apoptosis: GI Prophylaxis,
Glutamine and Zinc in Pediatric Critical Illness
Joseph Carcillo, MD
3:00pm–5:00pm
4652—Grant
Writing
PAS
Educational Workshop
Yerba
Buena Gardens Salon 2, SF Marriott
Leader:
William Hay, Aurora, CO
Target
Audience: Trainees, fellows, junior faculty, mid-level
faculty, and senior faculty.
The
purpose of this workshop is to review the most successful
methods for writing a grant application. NIH grant
applications will be emphasized and used for illustrations,
but the format will be general enough to apply to other
granting agency applications. Specific topics will include:
career timeline for different grants; organization of the
application; items to include in each section of the grant;
budget requirements; writing hints; resubmission strategies;
how to write the application to meet study section reviewer
criteria, common successes and common mistakes in writing
applications. A handout of the power point figures used in Dr.
Hay's talk will be available. There will be ample time for
general and personal questions from the attendees.
Objective:
–
Learn how to write an NIH grant.
Format:
Lecture, and question-and-answer period.
Designed
to meet elements of the core curriculum for pediatric
fellowship subspecialty training.
3:00pm–5:00pm
4654—The
Ins and Outs of Publishing a Scientific Manuscript
PAS
Educational Workshop
Yerba
Buena Gardens Salon 4, SF Marriott
Leader:
Edward Lawson, Baltimore, MD; Co-leader: Jane McGowan
Target
Audience: Fellows and junior faculty.
This
workshop will review basic principles of writing and
publishing the results of clinical research. We will discuss
the purpose and content of each section of a scientific
manuscript from Abstract to Discussion, as well as issues in
use of statistics, figures, and tables. Interactive exercises
in recognizing and correcting common errors will use examples
from manuscripts submitted for publication as well as from
published articles. A discussion of journal selection and the
journal review process will complete the workshop.
Participants may submit material prior to the meeting for
personal review by the workshop leaders, or bring problem
materials to the workshop for (anonymous) review and
discussion.
Objectives:
–
Identify the purpose and content of each of the sections of a
scientific manuscript.
– Recognize common errors in manuscript preparation.
– Understand how manuscripts are reviewed and selected for
publication.
Format:
PowerPoint presentation, round-table discussion of real-life
examples, hands-on problem-solving exercises, and
question-and-answer period.
Designed
to meet elements of the core curriculum for pediatric
fellowship subspecialty training.
3:00pm–5:00pm
4656—Newer
Mouse Technologies Targeted at Dissecting Mechanisms
PAS
Educational Workshop
Yerba
Buena Gardens Salon 5, SF Marriott
Leader:
Parviz Minoo, Los Angeles, CA; Co-leaders: Francesco J. DeMayo,
Ed Morrisey
Target
Audience: Clinician and basic scientists, including new
investigators, fellows and postdoctoral fellows.
The
use of transgenic mice has become commonplace in analysis of
developmental and physiological pathways. This technology has
contributed significantly to and continues to provide critical
information for understanding fundamental biological processes
and their clinical implications in health and disease. The
objective of this workshop is to discuss and review
state-of-the-art approaches using transgenic technologies in
mice, including genetically engineering the airways for the
regulated ablation and expression of genes, as well as
distinct examples from the speakers’ works on lung
development and gene regulation.
3:00pm–5:00pm
4658—NICHD:
How It Works and Opportunities for Research Support
PAS
Educational Workshop
Yerba
Buena Gardens Salon 6, SF Marriott
Leader:
Duane Alexander, Bethesda, MD; Co-leader: Linda Wright
Target
Audience: Trainees, fellows, and junior faculty.
Participants
in this seminar will receive information on how the NIH
receives, assigns, reviews and funds applications for support
of various types of research, training and career development.
The variety of support mechanisms available at different
career stages will be described, along with areas of special
current research interest to the National Institute of Child
Health and Human Development.
Objectives:
–
Areas of special current research interest to NICHD
– Support mechanisms for research, training, and career
development
Format:
Presentations followed by question and answer.
3:00pm–5:00pm
4662—Standardizing
Prescription of Fluids and Medications in the NICU:
Principles, Practical Tools and Applications
PAS
Educational Workshop
Yerba
Buena Gardens Salon 3, SF Marriott
Leader:
Joaquim Pinheiro, Albany, NY; Co-leaders: Amy Mitchell, Vinay
Vaidya
Target
Audience: Trainees, fellows, junior faculty, mid-level
faculty, senior faculty, community practitioners, pharmacists,
and nurses.
Emphasis
on patient safety has led some NICUs to implement standardized
dosing methods, replacing customized fluid and medication
dosing in neonates. JCAHO has mandated a transition from
"rule-of-6"-based prescription to standardized
concentrations. Without national standards, NICU practitioners
are struggling to comply with the mandate.
Workshop
goals are to review principles of error prevention in NICU,
focusing on standardized methods of prescription and
administration. The leaders will share their experience with
paper, electronic and logistic systems for standardizing
fluid, medication and TPN prescription.
Objectives:
–
Participants will learn a variety of practices and tools used
to implement standardized prescription in NICUs.
– Participants will have practiced multidisciplinary
development of solutions to standardized prescription relevant
to their institutions.
– Participants will learn about computerized methods for
rapid implementation of standardized infusions.
Format:
Short presentations, question-and-answer periods, and problem
solving in groups.
3:00pm–5:00pm
4670—Brain
Metabolism and Injury
PAS
Platform Session
Room
3020, Moscone West
Chairs:
Steven P. Miller and Frances J. Northington
Includes:
-
SPR
Fellow's Basic Research Award: The Neuron-Glia Lactate
Shuttle Protects Neurological Function in Neuron-Specific
Glucose Deficiency
Camille
Fung, David Geffen School of Medicine at UCLA, Los
Angeles, CA
3:00pm–5:00pm
4675—Obesity
I
PAS
Poster Symposium
Room
2002, Moscone West
Chairs:
Robert H. Lustig and Jennifer Miller
3:00pm–5:00pm
4680—Neonatal
Fetal Nutrition and Metabolism II
PAS
Platform Session
Room
3007-3011, Moscone West
Chairs:
Patti J. Thureen and Carol L. Wagner
3:00pm–5:00pm
4685—Neonatal
Pulmonary Hypertension: Novel Mechanisms and Therapies
PAS
Poster Symposium
Room
3022-3024, Moscone West
Chairs:
Judy L. Aschner and Robin H. Steinhorn
3:00pm–5:00pm
4690—Sepsis:
Pathogenesis and Outcomes
PAS
Platform Session
Room
3000, Moscone West
Chairs:
John H. Arnold and Joseph A. Carcillo
4:00pm–5:00pm
4700A—PIDS
3rd Annual Stanley A. Plotkin Lectureship in Vaccinology
PIDS
Alliance Society
Room
3003-3005, Moscone West
Chair:
Joseph W. St. Geme, III, Duke University School of Medicine,
Durham, NC
The
Pediatric Infectious Diseases Society has established the
Stanley A. Plotkin Lectureship in Vaccinology to honor Dr.
Plotkin, the Society's "Founding Father." The
lecture, which takes place at the annual PIDS meeting, is
sponsored by Sanofi Pasteur. Dr. Plotkin was medical director
at sanofi pasteur and remains a medical and scientific
advisor. The inaugural lecture was delivered by Dr. Plotkin in
2004.
-
Introduction
Larry
K. Pickering, National Immunization Program, Centers for
Disease Control and Prevention, Atlanta, GA
-
The
Role of Measles Elimination in Development of a National
Immunization Program
Walter
A. Orenstein, Emory University School of Medicine,
Atlanta, GA
Supported
by an unrestricted educational grant from sanofi pasteur
5:00pm–6:00pm
4750A—PIDS
Business Meeting
PIDS
Business Meeting
Room
3003-3005, Moscone West
5:15pm–6:45pm
Poster
Session III
PAS
Poster Session
Room
Levels 1 and 2, Moscone West
Posters
Available for Viewing: 12:00pm–6:45pm
Author Attendance: 5:15pm–6:45pm
Level
1:
– Critical Care
– Gastroenterology
– Genetics
– Neonatal Epidemiology and Follow Up
– Neonatal Pulmonology
– Neonatology
– Nephrology
– Pulmonology
Level
2:
– Developmental–Behavioral Pediatrics
– Emergency Medicine
– General Pediatrics
– Medical Education
6:15pm
4950A—PIDS
Annual Awards Dinner and Banquet
PIDS
Dinner
Room
Ralston Ballroom, Palace Hotel
Ticket
Required - inquire through the PIDS Office at 703-299-6764
6:30pm–9:00pm
A
New Paradigm for Growth
PAS
Industry Sponsored Symposium
Yerba
Buena Gardens Salon 8, SF Marriott
Target
Audience: Endocrinologists.
In
the past, physicians evaluating a child with short stature
focused on determining if the child had growth hormone
deficiency (GHD). Most children with GHD have low IGF-1
levels. This is referred to as secondary IGF-1 deficiency.
Children who are not GHD may also have low IGF-1 levels,
referred to as primary IGF-1 deficiency (Primary IGFD).
Children with Primary IGFD, in contrast to those with
secondary IGFD, would not be expected to respond to GH
treatment, but would require replacement with IGF-1. Now with
IGF-1 replacement therapy available, there are many questions,
surrounding the diagnosis of Primary IGFD. This symposium will
focus on the IGF-1 system, new clinical data, testing and
identification of candidates for IGF-1 treatment. Case studies
will be presented for a pragmatic approach to practicing
pediatric endocrinologists.
For
registration information please contact:
Laura
McCaskill
Phone: 858-345-1103
Email: lmccaskill@tier1group.com
Supported
by a grant from Tercica Pharmaceuticals
6:45pm–8:00pm
4980A—Lung
Club
Club
Yerba
Buena Gardens Salon 7, SF Marriott
-
Is
There a Role for Inhaled Nitric Oxide in the Prevention of
Chronic Lung Disease in the Preterm Infant
John
P. Kinsella, University of Colorado School of Medicine,
Children's Hospital, Denver, CO
Contact
for information:
Roberta A. Ballard, M.D.
Children's Hospital of Philadelphia
Phone: 215-590-1653
Email: ballard@email.chop.edu
Richard
J. Martin
Rainbow Babies & Children's Hospital
Phone: 216-844-3387
Email: rxm6@po.cwru.edu
Supported
in part by an unrestricted educational grant from Ross
Products Division, Abbott Laboratories
7:00pm
4990—APA Board Awardees Dinner
APA Dinner
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