Pediatric Academic Societies'
Annual Meeting

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Contact Information

Mail Address:

3400 Research Forest Dr., Ste B-7
The Woodlands, TX  77381 USA

Email:  info@pas-meeting.org

Telephone:  281-419-0052

Facsimile:  281-419-0082

 

2006 PAS Annual Meeting

April 29–May 2 
San Francisco, California

Daily Schedule (as of April 21, 2006) 


Friday, April 28

Saturday, April 29

Sunday, April 30

Monday, May 1

Tuesday, May 2


Monday, May 1       

6:00am–8:00am
Respiratory Viruses in the Development and Exacerbation of Asthma: Re-examining the Impact of Influenza and the Benefits of Immunization
PAS Industry Sponsored Symposium
Yerba Buena Gardens Salon 7, SF Marriott

Target Audience: Infectious diseases.

Asthma is the most common chronic pediatric disorder affecting nearly 6 million U.S. children under age 18. It accounts for over 640,000 annual emergency room visits and is the third leading cause of hospitalization in children.

The Centers for Disease Control and Prevention and other major medical and public health groups recommend influenza vaccination for all children with asthma. Yet, studies show even in the best years, only one-third are vaccinated.

Annual influenza vaccination is vital for all children with asthma, regardless of severity, to protect them from influenza and its complications.

The symposium will highlight the need for routine influenza vaccination for children with asthma, examine how to define the asthmatic child and review the importance of increasing recognition of the impact of influenza in this high-risk population.

For registration information please contact:

Dimara Almeida
Phone: (212) 886-2250
E-mail: rsvp@asthmaflu.com

A CME Satellite Symposium sponsored by the National Foundation for Infectious Diseases

Supported by a grant from Sanofi Pasteur

7:00am–8:00am
4020—Public Policy Council 20th Annual Legislative Breakfast Symposium
PPC Breakfast
Room 2002, Moscone West
Chair: Myron Genel, Yale University School of Medicine, New Haven, CT

Can Medicaid be "reformed" without adversely impacting access to care for children and adolescents? As a member of the Secretary of Health and Human Services' Medicaid Commission, Carol Berkowitz will provide an overview of the Commission's activities, the outcome of the ongoing deliberations of the Medicaid Commission, a preview of the next steps for the Commission and an outline of the role of the pediatric community in advocating for the critically important EPSDT program and opposing cost sharing.

  • Introduction
    Myron Genel, Yale University School of Medicine, New Haven, CT

  • Medicaid "Reform": Can We Preserve Our Children's Safety Net?
    Carol D. Berkowitz, Professor of Clinical Pediatrics, David Geffen School of Medicine at UCLA, Torrance, CA

  • Discussion

7:00am–8:00am
4040A—ASPN Stone and Bone Club
ASPN Committee
Sierra Suite B, SF Marriott

7:00am–8:00am
4050A—Congenital Thrombotic Thrombocytopenic Purpura (TTP) Registry
ASPHO Workshop
Golden Gate Hall A1, SF Marriott
Chair: David G. Motto, University of Michigan, Ann Arbor, MI

Last year we established that there was interest in the pediatric hematology community to establish a registry for patients with congenital TTP. This year we will describe the formation of the registry and how individual physicians can access it and contribute patient information. This registry will contain descriptive information regarding the presentation, diagnosis, treatment and outcome of patients with congenital TTP, along with a database of ADAMTS13 mutations. Information will also be provided regarding where physicians can obtain clinical and research laboratory testing for ADAMTS13 activity and mutation analysis.

7:00am–8:00am
4060A—Pediatric Cancer—Pharmacogenetics and Pharmacogenomics: Do They Have Practical Applications?
ASPHO Workshop
Golden Gate Hall A2-3, SF Marriott
Chairs: Brigitta U. Mueller, Baylor College of Medicine, Houston, TX; and Craig A. Mullen, University of Rochester Medical Center, Rochester, NY

This session will review genetic polymorphisms related to drug metabolism and their relationship to toxicity. Available pediatric data will be reviewed specifically related to current recommendations for genetic testing in relationship to specific agents, as well as dose modifications. This program will also contain a case review to highlight potential clinical scenarios in relationship to pharmacogenetic testing.

  • Pharmacogenetics in Clinical Trials
    Lisa Bomgaars, Texas Children's Cancer Center, Houston, TX

  • Pharmacogenetics and Toxicity Secondary to Cancer Therapy
    Fatih Okcu, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX

  • Case Discussion

7:00am–8:00am
4070—APA Regional Breakfasts
APA Breakfast
SF Marriott

Region I . . . . . . Golden Gate Hall B1
Region II . . . . . . Golden Gate Hall B2
Region III . . . . . Golden Gate Hall B3
Region IV . . . . . Golden Gate Hall C1
Region V . . . . . . Golden Gate Hall C2
Region VI. . . . . . Golden Gate Hall C3
Region VII . . . . . Laurel
Region VIII. . . . . Yerba Buena Gardens Salon I
Region IX & X . . Willow

8:00am–9:45am
4134—Neonatal Pharmacology
PAS Platform Session
Room 3014, Moscone West
Chairs: Joyce M. Koenig and Augusto Sola

8:00am–10:00am
4100—Making Pediatrics Family Friendly
PAS/APPD Topic Symposium
Room 2003-2007, Moscone West
Chairs: Carol D. Berkowitz, Harbor-UCLA Medical Center, Torrance, CA; and Richard E. Behrman, Federation of Pediatric Organizations, Inc., Menlo Park, CA

Target Audience: Pediatric clerkship directors, residency program directors, fellowship directors and division chiefs and department chairs, as well as those in training or faculty interested in a family-friendly environment.

The Federation of Pediatric Organizations (FOPO) released its Report of the Task Force on Women in Pediatrics in April 2005. The report recommends structural and functional changes in academic pediatrics so that family balance is possible during all stages of training. Specific steps to achieve this goal were outlined from medical student training up through senior pediatric faculty. It has been proposed that information should be collected from medical schools and training programs so that they can be rated as “family-friendly” in a manner analogous to Fortune 500 companies. Issues related to a family-friendly environment include flexible training and work schedules; provision of sufficient leave for maternity/paternity and eldercare; resources for childcare, after-school and lactation facilities; and extension of timelines for tenure and extramural funding.

  • Overview
    Carol D. Berkowitz, Professor of Clinical Pediatrics, David Geffen School of Medicine at UCLA, Torrance, CA
    Richard E. Behrman, Federation of Pediatric Organizations, Inc., Menlo Park, CA

  • The FOPO Report and the View of a Chair
    Bonita F. Stanton, Wayne State University School of Medicine, Children’s Hospital of Michigan, Detroit, MI

  • Part-Time Pediatrics: Faculty and Residents
    Rebecca R. S. Socolar, UNC - Chapel Hill, Chapel Hill, NC

  • Parenting During Medical School, Residency and Fellowship: Pregnancy, Parental Leave and Lactation
    Alison Volpe Holmes, Dartmouth-New Hampshire Family Practice Program, Concord, NH

  • The FOPO Task Force on Women Report and Program Director Perspectives
    Ann Burke, Wright State University, Dayton, OH

  • Creating a Great Place to Work™- Lessons from the 100 Best Companies to Work for in America
    Hal Adler, Great Place to Work Institute™, Inc., San Francisco, CA

  • Discussion

Sponsored jointly by the Association of Medical School Pediatric Department Chairs, the Association of Pediatric Program Directors and the Pediatric Academic Societies

Supported in part by an unrestricted educational grant from GATE Pharmaceuticals

8:00am–10:00am
4105—MRI of the Brain in Neonates
PAS Topic Symposium
Room 3022-3024, Moscone West
Chairs: Terrie E. Inder and Jeff J. Neil, St. Louis Children's Hospital, St. Louis, MO

Target Audience: Neonatologists, neurologists, radiologists and trainees.

Magnetic resonance (MR) imaging remains a rapidly evolving field, particularly in its application to newborn infants. This symposium will first review the basics of MR imaging methods (including conventional and diffusion MR imaging) and then highlight clinical applications of these methods to common neonatal clinical conditions in the term and premature infant. The talks will be targeted to clinicians and aimed to address key clinical questions such as:

– In which infants should I undertake an MR scan in my NICU? 
– What are the strengths and weakness of MRI/CT/cranial ultrasound? 
– How can I undertake MR imaging in my institution—safety, image sequences and interpretation? 
– When should I undertake an MR scan in the term or premature infant? 
– What do the abnormalities in the MR scan mean for long-term neurological outcome? 
– How should I use this information in my clinical practice in the NICU? 
– Where is MR imaging taking us in the next 10 years in newborn medicine?

  • A-B-C of M-R-I
    Jeffrey J. Neil, Washington University and St. Louis Children's Hospital, St. Louis, MO

  • Application of MR Imaging to the Term Infant
    Mary Rutherford, Hammersmith Hospital, London, UK

  • Application of MR Imaging to the Preterm Infant
    Terrie E. Inder, Washington University and St. Louis Children's Hospital, St. Louis, MO

  • X-Y-Z- of M-R-I—The Future with Advanced MR Methods
    Petra S. Huppi, Children's Hospital, University of Geneva, Geneva, Switzerland

8:00am–10:00am
4110—Pediatric Fluids and Hyponatremia: Are We Giving Too Much Water?
PAS/ASPN/LWPES Topic Symposium
Room 3007-3011, Moscone West
Chairs: John W. Foreman, Duke University Medical Center, Durham, NC; and D. Michael Foulds, University of Texas Health Science Center at San Antonio, San Antonio, TX

Target Audience: Nephrologists, general pediatricians, emergency room doctors, intensivists, hospitalists, endocrinologists and anyone who administers IV maintenance fluids.

In the 1950s, Holiday and Segar devised formulae for calculating intravenous maintenance fluids for infants and children who were unable to drink. These formulae have been taught and used now for over 40 years and have generally stood the test of time. However, several recent investigators have challenged these formulae and argued that they put children at risk of hyponatremia. Since Holiday and Segar devised these formulae, new information has arisen, such as the concept of non-osmotic stimulation of ADH release in sick children and our ability to measure ADH levels in plasma on a routine basis. Arieff and Ayus were the first to point out that children and women are at particular risk for developing hyponatremic encephalopathy. Moritz and Ayus have subsequently argued that hypotonic parenteral fluid should not be used unless there are ongoing free water losses or hypernatremia. In addition to this new clinical data, Verkman’s group has exciting data identifying molecular mechanisms of cerebral edema, including after water intoxication. Dr. Arieff will review who is at risk and why. Dr. Verkman’s group has developed data regarding mechanisms of cerebral edema in experimental animals. Dr. Moritz will describe the new concepts of maintenance fluids. Dr. Friedman will defend the current practice. At the end there will be time for an exchange between the speakers and the audience on the right fluid to use in today’s children.

  • Hyponatremic Encephalopathy: Special Risk Factors for Children and Women
    Allen I. Arieff, University of California San Francisco, San Francisco, CA

  • Aquaporin 4 and Cerebral Edema
    Alan S. Verkman, University of California San Francisco, San Francisco, CA

  • 0.9% Sodium Chloride: The New Approach to Maintenance Fluids in Pediatrics
    Michael L. Moritz, Children's Hospital of Pittsburgh, Pittsburgh, PA

  • Maintenance Therapy: Tried and True
    Aaron L. Friedman, Brown Medical School, Hasbro Children's Hospital, Providence, RI

Sponsored jointly by the AAP Section on Nephrology, the American Society of Pediatric Nephrology, the Lawson Wilkins Pediatric Endocrine Society and the Pediatric Academic Societies

8:00am–10:00am
4120—Cardiology—Translation Research and Clinical Studies
PAS Platform Session
Room 3020, Moscone West
Chairs: Daniel Bernstein and Bruce Gelb

8:00am–10:00am
4122—Children with Special Health Care Needs
PAS Platform Session
Room 2008, Moscone West
Chairs: Ardis L. Olson and Ruth E.K. Stein

8:00am–10:00am
4124—Genetics and Dysmorphology
PAS Platform Session
Room 2006, Moscone West
Chairs: Suzanne B. Cassidy and Mira Irons

8:00am–10:00am
4126—Health Services II
PAS Platform Session
Room 2004, Moscone West
Chairs: Kevin J. Dombkowski and Stephen M. Downs

8:00am–10:00am
4128—Hospital Medicine
PAS Platform Session
Room 2009-2011, Moscone West
Chairs: Daniel Rauch and John D. Tobin

8:00am–10:00am
4130—Infectious Diseases II
PAS/PIDS Platform Session
Room 3001, Moscone West
Chairs: Kathryn M. Edwards and Michael A. Gerber

8:00am–10:00am
4132—Mechanisms of Neonatal Lung Injury
PAS Platform Session
Room 3003-3005, Moscone West
Chairs: Vineet Bhandari and Vasanth H.S. Kumar

8:00am–10:00am
4136—Nutritional Disorders—Mechanisms
PAS Platform Session
Room 3000, Moscone West
Chairs: Conrad R. Cole and B U.K. Li

8:00am–10:00am
4138—Public Health and Prevention III
PAS Platform Session
Room 2002, Moscone West
Chairs: Chris Feudtner and Rita Mangione-Smith

8:00am–11:00am
4150—The Skinny on the Adipocyte
PAS/LWPES Mini Course
Room 3010-3012, Moscone West
Chairs: Silva A. Arslanian, University of Pittsburgh, Pittsburgh, PA; and Robert H. Lustig, University of California, San Francisco, CA

Target Audience: General pediatricians, gastroenterologists, endocrinologists, cardiologists, pulmonologists and adolescent medicine specialists.

Over the past five years much has been learned about the adipocyte. The ability of the adipocyte to function as an endocrine gland, elaborating inflammatory cytokines that result in free radical formation and premature apoptosis of the beta cell, is a relatively new concept. This mini course will comprehensively address many of the newest concepts in adipocyte function and their impact on health and disease. Further discussion will include new concepts on the interactions of IGF-II and other peptides' interactions with the adipocyte. Lastly, there will be a call for new approaches to the pediatric obesity epidemic.

  • Adipose Tissue as an Endocrine Organ
    Susan Fried, University of Maryland School of Medicine, Baltimore VA Medical Center, Baltimore, MD

  • Obesity and Inflammation
    Christopher Hug, Whitehead Institute and Children's Hospital, Cambridge, MA

  • Effects of GH, IGF-I and Insulin Therapies on Adiposity
    Zvi Laron, Schneider Children's Medical Center of Israel, Petah Tikva, Isreal

  • Pathology and Sequelae of Childhood Obesity in Adult Life
    Dennis M. Styne, University of California, Davis Medical Center, Sacramento, CA

Sponsored jointly by the Lawson Wilkins Pediatric Endocrine Society and the Pediatric Academic Societies

8:15am–10:15am
4180A—Chronic Organ Damage in Sickle Cell Disease: Diagnosis, Prevention and Treatment
ASPHO Symposium
Room 3016-3018, Moscone West
Chair: Russell E. Ware, St. Jude Children’s Hospital, Memphis, TN

Chronic organ damage is increasingly recognized as an important source of morbidity and mortality for young persons with sickle cell disease. This symposium will include descriptions of several prospective multicenter clinical trials that focus on the diagnosis, treatment and prevention of organ damage in this common hematological disorder.

After attending this session, it is expected that the learner will be able to:

1. Discuss ongoing prospective multicenter randomized clinical trials that focus on brain damage in pediatric patients with sickle cell anemia.
2. Describe prospective clinical trials that focus on spleen and kidney damage in very young patients with sickle cell anemia.
3. Describe new imaging modalities for transfusional iron overload in the liver and heart, as well as studies using new oral iron chelating agents for its therapeutic management.

  • Introduction and Overview
    Russell E. Ware, St. Jude Children's Research Hospital, Memphis, TN

  • Brain

    • Silent Infarct Transfusion (SIT) Trial
      Michael R. DeBaun, Washington University School of Medicine, St. Louis, MO

    • Stroke with Transfusions Changing to Hydroxyurea (SWiTCH) Trial
      Russell E. Ware, St. Jude Children's Research Hospital, Memphis, TN

  • Spleen and Kidney

    • Splenic Function in Young Children: Lessons from BABY HUG
      Zora R. Rogers, The University of Texas Southwestern Medical Center, Dallas, TX

    • Renal Function in Young Children: BABY HUG, Toddler HUG
      Sherri A. Zimmerman, Duke University Medical Center, Durham, NC

  • Liver and Heart

    • New Imaging Techniques for Transfusional Iron Overload
      Thomas D. Coates, Children's Hospital of Los Angeles, Los Angeles, CA

    • Oral Iron Chelators for the Management of Transfusional Iron Overload
      Alan R. Cohen, Children's Hospital of Philadelphia, Philadelphia, PA

  • Questions and Panel Discussion

9:00am–12:00pm
4220—Competency-Based Evaluation of EBM Skills in Pediatric Residency and Fellowship Programs
PAS Educational Workshop
Yerba Buena Gardens Salon 6, SF Marriott
Leader: Hans Kersten, Philadelphia, PA; Co-leaders: E. Douglas Thompson, John Frohna, Robert McGregor, Tahniat Syed, Erin Giudice, Susan Guralnick, Nancy Spector

Target Audience: Trainees, fellows, junior faculty, mid-level faculty, and senior faculty.

This interactive workshop will provide a framework for evaluation of EBM skills throughout pediatric educational programs and three different residency programs' approach to the development of an evaluation system for their EBM curricula. Participants will use three validated tools that measure EBM knowledge and EBM skills (e.g., formulating a question and searching and critiquing an article) by rotating through 30-minute small group sessions.

Objectives:

– Participants will learn an EBM evaluation framework.
– Participants will use validated EBM evaluation tools.
– Participants will develop EBM evaluation implementation strategy for their EBM curricula.

Format: Small group discussion, videotape, problem solving, and hands-on experience with tools.

Designed to meet elements of the core curriculum for pediatric fellowship subspecialty training.

9:00am–12:00pm
4222—Continuity Curriculum in the Age of Competencies: Yes We Can!
PAS Educational Workshop
Yerba Buena Gardens Salon 1, SF Marriott
Leader: Wendy Davis, Burlington, VT; Co-leaders: Rebecca Collins, Paula Algranati, Paul Darden, Jan Drutz, Marilyn Dumont-Driscoll, Susan Feigelman, Diane Kittredge, John Olsson, Sharon Riesen, Janet Serwint

Target Audience: Junior faculty, mid-level faculty, senior faculty, community practitioners.

Attendees will acquire skills needed to design a curriculum for use in the continuity setting, based on the APA Educational Guidelines and the ACGME Competencies. Workshop leaders will present a brief review of the Guidelines and Competencies. Attendees will rotate through small group discussions on curriculum topic selection, module development, competency-based evaluation, and overcoming barriers. Leaders will provide a framework and model tools for each discussion group.

Objectives:

– Acquire skills needed to develop a continuity curriculum using APA Educational Guidelines.
– Gain experience in designing brief, competency-based evaluation tools.
– Identify solutions to challenges of curriculum planning (e.g., 80-hour work week).

Format: Brief didactic introduction, followed by rotation of attendees through up to four stations for small group discussions.

9:00am–12:00pm
4223—Design and Conduct of Randomized Clinical Trials
PAS Educational Workshop
Pacific Suite B, SF Marriott
Leader: Mark Klebanoff, Bethesda, MD

Target Audience: Fellows, junior faculty, mid-level faculty, and senior faculty.

It is now almost universally required that randomized trials show new treatments to be superior to current therapy (or no therapy) before the new treatments are adopted. In this workshop we will go through the design and conduct of several clinical trials, from defining the question to conducting the final analysis. The format is didactic with extensive discussion, and we will base as much of the workshop as possible on real-world trials provided by the participants themselves.

Objectives:

– To understand the principles of trial design, conduct and analysis.
– To improve skills in reading publications of clinical trial results.

Format: Didactic sessions with discussion. Real-world examples will be provided by the participants themselves.

Designed to meet elements of the core curriculum for pediatric fellowship subspecialty training.

9:00am–12:00pm
4224—Getting Your Article Published: The Mysteries of Peer Review and the Decisions of Journals
PAS Educational Workshop
Yerba Buena Gardens Salon 10, SF Marriott
Leader: Howard Bauchner, Boston, MA

Target Audience: Fellows, junior faculty, and mid-level faculty.

Understanding the peer-review process is important for investigators. This workshop will review the peer-review process and help investigators prepare manuscripts for publication.

Objectives:

– To understand the peer-review process
– To improve submissions to peer-review journals

Format: Didactic presentation, discussion, and vignettes.

Designed to meet elements of the core curriculum for pediatric fellowship subspecialty training.

9:00am–12:00pm
4226—Leadership in the Workplace: A Neglected Competency in Faculty Development Training
PAS Educational Workshop
Yerba Buena Gardens Salon 2, SF Marriott
Leader: Christiane Corriveau, Washington, DC; Co-leaders: Ira Cohen, Karen Smith

Target Audience: Junior and mid-level faculty.

Effective leadership is essential to facilitating the transformation of the health care team in the U.S. Physicians have multiple opportunities to function as leaders in today's health care environment yet many physicians have not taken on these leadership roles, often citing lack of formal training in leadership and management skills. Drawing on their own personal experiences and leadership theories, participants will identify effective leadership behaviors, qualities, and skills. Through interactive exercises and reflective inquiry, participants will explore personal leadership qualities and skills needed for professional development and growth.

Objectives:

– To better understand the complex nature of leadership and its importance in the delivery of health care today
– To define leadership as a process
– To familiarize the learner with common leadership theories
– To better understand and reflect on one's personal leadership behaviors through a series of interactive exercises

Format: Participants will explore leadership theories and practices through interactive small group processes, video clip case-based discussions, and reflective inquiry.

9:00am–12:00pm
4228—New Resources for Teaching Developmental and Behavioral Pediatrics
PAS Educational Workshop
Yerba Buena Gardens Salon 11, SF Marriott
Leader: Steven Parker, Boston, MA

Target Audience: Fellows, junior faculty, mid-level faculty, senior faculty, and community practitioners.

The Division of Developmental and Behavioral Pediatrics at Boston Medical Center has created two DVDs entitled: "Developmental and Behavioral Pediatrics: Training Modules for Clinical Issues in Primary Care."

These DVDs are intended to enhance the teacher's ability to provide trainees with engaging and stimulating DBP training experiences and focus on 24 DBP issues during the first 5 years, including: language delays, social-emotional issues, temperament, developmental surveillance in primary care, developmental delays, active children, giving bad news, toilet training, enuresis, and encopresis, discipline, drugs/alcohol, cigarettes.

In this interactive workshop, we will introduce these unique training tools, and model how they can be used to teach DBP. At the conclusion of the workshop, each participant will receive a free set of the DVDs to use in their teaching.

Objective:

– Become familiarized with the use of new DVD training modules in Developmental and Behavioral Pediatrics.

Format: Interactive presentation. Will discuss the intent and format of the DVDs, and then model their use as a training resource.

9:00am–12:00pm
4230—Recognizing Common Biostatistical Errors: A Case-Based Approach
PAS Educational Workshop
Yerba Buena Gardens Salon 12, SF Marriott
Leader: Thomas Newman, San Francisco, CA; Co-leader: Susan Fisher-Owens

Target Audience: Trainees, fellows, junior faculty, mid-level faculty, and community practitioners.

This workshop uses multiple real examples from the pediatric literature to teach participants how to be more discriminating consumers of statistics. Topics to be covered include standard deviation vs. standard error of the mean, commonly violated assumptions of statistical tests including normality and independent sampling, between- vs. within-groups comparisons, "type 3" (dumb or careless) errors, odds ratios vs. relative risks, relative vs. absolute effect sizes, effect size exaggeration, and multiple comparisons. In the last part of the seminar, participants will have the opportunity to test what they have learned on a set of "unknown" examples.

Objectives:

– Choose the correct statistical test.
– Recognize common errors in biostatistics.
– Avoid common errors in biostatistics.

Format: Case-based question-and-answer period.

Designed to meet elements of the core curriculum for pediatric fellowship subspecialty training.

9:00am–12:00pm
4232—Resident Teachers: Preparing Residents To Be Effective Facilitators of Learning in the Outpatient Setting
PAS Educational Workshop
Yerba Buena Gardens Salon 13, SF Marriott
Leader: Nathaniel Beers, Washington, DC; Co-leaders: Dale Coddington, Linda Fu, Patience White

Target Audience: Trainees, fellows, junior faculty, and mid-level faculty.

Residents have been educators in the inpatient setting. As the role of residents is expanded in the outpatient, there are new skills required to be effective and efficient facilitators of learning in the outpatient setting. The workshop will offer an experience of a curriculum and its evaluation developed by three graduates of the Master Teacher Program at DC Children's. The curriculum includes modules on case-based teaching, precepting, and evaluation/feedback. There will be a discussion of the theory behind and descriptions of each of the modules and their evaluation, a chance to experience the modules and to problem solve around individual institutional barriers to implementation.

Objectives:

– To know the skills necessary for residents to be effective educators in the outpatient setting
– To discuss the lessons learned in developing and implementing a similar curriculum
– To understand how outpatient teaching can be utilized to meet ACGME competencies

Format: Opening presentation with majority of the time spent in small groups discussions on tools and implementation/barriers.

9:00am–12:00pm
4234—So You Are an Educator and Want To Be Promoted?: Academic Success for the Clinician–Educator
PAS Educational Workshop
Yerba Buena Gardens Salon 3, SF Marriott
Leader: Latha Chandran, Stony Brook, NY; Co-leaders: Lucy Osborn, Virginia Moyer

Target Audience: Fellows, junior faculty, and mid-level faculty.

This workshop takes the participants through a promotions committee decision-making process using real life examples to increase their understanding of the process as well as factors that facilitate and impede chances of promotion. The need for structured documentation using an educator portfolio, in addition to a standard C.V., will be evidenced and participants will create an initial version of their individual portfolios. Workshop leaders will share their own promotion experiences and institutional experiences in promotions committees.

Objectives:

– Enhance participant understanding of the variations in promotion processes at institutions.
– Demonstrate the usefulness of an educator portfolio for promotion of clinical educators.

Format: Interactive seminar, small group problem solving, case based learning, role-playing and large group discussions.

9:00am–12:00pm

4236—Teach to Your Strengths and Adapt to Your Learners! Understanding Individual Teaching and Learning Styles To Maximize Your Teaching Potential
PAS Educational Workshop
Yerba Buena Gardens Salon 4, SF Marriott
Leader: Heather McPhillips, Seattle, WA; Co-leaders: Richard Shugerman, Sherilyn Smith and Jordan Symons

Target Audience: Trainees, fellows, junior faculty, mid-level faculty, senior faculty, and community practitioners.

Participants in this highly interactive workshop will work to recognize their individual teaching strengths and learn to adapt their teaching style to individual learners' preferences. Participants will work together to develop a toolbox of learner-centered strategies for teaching in challenging situations.

Objectives:

– Participants will define their individual teaching style.
– Participants will better understand differences in learning styles.
– Participants will develop strategies to teach to their individual strengths.
– Participants will develop strategies to teach to learners with different learning needs.

Format: This session will be highly interactive with small-group and larger group discussion, shared problem solving and a small amount of videotaped examples.

9:00am–12:00pm
4238—Teaching Decision-Making and Proper Documentation in the Era of Electronic Medical Records
PAS Educational Workshop
Yerba Buena Gardens Salon 14, SF Marriott
Leader: John Schmidt, Ann Arbor, MI; Co-leaders: Jocelyn Schiller, Amy Fleming

Target Audience: fellows, junior faculty, mid-level faculty, and senior faculty.

Use of electronic medical records (EMR) promises greater efficiency and improved communication health-system wide. Workshop participants will discuss methods for teaching house staff and students how to take advantage of the efficiency of an EMR while also writing quality notes. Pediatric hospitalists from the University of Michigan will discuss the improvements seen in clarity and thoroughness of notes after the implementation of a variety of tools. We will demonstrate templates for medical documentation, including admission notes, daily progress notes, transfer notes and discharge summaries. We will discuss other interventions, including the development of educational sessions for trainees which focus on proper documenting techniques created with the input of clinicians, billing, and coding.

Objectives:

– Learn about attributes of an electronic medical record (EMR) which impact the quality of documentation.
– Develop strategies to educate trainees on proper documentation habits within an EMR system.
– Develop strategies to balance the efficiency of the EMR with billing, coding, and regulatory requirements for students and residents.

Format: The workshop will have a brief introduction in a question-answer format which will identify problems in EMR documentation. This will be followed by small-groups which will discuss solutions to these problems.

9:00am–12:00pm
4240—Utilization of Instructional Alignment for Resident Community-Based Projects
PAS Educational Workshop
Yerba Buena Gardens Salon 5, SF Marriott
Leader: Quimby McCaskill, Jacksonville, FL; Co-leaders: Colleen Kalynych, Elisa Zenni, Jeff Goldhagen, David Wood

Target Audience: Trainees, fellows, junior faculty, mid-level faculty, senior faculty, and community practitioners.

The Pediatric RRC requires "structured educational experiences that prepare residents for the role of advocate for the health of children within the community." Many programs are utilizing community-based projects to promote resident competence in this area. This workshop will introduce instructional alignment (i.e. aligning objectives with teaching and evaluation), as it applies to developing a sound curriculum towards residents achieving competence in community pediatrics through community-based projects. A videotape review and analysis will allow participants to become familiar with the benefits of and the essential components to instructional alignment. Small work groups will also be used to apply these concepts.

Objectives:

– Participants will be able to describe instructional alignment.
– Participants will begin to develop an instructional alignment protocol in community pediatrics utilizing community-based projects.
– Participants will describe ways in which to evaluate residents in national community pediatrics competencies correlated with ACGME competencies, and explore the value of electronic portfolios.

Format: Videotape, roundtable discussions, and small work groups.

9:00am–12:00pm
4242—Well Child Care for the Premature Infant
PAS Educational Workshop
Yerba Buena Gardens Salon 15, SF Marriott
Leader: Ricki Goldstein, Durham, NC; Co-leader: William Malcolm

Target Audience: Trainees, fellows, junior faculty, mid-level faculty, senior faculty, and community practitioners

After a brief overview of the common problems encountered by premature infants after discharge, this interactive workshop will engage the audience in the utilization of a new premature infant well-child check list being developed for office or clinic visits during the first 2 years of life. Several videos of pediatric well-child visits will be viewed which demonstrate common scenarios involving abnormal motor development and feeding patterns. After viewing each video, the workshop participants will complete either a standard checklist used in a pediatric practice or the one specifically designed for former premature infants. The key questions or observations used to detect various problems will be identified and indications for early intervention will be discussed.

Objectives:

– To become familiar with the common medical problems encountered by premature infants after discharge
– To recognize the red flags for early motor and feeding problems in premature infants after discharge
– To recognize indications for referring a premature infant for early intervention services

Format: (1) Video presentation of well child visit demonstrating various problems in premature infants; (2) participants to complete a new check list designed to detect various problems encountered in the premature infant; and (3) roundtable discussion of advantages and problems with new check list.

9:00am–12:00pm
4244—Education in the Digital Age: Designing and Developing Online Teaching Modules for Medical Learners
PAS Educational Workshop
Pacific Suite J, SF Marriott
Leader: Kadriye Lewis, Cincinnati, OH; Co-leaders: Michael FitzGerald

Target Audience: Fellows, junior faculty, mid-level faculty, senior faculty, community practitioners, and all medical educators.

Computer technology is becoming increasingly central to the area of teaching in most disciplines, and transformation to online instructional delivery method represents an exciting new way to structure teaching and learning. However, many educators, unfamiliar with the online pedagogy and instructional design process, simply transfer their courses directly from their lectures to an online text format. This satisfies the need to put a course online, but is not the most efficient or effective way to deliver instructional materials to residents and medical students. This workshop will provide an essential grounding for building effective online instructional modules while preparing medical educators for the digital age educational approaches.

Objectives:

– Identify the components of pedagogically effective module design and development.
– Learn to construct a learning module including assignments and activities.
– Use templates to guide the development process and rubrics to assess the strengths and weaknesses of developed modules.

Format: Showcase demonstration, discussion, and hands-on activities.

9:00am–12:00pm
4250—Emergency Medicine
APA Special Interest Group
Golden Gate Hall A2, SF Marriott
Chairs: Joan Bothner, bothner.joan@tchden.org; and Michael Kim, mkim@mcw.edu.

There has been a significant nationwide increase in the volume of pediatric patients presenting to emergency departments with psychiatric and behavioral issues due to a variety of reasons, which has resulted in a significant challenge to both the providers of pediatric emergency care and the facilities in which they work. The emergency medicine SIG meeting during 2006 PAS Annual Meeting will discuss this "psychiatric crisis in the emergency department." This topic will be presented in three parts; challenges in clinical evaluation and interventions, research opportunities and administrative challenges.

9:00am–12:00pm
4252—Injury Control
APA Special Interest Group
Pacific Suite A, SF Marriott
Chairs: Shari Barkin, sbarkin@wfubmc.edu; and Brian Johnston, bdj@u.washington.edu.

The Injury Control SIG convenes those individuals interested in the area of injury control at all stages of idea development and project implementation. During this session you will hear reports about what your colleagues are doing around the country in injury control. There will be time for constructive discussion after each of these brief presentations. We will also discuss ways to create an active network to stay informed about our colleagues areas of injury expertise and develop working collaborations beyond the annual meeting.

9:00am–12:00pm
4254—Integrative Pediatrics
APA Special Interest Group
Nob Hill A, SF Marriott
Chairs: Sharon Riesen, sriesen@ahs.llumc.edu; and David Steinhorn, d-steinhorn@northwestern.edu.

The Integrative Medicine SIG will meet together with the new AAP provisional Section for Complementary, Holistic and Integrative Medicine. We will provide a 3-hour multimedia, experiential presentation for all PAS visitors interested in finding out more about Complementary and Integrative Medicine and an opportunity to meet and network with other clinicians, educators and researchers interested in this topic. Our goal is to provide a forum to see the current state of complementary and alternative medicine (CAM) research, an opportunity to experience a complementary therapy (if they wish) and to ask about many of the CAM modalities most commonly used by our patients. Local practitioners from the San Francisco area will give hands-on demonstrations and explanations of their specific modality and will answer your questions, as time permits. Please take advantage of this unique opportunity to satisfy your curiosity or whet your appetite to find out about a field which many of our patients are already exploring.

9:00am–12:00pm
4256—Nutrition
APA Special Interest Group
Pacific Suite H, SF Marriott
Chairs: Sandy Hassink, shassink@nemours.org; and Robert Karp, robert.karp@downstate.edu.

The Nutrition SIG will continue with its emphasis on nutrition education in residency. Our project, "A Teacher's Guide to Pediatric Nutrition," is readily available at http://downstate.edu/peds/pednutrition. The model of "stepping stone education" is used with a primer, "Pediatric Nutrition Notes," as its foundation. A set of five introductions, Part 2, provide the tools for usage. Part 3 is a set of eight modules on pathophysiology, prevention evaluation and treatment of obesity through childhood. Part 4 contains more than 25 case-based teaching modules on disease processes affected by nutrition. The Teacher's Guide concludes with a module on evaluation of teaching applicable to any subject. This includes use of structured clinical observation for resident evaluation of taking a diet history and providing guidance.

Faculty and residents are invited to a 2-hour program with continental breakfast to explore use of the Teacher's Guide. We will provide model programs evaluating use of the Teacher's Guide for achieving basic skills of taking histories and providing guidance. Participants will join us for presentations, discussion and continental breakfast. Registration is not necessary. Queries are welcome by robert.karp@downstate.edu.

9:00am–12:00pm
4258—Practice-Based Research Networks
APA Special Interest Group
Pacific Suite C, SF Marriott
Chair: Robert Siegel, robertsiegel56@pol.net.

The Practice-Based Research Network SIG is highlighted by presentations of recent work done by the SIG members and works in progress. There will be an open discussion of issues facing practice-based research as an opportunity to discuss collaboration on projects and ways of fostering practice-based research network development.

10:15am–12:15pm
4300—SPR Presidential Plenary and Awards
SPR Presidential Plenary
Room 3002-3008, Moscone West
Chair: Philip W. Shaul, University of Texas Southwestern Medical Center, Dallas, TX

  • SPR Award Presentations

    • Student Research Awards
      Allison Blatz, Case Western Reserve University, Rainbow Babies & Children's Hospital, Cleveland, OH
      Mya Sendowski, University of California, San Francisco, CA
      Karin Batalden, Mayo Medical School, College of Medicine, Rochester, MN
      Prithy Martis, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
      Silvia Gonzaga, Children's Hospital of Philadelphia, PA
      Suzanne Schubbert, University of California, San Francisco, CA

    • House Officer Research Award
      Keri Anne Cohn, The Children's Hospital of Philadelphia, PA
      Sallie R Permar, Children's Hospital and Boston Medical Center, Boston, MA
      Shrena Patel, University of New Mexico, Albuquerque, NM

    • Fellow's Basic Research Award
      Camille Fung, David Geffen School of Medicine at UCLA, Los Angeles, CA
      Michael Hunter, Yale University School of Medicine, New Haven, CT
      Enkhsaikhan Purevjav, Baylor College of Medicine, Houston, TX

    • Fellow's Clinical Research Awards
      Deepika Bhatla, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
      Maria Miranda, Copenhagen University Hospital, Hvidovre, Denmark
      Joshua D. Schiffman, Stanford University, Palo Alto, CA

    • David G. Nathan Award in Hematology/Oncology
      Su Young Kim, National Institutes of Health, Bethesda, MD

    • Japan Pediatric Society Fellow Awards
      Hiroyuki Ishiguro, Tokai University School of Medicine, Isehara, Kanagawa, Japan
      Kyo Okada, Hino Municipal Hospital, Hino, Tokyo, Japan
      Yuka Wada, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan

    • Douglas K. Richardson Award for Perinatal and Pediatric Healthcare Research
      Marie C. McCormick, Harvard School of Public Health and Harvard Medical School, Boston, MA

    • Richard D. Rowe Award in Perinatal Cardiology
      Yong Zhao, Gladstone Institute of Cardiovascular Disease, University of California San Francisco

  • Young Investigator Award and Lecture:
    Protective and Non-protective Immune Responses Against Paramyxoviruses: Understanding Atypical Measles and Enhanced Respiratory Syncytial Virus Disease
    Fernando Pedro Polack, Johns Hopkins University, Baltimore, MD

  • Maureen Andrew Mentor Award and Lecture
    Donna M. Ferriero, University of California, San Francisco, CA

  • SPR Distinguished Service Award
    Thomas A. Hazinski, Vanderbilt University School of Medicine, Nashville, TN

  • E. Mead Johnson Awards for Research in Pediatrics and Lectures: 

    • Molecular Basis for Development of Human B Cell Responses to Viruses
      James E. Crowe, Professor of Pediatrics, Microbiology and Immunology, Ingram Professor, Vanderbilt University Medical Center, Nashville, TN

    • Cell Division, Genome Stability and Cancer
      David Pellman, The Ted Williams Senior Investigator, Dana-Farber Cancer Institute and Children’s Hospital, Boston, MA, Associate Professor of Pediatrics, Harvard Medical School, Boston, MA

  • Presidential Address
    Philip W. Shaul, University of Texas Southwestern Medical Center, Dallas, TX

*The E. Mead Johnson Awards are supported by an educational grant from Mead Johnson Nutritionals

10:15am–12:15pm
4320A—New Frontiers in Reproductive Science
LWPES Topic Symposium
Room 3001, Moscone West
Chairs: Ram K. Menon, University of Michigan, Ann Arbor, MI; and Henry Anhalt, Saint Barnabas Medical Center, Livingston, NJ

Target Audience: Endocrinologists, geneticists, developmental biologists and adolescent medicine.

The regulation of puberty remains one of the greatest mysteries of medicine. A child is born with all of the necessary components to undergo puberty at birth but this process is quiescent until puberty occurs. The attendee will learn the newest information on the biological regulators of puberty.

In addition, the attendee will be exposed to newer techniques available for preservation of fertility in a variety of different pathological states. Discussion will include the cryopreservation of the pre-pubertal ovary.

  • Kiss-1 and GPR54 as New Players in Gonadotropin Regulation and Puberty
    Ursula Kaiser, Brigham and Women's Hospital, Boston, MA

  • Modern Preservation of Fertility
    Kutluk Oktay, Weill Medical College of Cornell University, New York, NY

10:15am–12:15pm
4330—Endocrinology: Growth—Clinical
PAS/LWPES Platform Session
Room 3007-3011, Moscone West
Chairs: Jill D. Jacobson and Gadi B. Kletter

10:15am–12:15pm
4335—General Pediatrics III
PAS Platform Session
Room 2008, Moscone West
Chairs: Charles Feild and Lydia M. Furman

10:15am–12:15pm
4340—Hematology/Oncology III
PAS/ASPHO Platform Session
Room 3016-3018, Moscone West
Chairs: Robert Iannone and Mignon Loh

10:15am–12:15pm
4345—Intestinal Inflammation
PAS Poster Symposium
Room 3014, Moscone West
Chairs: Edward J. Hoffenberg and Elizabeth Mannick

10:15am–12:15pm
4347—Late-Breaker Abstract Session II: General Pediatrics
PAS Platform Session
Room 2004, Moscone West Convention Center
Chairs: Yvonne W. Wu and Paul C. Young

The "Late-Breaker" sessions include reports on clinical trials and other important and significant pediatric research, which might not have been ready for reporting at the time of the winter abstract deadline. Please be sure to review the content so you don't miss these very special sessions!

10:15am–12:15pm
4350—Mechanisms of Brain Injury
PAS Poster Symposium
Room 3020, Moscone West
Chairs: Maria Delivoria-Papadopoulos and Jeffrey M. Perlman

10:15am–12:15pm
4355—Neurodevelopmental Outcomes of NICU Graduates
PAS Poster Symposium
Room 3022-3024, Moscone West
Chairs: Scott A. Lorch and Michele C. Walsh

10:15am–12:15pm
4360—New Perspectives on ADHD
PAS Poster Symposium
Room 2002, Moscone West
Chairs: Marc A. Lerner and Mark L. Wolraich

10:15am–12:15pm
4365—Nitric Oxide and Oxygen: A Marriage Made in Heaven or Hell?
PAS Poster Symposium
Room 3003-3005, Moscone West
Chairs: Satyan Lakshminrusimha and Leif D. Nelin

12:00pm–1:00pm
4400A—ASPN Awards Luncheon
ASPN Luncheon
Yerba Buena Gardens Salon 7, SF Marriott

  • American Academy of Pediatrics Section on Nephrology – Henry L. Barnett Award

    • Introducer:
      Steven J. Wassner, Milton S. Hershey Medical Center, Hershey, PA

    • Presenter:
      Richard N. Fine, State University of New York at Stony Brook, Stony Brook, NY

    • Recipient: American Academy of Pediatrics Section on Nephrology—Henry L. Barnett Award
      Jose Strauss, Professor of Pediatrics Emeritus, Division of Pediatric Nephrology, University of Miami Miller School of Medicine, Founder and Program Chairman, Pediatric Nephrology Seminar XXXIII, Miami, FL

  • American Society of Pediatric Nephrology Founder's Awards

    • Introduction:
      Eileen D. Brewer, Professor and Chief, Pediatric Nephrology, Baylor College of Medicine/Texas Children’s Hospital, Houston, TX

    • Presenter:
      Sandra L. Watkins, Children's Hospital and Regional Medical Center, Seattle, WA

    • Recipient:
      Barbara Cole, Emeritus, Department of Pediatrics, Washington State Univeristy, St. Louis, MO

    • Introduction:
      Lisa M. Satlin, Mt. Sinai School of Medicine, New York, NY

    • Presenter:
      Sandra L. Watkins, Children's Hospital and Regional Medical Center, Seattle, WA

    • Recipient:
      Adrian Spitzer, Professor of Pediatrics, Albert Einstein College of Medicine, Bronx, NY

12:00pm–1:00pm
4410A—23rd Annual Audrey K. Brown Kernicterus Symposium
Club
Room 2003-2007, Moscone West
Chairs: David K. Stevenson, Stanford University School of Medicine, Stanford, CA; William J. Cashore, Women and Infants Hospital of Rhode Island, Providence, RI; and Vinod K. Bhutani, Stanford University School of Medicine, Stanford, CA

  • Organic Anion Transporter Protein 2 Gene Polymorphisms and Neonatal Hyperbilirubinemia
    Jon F. Watchko, Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA

  • The Potential Role of Unbound Bilirubin Measurements for the Management of Jaundiced Newborns
    Charles E. Ahlfors, L.W. Ligand, Vashon, WA

Contact for information:
David K. Stevenson, M.D.
Stanford University School of Medicine
Phone: 650-723-5711
E-mail: dstevenson@stanford.edu

Supported in part by an unrestricted educational grant from Natus Medical, Inc.

12:00pm–1:00pm
4420A—Bioethics Interest Group
Club
Room 2006, Moscone West
Chair: Susan Albersheim, British Columbia’s Children’s Hospital, University of British Columbia, Vancouver, Canada

Panel: Should All Newborns Be Screened for HIV?
Ram Yogev, Children's Memorial Hospital, Northwestern University, Chicago, IL
Ellen Wright Clayton, Vanderbilt University, Nashville, TN
Lainie Friedman Ross, University of Chicago, MacLean Center for Clinical Medical Ethics, Chicago, IL

Contact for information:
Susan Albersheim, M.D.
British Columbia's Children's Hospital
Phone: 604-875-2135
Email: salbersheim@ce.bc.ca

12:00pm–1:30pm
4430A—Perinatal Nutrition and Metabolism Club
Club
Room 2009-2011, Moscone West

  • Probiotics and Development of Intestinal Host Defense
    W. Allan Walker, Departments of Pediatrics and Nutrition, Harvard Medical School, Boston, MA

Contact for information:
Jane McGowan, M.D.
The Johns Hopkins Hospital
Phone: 410-955-4565
Email: jmcgowan@jhmi.edu

Supported in part by a restricted educational grant from Ross Products Division, Abbott Laboratories

12:00pm–1:30pm
4440—APA Luncheons
APA Luncheon
Golden Gate Hall B, SF Marriott

– Region Chairs
– SIG Chairs
– Fellows

12:00pm–6:45pm
Commercial Exhibits Open and Posters Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West

Posters Available for Viewing: 12:00pm–6:45pm
Author Attendance: 5:15pm–6:45pm

Level 1:
– Critical Care
– Gastroenterology
– Genetics
– Neonatal Epidemiology and Follow Up
– Neonatal Pulmonology
– Neonatology
– Nephrology
– Pulmonology

Level 2:
– Developmental–Behavioral Pediatrics
– Emergency Medicine
– General Pediatrics
– Medical Education

12:15pm–1:15pm
4470—The National Children's Study: Status and Future Plans
PAS/PPC Special Symposium
Room 3010-3012, Moscone West
Chair: Elena Fuentes-Afflick, University of California, San Francisco, CA

Target Audience: Practicing pediatricians, academic child health professionals, researchers, administrators and policymakers who are interested in child health across the lifespan. Professionals interested in the impact of environmental factors on health outcomes will also be interested.

This special symposium will present an update on the National Children's Study, which recently selected 7 vanguard centers and is prepared to begin recruitment of subjects. However, the President's budget proposal allocated no further funding and stated that the study would be terminated at the end of the current fiscal year. The panel presenters will discuss the current budgetary outlook, status of the study, options to implement the study and respond to questions from the audience.

Panelists

  • Elena Fuentes-Afflick, University of California, San Francisco, CA

  • Peter C. Scheidt, Director, National Children's Study, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD

  • Alan R. Fleischman, Chair, National Children's Study Federal Advisory Committee, New York Academy of Medicine, New York and National Institutes of Health, Bethesda, MD

  • David J. Schonfeld, Member, National Children's Study Federal Advisory Committee and Chair, AAP Committee on Research, Cincinnati, OH

Sponsored jointly by the Public Policy Council and the Pediatric Academic Societies

12:45pm–2:45pm
4490A—Exploring Inhibitors: Hemophilia A, Hemophilia B
ASPHO Industry Sponsored Symposium
Yerba Buena Gardens Salon 8, SF Marriott

Supported by a grant from ZLB Behring

1:00pm–2:45pm
4500—March of Dimes Prize in Developmental Biology Lecture
PAS Award
Room 3002-3008, Moscone West

Dr. Varshavsky is a pioneer in the study of ubiquitin, a tiny protein that has a very big job. Ubiquitin (from the Latin ubique meaning "everywhere," the source of the word "ubiquitous") is so named because it is essential to nearly every major activity in the life cycle of cells, including cell growth and division during embryo development, DNA repair, programmed cell death, immune response, and the nervous system. The ubiquitin system is the housekeeping mechanism by which the cell maintains a proper and healthy balance of proteins. Ubiquitin's role was unknown until the 1980s, when Dr. Varshavsky and colleagues elucidated it. This discovery revolutionized our understanding of the control of human cells, and ubiquitin quickly became one of the major areas of study in genetics, developmental biology, cell biology, and biochemistry. Today ubiquitin is a cornerstone of medical research into the causes and treatments of birth defects, neurodegenerative disease, infections, and cancer. Dr. Varshavsky receives the 2006 March of Dimes Prize for revealing and characterizing the biological significance of the ubiquitin system in the regulation of living cells.

  • Regulation by Proteolysis: The N-End Rule Pathway in Yeast and Mammals
    Alexander Varshavsky, Smits Professor of Cell Biology, California Institute of Technology, Pasadena, CA

Presented by the March of Dimes Birth Defects Foundation

1:45pm–5:15pm
4550—APA Presidential Plenary and Awards
APA Presidential Plenary
Room 2003-2007, Moscone West
Claibourne I. Dungy

Includes selected original science abstract presentations, as well as the Presidential Address, APA Outstanding Teaching Award and APA Research Award.

  • APA Outstanding Teaching Award
    J. Lindsey Lane

  • APA Research Award
    Neal Halfon, University of California, Los Angeles, CA

2:00pm–4:00pm
4580—Application of Translational Science to Vaccinology: Varicella-Zoster Virus and Human Papillomavirus
PAS/PIDS State of the Art Plenary
Room 3003-3005, Moscone West
Chairs: Ann M. Arvin, Stanford University School of Medicine, Stanford, CA; and Anna-Barbara Moscicki, University of California, San Francisco, CA

Target Audience: Infectious disease specialists, primary care pediatricians, immunologists and adolescent medicine physicians.

One of the major goals of infectious diseases research is to understand the pathogenesis of disease and to use this knowledge to prevent the illness through vaccination. An understanding of varicella pathogenesis led to the development of a successful vaccine, and further insights into long-term success of the vaccine and the future of varicella immunization are emerging. A more recent success story is that of human papillomavirus, in which basic science studies of pathogenesis led to the development of vaccines based on virus-like particles. These two examples serve as models of the success of translational science in combating infectious diseases.

  • New Insights into Varicella-Zoster Virus Pathogenesis
    Ann M. Arvin, Stanford University School of Medicine, Stanford, CA

  • MMRV and the Future of Immunization Against Varicella-Zoster Virus
    Anne A. Gershon, Columbia University, New York, NY

  • Pathogenesis of Human Papillomavirus Infections
    Anna-Barbara Moscicki, University of California, San Francisco, CA

  • Development of Virus-like Particles for Immunization Against Human Papillomavirus
    John T. Schiller, National Cancer Institute, National Institutes of Health, Bethesda, MD

Sponsored jointly by the Pediatric Infectious Diseases Society and the Pediatric Academic Societies

3:00pm–4:00pm
4600A—LWPES Trans-Pacific Lecture
LWPES Award
Room 3002-3008, Moscone West
Chair: Mark Sperling, Children's Hospital of Pittsburgh, Pittsburgh, PA

Target Audience: Geneticists, endocrinologists and molecular biologists.

This new lecture recognizes one outstanding scientist from the Pacific Rim. This talk will illuminate congenital adrenal disorders with particular focus on the relationship between newborn screening and molecular mechanisms.

  • Congenital Adrenal Disorders: From Newborn Screening to Molecular Mechanism
    Kenji Fujieda, Asahikawa Medical College, Asahikawa, Japan

3:00pm–5:00pm
4610—Cardiac Stem Cell Biology and Therapeutics
PAS Topic Symposium
Room 3001, Moscone West
Chair: Harold S. Bernstein, University of California, San Francisco, CA

Target Audience: Physicians, scientists and trainees with interest in pediatric cardiology, stem cell biology and reparative medicine.

This topic symposium is directed towards educating interested members about the state of the art in cardiac stem cell research, both the underlying biology and initial attempts in animals and humans at cardiac regenerative therapy. The discussion will range from hematopoietic stem cells to cardioblasts, as well as to how one assesses the results of stem cell infusion trials.

  • Recent History of Secondary Cardiac Myogenesis
    Harold S. Bernstein, University of California, San Francisco, CA

  • Mesenchymal Stem-Cell-Based Cardiac Regeneration
    Andrew Boyle, Johns Hopins University School of Medicine, Baltimore, MD

  • Cardioblasts
    Kenneth R. Chien, Mass General Hospital, Harvard Medical School, Boston, MA

  • Functional Assessment of Myogenic Stem Cells and Cardiomyocytes for Cardiac Cell Therapy
    Loren J. Field, Indiana University School of Medicine, Indianapolis, IN

3:00pm–5:00pm
4620—Hirschsprung’s Disease and Chronic Constipation: Medical and Surgical Approaches
PAS/NASPGHAN Topic Symposium
Room 3014, Moscone West
Chairs: B U.K. Li, Children's Memorial Hospital, Northwestern University School of Medicine, Chicago, IL; and Melvin B. Heyman, University of California San Francisco, San Francisco, CA

Target Audience: General pediatricians, pediatric gastroenterologists, pediatric surgeons and developmental biologists.

This symposium will focus on a common yet challenging problem constipation: the clinical, diagnostic, genetic and surgical aspects of Hirschsprung’s disease; and diagnostic testing, medical and surgical treatment of chronic constipation. In Hirschsprung’s disease, the clinical presentation (red flags) of, diagnostic testing for and genetic mutations found will be discussed. Surgical approaches including standard staged pull-thrus, single stage repairs, laparoscopic approaches and post-surgical obstructions will be reviewed. In chronic constipation, the differential diagnosis and diagnostic testing (findings in anorectal and colonic manometry, MRI and bead transit studies) will be presented. Medical and surgical therapeutic approaches will cover education, behavioral and biofeedback therapy, medical treatment (disimpaction and maintenance therapy) and antegrade enemas delivered via cecostomies. The specific approaches applicable to a general pediatric practice use will be identified.

  • Clinical and Genetics Aspects of Hirschsprung's Disease
    Cheryl E. Gariepy, University of Michigan Health System, Ann Arbor, MI

  • Surgical Approaches to Hirschsprung's Disease
    Daniel H. Teitelbaum, University of Michigan Hospitals, Ann Arbor, MI

  • Diagnostic Approaches to Chronic Constipation
    Samuel Nurko, Children's Hospital and Harvard University, Boston, MA

  • Therapeutic Approaches to Chronic Constipation
    Warren P. Bishop, Children's Hospital of Iowa, University of Iowa, Iowa City, Iowa

Sponsored jointly by the American Pediatric Surgical Association; the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition; and the Pediatric Academic Societies

3:00pm–5:00pm
4625A—Cancer Etiology
ASPHO Symposium
Room 3016-3018, Moscone West
Chairs: Doug K. Graham, University of Colorado at Denver and Health Sciences Center, Denver, CO; and Julie A. Ross, University of Minnesota, Minneapolis, MN

This program will highlight both clinical and basic science research into the causes of childhood cancer. The program will begin with an overview of the epidemiology of childhood cancer including incidence, trends and putative risk factors. Obstacles to conducting well-designed studies in North America will be discussed, and the establishment of a North American Childhood Cancer Research Network will be introduced as a means to help address some of these challenges. The program will follow with a discussion of genetic susceptibility to childhood cancer from single gene disorders with high individual risk but low population frequency to common population polymorphisms with low individual risk but high population frequency. In the final presentation, the role the family of tyrosine kinases has in the pathogenesis of childhood cancer will be addressed. Current research on a novel receptor kinase, Mer, will be presented to suggest a potential role of this proto-oncogene in the development of pediatric T cell leukemia and lymphoma.

After this session, participants should be able to:

1. Discuss the current state of knowledge regarding the epidemiology of childhood cancer in the United States.
2. Describe the major activities of the Childhood Cancer Research Network.
3. Identify the role of genetic susceptibility in the development of childhood cancer.
4. Describe the role of tyrosine kinases in the pathogenesis of pediatric cancer, and discuss how these oncogenes are being targeted in the development of new drugs.

  • Introduction
    Doug K. Graham, University of Colorado at Denver and Health Sciences Center, Denver, CO

  • Causes of Childhood Cancer: Where to Next?
    Julie A. Ross, University of Minnesota, Minneapolis, MN

  • Genetic Susceptibility to Cancer—The Weak and the Strong
    Stella M. Davies, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

  • Tyrosine Kinases as Oncogenes in Pediatric Cancer: The Role of the Mer Receptor Tyrosine Kinase in Lymphoblastic Leukemia and Lymphoma
    Doug K. Graham, University of Colorado at Denver and Health Sciences Center, Denver, CO

  • Question and Answer Session

3:00pm–5:00pm
4630A—Molecular Control of the Formation of the Renal Collecting System
ASPN Symposium
Room 3010-3012, Moscone West
Chairs: Lisa M. Satlin, Mount Sinai School of Medicine, New York, NY; and Norman D. Rosenblum, The Hospital for Sick Children, Toronto, Ontario, Canada

Target Audience: Clinicians, clinician-scientists and scientists interested in development, nephrology and human disease involving the urinary tract.

Kidney development depends on embryonic processes which pattern the collecting system consisting of the ureter, renal pelvis and calyces, and collecting ducts. Disruption of these processes in humans results in a spectrum of anomalies including vesicoureteral reflux, malformations of the pelvis and calyces, a decreased number of collecting ducts and cystic malformation of these ducts. Presentations in this symposium will highlight newly elucidated genetic mechanisms that control different aspects of collecting system formation. Analyses of genetic mouse models are demonstrating a critical role for Fibroblast Growth Factor Receptors in controlling growth and branching of the ureteric buds that give rise to collecting ducts. Recent evidence reveals a critical role for HNF1b, a transcription factor, in controlling collecting duct terminal differentiation and cyst formation via mechanisms involving PKDH1, the gene mutated in human autosomal recessive kidney disease. New genetic approaches are being harnessed to define molecular mechanisms that control formation of the vesico-ureteric orifice. Together, these discoveries and approaches are providing novel molecular insights into developmental nephrology and human disease.

  • Overview
    Norman D. Rosenblum, Professor of Paediatrics and Canada Research Chair in Developmental Nephrology, Division of Nephrology & Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

  • Role of Fibroblast Growth Factor Receptors in Kidney Development
    Carlton M. Bates, Children's Hospital of Columbus, Columbus, OH

  • Transcriptional Control of the Bradykinin B2 Receptor
    Samir S. El-Dahr, Tulane University School of Medicine, New Orleans, LA

  • Roles of HNF-1beta in Kidney Development and Disease
    Peter Igarashi, University of Texas Southwestern School of Medicine, Dallas, TX

  • Genes and VUR
    Ali Gharavi, Columbia University, New York, NY

3:00pm–5:00pm
4650—CPCCRN: The NICHD Collaborative Pediatric Critical Care Research Network
PAS Educational Workshop
Room 2004, Moscone West
Leader: Carol Nicholson, Bethesda, MD; Co-leader: Douglas Willson

Target Audience: Trainees, fellows, junior faculty, mid-level faculty, and community practitioners.

There are 10,500 critically ill and injured children admitted each year to the PICUs covered in the Network. We would welcome the opportunity to interact with all of the pediatric subspecialties in the context of PAS. Our work and our research are interwoven with each pediatric subspecialty as well as with pediatric surgery and surgical subspecialties.

Objectives:

– How cutting edge informatics can be used for collaborative pediatric research.
– Understand the Network structure, vision and function, in a multidisciplinary field.
– Learn about new approaches to nosocomial infection during critical illness.

Format: An introductory presentation of Network structure and function, with emphasis on innovation in collaborative research will begin the workshop. A series of pediatric critical care scientists will present some of the newer work being undertaken in the Network in informatics, sedation, immunology, infectious disease, and outcomes after pediatric critical illness and injury.

Here is a specific overview, with each speaker being available for questions, and audience interaction.

  • The CPCCRN: Overview
    Douglas Willson, MD

  • Functional Disability Outcomes in Pediatric Critical Care
    Murray Pollack, MD

  • Toward Science-Based Guidelines for Sedation and Mechanical Ventilation in Pediatric Critical Care
    Christopher Newth and/or Sunny Anand

  • Nosocomial Sepsis and Lymphocytic Apoptosis: GI Prophylaxis, Glutamine and Zinc in Pediatric Critical Illness
    Joseph Carcillo, MD

3:00pm–5:00pm
4652—Grant Writing
PAS Educational Workshop
Yerba Buena Gardens Salon 2, SF Marriott
Leader: William Hay, Aurora, CO

Target Audience: Trainees, fellows, junior faculty, mid-level faculty, and senior faculty.

The purpose of this workshop is to review the most successful methods for writing a grant application. NIH grant applications will be emphasized and used for illustrations, but the format will be general enough to apply to other granting agency applications. Specific topics will include: career timeline for different grants; organization of the application; items to include in each section of the grant; budget requirements; writing hints; resubmission strategies; how to write the application to meet study section reviewer criteria, common successes and common mistakes in writing applications. A handout of the power point figures used in Dr. Hay's talk will be available. There will be ample time for general and personal questions from the attendees.

Objective:

– Learn how to write an NIH grant.

Format: Lecture, and question-and-answer period.

Designed to meet elements of the core curriculum for pediatric fellowship subspecialty training.

3:00pm–5:00pm
4654—The Ins and Outs of Publishing a Scientific Manuscript
PAS Educational Workshop
Yerba Buena Gardens Salon 4, SF Marriott
Leader: Edward Lawson, Baltimore, MD; Co-leader: Jane McGowan

Target Audience: Fellows and junior faculty.

This workshop will review basic principles of writing and publishing the results of clinical research. We will discuss the purpose and content of each section of a scientific manuscript from Abstract to Discussion, as well as issues in use of statistics, figures, and tables. Interactive exercises in recognizing and correcting common errors will use examples from manuscripts submitted for publication as well as from published articles. A discussion of journal selection and the journal review process will complete the workshop. Participants may submit material prior to the meeting for personal review by the workshop leaders, or bring problem materials to the workshop for (anonymous) review and discussion.

Objectives:

– Identify the purpose and content of each of the sections of a scientific manuscript.
– Recognize common errors in manuscript preparation.
– Understand how manuscripts are reviewed and selected for publication.

Format: PowerPoint presentation, round-table discussion of real-life examples, hands-on problem-solving exercises, and question-and-answer period.

Designed to meet elements of the core curriculum for pediatric fellowship subspecialty training.

3:00pm–5:00pm
4656—Newer Mouse Technologies Targeted at Dissecting Mechanisms
PAS Educational Workshop
Yerba Buena Gardens Salon 5, SF Marriott
Leader: Parviz Minoo, Los Angeles, CA; Co-leaders: Francesco J. DeMayo, Ed Morrisey

Target Audience: Clinician and basic scientists, including new investigators, fellows and postdoctoral fellows.

The use of transgenic mice has become commonplace in analysis of developmental and physiological pathways. This technology has contributed significantly to and continues to provide critical information for understanding fundamental biological processes and their clinical implications in health and disease. The objective of this workshop is to discuss and review state-of-the-art approaches using transgenic technologies in mice, including genetically engineering the airways for the regulated ablation and expression of genes, as well as distinct examples from the speakers’ works on lung development and gene regulation.

3:00pm–5:00pm
4658—NICHD: How It Works and Opportunities for Research Support
PAS Educational Workshop
Yerba Buena Gardens Salon 6, SF Marriott
Leader: Duane Alexander, Bethesda, MD; Co-leader: Linda Wright

Target Audience: Trainees, fellows, and junior faculty.

Participants in this seminar will receive information on how the NIH receives, assigns, reviews and funds applications for support of various types of research, training and career development. The variety of support mechanisms available at different career stages will be described, along with areas of special current research interest to the National Institute of Child Health and Human Development.

Objectives:

– Areas of special current research interest to NICHD
– Support mechanisms for research, training, and career development

Format: Presentations followed by question and answer.

3:00pm–5:00pm
4662—Standardizing Prescription of Fluids and Medications in the NICU: Principles, Practical Tools and Applications
PAS Educational Workshop
Yerba Buena Gardens Salon 3, SF Marriott
Leader: Joaquim Pinheiro, Albany, NY; Co-leaders: Amy Mitchell, Vinay Vaidya

Target Audience: Trainees, fellows, junior faculty, mid-level faculty, senior faculty, community practitioners, pharmacists, and nurses.

Emphasis on patient safety has led some NICUs to implement standardized dosing methods, replacing customized fluid and medication dosing in neonates. JCAHO has mandated a transition from "rule-of-6"-based prescription to standardized concentrations. Without national standards, NICU practitioners are struggling to comply with the mandate.

Workshop goals are to review principles of error prevention in NICU, focusing on standardized methods of prescription and administration. The leaders will share their experience with paper, electronic and logistic systems for standardizing fluid, medication and TPN prescription.

Objectives:

– Participants will learn a variety of practices and tools used to implement standardized prescription in NICUs.
– Participants will have practiced multidisciplinary development of solutions to standardized prescription relevant to their institutions.
– Participants will learn about computerized methods for rapid implementation of standardized infusions.

Format: Short presentations, question-and-answer periods, and problem solving in groups.

3:00pm–5:00pm
4670—Brain Metabolism and Injury
PAS Platform Session
Room 3020, Moscone West
Chairs: Steven P. Miller and Frances J. Northington

Includes:

  • SPR Fellow's Basic Research Award: The Neuron-Glia Lactate Shuttle Protects Neurological Function in Neuron-Specific Glucose Deficiency
    Camille Fung, David Geffen School of Medicine at UCLA, Los Angeles, CA

3:00pm–5:00pm
4675—Obesity I
PAS Poster Symposium
Room 2002, Moscone West
Chairs: Robert H. Lustig and Jennifer Miller

3:00pm–5:00pm
4680—Neonatal Fetal Nutrition and Metabolism II
PAS Platform Session
Room 3007-3011, Moscone West
Chairs: Patti J. Thureen and Carol L. Wagner

3:00pm–5:00pm
4685—Neonatal Pulmonary Hypertension: Novel Mechanisms and Therapies
PAS Poster Symposium
Room 3022-3024, Moscone West
Chairs: Judy L. Aschner and Robin H. Steinhorn

3:00pm–5:00pm
4690—Sepsis: Pathogenesis and Outcomes
PAS Platform Session
Room 3000, Moscone West
Chairs: John H. Arnold and Joseph A. Carcillo

4:00pm–5:00pm
4700A—PIDS 3rd Annual Stanley A. Plotkin Lectureship in Vaccinology
PIDS Alliance Society
Room 3003-3005, Moscone West
Chair: Joseph W. St. Geme, III, Duke University School of Medicine, Durham, NC

The Pediatric Infectious Diseases Society has established the Stanley A. Plotkin Lectureship in Vaccinology to honor Dr. Plotkin, the Society's "Founding Father." The lecture, which takes place at the annual PIDS meeting, is sponsored by Sanofi Pasteur. Dr. Plotkin was medical director at sanofi pasteur and remains a medical and scientific advisor. The inaugural lecture was delivered by Dr. Plotkin in 2004.

  • Introduction
    Larry K. Pickering, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA

  • The Role of Measles Elimination in Development of a National Immunization Program
    Walter A. Orenstein, Emory University School of Medicine, Atlanta, GA

Supported by an unrestricted educational grant from sanofi pasteur

5:00pm–6:00pm
4750A—PIDS Business Meeting
PIDS Business Meeting
Room 3003-3005, Moscone West

5:15pm–6:45pm
Poster Session III
PAS Poster Session
Room Levels 1 and 2, Moscone West

Posters Available for Viewing: 12:00pm–6:45pm
Author Attendance: 5:15pm–6:45pm

Level 1:
– Critical Care
– Gastroenterology
– Genetics
– Neonatal Epidemiology and Follow Up
– Neonatal Pulmonology
– Neonatology
– Nephrology
– Pulmonology

Level 2:
– Developmental–Behavioral Pediatrics
– Emergency Medicine
– General Pediatrics
– Medical Education

6:15pm
4950A—PIDS Annual Awards Dinner and Banquet
PIDS Dinner
Room Ralston Ballroom, Palace Hotel

Ticket Required - inquire through the PIDS Office at 703-299-6764

6:30pm–9:00pm
A New Paradigm for Growth
PAS Industry Sponsored Symposium
Yerba Buena Gardens Salon 8, SF Marriott

Target Audience: Endocrinologists.

In the past, physicians evaluating a child with short stature focused on determining if the child had growth hormone deficiency (GHD). Most children with GHD have low IGF-1 levels. This is referred to as secondary IGF-1 deficiency. Children who are not GHD may also have low IGF-1 levels, referred to as primary IGF-1 deficiency (Primary IGFD). Children with Primary IGFD, in contrast to those with secondary IGFD, would not be expected to respond to GH treatment, but would require replacement with IGF-1. Now with IGF-1 replacement therapy available, there are many questions, surrounding the diagnosis of Primary IGFD. This symposium will focus on the IGF-1 system, new clinical data, testing and identification of candidates for IGF-1 treatment. Case studies will be presented for a pragmatic approach to practicing pediatric endocrinologists.

For registration information please contact:

Laura McCaskill
Phone: 858-345-1103
Email: lmccaskill@tier1group.com

Supported by a grant from Tercica Pharmaceuticals

6:45pm–8:00pm
4980A—Lung Club
Club
Yerba Buena Gardens Salon 7, SF Marriott

  • Is There a Role for Inhaled Nitric Oxide in the Prevention of Chronic Lung Disease in the Preterm Infant
    John P. Kinsella, University of Colorado School of Medicine, Children's Hospital, Denver, CO

Contact for information:
Roberta A. Ballard, M.D.
Children's Hospital of Philadelphia
Phone: 215-590-1653
Email: ballard@email.chop.edu

Richard J. Martin
Rainbow Babies & Children's Hospital
Phone: 216-844-3387
Email: rxm6@po.cwru.edu

Supported in part by an unrestricted educational grant from Ross Products Division, Abbott Laboratories

7:00pm
4990—APA Board Awardees Dinner
APA Dinner
 

 

   
 

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Last Updated: September 26, 2006