|
Saturday, April 29
8:00am–11:00am
2150—Basic Tools and Techniques of
Evidence-Based Medicine
PAS Educational Workshop
Room Pacific Suite F, SF Marriott
Leader: Kathleen Meert, Detroit, MI; Co-leaders: Barry
Markovitz, Mona McPherson
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, senior faculty,
and community practitioners.
Evidence-based medicine (EBM)
aims to judiciously apply best research evidence to the
prevention, detection and treatment of health disorders.
Workshop participants will learn to: (1) generate focused
clinical questions from case scenarios, (2) find the best
research evidence to answer clinical questions through
literature and database searching, (3) critically appraise
evidence for validity, effect size and applicability, and (4)
integrate critical appraisal with clinical expertise and
individual patient preferences. Methods will include case
discussions, demonstrations of electronic research databases
and pre-appraised evidence sources, small group critical
appraisals of recent articles, practice with EBM calculators,
and pre- and post-tests assessments.
Objectives:
– Participants will be able to
generate focused clinical questions from case scenarios.
– Participants will be able to find the best research
evidence to answer clinical questions through literature and
database searching.
– Participants will be able to critically appraise original
evidence for validity, effect size and applicability.
– Participants will be able to integrate critical appraisal
with clinical expertise and individual patient preferences.
Format: Formats/strategies that
will be used to accomplish the objectives include small group
discussions, question-and-answer period, examples, problem
solving, pre- and post-tests.
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
8:00am–11:00am
2153—Developing, Sustaining and Surviving
Mentoring Relationships: An Interactive Workshop for Mentees
and Mentors
PAS Educational Workshop
Willow, SF Marriott
Leader: Ivor Horn, Washington, DC; Co-leaders: Robert
Freishtat, Jill Joseph, Naomi Luban
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, and senior
faculty.
This interactive workshop will
use a case-based format to discuss mentoring as a tool for
achieving scientific and professional independence from the
mentee and mentor perspectives. Participants will be divided
into trainees/junior faculty and mid-level/senior faculty to
discuss the following three topics:
1. Establishing achievable goals
for mentoring relationships, choosing mentors and accepting
mentees.
2. Working effectively with mentors/mentees in light of the
'natural progression' of mentoring in a trainee/junior faculty
member's career.
3. Identifying and responding appropriately to challenges and
difficulties in the mentoring relationship.
This workshop will be lead by K
award-funded junior investigators and senior investigators
with extensive mentoring experience.
Objectives:
– To provide participants with
strategies they can use to develop and sustain successful
mentoring relationships
– To provide participants with tools to achieve productive
mentoring relationships that lead to scientific and
professional independence for the mentee
Format: Small group discussion
using a case based format.
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
8:00am–11:00am
2158—The National Survey of Children's
Health: Resources and Tips for Using New National and State
Data on Child and Adolescent Health
PAS Educational Workshop
Room Pacific Suite J, SF Marriott
Leader: Christina Bethell, Portland, OR; Co-leaders: Stephen
Blumberg, Debra Read
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, senior faculty,
and community practitioners.
The National Survey of Children's
Health (NSCH) is the largest, nationally representative survey
conducted with families to assess the health, well-being and
health care of children and youth (n = 102,000). Publicly
released in 2005, NSCH provides a wide range of national and
state-level data on the health of children, youth and
families. Participants will: 1) identify research topics that
can be addressed using the NSCH; 2) Obtain hands-on experience
using the Data Resource Center—a new resource to easily
obtain and download findings from the NSCH; 3) gt ideas on
using findings to stimulate efforts to improve care for
children, inform research and grant development and advance
evidence-based policy, program development, and advocacy.
Objectives:
– Identify the range of
research topics that can be addressed using these data.
– Obtain hands-on experience using the Data Resource Center
on Child and Adolescent Health (DRC)—a new resource for
pediatric clinicians, researchers, and families to easily
obtain and download findings from the NSCH (www.childhealthdata.org).
– Get ideas on presenting findings to enhance state and
local efforts to improve the health and health care of
children, youth, and families.
Format: Presentations, question
and answer, hands-on practice using an online data resource
center, case examples, real time technical assistance and
problem solving.
8:00am–11:00am
2160—Striving for Excellence: Using the
Model for Improvement To Transform Pediatric Practice
PAS Educational Workshop
Golden Gate Hall C1, SF Marriott
Leader: Lloyd Werk, Orlando, FL; Co-leader: Lynn Woods
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, senior faculty,
and community practitioners.
This session will demonstrate the
role of quality improvement interventions in transforming
pediatric practice. Recent reports from the Institute of
Medicine and guidance from professional societies recommend
adoption of systematic quality improvement interventions in
health care in order to promote best practices. This workshop
will review the context and evidence behind quality
improvement activities, introduce the Model for Improvement
(Nolan), and provide examples of tests of change. Through the
use of vignettes and their own clinical dilemmas, participants
will generative their own tests of change. Upon completion of
the workshop, participants will be able to apply lessons
learned within their own practice settings.
Objectives:
– Identify at least one
opportunity in their setting for which they can apply the
Model for Improvement to effect advancement of a best
practice.
– Use three questions to generate the aims, measures, and
change concepts needed to drive PDSA cycles.
– Generate a plan to test a change concept and describe how
they would use the result.
Format: The Striving for
Excellence workshop employs a balanced format rotating among
didactic instruction, illustrative games, and practical
exercises. The workshop starts with an introduction and needs
assessment and proceeds through some basic concepts to set the
stage. Participants are asked to generate some suggestions in
response to a video vignette. The Model for Improvement
(Nolan) is introduced and game played to draw out ways quality
improvement can be applied. The Model for Improvement is then
reviewed in detail and applied to the initial video vignette.
Aims, Measures, Change concepts are created as well as
illustrative PDSA cycles, both demonstrated and elicited from
participants. Change concepts from the needs assessment,
parking lot, and exercises are gathered together and developed
into tailored Aims, Measures, Change concepts and PDSA cycles
through an interactive tool.
9:45am–11:45am
2200A—Clinical Trials and Observational
Studies
ASPN Workshop
Room 2007, Moscone West
Chairs: Susan L. Furth, Johns Hopkins University, Baltimore,
MD; and Craig Wong, Children's Hospital of New Mexico,
Albuquerque, NM
Target Audience: Clinical
investigators and pediatric nephrologists.
This workshop will address
statistical, measurement, ethical and regulatory issues in
clinical research. We will discuss methodological issues in
randomized clinical trials when the sample size is limited, as
often occurs in pediatric studies. We will also address the
measurement of kidney function in large cohort studies.
Finally, we will have an extended discussion on the evolution
of the current regulatory system of clinical research in the
United States. This has evolved from concerns about ethical
issues and protection of subjects to concerns about protection
of the institution through compliance with inflexible
requirements. The session will end with suggestions on what
changes are needed and how to achieve them in the current
regulatory environment.
-
Introduction
Catherine Stehman-Breen, Amgen, Thousand Oaks, CA
-
Methodologic Issues in Clinical
Trials When Sample Size Is Limited
Tom Greene, The Cleveland Clinic, Cleveland, OH
-
Measurement of Glomerular
Filtration Rate in Large Cohort Studies: Design, Conduct
and Analysis
Alvaro Munoz, Bloomberg School of Public Health, Johns Hopkins
University, Baltimore, MD
-
The Dysregulation of Research
Norman Fost, University of Wisconsin Medical School, Madison, WI
Supported by an
unrestricted educational grant from the Kidney and Urology
Foundation of America, Inc. (KUFA)
11:45am–2:45pm
2408—Ethics in Research
PAS Educational Workshop
Golden Gate Hall C1, SF Marriott
Leader: Douglas Diekema, Seattle, WA; Co-leader: Susan
Albersheim
Target Audience: Trainees,
fellows, junior faculty.
Through presentations, small
group case discussion, and video, participants will explore:
1) the values that guide the ethical conduct of research; 2)
issues related to human subject research; 3) authorship and
publication practices; 4) conflict of interest; 5) scientific
misconduct. This course, designed for trainees and junior
researchers, will fulfill Public Health Service training grant
requirements in research ethics and the American Board of
Pediatrics subspecialty training requirements in clinical
research ethics. In addition, it will partially fulfill the
training requirements in ethics of the Resident Review
Committee of the Accreditation Council for Graduate Medical
Education.
Objectives:
– Discuss the values that guide
ethical research.
– Develop a system to protect human subjects during clinical
trials.
– Assess authorship criteria.
– Determine if a conflict of interest exists and propose a
resolution.
Format: Lecture with question and
answer, small group and large group case discussion and
videotape.
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
11:45am–2:45pm
2410—Like Water from Stone: Time Management
Essentials for Academic Pediatricians
PAS Educational Workshop
Yerba Buena Gardens Salon 13, SF Marriott
Leader: Hema Patel, Montreal, PQ, Canada; Co-leader: Saleem
Razack
Target Audience: Trainees,
fellows, and junior faculty.
Who needs more time? In this
workshop, you will see that time management is a behavior
issue, not actually a time issue. Improving the efficiency of
your available time will improve your productivity. Practical
tips on time management will be discussed in this workshop.
Using interactive techniques, participants will learn about
the theories of time management and develop specific tools to:
organize the day (calendar/agenda basics), run a meeting
effectively, organize the office (including tips on email
overload and frequent interruptions). Strategies to minimize
procrastination will be discussed. We will borrow tried and
true principles from the business world and demonstrate some
everyday applications for busy academic pediatricians.
Objectives:
– To provide the organizational
knowledge needed to manage time effectively
– To describe specific strategies (tools) for optimal time
utilization
Format: Participant interaction
will be essential in this workshop. Participants will do
self-assessment quizzes, small group problem-solving and have
a chance to try out suggested strategies (e.g., prioritizing)
for time management. Multiple interactive techniques will be
used including: roundtable discussion, break-out groups,
problem-solving and buzz groups.
11:45am–2:45pm
2414—Opportunities for Leadership
PAS Educational Workshop
Yerba Buena Gardens Salon 14, SF Marriott
Leader: Carol Berkowitz, Torrance, CA; Co-Leader, Surendra
Varma
Target Audience: Fellows, junior
faculty, mid-level faculty, senior faculty, and community
practitioners.
This workshop will discuss the
multiple paths to academic leadership. There will be three
distinct perspectives presents: (1) leadership at an
institutional level - climbing the academic ladder; (2)
leadership at an organizational level - opportunities to
become involved with national organizations such as the
American Academy of Pediatrics, the Ambulatory Pediatric
Association, American Pediatric Society; and (3) networking:
differences in gender styles and opportunities. There will be
a panel discussion following individual presentations and an
opportunity for workshop participants to discuss their
personal experiences.
Objectives:
– To learn from different
Roadmaps available for achievements in academic media
– Learn from the experiences of national pediatric leaders
– Diversity of skills of presenting speakers
Format: Presentations by four
speakers followed by a questions-and-answers period with
active participation from the audience.
11:45am–2:45pm
2416—Publishing Research in Pediatric
Education: The Devil Is in the Methods
PAS Educational Workshop
Pacific Suite J, SF Marriott
Leader: James Perrin, Boston, MA; Co-leaders: John Co and
Benjamin Siegel
Target Audience: Junior,
mid-level and senior faculty.
Increasing numbers of pediatric
faculty have taken on studies of pediatric education, and new
and promising techniques can help pediatric educators in these
investigations. Many academic centers have a wealth of
researchers who can collaborate with pediatric educators in
their efforts. This workshop provides guidance in choosing a
research question, determining how to study it using both
qualitative and quantitative methods, and writing up the study
for publication. Based on the experience of Ambulatory
Pediatrics, the leaders will share reasons for success and
failure in publishing research in pediatric education.
Participants will work on their own research questions as well
as studies that the journal has evaluated.
Objectives:
– To describe ways of defining
interesting questions in research in pediatric education
– To clarify strategies for the presentation of research
methods and findings for journal publication
– To compare and contrast qualitative and quantitative
research in pediatric education
Format: Case examples of research
papers sent to Ambulatory Pediatrics for review;
characterization of reasons for rejecting papers; brief,
didactic presentations on qualitative and quantitative methods
and on guides to publication and research problems for
participants to work on in small groups.
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
11:45am–2:45pm
2426—When the Honeymoon Ends: Strategies
for Junior Faculty
PAS Educational Workshop
Yerba Buena Gardens Salon 15, SF Marriott
Leader: Shari Barkin, Winston-Salem, NC; Co-leader: Elena
Fuentes-Afflick
Target Audience: Junior and
mid-level faculty.
What happens after a junior
faculty member's start-up package has been exhausted? This
workshop will explore common challenges and generate potential
strategies for junior to mid-level faculty. The first half of
the session will focus on basic elements of successful
academic careers: 1) assembling a productive team; 2)
responding to changes and transitions; 3) identifying
meaningful mentors; and 4) establishing a manageable timeframe
for academic life. During the second half of the session, we
will form small groups who will be given common dilemmas and
work together to develop potential solutions.
Objectives:
– To identify common challenges
that arise when start-up funds have been exhausted
– To generate strategies to address these common challenges
Format: Question and answer and
problem solving formats will be used.
12:00pm–3:00pm
2530—Underserved Populations Research
PAS Mini Course
Room 2008, Moscone West
Chairs: Peter Sherman, St. Barnabas Hospital, Bronx, NY; and
Wendy Hobson-Rohrer, University of Utah, Salt Lake City, UT
Target Audience:
Interns/residents and faculty mentors interested in
doing/teaching research with underserved populations.
Given the unmet health needs of
underserved children, it is important that physicians be
provided with the skills needed to engage in research in this
arena. This mini course will provide a framework for inspiring
clinicians to do research with underserved children as well as
teach pertinent skills. The goals of the workshop are to: 1)
generate interest in pursuing research with underserved
populations; 2) outline why research in this area is important
and discuss research priorities; 3) introduce ethical and
effective methods, e.g., community outreach, gaining community
trust and ensuring that your research is of benefit to the
community, and not just your CV, working with community-based
organizations; 4) outline effective research methodologies
used in this field (e.g., pilot studies, needs assessments,
focus groups, focused interviews, outcomes research); 5)
discuss non-financial resources such as organizations and
mentors; 6) discuss financial resources for this type of work,
e.g. CATCH grants.
-
Overview
Peter Sherman, Montefiore Medical Center, Bronx, NY
-
Effective Research Techniques in
Underserved Populations
David H. Rubin, St. Barnabas Hospital, Bronx, NY
-
Working with the Community
Glenn Flores, Center for the Advancement of Underserved Children,
Medical College of Wisconsin and Children's Research
Institute, Milwaukee, WI
-
Underserved Pediatrics
Populations Research: Where Do We Go From Here?
Iman Sharif, Children's Hospital at Montefiore, Bronx, NY
Discussion
3:15pm–5:15pm
2760—Designing a Longitudinal Curriculum in
Evidence-Based Medicine for Large Residency Programs
PAS Educational Workshop
Golden Gate Hall C3, SF Marriott
Leader: Srinivasan Suresh, Detroit, MI; Co-leaders: Anne
Mortensen, Misa Mi, Munirah Curtis, Renato Roxas, Joshua
Evans, Kate Sheppard, Lakshmi Srinivasan, Deepak Kamat
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, senior faculty,
and community practitioners.
Evidence-based medicine (EBM) is
a complementary approach to clinical practice that applies the
principles of clinical epidemiology to the traditional skills
of patient care. A longitudinal curriculum is vital in
inculcating this concept in medical students, residents and
fellows.
This workshop will enable
participants to effectively design an EBM curriculum to
trainees. The workshop leaders currently perform this activity
in a large residency program of about 100 residents. The
logistics of ensuring that all residents are exposed to the
spectrum of EBM, given their other responsibilities, will be
explained. Means of incorporating continual feedback in the
curriculum to achieve best clinical practices will also be
demonstrated.
Objectives:
– Ability to develop formal
clinical questions based on patient encounters
– Ability to develop skills in finding evidence based
medical literature
– Ability to explain the EBM process to peers and trainees
– Acquire the operational skills necessary to
institute/improve an EBM curriculum
Format: (1) Interactive
Discussion, (2) hands-on, real-time demonstration of
literature search strategies using Personal Digital Assistants
(PDA), and (3) problem solving, applying common clinical
vignettes.
3:15pm–5:15pm
2762—How To Evaluate Medical Literature
PAS Educational Workshop
Golden Gate Hall B3, SF Marriott
Leader: William King, Birmingham, AL
Target Audience: Trainees,
fellows, junior faculty, and other health care professionals.
How to Evaluate the Medical
Literature. All scientific work must be subjected to rigorous
critical appraisal. Although peer review precedes most
published medical reports, significant methodological flaws
survive the peer review process. Thus, the ultimate evaluation
and judgment of the quality of published reports remains with
the reader. This workshop will introduce the importance of
developing critical appraisal skill, discuss important
concepts related to manuscript and journal quality, identify
six potential problem areas in a study's methodology, review
and apply up to four quantifiable evaluation instruments,
assign quality scores to a journal article using one of the
instruments, discuss the elements of a good review and apply a
review quality instrument to rate the participant's review of
a journal article.
Objectives:
– Understand the importance of
developing critical appraisal skills.
– Understand the following concepts: quality filtering, peer
review, publication bias, journal quality indicators, CONSORT,
RQI.
– Identify and apply up to 4 evaluation instruments for
evaluating journal articles.
– Identify and apply a review quality instrument.
Format: Introductory lecture and
discussion, followed by the participant's application of an
evaluation instrument, participant quality scoring of a
published article and scoring of the critical review provided
by the participant (using a review quality instrument).
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
Sunday, April 30
8:00am–10:00am
3105—From Health Services Research to
Public Policy
PAS Topic Symposium
Room 2006, Moscone West
Chair: Gary L. Freed, University of Michigan, Ann Arbor, MI
Target Audience: Investigators,
clinicians and advocacy experts.
The contribution of research
regarding children is measured in its ability to improve
children's health and well being. Research findings that
contribute to public policy efforts have the potential to
improve the lives and well being of whole communities, states
and nations of children. Understanding the nature and
appreciating the role of such work is fundamentally important
for clinicians and researchers alike.
-
Overview
Gary L. Freed, University of Michigan, Ann Arbor, MI
-
Using Research To Confront Power:
Can P Values Speak to Justice?
Paul H. Wise, Stanford University, Stanford, CA
-
Where Research Meets Policy and
Politics: The Road to Health Reform for Children
Sara Rosenbaum, George Washington University, Washington, DC
-
Linking Health and School Goals
To Address Childhood Obesity
Joseph W. Thompson, University of Arkansas Medical Sciences, Little
Rock, AR
-
Addressing Children’s
Underinsurance Through Policy-Relevant Research
Matthew M. Davis, University of Michigan, Ann Arbor, MI
-
Discussion
8:00am–11:00am
3232—Build a Tutorial To Track Resident
Learning in Developmental–Behavioral Pediatrics
PAS Educational Workshop
Golden Gate Hall C1, SF Marriott
Leader: Henry Shapiro, St. Petersburg, FL; Co-leader: Frances
Glascoe and Nataly Arcila
Target Audience: Fellows, junior
faculty, and mid-level faculty.
This workshop will teach
participants to use the online tutorial on Developmental and
Behavioral Screening at www.dbpeds.org.
Participants will learn how they can track resident learning
activities, and produce individual and group reports. They
will also learn how to teach residents to track their own
progress. By the end of the workshop, participants will be
able to customize the tutorial for local use, know how to use
analysis tools, and contribute to further improvement and
evaluation of the tutorial tool. Participants will be give
access to the online tools needed to view reports and
participate in an online user group.
Objectives:
– Know how to view reports from
the online tutorial
– Know how to customize tutorials to reflect local needs
– Know how to use online tools to communicate with user
community
Format: Demonstration, direct
training, guided practice, small group brainstorming, and
facilitated group discussion.
8:00am–11:00am
3236—Evidence-Based Advocacy: Turning
Research into Action
PAS Educational Workshop
Golden Gate Hall C3, SF Marriott
Leader: Dennis Durbin, Philadelphia, PA; Co-leaders: Flaura
Winston, Suzanne Hill
Target Audience: junior faculty,
mid-level faculty, senior faculty, and community
practitioners.
Evidence-based advocacy
integrates the often independent, yet complementary, efforts
of clinicians, researchers, public health officials,
policymakers and the media to apply scientific principals to
widespread health promotion and prevention initiatives.
Through case-based illustrations, small-group skill building
and brainstorming exercises, workshop participants will learn
the critical steps involved in translating research results
into a variety of complementary advocacy activities to advance
children's health and safety. Strategies including public
education through the media, social marketing techniques,
legislative advocacy and working collaboratively with industry
will be reviewed and discussed. At the completion of the
workshop, participants will better understand how to plan and
conduct successful advocacy activities for the children in
their communities and will know how to access relevant
resources in support of their work.
Objectives:
– Learn the steps involved in
translating research into a variety of advocacy activities.
– Understand the complementary nature of distinct advocacy
activities.
– Practice translating research results into messaging.
– Develop a strategic plan for advocacy.
Format: Case-based
demonstrations, group discussion, and small break-out group
skill-building.
8:00am–11:00am
3240—Manuscript Preparation and the Process
of Peer-Reviewed Publication
PAS Educational Workshop
Willow, SF Marriott
Leader: Stephen Daniels, Denver, CO; Co-leaders: Thomas Welch,
Robert Wilmott, Sarah Long
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, senior faculty,
community practitioners.
This interactive workshop will
address multiple aspects of publication in scientific journals
and provides insights from editors of The Journal of
Pediatrics on the publication process. Presenters will discuss
preparation of materials, including the initial decision that
the data are sufficient to justify publication. Issues related
to manuscript writing will include length, focus, adherence to
journal formats, and referencing. The editorial process, from
submission to publication, will be described in depth, with
particular attention to ways in which authors can interact
with journal editors. Another section of the workshop will
cover ethical issues in publication including review boards,
authorship, duplicate publication, intellectual property
rights, and conflict of interest. There will be open
discussion of sample cases and questions derived from the
experiences of the participants.
Objectives:
– To learn about preparing and
submitting work for publication in peer-reviewed journals.
– To discuss ethical issues related to publication of
research and clinical work.
– To have the opportunity to ask and have answered questions
about publication and to offer insights.
Format: Open discussion,
question-and-answer.
2:00pm–5:00pm
3761—Enhancing Education with Medical
Journals
PAS Educational Workshop
Willow, SF Marriott
Leader: Graham McMahon, Boston, MA; Co-leader: Julie
Ingelfinger
Target Audience: Fellows, junior
faculty, mid-level faculty, senior faculty, and community
practitioners.
This workshop will explore some
novel approaches to learning using medical journals. We will
explore some innovative uses of primary data to address core
competencies together. We will examine the use of primary data
for teaching statistics in real time, compare original data to
textbook and database material and demonstrate how original
articles can be used to teach study design and stimulate new
research questions. We will present an exercise using case
material for interactive discussions of management and will
show how educators can harness the unique power of audiovisual
material to optimize learning. We will participate in an
exercise to illustrate the peer-review process, illustrate a
series of resources that are available online and share our
experience using medical essays to generate reflection and
introspection in small groups.
Objectives:
– Learn novel approaches to
teaching with medical journals.
– Teaching core competencies using medical journals.
Format: Presentation, discussion,
and interactive exercises.
2:00pm–5:00pm
3765—High-Fidelity Pediatric Simulation:
Setting a National Human Performance and Patient Safety
Research and Training Agenda
PAS Educational Workshop
Yerba Buena Gardens Salon 2, SF Marriott
Leader: Louis Halamek, Palo Alto, CA; Co-leaders: Mary
Patterson, Joseph Lopreiato
Target Audience: Trainees,
fellows, junior faculty, and mid-level faculty, senior
faculty.
The goal of this workshop is to
bring together those who are interested in using high fidelity
multidisciplinary pediatric simulation to improve the training
of healthcare professionals and in establishing the evidence
base to support the use of this methodology. This will be an
interactive panel-led session coupled with video presentations
and small breakout group discussions that will allow
participants to identify the elements of a national
simulation-based research and training agenda and a strategy
for implementation of such a plan. Participants will learn
what they can do on the local and national levels to validate
and disseminate its use.
Objectives:
– Define high fidelity
simulation.
– Describe the unique challenges of pediatric simulation.
– Understand why a national research and training agenda is
indicated.
– Develop the major elements of this agenda and develop an
action plan.
Format: I plan to use the three
panelists to lead a facilitated, interactive discussion with
the audience in order to accomplish the workshop objectives
(setting a national agenda and creating an action plan).
2:00pm–5:00pm
3768—Securing a Faculty Position: A
Practical Guide for Residents, Fellows, Junior Faculty and
Their Mentors
PAS Educational Workshop
Yerba Buena Gardens Salon 10, SF Marriott
Leader: Claibourne Dungy, Iowa City, IA; Co-leader: Thomas
DeWitt
Target Audience: Trainees,
fellows, and junior faculty.
Applying for a faculty position
can appear to be a daunting project for many residents,
fellows and junior faculty due, in large part, to the lack of
readily available information on the process of interviewing
and negotiating for faculty appointment in academic medicine.
This workshop discusses the standard procedures used when
applying and interviewing for a faculty position in academic
medicine. From the submission of the resume to the negotiation
of the offer package, this workshop will serve as a practical
guide to trainees, fellows and junior faculty wishing to
secure a position in academic medicine. Through the
presentation of material, discussion, and role-playing,
participants will become familiar with the processes involved
in the application and negotiation process for a faculty
position.
Objectives:
– Ability to negotiate for a
faculty position
– Knowledge of standard procedures for the interview process
Format: Presentation of material,
question-and-answer period, and role-playing.
2:00pm–5:00pm
3772—Teaching Residents To Teach Basic
Parenting Skills
PAS Educational Workshop
Yerba Buena Gardens Salon 5, SF Marriott
Leader: Robert Sege, Boston, MA; Co-leader: Karen Miller
Target Audience: Fellows and
junior, mid-level and senior faculty.
Parents seek advice from their
pediatrician about child development and behavior management.
Formal education in these topics allows residents to develop
an approach to counseling that is both evidence-based and
suited to the needs and cultural values of the patient and
family. The Boston Floating Hospital residency implemented a
comprehensive approach to address resident learning needs in
parenting education in the fall of 2003. This session uses a
highly interactive approach (including a simulated resident
session) to help faculty members develop structured programs
in resident education concerning common parenting concerns.
Participants will also have an opportunity to review sample
resources, including the new AAP Connected Kids: Safe, Strong
Secure program.
Objectives:
– Learn an approach to teaching
residents about parenting issues.
– Experience and discuss specific interactive teaching
techniques.
– Become familiar with resources available to support
parenting education.
Format: Introductory didactic
instruction, with small group interactive activities. A
simulated resident session will serve as a focal point of
discussion.
4:15pm–5:45pm
3805—Fetal Homeland Security: New Insights
into Old Threats
PAS State of the Art Plenary
Room 3002-3008, Moscone West
Chairs: Phil W. Shaul, University of Texas Southwestern
Medical Center, Dallas, TX; and Rashmin C. Savani, University
of Texas Southwestern Medical Center, Dallas, TX
Target Audience: Neonatologists,
pediatricians and researchers interested in perinatal biology.
In addition to premature birth,
there are a select number of maternal conditions that have
marked negative impact on the well being of the fetus and
newborn. This symposium will highlight recent advances in our
understanding of these classical threats to our most
vulnerable pediatric patient population.
First, new knowledge of the
mechanisms by which maternal diabetes alters embryonic and
fetal development will be discussed. Second, the newly
discovered role of circulating anti-angiogenic proteins of
placental origin in the pathogenesis of preeclampsia will be
presented. Finally, novel mechanisms by which biochemical
events in the fetal lung trigger the initiation of labor will
be discussed. Further advances in each of these realms will
ultimately lead to new therapies to protect the fetus and
yield healthy outcomes at term.
-
Mechanisms by Which Maternal
Diabetes Modifies Embryonic and Fetal Development
Kelle H. Moley, Washington University School of Medicine, St. Louis, MO
-
Role of Circulating Anti-angiogenic
Proteins of Placental Origin in the Pathogenesis of
Preeclampsia
S. Ananth Karumanchi, Harvard Medical School, Beth Isreal Deaconess
Medical Center, Boston, MA
-
Fetal–Maternal Signaling in the
Initiation of Labor
Carole R. Mendelson, University of Texas Southwestern Medical Center,
Dallas, TX
4:15pm–5:45pm
3810—RNA Interference, Technological
Development of siRNAs and Potential Treatments for Childhood
Diseases
PAS State of the Art Plenary
Room 3016-3018, Moscone West
Chair: R. Alan B. Ezekowitz, Harvard Medical School,
Massachusetts General Hospital, Boston, MA
Target Audience: Basic scientists
studying a broad range of childhood diseases, translational
scientists of all disciplines studying clinical implications
of basic science research, clinical scientists studying
childhood and other diseases in need of improved therapies and
clinicians interested in cutting-edge science and its medical
implications.
RNA interference is a recently
discovered, naturally occurring intracellular process that
regulates gene expression through the silencing of specific
mRNAs. Methods of harnessing this natural pathway are being
developed that allow the catalytic degradation of targeted
mRNAs using specifically designed complementary small
inhibitory RNAs (siRNA). siRNAs are being chemically modified
to acquire drug-like properties. Numerous recent high-profile
publications have provided proofs of concept that RNA
interference may be useful therapeutically. Much of the design
of these siRNAs can be accomplished bioinformatically, thus
potentially expediting drug discovery and opening new avenues
of therapy for many childhood diseases including uncommon
pediatric and orphan diseases. A discussion of the science
behind RNA interference will be followed by a presentation of
the potential practical issues in applying this technology to
disease. The program then describes two therapeutic programs
currently under way with applications to pediatric diseases. A
question-and-answer time will follow each discussion.
-
The Science of RNA Interference
John J. Rossi, Beckman Research Institute of City of Hope, Duarte, CA
-
RNA Interference and Its
Potential Applications for Controlling Disease
Judy Lieberman, CBR Institute for Biomedical Research and Harvard
Medical School, Boston, MA
-
Silencing the VEGF Pathway with
siRNAs and the Potential Application to Retinopathy of
Prematurity
Pamela Pavco, Sirna Therapeutics, Boulder, CO
-
siRNA as Therapy for Respiratory
Syncytial Virus
John P. DeVincenzo, University of Tennessee School of Medicine,
Memphis, TN
4:15pm–6:15pm
3820—New Resident Work Hours and Quality
Care—Synergistic or Antagonistic?
PAS/PPC State of the Art Plenary
Room 2006, Moscone West
Chair: Richard E. Behrman, Federation of Pediatric
Organizations, Inc., Menlo Park, CA
The session will identify and
address continuing issues regarding resident work hours
specifically and the general climate in which resident
training occurs in light of the recent ACGME limits on
resident work hours. In particular, panelists will discuss
what impact the changes are having on both the quality of
patient care and the quality of resident education in
pediatrics. Participants will hear from three different
perspectives, representing the Accreditation Council for
Graduate Medical Education (ACGME), Resident Review Committee
(RRC) and directors of pediatric residency programs.
-
Overview
Richard E. Behrman, Federation of Pediatric Organizations, Inc., Menlo
Park, CA
-
ACGME Perspective
David C. Leach, Accreditation Council for Graduate Medical Education,
Chicago, IL
-
Residency Review Committee
Perspective
M. Douglas Jones, Professor, Department of Pediatrics, Section of
Neonatology, University of Colorado School of Medicine,
Denver, CO
-
Pediatric Program Director's
Perspective
Theodore Sectish, Stanford University Medical School, Palo Alto, CA
-
Discussion
Sponsored jointly by
the Public Policy Council, the Public Policy Advocacy
Committee of the Ambulatory Pediatric Association and the
Pediatric Academic Societies
Monday, May 1
8:00am–10:00am
4100—Making Pediatrics Family Friendly
PAS/APPD Topic Symposium
Room 2003-2007, Moscone West
Chairs: Carol D. Berkowitz, Harbor-UCLA Medical Center,
Torrance, CA; and Richard E. Behrman, Federation of Pediatric
Organizations, Inc., Menlo Park, CA
Target Audience: Pediatric
clerkship directors, residency program directors, fellowship
directors and division chiefs and department chairs, as well
as those in training or faculty interested in a
family-friendly environment.
The Federation of Pediatric
Organizations (FOPO) released its Report of the Task Force on
Women in Pediatrics in April 2005. The report recommends
structural and functional changes in academic pediatrics so
that family balance is possible during all stages of training.
Specific steps to achieve this goal were outlined from medical
student training up through senior pediatric faculty. It has
been proposed that information should be collected from
medical schools and training programs so that they can be
rated as “family-friendly” in a manner analogous to
Fortune 500 companies. Issues related to a family-friendly
environment include flexible training and work schedules;
provision of sufficient leave for maternity/paternity and
eldercare; resources for childcare, after-school and lactation
facilities; and extension of timelines for tenure and
extramural funding.
-
Overview
Carol D. Berkowitz, Professor of Clinical Pediatrics, David Geffen
School of Medicine at UCLA, Torrance, CA
Richard E. Behrman, Federation of
Pediatric Organizations, Inc., Menlo Park, CA
-
The FOPO Report and the View of a
Chair
Bonita F. Stanton, Wayne State University School of Medicine,
Children’s Hospital of Michigan, Detroit, MI
-
Part-Time Pediatrics: Faculty and
Residents
Rebecca R. S. Socolar, UNC - Chapel Hill, Chapel Hill, NC
-
Parenting During Medical School,
Residency and Fellowship: Pregnancy, Parental Leave and
Lactation
Alison Volpe Holmes, Dartmouth-New Hampshire Family Practice Program,
Concord, NH
-
The FOPO Task Force on Women
Report and Program Director Perspectives
Ann Burke, Wright State University, Dayton, OH
-
Creating a Great Place to Work™-
Lessons from the 100 Best Companies to Work for in America
Hal Adler, Great Place to Work Institute™, Inc., San Francisco, CA
-
Discussion
Sponsored jointly by
the Association of Medical School Pediatric Department Chairs,
the Association of Pediatric Program Directors and the
Pediatric Academic Societies
Supported in part by
an unrestricted educational grant from GATE Pharmaceuticals
9:00am–12:00pm
4220—Competency-Based Evaluation of EBM
Skills in Pediatric Residency and Fellowship Programs
PAS Educational Workshop
Yerba Buena Gardens Salon 6, SF Marriott
Leader: Hans Kersten, Philadelphia, PA; Co-leaders: E. Douglas
Thompson, John Frohna, Robert McGregor, Tahniat Syed, Erin
Giudice, Susan Guralnick, Nancy Spector
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, and senior
faculty.
This interactive workshop will
provide a framework for evaluation of EBM skills throughout
pediatric educational programs and three different residency
programs' approach to the development of an evaluation system
for their EBM curricula. Participants will use three validated
tools that measure EBM knowledge and EBM skills (e.g.,
formulating a question and searching and critiquing an
article) by rotating through 30-minute small group sessions.
Objectives:
– Participants will learn an
EBM evaluation framework.
– Participants will use validated EBM evaluation tools.
– Participants will develop EBM evaluation implementation
strategy for their EBM curricula.
Format: Small group discussion,
videotape, problem solving, and hands-on experience with
tools.
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
9:00am–12:00pm
4223—Design and Conduct of Randomized
Clinical Trials
PAS Educational Workshop
Pacific Suite B, SF Marriott
Leader: Mark Klebanoff, Bethesda, MD
Target Audience: Fellows, junior
faculty, mid-level faculty, and senior faculty.
It is now almost universally
required that randomized trials show new treatments to be
superior to current therapy (or no therapy) before the new
treatments are adopted. In this workshop we will go through
the design and conduct of several clinical trials, from
defining the question to conducting the final analysis. The
format is didactic with extensive discussion, and we will base
as much of the workshop as possible on real-world trials
provided by the participants themselves.
Objectives:
– To understand the principles
of trial design, conduct and analysis.
– To improve skills in reading publications of clinical
trial results.
Format: Didactic sessions with
discussion. Real-world examples will be provided by the
participants themselves.
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
9:00am–12:00pm
4224—Getting Your Article Published: The
Mysteries of Peer Review and the Decisions of Journals
PAS Educational Workshop
Yerba Buena Gardens Salon 10, SF Marriott
Leader: Howard Bauchner, Boston, MA
Target Audience: Fellows, junior
faculty, and mid-level faculty.
Understanding the peer-review
process is important for investigators. This workshop will
review the peer-review process and help investigators prepare
manuscripts for publication.
Objectives:
– To understand the peer-review
process
– To improve submissions to peer-review journals
Format: Didactic presentation,
discussion, and vignettes.
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
9:00am–12:00pm
4230—Recognizing Common Biostatistical
Errors: A Case-Based Approach
PAS Educational Workshop
Yerba Buena Gardens Salon 12, SF Marriott
Leader: Thomas Newman, San Francisco, CA; Co-leader: Susan
Fisher-Owens
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, and community
practitioners.
This workshop uses multiple real
examples from the pediatric literature to teach participants
how to be more discriminating consumers of statistics. Topics
to be covered include standard deviation vs. standard error of
the mean, commonly violated assumptions of statistical tests
including normality and independent sampling, between- vs.
within-groups comparisons, "type 3" (dumb or
careless) errors, odds ratios vs. relative risks, relative vs.
absolute effect sizes, effect size exaggeration, and multiple
comparisons. In the last part of the seminar, participants
will have the opportunity to test what they have learned on a
set of "unknown" examples.
Objectives:
– Choose the correct
statistical test.
– Recognize common errors in biostatistics.
– Avoid common errors in biostatistics.
Format: Case-based
question-and-answer period.
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
3:00pm–5:00pm
4652—Grant Writing
PAS Educational Workshop
Yerba Buena Gardens Salon 2, SF Marriott
Leader: William Hay, Aurora, CO
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, and senior
faculty.
The purpose of this workshop is
to review the most successful methods for writing a grant
application. NIH grant applications will be emphasized and
used for illustrations, but the format will be general enough
to apply to other granting agency applications. Specific
topics will include: career timeline for different grants;
organization of the application; items to include in each
section of the grant; budget requirements; writing hints;
resubmission strategies; how to write the application to meet
study section reviewer criteria, common successes and common
mistakes in writing applications. A handout of the power point
figures used in Dr. Hay's talk will be available. There will
be ample time for general and personal questions from the
attendees.
Objective:
– Learn how to write an NIH
grant.
Format: Lecture, and
question-and-answer period.
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
3:00pm–5:00pm
4654—The Ins and Outs of Publishing a
Scientific Manuscript
PAS Educational Workshop
Yerba Buena Gardens Salon 4, SF Marriott
Leader: Edward Lawson, Baltimore, MD; Co-leader: Jane McGowan
Target Audience: Fellows and
junior faculty.
This workshop will review basic
principles of writing and publishing the results of clinical
research. We will discuss the purpose and content of each
section of a scientific manuscript from Abstract to
Discussion, as well as issues in use of statistics, figures,
and tables. Interactive exercises in recognizing and
correcting common errors will use examples from manuscripts
submitted for publication as well as from published articles.
A discussion of journal selection and the journal review
process will complete the workshop. Participants may submit
material prior to the meeting for personal review by the
workshop leaders, or bring problem materials to the workshop
for (anonymous) review and discussion.
Objectives:
– Identify the purpose and
content of each of the sections of a scientific manuscript.
– Recognize common errors in manuscript preparation.
– Understand how manuscripts are reviewed and selected for
publication.
Format: PowerPoint presentation,
round-table discussion of real-life examples, hands-on
problem-solving exercises, and question-and-answer period.
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
3:00pm–5:00pm
4658—NICHD: How It Works and Opportunities
for Research Support
PAS Educational Workshop
Yerba Buena Gardens Salon 6, SF Marriott
Leader: Duane Alexander, Bethesda, MD; Co-leader: Linda Wright
Target Audience: Trainees,
fellows, and junior faculty.
Participants in this seminar will
receive information on how the NIH receives, assigns, reviews
and funds applications for support of various types of
research, training and career development. The variety of
support mechanisms available at different career stages will
be described, along with areas of special current research
interest to the National Institute of Child Health and Human
Development.
Objectives:
– Areas of special current
research interest to NICHD
– Support mechanisms for research, training, and career
development
Format: Presentations followed by
question and answer.
Tuesday, May 2
8:00am–10:00am
5100—Ethical Issues in Housing Health
Hazard Research Involving Children
PAS Topic Symposium
Room 2003-2005, Moscone West
Chair: Bernard Lo, University of California San Francisco, San
Francisco, CA
Target Audience: A broad
pediatric audience with the goal of promoting understanding of
ethical issues in conducting community-based research,
especially housing hazard research.
Children’s homes may contain
hazards that can cause lead toxicity, trigger asthma or result
in serious injuries or poisoning. A 2001 court decision, in
Grimes versus Kennedy Krieger Institute, highlighted ethical
issues in housing-related research and led to substantial
controversy and confusion. Many ethical dilemmas occur because
research participants are often poor, members of a minority
group and have few affordable housing options. Moreover,
carrying out research in the home raises unique ethical
issues. A forthcoming report from National Academies of
Science (NAS) will offer recommendations for conducting
research on this topic. This panel will present these NAS
recommendations and discuss how they might be applied to
specific projects in housing research involving children.
Specific issues to be discussed include innovations in
research design and informed consent, responding to risks
observed in the home, the role of researchers and IRBs and
community involvement in research. Audience participation will
be encouraged.
-
Recommendations from the National
Academies of Science
Bernard Lo, University of California San Francisco, San Francisco, CA
-
Protecting Vulnerable Research
Participants While Allowing Valuable Research To Be
Carried Out
Alan R. Fleischman, Chair, National Children's Study Federal Advisory
Committee, New York Academy of Medicine, New York and
National Institutes of Health, Bethesda,
MD
-
Innovations in Study Design and
Informed Consent in Housing Hazard Research Involving
Children
Bruce P. Lanphear, Cincinnati Children's Environmental Health Center,
Cincinnati Children’s Hospital Medical Center,
Cincinnati, OH
-
Resolving Ethical Dilemmas in
Housing Hazard Research Through Community Participation
Brenda Eskenazi, University of California Berkeley, Berkeley CA
-
Discussion
8:45am–11:45am
5216—How To Change the World in an Hour a
Month: Skills for Effective and Efficient Leadership in
Community Health and Child Advocacy
PAS Educational Workshop
Yerba Buena Gardens Salon 4, SF Marriott
Leader: Andy Aligne, Rochester, NY; Co-leaders: Laura Jean
Shipley, Jeffrey Kaczorowski, Danielle Thomas-Taylor
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, senior faculty,
and community practitioners.
This workshop will enable
attendees to leverage their time more effectively when working
outside the clinical setting to improve child health at the
community level. Facilitated group exercises will improve
skills in some or all of the following: time management,
teamwork, coping with change, getting involved with
community-based organizations, cultural observation, speaking
to the media, project planning and evidence-based community
health.
Objectives:
– Time management
– Speaking to the media
– Project planning
– Evidence-based community health
Format: Group exercises and group
problem solving.
8:45am–11:45am
5218—Integrating Evidence-Based Medicine
into the Pediatric Curriculum
PAS Educational Workshop
Yerba Buena Gardens Salon 10, SF Marriott
Leader: John Frohna, Ann Arbor, MI; Co-leaders: Nader Shaikh,
Stephen Park and Russ Kolarik
Target Audience: Trainees,
fellows, junior faculty and mid-level faculty.
Practicing evidence-based
medicine (EBM) is essential for lifelong learning and critical
thinking among pediatric residents/fellows. With multiple
demands on the curriculum, programs have found it difficult to
make time and space to incorporate this material. This
interactive workshop will simplify the curriculum development
process for others wishing to launch or enhance their EBM
educational program. Participants will work in small groups to
(a) identify core EBM competencies to be taught, (b) develop
practical educational strategies to integrate these
competencies into a variety of venues and (c) discuss methods
for evaluating the curriculum's effectiveness. The session
will conclude with a participant-generated discussion of
useful pearls for teaching EBM across different settings.
Participants will receive sample curricular materials and a
list of resources that can foster the teaching and practice of
EBM.
Objectives:
– Participants will understand
the core competencies addressing EBM in residency/fellowship
education.
– Participants will develop skills in curricular design
related to EBM.
Format: Brief didactic overview,
small group discussions and question-and-answer period.
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
8:45am–11:45am
5224—Using Electronic Health Records for
Pediatric Research and Quality Improvement
PAS Educational Workshop
Yerba Buena Gardens Salon 13, SF Marriott
Leader: Robert Grundmeier, Philadelphia, PA; Co-leaders:
Christoph Lehmann, Su-Ting Li, Stuart Weinberg, William Adams,
Richard Shiffman, Aaron Carroll
Target Audience: Trainees,
fellows, and junior faculty.
While the potential of the
electronic health record (EHR) as a permanent data repository
has gained widespread acceptance, this workshop will introduce
the implications for research and quality improvement (QI)
efforts. Participants will work together in small groups to
design a research question that may be answerable with EHR
data. Using sample data, each group will extract and
manipulate data from the EHR in order to address their
question. Participants are expected to raise methodological
questions based on the exercises and their previous
experiences. An expert panel will respond to these questions
and provide solutions.
Objectives:
– Participants will better
understand electronic health record (EHR) technologies and the
strengths and weakness of EHR data.
– Participants will learn to extract and process aggregate
EHR.
– Participants will better understand regulatory issues
related to IRB guidelines, HIPAA, and data use agreements.
Format: A brief dadaistic lecture
will introduce key aspects of working with EHR data. Hands-on
exercises mentored by medical informaticians will be completed
in small groups with a demonstration dataset. An expert panel
will respond to the participant's questions.
12:45pm–3:45pm
5650—Recent Advances in Understanding and
Treating Neonatal Chronic Lung Disease
PAS Hot Topic
Room 3002-3008, Moscone West
Chairs: Richard D. Bland, Stanford University School of
Medicine, Stanford, CA; and Bernard Thebaud, University of
Alberta, Edmonton, AB, Canada
Target Audience: Neonatologists
involved in the care of premature infants, pulmonologists and
general pediatricians who care for children suffering the ill
effects of neonatal chronic lung disease and clinician
scientists with a research interest in normal and disordered
development of the lung and its circulation.
A symposium to honor Dr. William
Northway and Dr. Jacqueline Coalson for their seminal
discoveries of bronchopulmonary dysplasia (BPD) in human
babies and premature baboons, as we approach the 40th
anniversary of Dr. Northway’s initial description of BPD and
the 25th anniversary of Dr. Coalson’s initial papers on the
Southwest Foundation’s authentic model of BPD in non-human
primates. The program will focus on recent advances in the
basic biology of lung development, its dysregulation in BPD
and implications for novel treatment strategies. The intent is
to improve understanding of the mechanisms that regulate the
formation of alveoli, pulmonary capillaries and extracellular
matrix components in the developing lung, with consideration
of some of the adverse conditions that may contribute to
impaired lung growth and development in BPD. This knowledge
will provide rationale for introducing novel strategies to
help treat or prevent neonatal chronic lung disease.
-
Introduction
Alan H. Jobe, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
-
BPD in Babies: An Historical
Perspective
William H. Northway, Lucile Salter Packard Hospital, Palo Alto, CA
-
BPD in Baby Baboons: An Evolving
Saga
Jacqueline J. Coalson, UT Health Sciences Center at San Antonio, San
Antonio, TX
-
Lung Septation and Its
Dysregulation in BPD
Jacques R. Bourbon, Universite Paris XII - Faculte de Medecine, Creteil,
France
-
Lung Angiogenesis and Its
Dysregulation in BPD
Steven H. Abman, University of Colorado School of Medicine, The
Children’s Hospital, Denver, CO
-
Lung Elastin and Its
Dysregulation in BPD
Richard D. Bland, Stanford University School of Medicine, Stanford, CA
-
Novel Ways To Treat or Prevent
BPD
Bernard Thebaud, University of Alberta, Edmonton, Alberta, Canada
1:45pm–3:45pm
5720—Autosomal Recessive Polycystic Kidney
Disease (ARPKD): New Insights and Clinical Perspectives
PAS/ASPN/NASPGHAN Topic Symposium
Room 3010-3012, Moscone West
Chairs: Philip Rosenthal, University of California, San
Francisco, San Francisco, CA; and Lisa M. Guay-Woodford,
University of Alabama at Birmingham, Birmingham, AL
Target Audience: Pediatricians,
pediatric nephrologists, pediatric gastroenterologists,
neonatalogists and developmental biologists.
ARPKD is a developmental disorder
of the kidneys and liver caused by mutations in the PKHD1
gene. Fibrocystin/polyductin, the protein encoded by PKHD1, is
expressed on the primary cilia of renal and bile duct
epithelial cells. Several lines of evidence indicate that the
PKHD1 transcriptional profile is complex with extensive splice
variants. While the function of these transcripts and the
polypeptides that they encode is not well understood, these
proteins seem to play critical roles in establishing and
maintaining the tubular architecture. This symposium will
discuss the complex transcriptional profile of PKHD1 and the
role of these gene products in renal as well as biliary
epithelia. Given that ARPKD has a high perinatal mortality due
to oligohydramnios and resultant respiratory insufficiency,
current concepts regarding the interplay between the
developing kidney, the placenta and the developing lung will
be discussed. Finally, a clinical perspective based on the
on-going NHGRI-sponsored natural history study will focus on
ARPKD-associated morbidities and disease progression.
-
Transcriptional Complexity of
PKHD1: Implications for Development and Disease
Pathogenesis
Gregory G. Germino, Johns Hopkins University, Baltimore, MD
-
Pathobiology of Biliary Epithelia
in ARPKD
Tatyana Masyuk, Mayo Clinic College of Medicine, Rochester, MN
-
Oligohydramnios: Current Concepts
and Implications for Pulmonary Development
F. Sessions Cole, Washington University School of Medicine, St. Louis
Children's Hospital, St. Louis, MO
-
Report on the NIH ARPKD/CHF
Natural History Study
Meral Gunay-Aygun, National Human Genome Research Institute (NHGRI),
Bethesda, MD
Sponsored jointly by
the American Society of Pediatric Nephrology; the North
American Society for Pediatric Gastroenterology, Hepatology
and Nutrition; and the Pediatric Academic Societies
|
