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Saturday, April 29
8:00am–11:00am
2100—Adult Stem Cells—A Primer for the
Clinician
PAS/ASPHO Mini Course
Room 3014, Moscone West
Chairs: Jakub Tolar, University of Minnesota, Minneapolis, MN;
and Mervin C. Yoder, Jr., Indiana University School of
Medicine, Indianapolis, IN
Target Audience:
Hematologists/oncologists, endocrinologists, basic scientists
and neurologists.
Adult stem cells represent a
technology that is being intensively investigated currently,
and this research may have wide implications for human health.
This mini course will focus on recent research and potential
applications in human health.
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Introduction
Jakub Tolar, University of Minnesota, Minneapolis, MN
Mervin C. Yoder, Indiana
University School of Medicine, Indianapolis, IN
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Multipotent Adult Progenitor
Cell: Hype or Reality?
Catherine M. Verfaillie, University of Minnesota, Minneapolis, MN
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Mesenchymal Stem Cell: Harnessing
the Power of Adult Stem Cells To Repair Tissues
Darwin Prockop, Tulane University Health Science Center, New Orleans,
LA
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Hierarchy of Endothelial
Progenitors in Human Blood and Blood Vessels
David A. Ingram, Indiana University School of Medicine, Indianapolis,
IN
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Cancer Stem Cell: Concept of
Human Leukemic Development
Craig T. Jordan, James P. Wilmot Cancer Center, University of Rochester
School of Medicine, Rochester, NY
Sponsored jointly by
the American Society of Pediatric Hematology/Oncology and the
Pediatric Academic Societies
8:00am–11:00am
2125—New Considerations for the Growth Rate
of the Preterm Infant: Too Fast or Not Fast Enough?—A Review
of the Evidence
PAS Mini Course
Room 3002-3008, Moscone West
Chairs: Frank R. Greer, University of Wisconsin, Madison, WI;
and William W. Hay, Jr., University of Colorado, Aurora, CO
Target Audience: Neonatologists,
hospitalists who take care of preterm infants, nutritionists
and general pediatricians.
Recent nutritional emphasis in
the NICU has been to achieve the normal intrauterine growth
rate with more aggressive nutritional support for the low
birth weight infant. In general, this has been difficult to
achieve, and new evidence from long-term follow up studies
shows that preterm infants are at an increased risk of
developing the metabolic syndrome including obesity, type 2
diabetes and cardiovascular disease. This implies that the
organs in the early life of the preterm infant may be
programmed adversely by nutritional therapy. This raises the
questions of how fast these infants should grow (including
catch up growth), the importance of the composition of this
growth and the urgency for defining the necessary balance
between growth of the brain and the rest of the body.
Ultimately, providers may want to revise the long-term and
short-term goals for feeding very low birth weight or
extremely low birth weight infants. This mini course will
present evidence to help answer these questions and provide
discussion about related practice recommendations.
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Overview
Frank R. Greer, University of Wisconsin, Madison, WI
William W. Hay, University of
Colorado Health Sciences Center, Aurora, CO
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Macronutrient Requirements for
Growth of Preterm Infants—Upper and Lower Limits
(Energy, Fat, CHO, Protein)
Scott C. Denne, Indiana University School of Medicine, James Whitcomb
Riley Hospital, Indianapolis, IN
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Aggressive Nutritional Support of
the Preterm Infant Revisited—Evidence for Efficacy and
Safety
Patti J. Thureen, University of Colorado Health Sciences Center,
Denver, CO
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Adverse Outcomes of Rapid Somatic
Growth and Alterations of Body Composition in the Low
Birth Weight Infant
Frank R. Greer, University of Wisconsin, Madison, WI
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Fatty Acids and Neuronal
Development
Susan E. Carlson, University of Kansas Medical Center, Kansas City, KS
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Iron and Development of the Brain
Michael K. Georgieff, University of Minnesota School of Medicine,
Minneapolis, MN
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Nutritional Influences on
Structural and Functional Maturation of the Developing
Brain During Extended Postnatal Period
Steve H. Zeisel, The University of North Carolina, Chapel Hill, NC
8:00am–11:00am
2130—Newborn Hearing Screening: From the
Bedside to Beyond
PAS/PIDS Mini Course
Room 3010, Moscone West
Chairs: Mark R. Schleiss and Lisa Ann Schimmenti, University
of Minnesota Medical School, Minneapolis, MN
Target Audience: General
pediatricians, geneticists and infectious disease specialists.
Sensorineural hearing loss (SNHL)
in infants is the most common birth defect, and early
detection improves outcome. Evidence from the CDC reveals that
less than one half of screened babies are followed up. One
possible reason is the low positive predictive value of
bedside screening. There is a critical need to augment current
strategies to prevent late diagnosis of SNHL. One solution is
to propose second-tier testing for the most common causes of
SNHL, as the most common causes of newborn hearing loss are
infectious and genetic. Of infectious causes, cytomegalovirus
(CMV) is the most common. Evidence of CMV infection can be
found in 1% of newborns, with 10–15% developing hearing loss
or other CNS abnormalities. Of the genetic causes, mutations
in GJB2/GJB6 are the most common and are identified in up to
one half of individuals with SNHL. The goal of this program
will be to examine evidence for inclusion of infectious and
genetic screening to augment current newborn screening
protocols.
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Diagnostic Evaluation and
Management of Childhood Hearing Loss
Margaret Alene Kenna, Children's Hospital Boston, Boston, MA
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Range of Mutations in
GJB2-Associated Hearing Loss
Lisa Ann Schimmenti, University of Minnesota Medical School,
Minneapolis, MN
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Congenital Cytomegalovirus
Infection and Hearing Loss
Karen B. Fowler, University of Alabama at Birmingham, Birmingham, AL
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Newborn Hearing Screening:
Audiologic Assessment
Yvonne Sininger, University of California Los Angeles, Los Angeles, CA
Sponsored jointly by
the Pediatric Infectious Diseases Society and the Pediatric
Academic Societies
8:00am–12:00pm
2180A—LWPES Plenary Session I
LWPES Plenary Session
Room 3007-3009, Moscone West
Chairs: Lynne Levitsky, Massachusetts General Hospital,
Boston, MA; Henry Anhalt, Saint Barnabas Medical Center,
Livingston, NJ; and Alan D. Rogol, University of Virginia,
Charlottesville, VA
Target Audience:
Endocrinologists, nephrologists, cardiologists, general
pediatricians, immunologists, geneticists and molecular
biologists.
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Opening Remarks
Lynne L. Levitsky, Massachusetts General Hospital, Boston, MA
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Lawson Wilkins Lecture:
Recent years have witnessed a
significant revision of the traditional view of fat cells
as simple stores of excess energy. Studies in the
speaker's lab as well as many others have clearly
demonstrated that adipocytes produce and regulate many
metabolic and hormonal signals, which generate profound
effects on systemic endocrine equilibrium. In his earlier
studies, he also demonstrated that these cells exhibit an
inflammatory capacity that is abnormal in obesity and key
to the pathogenesis of insulin resistance and diabetes.
Recently, he identified a key molecular mechanism
underlying the link between inflammatory responses and
insulin action. This pathway involves obesity-related
activation of the serine, threonine kinase, JNK, and the
consequent inhibition of insulin receptor signaling via
phosphorylation of a substrate of insulin receptor, IRS-1.
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Integration of Metabolic and
Inflammatory Pathways in Metabolic Disease
Gokhan S. Hotamisligil, Harvard School of Public Health, Boston, MA
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Robert Blizzard Lecture:
One of the greatest questions
asked of physicians caring for children with autoimmune
diabetes is "why did this happen?" This session
will unravel some of the mysteries surrounding the
etiology and pathogenesis of autoimmune diabetes from an
investigator who has dedicated his life to this issue.
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On the Unravelling of the
Etiopathogenesis of Type 1 Diabetes: Are We Stuck or
Are We Winning?
Gian Franco Bottazzo, Ospedale Pediatrico Bambino Gesú, Scientific
Institute, Rome, Italy
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Break
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Esoterix Lecture:
The attendee will familiarize
him/herself with newer molecular mechanisms of growth
failure that are due to abnormalities in receptor and
post-receptor translation of GH signaling.
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Molecular Mechanisms and Defects
in Growth Hormone Receptor Signaling
Peter Rotwein, Oregon Health and Science University, Portland, OR
9:00am–11:00am
2196—Modulators of Bronchopulmonary
Dysplasia
PAS Platform Session
Room 3003-3005, Moscone West
Chairs: Suhas G. Kallapur and Lawrence M. Nogee
Supported by an unrestricted educational grant from Dey,
L.P.
12:00pm–3:00pm
2505—Embryonic Stem Cells: A Primer for
Clinicians
PAS Mini Course
Room 3014, Moscone West
Chair: Michael T. Longaker, Stanford University, Stanford, CA
Embryonic stem cells offer
incredible promise for treating diseases affecting both
children and adults. This mini course will provide an overview
of stem cells and a basic understanding of how to derive human
embryonic stem cells, recent research and ethical
considerations. After attending this session, attendee will
have a better understanding of: 1) what are embryonic stem
cells; 2) how human embryonic stem cells are derived; 3)
recent progress in human embryonic stem cell research; 4)
ethical considerations in human embryonic stem cells.
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Stem Cells: Embryonic, Adult and
Cancer
Michael T. Longaker, Stanford University, Stanford, CA
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What It Takes Clinically To Get
an Embryonic Stem Cell
Linda C. Giudice, University of California, San Francisco, San
Francisco, CA
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What Can You Do with an Embryonic
Stem Cell in Research
Renee Reijo Pera, University of California, San Francisco, San
Francisco, CA
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Ethical and Oversight
Considerations in Human Embryonic Stem Cell Research
Hank Greely, Stanford University, Stanford, CA
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Panel Discussion
Supported in part by an unrestricted educational grant from
Treuman Katz Center for Pediatric Bioethics - Seattle
Children's Hospital
12:00pm–3:00pm
2510—Inherited Disorders Caused by
Inappropriate Apoptosis
PAS Mini Course
Room 3010, Moscone West
Chairs: Cynthia J. Tifft, Children's National Medical Center,
Washington, DC; and Hans Andersson, Tulane University Medical
Center, New Orleans, LA
Target Audience: Pediatric
researchers interested in genetic basis of disease and
apoptosis.
This session will describe the
recent findings of the role of apoptosis in the pathogenesis
of genetic diseases. Inappropriate apoptosis and acquired
resistance to apoptosis are important mechanisms in some
genetic disorders and a better understanding of this role is
expected to lead to potential therapies.
Inappropriate apoptosis has been
implicated in the causation of several inherited disorders
with specific interest for pediatricians. The pathophysiology
of inherited neurodegenerative disorders have long eluded
explanation and recent studies suggest that storage of
abnormal compounds in lysosomes act as a trigger for
apoptosis. Additionally, nephropathic cystinosis has recently
been shown to be caused by inappropriate onset of apoptosis
caused by abnormal cystinylation. This session will provide a
clinical perspective on the role of apoptosis in genetic
disorders affecting the pediatric population.
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Overview
Hans C. Andersson, Tulane University Medical School, New Orleans, LA
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Microglial Activation and
Inflammation Precedes Apoptosis in Tay-Sachs Disease
Cynthia J. Tifft, Children's National Medical Center, Washington, DC
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Lysosomal Cystine Enhances
Apoptosis and Yields the Nephropathic Cystinotic Phenotype
Jess G. Thoene, Tulane University School of Medicine, New Orleans, LA
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Niemann Pick Disease, Type C:
Glycolipid Gridlock and Apoptosis
Marc C. Patterson, Columbia University Medical Center, New York, NY
- Role of GM1-Ganglioside
in ER-and Mitochondrial-Mediated Neuronal Apoptosis
Alessandra D'Azzo, St. Jude
Children’s Research Hospital, Memphis, TN
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Discussion
1:00pm–3:00pm
2610—Genetics and Epigenetics of Neonatal
Disease
PAS Platform Session
Room 3022, Moscone West
Chairs: Aaron Hamvas and Jeffrey C. Murray
1:30pm–3:30pm
2670A—Controversies in Care in Pediatric
Endocrinology—The Great Debates
LWPES Workshop
Room 3001, Moscone West
Chairs: William Clarke, University of Virginia,
Charlottesville, VA; and Henry Anhalt, St. Barnabas Medical
Center, Livingston, NJ
Target Audience:
Endocrinologists, general pediatricians and adolescent
medicine specialists.
The attendee will be part of a
lively debate on a number of areas of controversy in pediatric
state-of-the-art diabetes management.
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Is Primary Prevention of Type 1
Diabetes Possible?
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Pro—Desmond A. Schatz, University of Florida, Gainesville, FL
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Con—Dorothy J. Becker, Children's Hospital of Pittsburgh, Pittsburgh, PA
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Should Glucose Sensors Be
Routinely Used?
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Pro—Stuart Alan Weinzimer, Yale School of Medicine, New Haven, CT
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Con—Darrell M. Wilson, Stanford University Medical Center, Stanford, CA
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Should Metformin Be Used To Treat
Pediatric Patients with Insulin Resistance?
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Pro—Michael S. Freemark, Duke University Medical Center, Durham, NC
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Con—Philip Scott Zeitler, University of Colorado at Denver and Health
Sciences Center, Denver, CO
3:00pm–5:00pm
2710A—Hematopoietic Cell
Transplantation—An Update
ASPHO Symposium
Room 3016-3018, Moscone West
Chairs: Jakub Tolar and K. Scott Baker, University of
Minnesota, Minneapolis, MN
The program will begin with a
review of unrelated umbilical cord blood transplantation, now
a common practice in the treatment of pediatric malignancies.
The program will follow with a presentation of the most recent
data on reduced intensity hematopoietic cell transplantation
for treatment of malignant and non-malignant diseases in
children. The symposium will conclude with an overview of
immune implications of mesenchymal stem cell infusion,
including their use for graft versus host disease prophylaxis
and treatment. Cellular therapy has yielded notable successes
in the past decade and holds considerable promise, and one
should walk away from the session with a realistic overview of
the possibilities and limitations of cellular therapy for
childhood cancer.
After attending this session, it
is expected that the learner will be able to:
1. Identify efficacious cellular
therapy approaches.
2. Recognize the limitations of cellular therapy for childhood
cancer.
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Introduction
Jakub Tolar, University of Minnesota, Minneapolis, MN
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Umbilical Cord Blood
Transplantation: Current Practice and Future Innovations
John E. Wagner, University of Minnesota Medical School, Minneapolis, MN
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Non-myeloablative Hematopoietic
Cell Transplantation in Children
Morris Kletzel, Northwestern University Feinberg School of Medicine,
Chicago, IL
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Immunobiology of Mesenchymal Stem
Cells
Katarina Le Blanc, Karolinska University, Stockholm, Sweden
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Question and Answer Session
3:15pm–5:15pm
2725—Integrating Genetic Susceptibility and
Environmental Influences in Pediatric Research
PAS Topic Symposium
Room 2008, Moscone West
Chair: Bruce P. Lanphear, Cincinnati Children's Environmental
Health Center, Cincinnati Children’s Hospital Medical
Center, Cincinnati, OH
Target Audience: A broad
pediatric audience with the goal of promoting
interdisciplinary understanding and greater integration of
genetic and environmental research.
Asthma, preterm birth, ADHD and
other prevalent pediatric conditions are widely recognized to
result from interactions of environmental influences and
genetic susceptibility. Tremendous progress has been made in
measuring both environmental and genetic risk factors.
Increasingly, researchers are moving beyond ecological methods
(e.g., questionnaires, air monitoring) to directly measure in
humans hundreds of environmental chemicals, from nicotine to
metals to DDT and phthalates. Similarly, unprecedented
innovation has led rapidly to high-throughput methods that
assess DNA variation across large cohorts. New
interdisciplinary collaborations that integrate state of the
art approaches to both environmental and genetic influences
should greatly improve our ability to predict and prevent
disease and disability. Such studies will be critical for
understanding mechanistic pathways, defining susceptible
subpopulations and developing effective interventions. This
session will provide an overview of gene–environment
research, describe recent advances in biomarkers of
environmental exposure and review new methods for measuring
genetic variability.
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Gene–Environment Interaction in
Common Pediatric Conditions: Conceptual Overview and
Recent Evidence
Robert S. Kahn, Cincinnati Children’s Hospital Medical Center,
University of Cincinnati College of Medicine, Cincinnati,
OH
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Advances in Biomarkers of
Environmental Exposure in Pediatric Research
Bruce P. Lanphear, Cincinnati Children's Environmental Health Center,
Cincinnati Children’s Hospital Medical Center,
Cincinnati, OH
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Measuring Genetic Susceptibility
to the Environment: Study Designs and Genotyping Methods
Robert O. Wright, Harvard Children's Environmental Health Center,
Boston Children's Hospital and the Harvard School of
Public Health, Boston, MA
3:15pm–5:15pm
2730—Mechanisms of Hypertension in the
Molecular Era
PAS/ASPN/IPHA/LWPES Topic Symposium
Room 2003-2005, Moscone West
Chairs: Bruce Z. Morgenstern, Phoenix Children's Hospital,
Phoenix, AZ; and Julie R. Ingelfinger, Massachusetts General
Hospital, Boston, MA
Target Audience: General
pediatricians, nephrologists, endocrinologists and
neonatologists.
Our understanding of the
pathophysiology of hypertension has been changing rapidly due
to advances in molecular genetics, most notably the
identification of several single-gene defects that cause
hypertension. This session will update participants on the
latest advances in our knowledge of molecular mechanisms of a
variety of forms of hypertension.
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Role of Dopamine Receptors
Pedro A. Jose, Georgetown University Medical Center, Washington, DC
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Perinatal Programming and the
Development of Hypertension
Lori Woods, Oregon Health & Science University, Portland, OR
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Low Renin Hypertension in
Childhood
Maria I. New, Mount Sinai School of Medicine, New York, NY
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WNK Kinases and Blood Pressure
Regulation
Richard Lifton, Yale University School of Medicine, New Haven, CT
Sponsored jointly by
the American Society of Pediatric Nephrology, the
International Pediatric Hypertension Association, the Lawson
Wilkins Pediatric Endocrine Society and the Pediatric Academic
Societies
3:15pm–5:15pm
2763—New Approaches in Stem Cell Technology
PAS Educational Workshop
Golden Gate Hall A1, SF Marriott
Leader: Kathleen Sakamoto, Los Angeles, CA; Co-leaders: Ed
Horwitz, Harley Kornblum, and Punam Malik
Recent advances in molecular and
cellular techniques have provided new approaches to studying
the role of gene function in a variety of cell types,
including stem cells. It is critical for pediatricians and
pediatric subspecialists to understand the basis and use of
these emerging technologies. This workshop will provide an
overview of new methods that are currently being used to study
stem cells. The topics include RNA interference (RNAi),
isolation and purification of stem cells, gene expression
profiling, and gene therapy. Upon completion of this workshop,
participants will be able to describe (a) uses of RNAi in stem
cells, (b) approaches to isolate and purify mesenchymal stem
cells, (c) characterization of neural stem cells using
expression profiling, and (d) applications of gene therapy and
stem cells.
3:15pm–5:15pm
2767—How Do I Incorporate Proteomics
Technology Into My Research?
PAS Educational Workshop
Golden Gate Hall A3, SF Marriott
Leader: Anne Murphy, Johns Hopkins University School of
Medicine, Baltimore, MD; and Co-leader: James Schilling,
Stanford University School of Medicine, Stanford, CA
Laboratory scientists,
physician-scientists and trainees as well as clinical
scientists interested in disease biomarkers.
Proteomics is a technology driven
field. Many investigators not currently employing these
technologies would love to incorporate them into their
research. This workshop will address some strategies for
investigators contemplating the use of the gel,
mass-spectrometry, and array based approaches. Discussions of
strategies to choose technologies to match the question,
strategies for assessing post-translational modifications, and
how to best work with a core facility will be addressed. The
workshop attendees should emerge with an understanding of the
strengths and weaknesses of various broad-based proteomic
technologies. This will permit them to match techniques with
an experimental question and to maximize interactions with
core facilities already in place within their institutions.
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Approaches To Analyze The
Phosphoproteome
Anne M. Murphy, Johns Hopkins University School of Medicine, Baltimore,
MD
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Overview of Approaches
David R. Graham, Johns Hopkins University-Bayview Campus, Baltimore, MD
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Sample preparation
James Malone, Washington University School of Medicine, St. Louis, MO
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Mass Tagging Approaches to
Biomarker Discovery
K.W. Michael Siu, Centre for Research in Mass Spectrometry, York
University, Toronto, Ontario Canada
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Statistics and Data Analysis
Robert Tibshirani, Stanford University, Stanford, CA
Supported in part by an unrestricted educational grant from
Applied Biosystems and GE Healthcare
3:45pm–5:15pm
2785A—Celiac Disease for the
Non-gastroenterologist
LWPES Workshop
Room 3010, Moscone West
Chair: Michelle M. Pietzak, Children's Hospital of Los
Angeles, Los Angeles, CA
Target Audience:
Gastroenterologists and endocrinologists.
Celiac disease affects
approximately 10-15% of children with diabetes. Often times
the screening tests are vexing. This workshop is aimed at
clarifying the disease process and how to diagnose it.
-
Celiac Disease for the
Non-gastroenterologist
Michelle M. Pietzak, Children's Hospital of Los Angeles, Los Angeles,
CA
3:45pm–5:15pm
2790A—Hyperthyroidism
LWPES Workshop
Room 3000, Moscone West
Chair: Scott A. Rivkees, Yale School of Medicine, New Haven,
CT
Target Audience: Generalists.
Much controversy exists about the
most effective and safest treatments for hyperthyroidism in
children. This workshop will clarify some of the newer
evidence based approaches to the diagnosis and management of
hyperthyroidism, with a special emphasis on radioactive
ablation.
3:45pm–5:15pm
2795A—Neonatal Diabetes
LWPES Workshop
Room 3001, Moscone West
Chair: Mark A. Sperling, Children's Hospital of Pittsburgh,
Pittsburgh, PA
Target Audience: Endocrinologists
and neonatologists.
Over the past few years much has
been learned about the pathogenesis of neonatal diabetes. This
workshop will impart knowledge on important considerations in
the diagnosis and work-up of this rare condition.
Sunday, April 30
8:00am–10:00am
3100—Advances in Pathogenesis, Diagnosis
and Management of Kawasaki Disease
PAS/PIDS Topic Symposium
Room 3001, Moscone West
Chairs: Marian Melish, University of Hawaii, Kapiolani
Children's Hospital, Honolulu, HI; and Stanford T. Shulman,
Children's Memorial Hospital, Northwestern University,
Feinberg School of Medicine, Chicago, IL
Target Audience: Infectious
disease specialists, cardiologists, rheumatologists,
immunologists and primary care pediatricians.
Cloning the IgA antibody response
in acute Kawasaki Disease has led to exciting new insights
into the etiology and pathogenesis of this enigmatic illness.
The diagnosis of incomplete Kawasaki Disease remains a
significant clinical problem, and new guidelines have been
published to help the clinician in making this diagnosis.
Approximately 10–15% of children with acute Kawasaki Disease
do not respond to conventional intravenous gammaglobulin and
aspirin therapy, and new data regarding treatment with
steroids and Remicade are emerging. Knowledge regarding
optimal management of cardiac complications and long-term
outcome continues to evolve as patients diagnosed with
Kawasaki Disease in the 1970s and 1980s age.
-
Overview
Marian E. Melish, University of Hawaii, Kapiolani Children's Hospital,
Honolulu, HI
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IgA Response in Acute Kawasaki
Disease Targets Inclusion Bodies in Acute Kawasaki Disease
Bronchial Epithelium
Anne H. Rowley, Northwestern University, Children's Memorial Hospital,
Chicago, IL
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Clinical Dilemma of Diagnosing
Incomplete Kawasaki Disease
Jane C. Burns, University of California, San Diego, CA
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Treatment of Refractory Kawasaki
Disease
Stanford T. Shulman, Children's Memorial Hospital, Northwestern
University, Feinberg School of Medicine, Chicago, IL
-
Management of Cardiac
Complications and Long-Term Outcome
Jane W. Newburger, Harvard University, Children’s Hospital of Boston,
Boston, MA
Sponsored jointly by
the Pediatric Infectious Diseases Society and the Pediatric
Academic Societies
8:00am–10:00am
3110—Probiotics in Necrotizing
Enterocolitis—Their Clinical Effect and Possible Mechanisms
PAS/ASPR/JPS/NASPGHAN Topic Symposium
Room 3003-3005, Moscone West
Chairs: W. Allan Walker, Harvard Medical School, Boston, MA;
and Yuichiro Yamashiro, Juntendo University School of
Medicine, Tokyo, Japan
Target Audience: Neonatologists,
gastroenterologists, pediatric surgeons, NICU nurses and
bacteriologists in perinatal medicine.
Necrotizing enterocolitis (NEC)
is a serious gastrointestinal disease seen predominantly in
very low birth weight (VLBW) and extremely low birth weight (ELBW)
infants. NEC is probably a complex, multifactorial disease.
Currently, the precise pathogenic mechanisms remain to be
elucidated; however, clinical use of probiotics has been
reported to be useful for preventing NEC development in VLBW
and ELBW infants. This session will provide us the current
knowledge about the role of probiotics in the management of
NEC.
-
Fifteen-Year's Experience of
Early Administration of Bifidobacterium Breve to Preterm
Infants
H. Kitajima, Osaka Medical Center and Research Institute for Maternal
and Child Health, Osaka, Japan
-
Oral Probiotics Reduces Incidence
of NEC in VLBW Infants
H. C. Lin, China Medical University, Taichung, Taiwan
-
Effects of Probiotics on the
Immunological Development and Short Chain Fatty Acids in
ELBW and VLBW Infants
Yoshikazu Ohtsuka, Juntendo University School of Medicine, Bunkyo-ku,
Japan
-
Possible Role of Probiotic
Supplementation for Prevention from NEC
Michael S. Caplan, Northwestern University, Evanston, IL
Sponsored jointly by
the Asian Society for Pediatric Research; Japan Pediatric
Society; North American Society for Pediatric
Gastroenterology, Hepatology & Nutrition and the Pediatric
Academic Societies
8:00am–10:00am
3125—Developmental Origins of Adult
Disease—Metabolism
PAS Platform Session
Room 3010-3012, Moscone West
Chairs: William W. Hay and Rebecca A. Simmons
8:00am–10:00am
3145—Genetic Basis of Disease: Pathogenesis
and Treatment
PAS Platform Session
Room 3000, Moscone West
Chairs: George A. Diaz and
Brendan H. Lee
Includes
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SPR Fellow's Basic Research
Award: Conditional Mutagenesis of the Homeobox Gene [italic]Hhex[/italic]
Reveals Novel and Essential Roles in Development of the
Liver and Extrahepatic Biliary Tract
Michael Hunter, Yale University School of Medicine, New Haven, CT
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SPR Student Research Award: Germ
Line [italic]KRAS[/italic] Mutations Encoding Proteins
with Novel Biochemical and Functional Properties Cause
Disorders of the Noonan Syndrome Spectrum
Suzanne Schubbert, University of California, San Francisco, CA
8:00am–11:00am
3240—Manuscript Preparation and the Process
of Peer-Reviewed Publication
PAS Educational Workshop
Willow, SF Marriott
Leader: Stephen Daniels, Denver, CO; Co-leaders: Thomas Welch,
Robert Wilmott, Sarah Long
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, senior faculty,
community practitioners.
This interactive workshop will
address multiple aspects of publication in scientific journals
and provides insights from editors of The Journal of
Pediatrics on the publication process. Presenters will discuss
preparation of materials, including the initial decision that
the data are sufficient to justify publication. Issues related
to manuscript writing will include length, focus, adherence to
journal formats, and referencing. The editorial process, from
submission to publication, will be described in depth, with
particular attention to ways in which authors can interact
with journal editors. Another section of the workshop will
cover ethical issues in publication including review boards,
authorship, duplicate publication, intellectual property
rights, and conflict of interest. There will be open
discussion of sample cases and questions derived from the
experiences of the participants.
Objectives:
– To learn about preparing and
submitting work for publication in peer-reviewed journals.
– To discuss ethical issues related to publication of
research and clinical work.
– To have the opportunity to ask and have answered questions
about publication and to offer insights.
Format: Open discussion,
question-and-answer.
Designed to meet elements of the
core curriculum for pediatric fellowship subspecialty
training.
9:45am–11:45am
3300A—Pure Red Cell Aplasia
ASPHO Symposium
Room 3016-3018, Moscone West
Chair: Jeffrey M. Lipton, Schneider Children’s Hospital, New
Hyde Park, NY
The pure red cell aplasias (PRCA)
represent a form of bone marrow restricted to the erythroid
lineage. Research has led to new insights into the molecular
basis of erythroid development. Transcriptional regulation of
erythropoiesis will be discussed in this symposium. In
pediatrics, intrinsic stem/progenitor cell defects are the
most important cause of red cell failure. One of the most
common forms of pure red cell aplasia in pediatric patients is
Diamond-Blackfan Anemia. The clinical and molecular basis of
this disease will be presented. Congenital dyserythropoietic
anemias (CDA) are rare forms of erythroid cytopenias. New
information on the pathophysiology of CDA will be presented
during this symposium.
After attending this session, it
is expected that the learner will be able to:
1. Describe the biology of
erythropoiesis.
2. Describe the clinical presentation and molecular basis of
Diamond-Blackfan Anemia.
3. Describe the clinical presentation and pathophysiology of
congenital dyserythropoietic anemia.
-
Introduction: How
"Pure" Is Pure Red Blood Cell Aplasia?
Jeffrey M. Lipton, Schneider Children's Hospital, New Hyde Park, NY
-
Biology of Erythroid Development
Mitchell Weiss, Children's Hospital of Phiadelphia, Philadelphia, PA
-
Clinical and Molecular Biology of
Diamond-Blackfan Anemia
Adrianna Vlachos, Schneider Children's Hospital, New Hyde Park, NY
-
Congenital Dyserythropoietic
Anemias 2006: Where Are We Now?
Bertil E. Glader, Stanford University School of Medicine, Stanford, CA
-
Question and Answer Session
2:00pm–4:00pm
3705—Infections at the
Maternal–Placental–Fetal Interface: Immunopathogenesis of
Group B Streptococcus, Listeria monocytogenes and
Cytomegalovirus
PAS/PIDS Topic Symposium
Room 3022-3024, Moscone West
Chairs: John R. Schreiber, University of Minnesota Medical
School and University of Minnesota Children's
Hospital/Fairview, Minneapolis, MN; and Robert F. Pass,
University of Alabama at Birmingham, Birmingham, AL
Target Audience: Neonatologists,
infectious disease specialists, immunologists, developmental
biologists and general pediatricians.
Infections in newborns commonly
result from acquisition either during the delivery process or
transplacentally. The host and pathogen factors that
contribute to acquisition of infections at the
maternal–placental–fetal interface are poorly understood.
This symposium will review the basic science and
immunopathogenesis of three diverse pathogens that all share
the ability to cause infections at the placental level:
cytomegalovirus, group B streptococcus, and Listeria
monocytogenes.
-
Intrauterine Cytomegalovirus
Infection, Transplacental Spread of Virus and Control by
Maternal Immunity
Lenore Pereira, University of California San Francisco, San Francisco,
CA
-
Host and Bacterial Factors in
Invasive Group B Streptococcal Infection
Craig E. Rubens, University of Washington, Seattle, WA
-
Listeriosis in the Pregnant
Guinea Pig: A Model of Vertical Transmission
Daniel A. Portnoy, University of California Berkeley, Berkeley, CA
-
Discussion
Sponsored jointly by
the Pediatric Infectious Diseases Society and the Pediatric
Academic Societies
2:00pm–4:00pm
3722—Neonatal Lung Inflammation: Mechanisms
and Clinical Implications
PAS Platform Session
Room 3014, Moscone West
Chairs: Rose M. Viscardi and Stephen E. Welty
Supported by an unrestricted educational grant from Dey,
L.P.
2:00pm–4:00pm
3732—Pulmonary and Cardiac Development:
Transcriptional Control and Stem Cells
PAS Platform Session
Room 2004, Moscone West
Chairs: Lawrence M. Nogee and George A. Porter
Includes
-
SPR Student Research Award:
Critical Requirement of C/EBP[alpha] for Lung Maturation
and Funct
Prithy Martis, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
-
Role of MicroRNAs in
Cardiogenesis
Yong Zhao, Gladstone Institute of Cardiovascular Disease, University of
California San Francisco
2:00pm–5:00pm
3750—Endocrine Disrupters
PAS/LWPES Mini Course
Room 3010-3012, Moscone West
Chairs: Mary M. Lee, University of Massachusetts Medical
School, Worcester, MA; and Henry Anhalt, Saint Barnabas
Medical Center, Livingston, NJ
Target Audience:
Endocrinologists, generalists, neonatologists and basic
scientists.
Concerns regarding clinical
consequences of endocrine disrupting chemicals have increased
over the past decade as researchers have documented
detrimental effects in wildlife. Federal attention to
endocrine disrupters began in earnest in 1996 when the U.S.
Congress passed the Food Quality Protection Act and amended
the Safe Drinking Water Act. These laws mandated testing to
determine if pesticides and industrial chemicals might behave
like hormones; therefore, the U.S. EPA formed the Endocrine
Disrupters Screening and Advisory Committee. In addition to
direct effects, some environmental disrupters act through
non-genomic actions, some of which persist for several
generations. This program presenting innovative studies on
mechanisms of action of endocrine disruptors will be of
critical interest to endocrinologists, both clinical and basic
scientists, as well as public health experts.
-
Prenatal Programming with
Estrogen/Estrogen Mimetics
Kenneth S. Korach, National Institute of Environmental Health Sciences,
Research Triangle Park, NC
-
Epigenetic Transgenerational
Actions of Endocrine Disruptors on Male Fertility and
Other Diseases
Michael K. Skinner, Washington State University, Pullman, WA
-
Prenatal Programming with Native
and Environmental Steroids
Vasantha Padmanabhan, University of Michigan, Ann Arbor, MI
Sponsored jointly by
the Lawson Wilkins Pediatric Endocrine Society and the
Pediatric Academic Societies
4:15pm–5:45pm
3805—Fetal Homeland Security: New Insights
into Old Threats
PAS State of the Art Plenary
Room 3002-3008, Moscone West
Chairs: Phil W. Shaul, University of Texas Southwestern
Medical Center, Dallas, TX; and Rashmin C. Savani, University
of Texas Southwestern Medical Center, Dallas, TX
Target Audience: Neonatologists,
pediatricians and researchers interested in perinatal biology.
In addition to premature birth,
there are a select number of maternal conditions that have
marked negative impact on the well being of the fetus and
newborn. This symposium will highlight recent advances in our
understanding of these classical threats to our most
vulnerable pediatric patient population.
First, new knowledge of the
mechanisms by which maternal diabetes alters embryonic and
fetal development will be discussed. Second, the newly
discovered role of circulating anti-angiogenic proteins of
placental origin in the pathogenesis of preeclampsia will be
presented. Finally, novel mechanisms by which biochemical
events in the fetal lung trigger the initiation of labor will
be discussed. Further advances in each of these realms will
ultimately lead to new therapies to protect the fetus and
yield healthy outcomes at term.
-
Mechanisms by Which Maternal
Diabetes Modifies Embryonic and Fetal Development
Kelle H. Moley, Washington University School of Medicine, St. Louis, MO
-
Role of Circulating Anti-angiogenic
Proteins of Placental Origin in the Pathogenesis of
Preeclampsia
S. Ananth Karumanchi, Harvard Medical School, Beth Isreal Deaconess
Medical Center, Boston, MA
-
Fetal–Maternal Signaling in the
Initiation of Labor
Carole R. Mendelson, University of Texas Southwestern Medical Center,
Dallas, TX
4:15pm–5:45pm
3810—RNA Interference, Technological
Development of siRNAs and Potential Treatments for Childhood
Diseases
PAS State of the Art Plenary
Room 3016-3018, Moscone West
Chair: R. Alan B. Ezekowitz, Harvard Medical School,
Massachusetts General Hospital, Boston, MA
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