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Saturday, April 29
8:00am–11:00am
2100—Adult Stem Cells—A Primer for the
Clinician
PAS/ASPHO Mini Course
Room 3014, Moscone West
Chairs: Jakub Tolar, University of Minnesota, Minneapolis, MN;
and Mervin C. Yoder, Jr., Indiana University School of
Medicine, Indianapolis, IN
Target Audience:
Hematologists/oncologists, endocrinologists, basic scientists
and neurologists.
Adult stem cells represent a
technology that is being intensively investigated currently,
and this research may have wide implications for human health.
This mini course will focus on recent research and potential
applications in human health.
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Introduction
Jakub Tolar, University of Minnesota, Minneapolis, MN
Mervin C. Yoder, Indiana
University School of Medicine, Indianapolis, IN
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Multipotent Adult Progenitor
Cell: Hype or Reality?
Catherine M. Verfaillie, University of Minnesota, Minneapolis, MN
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Mesenchymal Stem Cell: Harnessing
the Power of Adult Stem Cells To Repair Tissues
Darwin Prockop, Tulane University Health Science Center, New Orleans,
LA
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Hierarchy of Endothelial
Progenitors in Human Blood and Blood Vessels
David A. Ingram, Indiana University School of Medicine, Indianapolis,
IN
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Cancer Stem Cell: Concept of
Human Leukemic Development
Craig T. Jordan, James P. Wilmot Cancer Center, University of Rochester
School of Medicine, Rochester, NY
Sponsored jointly by
the American Society of Pediatric Hematology/Oncology and the
Pediatric Academic Societies
8:00am–11:00am
2120—Management of Childhood Hypertension:
Guidelines and Controversies
PAS/ASPN/IPHA Mini Course
Room 2003-2005, Moscone West
Chairs: Steven R. Daniels, University of Colorado, Denver, CO;
and Ronald J. Portman, University of Texas Medical School,
Houston, TX
Target Audience: General
pediatricians, emergency medicine physicians, hospitalists,
intensivists, nephrologists and cardiologists.
The 2004 NHLBI guidelines for the
evaluation and management of childhood hypertension answered
many questions about how to approach hypertensive children,
but left others unanswered. This mini course is designed to
address some of the more controversial aspects of managing
hypertensive children, with the hope of stimulating further
discussion about the optimal approach to these patients.
Practical approaches to clinical management will be
emphasized.
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Overview
Stephen R. Daniels, The Children's Hospital/University of Colorado,
Denver, CO
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Overview of Treatment Guidelines
from the 4th Report
Bonita E. Falkner, Thomas Jefferson University, Philadelphia, PA
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Management of Pre-hypertension:
Lifestyle Changes or Pharmacologic Treatment?
Shawna D. Nesbitt, University of Texas Southwestern Medical Center,
Dallas, TX
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Choice of Agent for Children with
Primary Hypertension
Joseph T. Flynn, Children's Hospital at Montefiore, Bronx, NY
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Treatment of Severe Hypertension
in Ambulatory and Inpatient Settings
Joshua Samuels, University of Texas, Houston, TX
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Treatment of Hypertension in
Special Populations
Donald L. Batisky, Columbus Children's Hospital/The Ohio State
University College of Medicine, Columbus, OH
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Discussion
Sponsored jointly by
the American Society of Pediatric Nephrology, the
International Pediatric Hypertension Association and the
Pediatric Academic Societies
8:00am–12:00pm
2180A—LWPES Plenary Session I
LWPES Plenary Session
Room 3007-3009, Moscone West
Chairs: Lynne Levitsky, Massachusetts General Hospital,
Boston, MA; Henry Anhalt, Saint Barnabas Medical Center,
Livingston, NJ; and Alan D. Rogol, University of Virginia,
Charlottesville, VA
Target Audience:
Endocrinologists, nephrologists, cardiologists, general
pediatricians, immunologists, geneticists and molecular
biologists.
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Opening Remarks
Lynne L. Levitsky, Massachusetts General Hospital, Boston, MA
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Lawson Wilkins Lecture:
Recent years have witnessed a
significant revision of the traditional view of fat cells
as simple stores of excess energy. Studies in the
speaker's lab as well as many others have clearly
demonstrated that adipocytes produce and regulate many
metabolic and hormonal signals, which generate profound
effects on systemic endocrine equilibrium. In his earlier
studies, he also demonstrated that these cells exhibit an
inflammatory capacity that is abnormal in obesity and key
to the pathogenesis of insulin resistance and diabetes.
Recently, he identified a key molecular mechanism
underlying the link between inflammatory responses and
insulin action. This pathway involves obesity-related
activation of the serine, threonine kinase, JNK, and the
consequent inhibition of insulin receptor signaling via
phosphorylation of a substrate of insulin receptor, IRS-1.
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Integration of Metabolic and
Inflammatory Pathways in Metabolic Disease
Gokhan S. Hotamisligil, Harvard School of Public Health, Boston, MA
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Robert Blizzard Lecture:
One of the greatest questions
asked of physicians caring for children with autoimmune
diabetes is "why did this happen?" This session
will unravel some of the mysteries surrounding the
etiology and pathogenesis of autoimmune diabetes from an
investigator who has dedicated his life to this issue.
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On the Unravelling of the
Etiopathogenesis of Type 1 Diabetes: Are We Stuck or
Are We Winning?
Gian Franco Bottazzo, Ospedale Pediatrico Bambino Gesú, Scientific
Institute, Rome, Italy
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Break
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Esoterix Lecture:
The attendee will familiarize
him/herself with newer molecular mechanisms of growth
failure that are due to abnormalities in receptor and
post-receptor translation of GH signaling.
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Molecular Mechanisms and Defects
in Growth Hormone Receptor Signaling
Peter Rotwein, Oregon Health and Science University, Portland, OR
12:00pm–3:00pm
2505—Embryonic Stem Cells: A Primer for
Clinicians
PAS Mini Course
Room 3014, Moscone West
Chair: Michael T. Longaker, Stanford University, Stanford, CA
Embryonic stem cells offer
incredible promise for treating diseases affecting both
children and adults. This mini course will provide an overview
of stem cells and a basic understanding of how to derive human
embryonic stem cells, recent research and ethical
considerations. After attending this session, attendee will
have a better understanding of: 1) what are embryonic stem
cells; 2) how human embryonic stem cells are derived; 3)
recent progress in human embryonic stem cell research; 4)
ethical considerations in human embryonic stem cells.
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Stem Cells: Embryonic, Adult and
Cancer
Michael T. Longaker, Stanford University, Stanford, CA
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What It Takes Clinically To Get
an Embryonic Stem Cell
Linda C. Giudice, University of California, San Francisco, San
Francisco, CA
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What Can You Do with an Embryonic
Stem Cell in Research
Renee Reijo Pera, University of California, San Francisco, San
Francisco, CA
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Ethical and Oversight
Considerations in Human Embryonic Stem Cell Research
Hank Greely, Stanford University, Stanford, CA
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Panel Discussion
Supported in part by an unrestricted educational grant from
Treuman Katz Center for Pediatric Bioethics - Seattle
Children's Hospital
2:15pm–5:15pm
2700—Educating Pediatric Fellows in a
Competency-Based World
PAS/APPD Mini Course
Room 2007, Moscone West
Chairs: Susan Guralnick, Stony Brook University Medical
Center, Stony Brook, NY; and Joseph Gilhooly, Oregon Health
and Science University, Portland, OR
Target Audience: Attendees
involved with fellowship programs.
Competency-based education is now
the standard for residency education. Residency programs have
integrated the ACGME Core Competencies into their curricula
and assessment methods. It is now time for fellowships to
enter the “competency” arena, and there is much to be
accomplished. This program will focus on several areas of
fellowship education including: the new RRC common
requirements for subspecialty training, development of a
competency-based fellowship curriculum, competency-based
assessment tools, and pediatric subspecialty fellows as
teachers. Attendees are encouraged to bring tools and ideas
for discussion and development. Attendees should leave with
useful materials to bring back to their home programs.
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Overview
Susan Guralnick, Stony Brook University Medical Center, Stony Brook, NY
Joseph Gilhooly, Oregon Health
& Science University, Portland, OR
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A Brave New World! New Common
Requirements for Subspecialty Training—Implementing the
Competencies
Carol Carraccio, Professor of Pediatrics and Associate Chair for
Education, University of Maryland School of Medicine,
Baltimore, MD
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"Survivor ACGME"—Fellowship
Competencies in Action
Joseph Gilhooly, Oregon Health & Science University, Portland, OR
John D. Mahan, Children’s
Hospital, The Ohio State University, Columbus, OH
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Turning to Fellows as Teachers:
From Curricula to Evaluation
Nancy D. Spector, St. Christopher's Hospital for Children,
Philadelphia, PA
Susan Guralnick, Stony Brook
University Medical Center, Stony Brook, NY
Sponsored jointly by
the Association of Pediatric Program Directors and the
Pediatric Academic Societies
Supported by an unrestricted educational grant from Dey,
L.P.
3:15pm–5:15pm
2730—Mechanisms of Hypertension in the
Molecular Era
PAS/ASPN/IPHA/LWPES Topic Symposium
Room 2003-2005, Moscone West
Chairs: Bruce Z. Morgenstern, Phoenix Children's Hospital,
Phoenix, AZ; and Julie R. Ingelfinger, Massachusetts General
Hospital, Boston, MA
Target Audience: General
pediatricians, nephrologists, endocrinologists and
neonatologists.
Our understanding of the
pathophysiology of hypertension has been changing rapidly due
to advances in molecular genetics, most notably the
identification of several single-gene defects that cause
hypertension. This session will update participants on the
latest advances in our knowledge of molecular mechanisms of a
variety of forms of hypertension.
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Role of Dopamine Receptors
Pedro A. Jose, Georgetown University Medical Center, Washington, DC
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Perinatal Programming and the
Development of Hypertension
Lori Woods, Oregon Health & Science University, Portland, OR
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Low Renin Hypertension in
Childhood
Maria I. New, Mount Sinai School of Medicine, New York, NY
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WNK Kinases and Blood Pressure
Regulation
Richard Lifton, Yale University School of Medicine, New Haven, CT
Sponsored jointly by
the American Society of Pediatric Nephrology, the
International Pediatric Hypertension Association, the Lawson
Wilkins Pediatric Endocrine Society and the Pediatric Academic
Societies
3:15pm–5:15pm
2774—Telemedicine and Its Applications in
Pediatrics: Improving Quality and Addressing Access Barriers
PAS Educational Workshop
Golden Gate Hall C2, SF Marriott
Leader: James Marcin, Sacramento, CA; Co-leader: Stacey Cole
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, senior faculty,
and community practitioners.
This workshop will provide an
overview of telemedicine, and demonstrate how telemedicine
assists in the care of pediatric patients in various settings.
Interactive lectures will be given on the critical components
of a successful telemedicine program. Video clips of
consultations and interviews will be shown to provide an
understanding of telemedicine from various perspectives. A
step-by-step process will be laid out to help evaluate the
possibility of using telemedicine for their services.
Panelists: Juan Trujano, Anita
Grady and Kristi MacLeod
Objectives:
– To understand the technology
of telemedicine, including telecommunications.
– To become familiar with the important structural,
managerial and financial considerations of telemedicine.
– To understand the impact of telemedicine on measures of
quality of care and satisfaction.
Format: This workshop will
primarily be conducted in a lecture/panel format. Sessions
will be interactive and include discussion, sample video
clips, and a live demonstration of equipment and telemedicine
consultations.
4:00pm–7:30pm
Commercial Exhibits Open and Posters
Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West
Posters Available for Viewing:
4:00pm–7:30pm
Author Attendance: 5:15pm–7:15pm
Level 1:
– Developmental Biology
– Endocrinology
– Hematology–Oncology
– Neonatal Infectious Diseases
– Neonatology
– Nephrology
Level 2:
– Cardiology
– Developmental–Behavioral Pediatrics
– General Pediatrics
– Medical Education
– Neurology
5:15pm–7:15pm
Poster Session I and PAS Opening Reception
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
4:00pm–7:30pm
Author Attendance: 5:15pm–7:15pm
Level 1:
– Developmental Biology
– Endocrinology
– Hematology–Oncology
– Neonatal Infectious Diseases
– Neonatology
– Nephrology
Level 2:
– Cardiology
– Developmental–Behavioral Pediatrics
– General Pediatrics
– Medical Education
– Neurology
Includes:
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SPR Student Research Award:
Resuscitation of Non-Viable Infants: Will
Neonatologists[apos] Practice Change After the Born-Alive
Infant Protection Act?
Mya Sendowski, University of California, San Francisco, CA
Sunday, April 30
8:00am–10:00am
3100—Advances in Pathogenesis, Diagnosis
and Management of Kawasaki Disease
PAS/PIDS Topic Symposium
Room 3001, Moscone West
Chairs: Marian Melish, University of Hawaii, Kapiolani
Children's Hospital, Honolulu, HI; and Stanford T. Shulman,
Children's Memorial Hospital, Northwestern University,
Feinberg School of Medicine, Chicago, IL
Target Audience: Infectious
disease specialists, cardiologists, rheumatologists,
immunologists and primary care pediatricians.
Cloning the IgA antibody response
in acute Kawasaki Disease has led to exciting new insights
into the etiology and pathogenesis of this enigmatic illness.
The diagnosis of incomplete Kawasaki Disease remains a
significant clinical problem, and new guidelines have been
published to help the clinician in making this diagnosis.
Approximately 10–15% of children with acute Kawasaki Disease
do not respond to conventional intravenous gammaglobulin and
aspirin therapy, and new data regarding treatment with
steroids and Remicade are emerging. Knowledge regarding
optimal management of cardiac complications and long-term
outcome continues to evolve as patients diagnosed with
Kawasaki Disease in the 1970s and 1980s age.
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Overview
Marian E. Melish, University of Hawaii, Kapiolani Children's Hospital,
Honolulu, HI
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IgA Response in Acute Kawasaki
Disease Targets Inclusion Bodies in Acute Kawasaki Disease
Bronchial Epithelium
Anne H. Rowley, Northwestern University, Children's Memorial Hospital,
Chicago, IL
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Clinical Dilemma of Diagnosing
Incomplete Kawasaki Disease
Jane C. Burns, University of California, San Diego, CA
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Treatment of Refractory Kawasaki
Disease
Stanford T. Shulman, Children's Memorial Hospital, Northwestern
University, Feinberg School of Medicine, Chicago, IL
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Management of Cardiac
Complications and Long-Term Outcome
Jane W. Newburger, Harvard University, Children’s Hospital of Boston,
Boston, MA
Sponsored jointly by
the Pediatric Infectious Diseases Society and the Pediatric
Academic Societies
8:00am–10:00am
3105—From Health Services Research to
Public Policy
PAS Topic Symposium
Room 2006, Moscone West
Chair: Gary L. Freed, University of Michigan, Ann Arbor, MI
Target Audience: Investigators,
clinicians and advocacy experts.
The contribution of research
regarding children is measured in its ability to improve
children's health and well being. Research findings that
contribute to public policy efforts have the potential to
improve the lives and well being of whole communities, states
and nations of children. Understanding the nature and
appreciating the role of such work is fundamentally important
for clinicians and researchers alike.
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Overview
Gary L. Freed, University of Michigan, Ann Arbor, MI
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Using Research To Confront Power:
Can P Values Speak to Justice?
Paul H. Wise, Stanford University, Stanford, CA
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Where Research Meets Policy and
Politics: The Road to Health Reform for Children
Sara Rosenbaum, George Washington University, Washington, DC
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Linking Health and School Goals
To Address Childhood Obesity
Joseph W. Thompson, University of Arkansas Medical Sciences, Little
Rock, AR
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Addressing Children’s
Underinsurance Through Policy-Relevant Research
Matthew M. Davis, University of Michigan, Ann Arbor, MI
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Discussion
8:00am–10:00am
3145—Genetic Basis of Disease: Pathogenesis
and Treatment
PAS Platform Session
Room 3000, Moscone West
Chairs: George A. Diaz and
Brendan H. Lee
Includes:
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SPR Fellow's Basic Research
Award: Conditional Mutagenesis of the Homeobox Gene [italic]Hhex[/italic]
Reveals Novel and Essential Roles in Development of the
Liver and Extrahepatic Biliary Tract
Michael Hunter, Yale University School of Medicine, New Haven, CT
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SPR Student Research Award: Germ
Line [italic]KRAS[/italic] Mutations Encoding Proteins
with Novel Biochemical and Functional Properties Cause
Disorders of the Noonan Syndrome Spectrum
Suzanne Schubbert, University of California, San Francisco, CA
11:00am–4:00pm
Commercial Exhibits Open and Posters
Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West
Posters Available for Viewing:
11:00am–4:00pm
Author Attendance: 12:00pm–2:00pm
Level 1:
– Allergy, Immunology and Rheumatology
– Developmental-Behavioral Pediatrics
– Endocrinology
– Infectious Diseases
– General Pediatrics
– Hematology–Oncology
Level 2:
– Cardiology
– Neonatal Neurology
– Neonatology
12:00pm–2:00pm
Poster Session II
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
11:00am–4:00pm
Author Attendance: 12:00pm–2:00pm
Level 1:
– Allergy, Immunology and Rheumatology
– Developmental-Behavioral Pediatrics
– Endocrinology
– Infectious Diseases
– General Pediatrics
– Hematology–Oncology
Level 2:
– Cardiology
– Neonatal Neurology
– Neonatology
Includes:
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SPR Clinical Research Award:
Accelerated Development in the Visual Areas of Preterm
Infants? A Voxel-Based Morphometry Study on Diffusion
Tensor MR Imaging (DTI)
Maria Miranda, Copenhagen University Hospital, Hvidovre, Denmark
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SPR Fellow's Basic Research
Award: Myopalladin Mutations and Inherited
Cardiomyopathies
Enkhsaikhan Purevjav, Baylor College of Medicine, Houston, TX
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SPR Fellow's Clinical Research
Award: Novel Genotyping Technology To Classify Childhood
Leukemia
Joshua D. Schiffman, Stanford University, Palo Alto, CA
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SPR House Officer Research Award:
Erythropoietin Protein Expression in the Developing Human
Eye
Shrena Patel, University of New Mexico, Albuquerque, NM
2:00pm–4:00pm
3710—Non-Growth Related Issues in Girls
with Turner Syndrome
PAS/LWPES Topic Symposium
Room 3003-3005, Moscone West
Chairs: Judith G. Hall, The University of British Columbia and
BC Children's Hospital, Vancouver, BC, Canada; and Paul H.
Saenger, Montefiore Medical Center, The Bronx, NY
Target Audience: Geneticists,
endocrinologists, cardiologists and developmental
pediatricians.
Although the focus of the
pediatric endocrine community has been primarily on the growth
issues of girls with Turner Syndrome, other non-growth issues
continue to be described. This topic symposium will highlight
these non-growth-related issues and illuminate the problems
and strategies of dealing with them.
-
Evaluation of Congenital and
Acquired Heart Disease in Turner Syndrome
Carolyn A. Bondy, National Institute of Child Health and Human
Development, Bethesda, MD
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Skeletal Health
Vladamir K. Bakalov, National Institute of Child Health and Human
Development, Bethesda, MD
-
Non-verbal Learning Disabilities
Marsha L. Davenport, University of North Carolina at Chapel Hill,
Chapel Hill, NC
Sponsored jointly by
the Lawson Wilkins Pediatric Endocrine Society and the
Pediatric Academic Societies
2:00pm–4:00pm
3732—Pulmonary and Cardiac Development:
Transcriptional Control and Stem Cells
PAS Platform Session
Room 2004, Moscone West
Chairs: Lawrence M. Nogee and George A. Porter
Includes
-
SPR Student Research Award:
Critical Requirement of C/EBP[alpha] for Lung Maturation
and Funct
Prithy Martis, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
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Role of MicroRNAs in
Cardiogenesis
Yong Zhao, Gladstone Institute of Cardiovascular Disease, University of
California San Francisco
4:15pm–5:45pm
3810—RNA Interference, Technological
Development of siRNAs and Potential Treatments for Childhood
Diseases
PAS State of the Art Plenary
Room 3016-3018, Moscone West
Chair: R. Alan B. Ezekowitz, Harvard Medical School,
Massachusetts General Hospital, Boston, MA
Target Audience: Basic scientists
studying a broad range of childhood diseases, translational
scientists of all disciplines studying clinical implications
of basic science research, clinical scientists studying
childhood and other diseases in need of improved therapies and
clinicians interested in cutting-edge science and its medical
implications.
RNA interference is a recently
discovered, naturally occurring intracellular process that
regulates gene expression through the silencing of specific
mRNAs. Methods of harnessing this natural pathway are being
developed that allow the catalytic degradation of targeted
mRNAs using specifically designed complementary small
inhibitory RNAs (siRNA). siRNAs are being chemically modified
to acquire drug-like properties. Numerous recent high-profile
publications have provided proofs of concept that RNA
interference may be useful therapeutically. Much of the design
of these siRNAs can be accomplished bioinformatically, thus
potentially expediting drug discovery and opening new avenues
of therapy for many childhood diseases including uncommon
pediatric and orphan diseases. A discussion of the science
behind RNA interference will be followed by a presentation of
the potential practical issues in applying this technology to
disease. The program then describes two therapeutic programs
currently under way with applications to pediatric diseases. A
question-and-answer time will follow each discussion.
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The Science of RNA Interference
John J. Rossi, Beckman Research Institute of City of Hope, Duarte, CA
-
RNA Interference and Its
Potential Applications for Controlling Disease
Judy Lieberman, CBR Institute for Biomedical Research and Harvard
Medical School, Boston, MA
-
Silencing the VEGF Pathway with
siRNAs and the Potential Application to Retinopathy of
Prematurity
Pamela Pavco, Sirna Therapeutics, Boulder, CO
-
siRNA as Therapy for Respiratory
Syncytial Virus
John P. DeVincenzo, University of Tennessee School of Medicine,
Memphis, TN
4:15pm–6:15pm
3845—Endocrinology: Insulin
Resistance/Obesity
PAS/LWPES Poster Symposium
Room 3003-3005, Moscone West
Chairs: I. David Schwartz and Svetlana Ten
4:15pm–6:15pm
3875—Neonatal Pulmonary Hypertension
PAS Poster Symposium
Room 2002, Moscone West
Chairs: Steven H. Abman and Bernard Thebaud
Monday, May 1
8:00am–10:00am
4120—Cardiology—Translation Research and
Clinical Studies
PAS Platform Session
Room 3020, Moscone West
Chairs: Daniel Bernstein and Bruce Gelb
8:00am–11:00am
4150—The Skinny on the Adipocyte
PAS/LWPES Mini Course
Room 3010-3012, Moscone West
Chairs: Silva A. Arslanian, University of Pittsburgh,
Pittsburgh, PA; and Robert H. Lustig, University of
California, San Francisco, CA
Target Audience: General
pediatricians, gastroenterologists, endocrinologists,
cardiologists, pulmonologists and adolescent medicine
specialists.
Over the past five years much has
been learned about the adipocyte. The ability of the adipocyte
to function as an endocrine gland, elaborating inflammatory
cytokines that result in free radical formation and premature
apoptosis of the beta cell, is a relatively new concept. This
mini course will comprehensively address many of the newest
concepts in adipocyte function and their impact on health and
disease. Further discussion will include new concepts on the
interactions of IGF-II and other peptides' interactions with
the adipocyte. Lastly, there will be a call for new approaches
to the pediatric obesity epidemic.
-
Adipose Tissue as an Endocrine
Organ
Susan Fried, University of Maryland School of Medicine, Baltimore VA
Medical Center, Baltimore, MD
-
Obesity and Inflammation
Christopher Hug, Whitehead Institute and Children's Hospital,
Cambridge, MA
-
Effects of GH, IGF-I and Insulin
Therapies on Adiposity
Zvi Laron, Schneider Children's Medical Center of Israel, Petah Tikva,
Isreal
-
Pathology and Sequelae of
Childhood Obesity in Adult Life
Dennis M. Styne, University of California, Davis Medical Center,
Sacramento, CA
Sponsored jointly by
the Lawson Wilkins Pediatric Endocrine Society and the
Pediatric Academic Societies
10:15am–12:15pm
4365—Nitric Oxide and Oxygen: A Marriage
Made in Heaven or Hell?
PAS Poster Symposium
Room 3003-3005, Moscone West
Chairs: Satyan
Lakshminrusimha and Leif D. Nelin
3:00pm–5:00pm
4610—Cardiac Stem Cell Biology and
Therapeutics
PAS Topic Symposium
Room 3001, Moscone West
Chair: Harold S. Bernstein, University of California, San
Francisco, CA
Target Audience: Physicians,
scientists and trainees with interest in pediatric cardiology,
stem cell biology and reparative medicine.
This topic symposium is directed
towards educating interested members about the state of the
art in cardiac stem cell research, both the underlying biology
and initial attempts in animals and humans at cardiac
regenerative therapy. The discussion will range from
hematopoietic stem cells to cardioblasts, as well as to how
one assesses the results of stem cell infusion trials.
-
Recent History of Secondary
Cardiac Myogenesis
Harold S. Bernstein, University of California, San Francisco, CA
-
Mesenchymal Stem-Cell-Based
Cardiac Regeneration
Andrew Boyle, Johns Hopkins University, Baltimore, MD
-
Cardioblasts
Kenneth R. Chien, Mass General Hospital, Harvard Medical School,
Boston, MA
-
Functional Assessment of Myogenic
Stem Cells and Cardiomyocytes for Cardiac Cell Therapy
Loren J. Field, Indiana University School of Medicine, Indianapolis, IN
3:00pm–5:00pm
4690—Sepsis: Pathogenesis and Outcomes
PAS Platform Session
Room 3000, Moscone West
Chairs: John H. Arnold and Joseph A. Carcillo
Tuesday, May 2
8:00am–10:00am
5110A—Inflammation in Uremic
Pathophysiology
ASPN Symposium
Room 3010-3012, Moscone West
Chairs: H. William Schnaper, Northwestern University Feinberg
School of Medicine, Chicago, IL; and Robert H.K. Mak, Oregon
Health and Science University, Portland, OR
Target Audience: Pediatric
nephrologists and fellows, basic scientists, pathologists and
immunologists.
Recent evidence has strongly
suggested that the manifestations of uremia are caused in
large part by activation of inflammatory pathways. This
symposium will review the syndromic events that can be
attributed to uremic inflammation and include oxidant injury,
cytokine production and its end-organ effects on the body
tissues.
-
Oxidant Injury in ESRD
Jonathan Himmelfarb, Maine Medical Center, Portland, ME
-
MIA (Malnutrition, Inflammation,
Atherosclerosis) Syndrome in ESRD
Joel D. Kopple, Harbor-UCLA Medical Center, David Geffen School of
Medicine at UCLA, UCLA School of Public Health, Torrance,
CA
-
Leptin and Melanocortin Signaling
in Chronic Kidney Disease
Robert H.K. Mak, Oregon Health and Science University, Portland, OR
-
Molecular Pathophysiology of
Muscle Catabolism in Uremia: Effect of Acidosis and
Inflammation
William E. Mitch, Baylor College of Medicine, Houston, TX
Supported by an unrestricted educational grant from Abbott
8:00am–10:00am
5150—Cardiology—Genetics and Development
PAS Platform Session
Room 3000, Moscone West
Chairs: H. Scott Baldwin and Marlene Rabinovitch
Includes
-
SPR Student Research Award:
Mutations in [italic]JPH2-[/italic]Encoded Junctophilin 2
as a Novel Pathogenic Mechanism in Hypertrophic
Cardiomyopathy
Karin Batalden, Mayo Medical School, College of Medicine, Rochester, MN
8:00am–10:00am
5158—Endocrinology: Diabetes—Immune
Mediated
PAS Poster Symposium
Room 3020, Moscone West
Chairs: Bruce A. Boston and Susan B. Nunez
8:00am–10:00am
5168—Oxidants, Antioxidants and the Battles
They Wage
PAS Poster Symposium
Room 3014, Moscone West
Chairs: Jonathan M. Davis and Charles V. Smith
10:00am–12:00pm
5350—Revisiting NICU's Old Standbys: What's
the Evidence?
PAS Hot Topic
Room 3002-3008, Moscone West
Chairs: David Edwards, Hammersmith, UK; and Kristi L.
Watterberg, University of New Mexico, Albuquerque, NM
Target Audience: Neonatologists.
Although research continues to
promote advances in neonatal medicine, much of neonatal
practice is still not necessarily evidence-based. In this
session, we will take a look at several common neonatal
practices and the evidence that does–or does not–support
their use.
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Sodium Bicarbonate for Metabolic
Acidosis: Basic Therapy or Basically Useless Therapy?
Judy L. Aschner, Vanderbilt University Medical Center, Nashville, TN
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Transfusions in Premature
Infants: Too Much of a Good Thing or Not Enough?
Robin K. Ohls, University of New Mexico School of Medicine,
Albuquerque, NM
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Preterm Circulatory Compromise:
Which Inotrope in Which Baby?
Nick Evans, Royal Prince Alfred Hospital and University of Sydney,
Australia
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Analgesia in the Premature
Infant: Controlling Their Pain or Ours?
Johannes N. van den Anker, Children's National Medical Center,
Washington, DC
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Discussion
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