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Saturday,
April 29
6:00am–8:00am
Diagnosis,
Treatment and Cost Analysis of Growth Hormone Deficiency
Industry Sponsored Symposium
Yerba Buena Gardens Salon 8, SF Marriott
Target
Audience: Endocrinologists.
The
guidelines from the American Association of Clinical
Endocrinologists advocate early initiation of growth-hormone
replacement therapy in appropriate patients. Accurate
diagnosis of growth-hormone deficiency is complicated by other
potential causes of idiopathic short stature, including
growth-hormone resistance, hypothyroidism, chronic systemic
disease, Turner syndrome, or skeletal disorder, which must be
eliminated before growth-hormone replacement therapy
commences. Topics to be covered in this symposium include
differential diagnosis in patients with growth-hormone
deficiency, recognizing and overcoming difficulties in
achieving an accurate diagnosis, differentiation between IGF
resistance and IGF deficiency, and practical and clinical
guidelines in developing and maintaining an appropriate
therapeutic growth-hormone management strategy.
For
registration information please contact:
Shannon Monteith
Phone: (800) 960-0256
Email: smonteith@vindicomeded.com
Supported by a grant from Gate Pharmaceuticals (a Division
of Teva)
8:00am–11:00am
2100—Adult Stem Cells—A Primer for the
Clinician
PAS/ASPHO Mini Course
Room 3014, Moscone West
Chairs: Jakub Tolar, University of Minnesota, Minneapolis, MN; and
Mervin C. Yoder, Jr., Indiana University School of Medicine,
Indianapolis, IN
Target
Audience: Hematologists/oncologists, endocrinologists, basic
scientists and neurologists.
Adult
stem cells represent a technology that is being intensively
investigated currently, and this research may have wide
implications for human health. This mini course will focus on
recent research and potential applications in human health.
-
Introduction
Jakub Tolar, University of Minnesota, Minneapolis, MN
Mervin
C. Yoder, Indiana University School of Medicine,
Indianapolis, IN
-
Multipotent Adult Progenitor
Cell: Hype or Reality?
Catherine M. Verfaillie, University of Minnesota, Minneapolis, MN
-
Mesenchymal Stem Cell: Harnessing
the Power of Adult Stem Cells To Repair Tissues
Darwin Prockop, Tulane University Health Science Center, New Orleans,
LA
-
Hierarchy of Endothelial
Progenitors in Human Blood and Blood Vessels
David A. Ingram, Indiana University School of Medicine, Indianapolis,
IN
-
Cancer Stem Cell: Concept of
Human Leukemic Development
Craig T. Jordan, James P. Wilmot Cancer Center, University of Rochester
School of Medicine, Rochester, NY
Sponsored
jointly by the American Society of Pediatric
Hematology/Oncology and the Pediatric Academic Societies
8:00am–11:00am
2125—New Considerations for the Growth Rate
of the Preterm Infant: Too Fast or Not Fast Enough?—A Review
of the Evidence
PAS Mini Course
Room 3002-3008, Moscone West
Chairs: Frank R. Greer, University of Wisconsin, Madison, WI; and
William W. Hay, Jr., University of Colorado, Aurora, CO
Target
Audience: Neonatologists, hospitalists who take care of
preterm infants, nutritionists and general pediatricians.
Recent
nutritional emphasis in the NICU has been to achieve the
normal intrauterine growth rate with more aggressive
nutritional support for the low birth weight infant. In
general, this has been difficult to achieve, and new evidence
from long-term follow up studies shows that preterm infants
are at an increased risk of developing the metabolic syndrome
including obesity, type 2 diabetes and cardiovascular disease.
This implies that the organs in the early life of the preterm
infant may be programmed adversely by nutritional therapy.
This raises the questions of how fast these infants should
grow (including catch up growth), the importance of the
composition of this growth and the urgency for defining the
necessary balance between growth of the brain and the rest of
the body. Ultimately, providers may want to revise the
long-term and short-term goals for feeding very low birth
weight or extremely low birth weight infants. This mini course
will present evidence to help answer these questions and
provide discussion about related practice recommendations.
-
Overview
Frank R. Greer, University of Wisconsin, Madison, WI
William
W. Hay, University of Colorado Health Sciences Center,
Aurora, CO
-
Macronutrient Requirements for
Growth of Preterm Infants—Upper and Lower Limits
(Energy, Fat, CHO, Protein)
Scott C. Denne, Indiana University School of Medicine, James Whitcomb
Riley Hospital, Indianapolis, IN
-
Aggressive Nutritional Support of
the Preterm Infant Revisited—Evidence for Efficacy and
Safety
Patti J. Thureen, University of Colorado Health Sciences Center,
Denver, CO
-
Adverse Outcomes of Rapid Somatic
Growth and Alterations of Body Composition in the Low
Birth Weight Infant
Frank R. Greer, University of Wisconsin, Madison, WI
-
Fatty Acids and Neuronal
Development
Susan E. Carlson, University of Kansas Medical Center, Kansas City, KS
-
Iron and Development of the Brain
Michael K. Georgieff, University of Minnesota School of Medicine,
Minneapolis, MN
-
Nutritional Influences on
Structural and Functional Maturation of the Developing
Brain During Extended Postnatal Period
Steve H. Zeisel, The University of North Carolina, Chapel Hill, NC
8:00am–11:00am
2155—Gender-Variant Youth: The Role of the
Pediatrician
PAS Educational Workshop
Laurel, SF Marriott
Leader: Irene Sills, Albany, NY; Co-leader: Arlene Lev
Target
Audience: Trainees, fellows, junior faculty, mid-level
faculty, senior faculty, and community practitioners.
This
workshop is an overview of sexual and gender identity
development in children and youth focusing on understanding
the needs of transgender and transsexual youth. By review of
case presentations, attendees will gain skills and knowledge
in how to assist parents of children with gender variant
behavior, children with gender identity confusion, and
adolescents who exhibit cross-gender behaviors. Ethical
considerations in the care of this population will be
presented and discussed. Current standards for hormonal
therapy will be reviewed.
Objectives:
–
The participant will demonstrate an understanding of the
developmental appropriateness of youth with gender variant
behavior.
– The participant will prepare to assist children and
adolescents with gender variant behavior and their families.
– The participant will demonstrate an understanding of the
ethical issues in the medical care of transgendered
adolescents.
Format:
a) Short didactic presentation; b) discussions of scenarios
that might present to the pediatrician; c) viewing of a short
videotape; and d) roundtable discussion of ethical issues.
8:00am–12:00pm
2180A—LWPES Plenary Session I
LWPES Plenary Session
Room 3007-3009, Moscone West
Chairs: Lynne Levitsky, Massachusetts General Hospital, Boston, MA;
Henry Anhalt, Saint Barnabas Medical Center, Livingston, NJ;
and Alan D. Rogol, University of Virginia, Charlottesville, VA
Target
Audience: Endocrinologists, nephrologists, cardiologists,
general pediatricians, immunologists, geneticists and
molecular biologists.
-
Opening Remarks
Lynne L. Levitsky, Massachusetts General Hospital, Boston, MA
-
Lawson
Wilkins Lecture:
Recent
years have witnessed a significant revision of the
traditional view of fat cells as simple stores of excess
energy. Studies in the speaker's lab as well as many
others have clearly demonstrated that adipocytes produce
and regulate many metabolic and hormonal signals, which
generate profound effects on systemic endocrine
equilibrium. In his earlier studies, he also demonstrated
that these cells exhibit an inflammatory capacity that is
abnormal in obesity and key to the pathogenesis of insulin
resistance and diabetes. Recently, he identified a key
molecular mechanism underlying the link between
inflammatory responses and insulin action. This pathway
involves obesity-related activation of the serine,
threonine kinase, JNK, and the consequent inhibition of
insulin receptor signaling via phosphorylation of a
substrate of insulin receptor, IRS-1.
-
Integration of Metabolic and
Inflammatory Pathways in Metabolic Disease
Gokhan S. Hotamisligil, Harvard School of Public Health, Boston, MA
-
Robert
Blizzard Lecture:
One
of the greatest questions asked of physicians caring for
children with autoimmune diabetes is "why did this
happen?" This session will unravel some of the
mysteries surrounding the etiology and pathogenesis of
autoimmune diabetes from an investigator who has dedicated
his life to this issue.
-
On the Unravelling of the
Etiopathogenesis of Type 1 Diabetes: Are We Stuck or
Are We Winning?
Gian Franco Bottazzo, Ospedale Pediatrico Bambino Gesú, Scientific
Institute, Rome, Italy
-
Break
-
Esoterix
Lecture:
The
attendee will familiarize him/herself with newer molecular
mechanisms of growth failure that are due to abnormalities
in receptor and post-receptor translation of GH signaling.
-
Molecular Mechanisms and Defects
in Growth Hormone Receptor Signaling
Peter Rotwein, Oregon Health and Science University, Portland, OR
11:45am–2:45pm
2424—Treatment of the Metabolic Syndrome in
Children and Adolescents
PAS Educational Workshop
Golden Gate Hall A1, SF Marriott
Leader: J. Darrell Nesmith, Little Rock, AR; Co-leaders: Alba Morales,
Mohammad Ilyas, Lisa Lubsch
Target
Audience: Endocrinologists, trainees, fellows, junior faculty,
mid-level faculty, senior faculty, and community
practitioners.
The
rise in pediatric obesity and metabolic syndrome is well
established. Less understood for the pediatrician is the
treatment of the metabolic syndrome. In this workshop, we aim
to: 1) briefly discuss the epidemiology of the metabolic
syndrome in children and adolescents, 2) discuss
non-pharmacologic and pharmacologic treatment of the metabolic
syndrome, and 3) review a stepped approach in treating
adolescents with the metabolic syndrome.
This
workshop will be largely case-based. Come prepared to devise
treatment plans in a small group setting. Participants are
invited to bring their own cases for discussion.
Objectives:
Participants
will:
–
Learn the epidemiology of the metabolic syndrome in children
and adolescents.
– Become familiar with existing treatment guidelines for
components of the metabolic syndrome in children and
adolescents.
– Identify gaps in the literature regarding treatment
guidelines of the metabolic syndrome in children and
adolescents.
– Consider pharmacologic treatment options of metabolic
syndrome treatment based on the available evidence.
Format:
A short didactic presentation will be given on diabetes,
hypertension, and dyslipidemia treatments from a diabetologist,
nephrologist, and endocrinologist respectively. Existing
published guidelines will be presented while gaps in the
literature regarding treatment will be discussed. Following
these short didactic presentations, small groups (at tables)
will work on cases which will be presented, and a treatment
plan will be derived by each group. At the end of these
roundtable work group discussions, the group as a whole will
discuss the treatment plans. Actual cases will be used when
possible (with appropriate de-identifiers) and their treatment
plans discussed.
12:00pm–3:00pm
2505—Embryonic Stem Cells: A Primer for
Clinicians
PAS Mini Course
Room 3014, Moscone West
Chair: Michael T. Longaker, Stanford University, Stanford, CA
Embryonic
stem cells offer incredible promise for treating diseases
affecting both children and adults. This mini course will
provide an overview of stem cells and a basic understanding of
how to derive human embryonic stem cells, recent research and
ethical considerations. After attending this session, attendee
will have a better understanding of: 1) what are embryonic
stem cells; 2) how human embryonic stem cells are derived; 3)
recent progress in human embryonic stem cell research; 4)
ethical considerations in human embryonic stem cells.
-
Stem Cells: Embryonic, Adult and
Cancer
Michael T. Longaker, Stanford University, Stanford, CA
-
What It Takes Clinically To Get
an Embryonic Stem Cell
Linda C. Giudice, University of California, San Francisco, San
Francisco, CA
-
What Can You Do with an Embryonic
Stem Cell in Research
Renee Reijo Pera, University of California, San Francisco, San
Francisco, CA
-
Ethical and Oversight
Considerations in Human Embryonic Stem Cell Research
Hank Greely, Stanford University, Stanford, CA
-
Panel Discussion
Supported in part by an
unrestricted educational grant from Treuman Katz Center for
Pediatric Bioethics - Seattle Children's Hospital
1:30pm–3:30pm
2670A—Controversies in Care in Pediatric
Endocrinology—The Great Debates
LWPES Workshop
Room 3001, Moscone West
Chairs: William Clarke, University of Virginia, Charlottesville, VA;
and Henry Anhalt, St. Barnabas Medical Center, Livingston, NJ
Target
Audience: Endocrinologists, general pediatricians and
adolescent medicine specialists.
The
attendee will be part of a lively debate on a number of areas
of controversy in pediatric state-of-the-art diabetes
management.
-
Is Primary Prevention of Type 1
Diabetes Possible?
-
Pro—Desmond A. Schatz, University of Florida, Gainesville, FL
-
Con—Dorothy J. Becker, Children's Hospital of Pittsburgh, Pittsburgh, PA
-
Should Glucose Sensors Be
Routinely Used?
-
Pro—Stuart Alan Weinzimer, Yale School of Medicine, New Haven, CT
-
Con—Darrell M. Wilson, Stanford University Medical Center, Stanford, CA
-
Should Metformin Be Used To Treat
Pediatric Patients with Insulin Resistance?
-
Pro—Michael S. Freemark, Duke University Medical Center, Durham, NC
-
Con—Philip Scott Zeitler, University of Colorado at Denver and Health
Sciences Center, Denver, CO
1:30pm–3:30pm
2675A—Controversies in the Management of
Non-classical Congenital Adrenal Hyperplasia
LWPES Workshop
Room 3000, Moscone West
Chairs: Perrin White, University of Texas Southwestern Medical Center,
Dallas, TX; and Ieuan Hughes, University of Cambridge,
Cambridge, UK
Target
Audience: Neonatologists, endocrinologists, generalists and
adolescent medicine specialists.
Non-classical
adrenal hyperplasia (NCAH) occurs more commonly than does the
classical form and may masquerade as hirsutism, acne and
menstrual cycle dysfunction. NCAH must be considered in the
differential diagnosis of these relatively common conditions.
The diagnosis of NCAH is being made more frequently today as a
result of greater access to genotyping available through many
commercial laboratories. Once the diagnosis is made, however,
the controversies begin. Who should have stress-dose
glucocorticoids and who should have prenatal screening are
some of the controversial issues.
-
Glucocorticoid Coverage and
Treatment in Non-classical Adrenal Hyperplasia
Mitchell E. Geffner, Children's Hospital Los Angeles, Los Angeles, CA
-
Role or No Role of Prenatal
Diagnosis and Newborn Screening in Non-classical Adrenal
Hyperplasia
Patricia A. Donohoue, The Children's Hospital of Iowa at the University
of Iowa Hospitals and Clinics, Iowa City, IA
-
Fertility in Patients with
Non-classical Adrenal Hyperplasia
Marcelle Cedars, University of California-San Francisco, San Francisco,
CA
2:15pm–5:15pm
2700—Educating Pediatric Fellows in a
Competency-Based World
PAS/APPD Mini Course
Room 2007, Moscone West
Chairs: Susan Guralnick, Stony Brook University Medical Center, Stony
Brook, NY; and Joseph Gilhooly, Oregon Health and Science
University, Portland, OR
Target
Audience: Attendees involved with fellowship programs.
Competency-based
education is now the standard for residency education.
Residency programs have integrated the ACGME Core Competencies
into their curricula and assessment methods. It is now time
for fellowships to enter the “competency” arena, and there
is much to be accomplished. This program will focus on several
areas of fellowship education including: the new RRC common
requirements for subspecialty training, development of a
competency-based fellowship curriculum, competency-based
assessment tools, and pediatric subspecialty fellows as
teachers. Attendees are encouraged to bring tools and ideas
for discussion and development. Attendees should leave with
useful materials to bring back to their home programs.
-
Overview
Susan Guralnick, Stony Brook University Medical Center, Stony Brook, NY
Joseph
Gilhooly, Oregon Health & Science University,
Portland, OR
-
A Brave New World! New Common
Requirements for Subspecialty Training—Implementing the
Competencies
Carol Carraccio, Professor of Pediatrics and Associate Chair for
Education, University of Maryland School of Medicine,
Baltimore, MD
-
"Survivor ACGME"—Fellowship
Competencies in Action
Joseph Gilhooly, Oregon Health & Science University, Portland, OR
-
John
D. Mahan, Children’s Hospital, The Ohio State
University, Columbus, OH
-
Turning to Fellows as Teachers:
From Curricula to Evaluation
Nancy D. Spector, St. Christopher's Hospital for Children,
Philadelphia, PA
Susan
Guralnick, Stony Brook University Medical Center, Stony
Brook, NY
Sponsored
jointly by the Association of Pediatric Program Directors and
the Pediatric Academic Societies
Supported by an unrestricted educational grant from Dey,
L.P.
2:15pm–5:15pm
2705—Vitamin D: More Than Just Calcium and
Bone
PAS/LWPES Mini Course
Room 3007-3009, Moscone West
Chairs: Catherine M. Gordon, Children's Hospital of Boston, Boston, MA;
and Linda A. DiMeglio, Indiana University, Indianapolis, IN
Target
Audience: General pediatricians, gastroenterologists,
endocrinologists and hematologists/oncologists.
The
understanding of the role of vitamin D in health and illness
is becoming more complex. Both skeletal and extra-skeletal
actions have been described, and vitamin D analogs are being
explored for their anti-proliferative effects. The attendee
will gain both clinically relevant epidemiological knowledge
as well as review the calcemic and non-calcemic actions of
Vitamin D.
-
What Is the Evidence for Vitamin
D Deficiency in Children?
Frank R. Greer, University of Wisconsin, Madison, WI
-
Vitamin D and Extra-Skeletal
Actions in Health
Michael F. Holick, Boston University School of Medicine, Boston, MA
-
Non-calcemic Actions of Vitamin D
Receptor Ligands
Sunil Nagpal, Women's Health & Musculoskeletal Biology,
Collegeville PA
Sponsored
jointly by the Lawson Wilkins Pediatric Endocrine Society and
the Pediatric Academic Societies
3:15pm–5:15pm
2730—Mechanisms of Hypertension in the
Molecular Era
PAS/ASPN/IPHA/LWPES Topic Symposium
Room 2003-2005, Moscone West
Chairs: Bruce Z. Morgenstern, Phoenix Children's Hospital, Phoenix, AZ;
and Julie R. Ingelfinger, Massachusetts General Hospital,
Boston, MA
Target
Audience: General pediatricians, nephrologists,
endocrinologists and neonatologists.
Our
understanding of the pathophysiology of hypertension has been
changing rapidly due to advances in molecular genetics, most
notably the identification of several single-gene defects that
cause hypertension. This session will update participants on
the latest advances in our knowledge of molecular mechanisms
of a variety of forms of hypertension.
-
Role of Dopamine Receptors
Pedro A. Jose, Georgetown University Medical Center, Washington, DC
-
Perinatal Programming and the
Development of Hypertension
Lori Woods, Oregon Health & Science University, Portland, OR
-
Low Renin Hypertension in
Childhood
Maria I. New, Mount Sinai School of Medicine, New York, NY
-
WNK Kinases and Blood Pressure
Regulation
Richard Lifton, Yale University School of Medicine, New Haven, CT
Sponsored
jointly by the American Society of Pediatric Nephrology, the
International Pediatric Hypertension Association, the Lawson
Wilkins Pediatric Endocrine Society and the Pediatric Academic
Societies
3:45pm–5:15pm
2785A—Celiac Disease for the
Non-gastroenterologist
LWPES Workshop
Room 3010, Moscone West
Chair: Michelle M. Pietzak, Children's Hospital of Los Angeles, Los
Angeles, CA
Target
Audience: Gastroenterologists and endocrinologists.
Celiac
disease affects approximately 10-15% of children with
diabetes. Often times the screening tests are vexing. This
workshop is aimed at clarifying the disease process and how to
diagnose it.
-
Celiac Disease for the
Non-gastroenterologist
Michelle M. Pietzak, Children's Hospital of Los Angeles, Los Angeles,
CA
3:45pm–5:15pm
2790A—Hyperthyroidism
LWPES Workshop
Room 3000, Moscone West
Chair: Scott A. Rivkees, Yale School of Medicine, New Haven, CT
Target
Audience: Generalists.
Much
controversy exists about the most effective and safest
treatments for hyperthyroidism in children. This workshop will
clarify some of the newer evidence based approaches to the
diagnosis and management of hyperthyroidism, with a special
emphasis on radioactive ablation.
3:45pm–5:15pm
2795A—Neonatal Diabetes
LWPES Workshop
Room 3001, Moscone West
Chair: Mark A. Sperling, Children's Hospital of Pittsburgh, Pittsburgh,
PA
Target
Audience: Endocrinologists and neonatologists.
Over
the past few years much has been learned about the
pathogenesis of neonatal diabetes. This workshop will impart
knowledge on important considerations in the diagnosis and
work-up of this rare condition.
4:00pm–7:30pm
Commercial Exhibits Open and Posters
Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West
Posters
Available for Viewing: 4:00pm–7:30pm
Author Attendance: 5:15pm–7:15pm
Level
1:
– Developmental Biology
– Endocrinology
– Hematology–Oncology
– Neonatal Infectious Diseases
– Neonatology
– Nephrology
Level
2:
– Cardiology
– Developmental–Behavioral Pediatrics
– General Pediatrics
– Medical Education
– Neurology
5:15pm–6:00pm
2800—Clinical Pediatric Hypertension
PAS/ASPN/IPHA Poster Symposium
Room 2004, Moscone West
Chairs: Stephen R. Daniels and Deborah P. Jones
Sponsored
jointly by the International Pediatric Hypertension
Association and the American Society of Pediatric Nephrology
5:15pm–7:15pm
Poster Session I and PAS Opening Reception
PAS Poster Session
Levels 1 and 2, Moscone West
Posters
Available for Viewing: 4:00pm–7:30pm
Author Attendance: 5:15pm–7:15pm
Level
1:
– Developmental Biology
– Endocrinology
– Hematology–Oncology
– Neonatal Infectious Diseases
– Neonatology
– Nephrology
Level
2:
– Cardiology
– Developmental–Behavioral Pediatrics
– General Pediatrics
– Medical Education
– Neurology
Includes:
-
SPR Student Research Award:
Resuscitation of Non-Viable Infants: Will Neonatologists'
Practice Change After the Born-Alive Infant Protection
Act?
Mya Sendowski, University of California, San Francisco, CA
Sunday,
April 30
7:45am–9:00am
3080A—LWPES Business Meeting
LWPES Business Meeting
Room 3007-3011, Moscone West
8:00am–10:00am
3125—Developmental Origins of Adult
Disease—Metabolism
PAS Platform Session
Room 3010-3012, Moscone West
Chairs: William W. Hay and Rebecca A. Simmons
9:00am–10:00am
3290A—LWPES Presidential Lecture
LWPES Presidential Plenary
Room 3007-3011, Moscone West
Chair: Alan D. Rogol, University of Virginia, Charlottesville, VA
Target
Audience: Endocrinologists.
Judson J. Van Wyk Prize
Melvin M. Grumbach,
Alan
D. Rogol, University of Virginia, Charlottesville, VA
Pediatric Endocrinology Past and
Present: Are We Ready for the Future?
Lynne L. Levitsky, Massachusetts General Hospital, Boston, MA
10:00am–11:45am
3325A—Endocrinology/Diabetes Awards
LWPES Platform Session
Room 3007-3011, Moscone West
Chairs: To be announced
LWPES
Clinical Scholars Presentations
11:00am–4:00pm
Commercial Exhibits Open and Posters
Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West
Posters
Available for Viewing: 11:00am–4:00pm
Author Attendance: 12:00pm–2:00pm
Level
1:
– Allergy, Immunology and Rheumatology
– Developmental-Behavioral Pediatrics
– Endocrinology
– Infectious Diseases
– General Pediatrics
– Hematology–Oncology
Level
2:
– Cardiology
– Neonatal Neurology
– Neonatology
12:00pm–2:00pm
Poster Session II
PAS Poster Session
Levels 1 and 2, Moscone West
Posters
Available for Viewing: 11:00am–4:00pm
Author Attendance: 12:00pm–2:00pm
Level
1:
– Allergy, Immunology and Rheumatology
– Developmental-Behavioral Pediatrics
– Endocrinology
– Infectious Diseases
– General Pediatrics
– Hematology–Oncology
Level
2:
– Cardiology
– Neonatal Neurology
– Neonatology
Includes:
-
SPR Clinical Research Award:
Accelerated Development in the Visual Areas of Preterm
Infants? A Voxel-Based Morphometry Study on Diffusion
Tensor MR Imaging (DTI)
Maria Miranda, Copenhagen University Hospital, Hvidovre, Denmark
-
SPR Fellow's Basic Research
Award: Myopalladin Mutations and Inherited
Cardiomyopathies
Enkhsaikhan Purevjav, Baylor College of Medicine, Houston, TX
-
SPR Fellow's Clinical Research
Award: Novel Genotyping Technology To Classify Childhood
Leukemia
Joshua D. Schiffman, Stanford University, Palo Alto, CA
-
SPR House Officer Research Award:
Erythropoietin Protein Expression in the Developing Human
Eye
Shrena Patel, University of New Mexico, Albuquerque, NM
2:00pm–4:00pm
3710—Non-Growth Related Issues in Girls
with Turner Syndrome
PAS/LWPES Topic Symposium
Room 3003-3005, Moscone West
Chairs: Judith G. Hall, The University of British Columbia and BC
Children's Hospital, Vancouver, BC, Canada; and Paul H.
Saenger, Montefiore Medical Center, The Bronx, NY
Target
Audience: Geneticists, endocrinologists, cardiologists and
developmental pediatricians.
Although
the focus of the pediatric endocrine community has been
primarily on the growth issues of girls with Turner Syndrome,
other non-growth issues continue to be described. This topic
symposium will highlight these non-growth-related issues and
illuminate the problems and strategies of dealing with them.
-
Evaluation of Congenital and
Acquired Heart Disease in Turner Syndrome
Carolyn A. Bondy, National Institute of Child Health and Human
Development, Bethesda, MD
-
Skeletal Health
Vladamir K. Bakalov, National Institute of Child Health and Human
Development, Bethesda, MD
-
Non-verbal Learning Disabilities
Marsha L. Davenport, University of North Carolina at Chapel Hill,
Chapel Hill, NC
Sponsored
jointly by the Lawson Wilkins Pediatric Endocrine Society and
the Pediatric Academic Societies
2:00pm–5:00pm
3750—Endocrine Disrupters
PAS/LWPES Mini Course
Room 3010-3012, Moscone West
Chairs: Mary M. Lee, University of Massachusetts Medical School,
Worcester, MA; and Henry Anhalt, Saint Barnabas Medical
Center, Livingston, NJ
Target
Audience: Endocrinologists, generalists, neonatologists and
basic scientists.
Concerns
regarding clinical consequences of endocrine disrupting
chemicals have increased over the past decade as researchers
have documented detrimental effects in wildlife. Federal
attention to endocrine disrupters began in earnest in 1996
when the U.S. Congress passed the Food Quality Protection Act
and amended the Safe Drinking Water Act. These laws mandated
testing to determine if pesticides and industrial chemicals
might behave like hormones; therefore, the U.S. EPA formed the
Endocrine Disrupters Screening and Advisory Committee. In
addition to direct effects, some environmental disrupters act
through non-genomic actions, some of which persist for several
generations. This program presenting innovative studies on
mechanisms of action of endocrine disruptors will be of
critical interest to endocrinologists, both clinical and basic
scientists, as well as public health experts.
-
Prenatal Programming with
Estrogen/Estrogen Mimetics
Kenneth S. Korach, National Institute of Environmental Health Sciences,
Research Triangle Park, NC
-
Epigenetic Transgenerational
Actions of Endocrine Disruptors on Male Fertility and
Other Diseases
Michael K. Skinner, Washington State University, Pullman, WA
-
Prenatal Programming with Native
and Environmental Steroids
Vasantha Padmanabhan, University of Michigan, Ann Arbor, MI
Sponsored
jointly by the Lawson Wilkins Pediatric Endocrine Society and
the Pediatric Academic Societies
4:15pm–5:45pm
3805—Fetal Homeland Security: New Insights
into Old Threats
PAS State of the Art Plenary
Room 3002-3008, Moscone West
Chairs: Phil W. Shaul, University of Texas Southwestern Medical Center,
Dallas, TX; and Rashmin C. Savani, University of Texas
Southwestern Medical Center, Dallas, TX
Target
Audience: Neonatologists, pediatricians and researchers
interested in perinatal biology.
In
addition to premature birth, there are a select number of
maternal conditions that have marked negative impact on the
well being of the fetus and newborn. This symposium will
highlight recent advances in our understanding of these
classical threats to our most vulnerable pediatric patient
population.
First,
new knowledge of the mechanisms by which maternal diabetes
alters embryonic and fetal development will be discussed.
Second, the newly discovered role of circulating anti-angiogenic
proteins of placental origin in the pathogenesis of
preeclampsia will be presented. Finally, novel mechanisms by
which biochemical events in the fetal lung trigger the
initiation of labor will be discussed. Further advances in
each of these realms will ultimately lead to new therapies to
protect the fetus and yield healthy outcomes at term.
-
Mechanisms by Which Maternal
Diabetes Modifies Embryonic and Fetal Development
Kelle H. Moley, Washington University School of Medicine, St. Louis, MO
-
Role of Circulating Anti-angiogenic
Proteins of Placental Origin in the Pathogenesis of
Preeclampsia
S. Ananth Karumanchi, Harvard Medical School, Beth Isreal Deaconess
Medical Center, Boston, MA
-
Fetal–Maternal Signaling in the
Initiation of Labor
Carole R. Mendelson, University of Texas Southwestern Medical Center,
Dallas, TX
4:15pm–5:45pm
3810—RNA Interference, Technological
Development of siRNAs and Potential Treatments for Childhood
Diseases
PAS State of the Art Plenary
Room 3016-3018, Moscone West
Chair: R. Alan B. Ezekowitz, Harvard Medical School, Massachusetts
General Hospital, Boston, MA
Target
Audience: Basic scientists studying a broad range of childhood
diseases, translational scientists of all disciplines studying
clinical implications of basic science research, clinical
scientists studying childhood and other diseases in need of
improved therapies and clinicians interested in cutting-edge
science and its medical implications.
RNA
interference is a recently discovered, naturally occurring
intracellular process that regulates gene expression through
the silencing of specific mRNAs. Methods of harnessing this
natural pathway are being developed that allow the catalytic
degradation of targeted mRNAs using specifically designed
complementary small inhibitory RNAs (siRNA). siRNAs are being
chemically modified to acquire drug-like properties. Numerous
recent high-profile publications have provided proofs of
concept that RNA interference may be useful therapeutically.
Much of the design of these siRNAs can be accomplished
bioinformatically, thus potentially expediting drug discovery
and opening new avenues of therapy for many childhood diseases
including uncommon pediatric and orphan diseases. A discussion
of the science behind RNA interference will be followed by a
presentation of the potential practical issues in applying
this technology to disease. The program then describes two
therapeutic programs currently under way with applications to
pediatric diseases. A question-and-answer time will follow
each discussion.
-
The Science of RNA Interference
John J. Rossi, Beckman Research Institute of City of Hope, Duarte, CA
-
RNA Interference and Its
Potential Applications for Controlling Disease
Judy Lieberman, CBR Institute for Biomedical Research and Harvard
Medical School, Boston, MA
-
Silencing the VEGF Pathway with
siRNAs and the Potential Application to Retinopathy of
Prematurity
Pamela Pavco, Sirna Therapeutics, Boulder, CO
-
siRNA as Therapy for Respiratory
Syncytial Virus
John P. DeVincenzo, University of Tennessee School of Medicine,
Memphis, TN
4:15pm–6:15pm
3845—Endocrinology: Insulin
Resistance/Obesity
PAS/LWPES Poster Symposium
Room 3003-3005, Moscone West
Chairs: I. David Schwartz and Svetlana Ten
4:15pm–6:15pm
3850—Human Milk and Breastfeeding
PAS Poster Symposium
Room 3001, Moscone West
Chairs: Sheela R. Geraghty and Ardythe L. Morrow
7:00pm–9:00pm
Practical and Scientific Approaches to Growth
Hormone: From Pediatrics to Adults
PAS Industry Sponsored Symposium
Golden Gate Hall A1-3, SF Marriott
Target
Audience: Endocrinologists.
The
relevance of age and developmental stage to the diagnosis and
management of growth hormone deficiency, especially with
regard to the transitional period between childhood and
adulthood, warrants further elucidation, discussion and
education. The symposia “Practical and Scientific Approaches
to Growth Hormone: From Pediatrics to Adulthood” will aim to
present scientifically-based clinical, as well as practical,
approaches to the management of growth hormone deficiency
during this developmental continuum. Difficulties in
assessment, treatment dosage requirements and overall
management of the pediatric patient transitioning into
adulthood create the need for endocrinologists and endocrine
nurses to be further educated in this area.
For
registration information please contact:
Shannon Monteith
Phone: (800) 960-0256
Email: smonteith@vindicomeded.com
Supported by a grant from Novo Nordisk
Monday,
May 1
8:00am–10:00am
4110—Pediatric Fluids and Hyponatremia: Are
We Giving Too Much Water?
PAS/ASPN/LWPES Topic Symposium
Room 3007-3011, Moscone West
Chairs: John W. Foreman, Duke University Medical Center, Durham, NC;
and D. Michael Foulds, University of Texas Health Science
Center at San Antonio, San Antonio, TX
Target
Audience: Nephrologists, general pediatricians, emergency room
doctors, intensivists, hospitalists, endocrinologists and
anyone who administers IV maintenance fluids.
In
the 1950s, Holiday and Segar devised formulae for calculating
intravenous maintenance fluids for infants and children who
were unable to drink. These formulae have been taught and used
now for over 40 years and have generally stood the test of
time. However, several recent investigators have challenged
these formulae and argued that they put children at risk of
hyponatremia. Since Holiday and Segar devised these formulae,
new information has arisen, such as the concept of non-osmotic
stimulation of ADH release in sick children and our ability to
measure ADH levels in plasma on a routine basis. Arieff and
Ayus were the first to point out that children and women are
at particular risk for developing hyponatremic encephalopathy.
Moritz and Ayus have subsequently argued that hypotonic
parenteral fluid should not be used unless there are ongoing
free water losses or hypernatremia. In addition to this new
clinical data, Verkman’s group has exciting data identifying
molecular mechanisms of cerebral edema, including after water
intoxication. Dr. Arieff will review who is at risk and why.
Dr. Verkman’s group has developed data regarding mechanisms
of cerebral edema in experimental animals. Dr. Moritz will
describe the new concepts of maintenance fluids. Dr. Friedman
will defend the current practice. At the end there will be
time for an exchange between the speakers and the audience on
the right fluid to use in today’s children.
-
Hyponatremic Encephalopathy:
Special Risk Factors for Children and Women
Allen I. Arieff, University of California San Francisco, San Francisco,
CA
-
Aquaporin 4 and Cerebral Edema
Alan S. Verkman, University of California San Francisco, San Francisco,
CA
-
0.9% Sodium Chloride: The New
Approach to Maintenance Fluids in Pediatrics
Michael L. Moritz, Children's Hospital of Pittsburgh, Pittsburgh, PA
-
Maintenance Therapy: Tried and
True
Aaron L. Friedman, Brown Medical School, Hasbro Children's Hospital,
Providence, RI
Sponsored
jointly by the AAP Section on Nephrology, the American Society
of Pediatric Nephrology, the Lawson Wilkins Pediatric
Endocrine Society and the Pediatric Academic Societies
8:00am–11:00am
4150—The Skinny on the Adipocyte
PAS/LWPES Mini Course
Room 3010-3012, Moscone West
Chairs: Silva A. Arslanian, University of Pittsburgh, Pittsburgh, PA;
and Robert H. Lustig, University of California, San Francisco,
CA
Target
Audience: General pediatricians, gastroenterologists,
endocrinologists, cardiologists, pulmonologists and adolescent
medicine specialists.
Over
the past five years much has been learned about the adipocyte.
The ability of the adipocyte to function as an endocrine
gland, elaborating inflammatory cytokines that result in free
radical formation and premature apoptosis of the beta cell, is
a relatively new concept. This mini course will
comprehensively address many of the newest concepts in
adipocyte function and their impact on health and disease.
Further discussion will include new concepts on the
interactions of IGF-II and other peptides' interactions with
the adipocyte. Lastly, there will be a call for new approaches
to the pediatric obesity epidemic.
-
Adipose Tissue as an Endocrine
Organ
Susan Fried, University of Maryland School of Medicine, Baltimore VA
Medical Center, Baltimore, MD
-
Obesity and Inflammation
Christopher Hug, Whitehead Institute and Children's Hospital,
Cambridge, MA
-
Effects of GH, IGF-I and Insulin
Therapies on Adiposity
Zvi Laron, Schneider Children's Medical Center of Israel, Petah Tikva,
Isreal
-
Pathology and Sequelae of
Childhood Obesity in Adult Life
Dennis M. Styne, University of California, Davis Medical Center,
Sacramento, CA
Sponsored
jointly by the Lawson Wilkins Pediatric Endocrine Society and
the Pediatric Academic Societies
10:15am–12:15pm
4320A—New Frontiers in Reproductive Science
LWPES Topic Symposium
Room 3001, Moscone West
Chairs: Ram K. Menon, University of Michigan, Ann Arbor, MI; and Henry
Anhalt, Saint Barnabas Medical Center, Livingston, NJ
Target
Audience: Endocrinologists, geneticists, developmental
biologists and adolescent medicine.
The
regulation of puberty remains one of the greatest mysteries of
medicine. A child is born with all of the necessary components
to undergo puberty at birth but this process is quiescent
until puberty occurs. The attendee will learn the newest
information on the biological regulators of puberty.
In
addition, the attendee will be exposed to newer techniques
available for preservation of fertility in a variety of
different pathological states. Discussion will include the
cryopreservation of the pre-pubertal ovary.
-
Kiss-1 and GPR54 as New Players
in Gonadotropin Regulation and Puberty
Ursula Kaiser, Brigham and Women's Hospital, Boston, MA
-
Modern Preservation of Fertility
Kutluk Oktay, Weill Medical College of Cornell University, New York, NY
10:15am–12:15pm
4330—Endocrinology: Growth—Clinical
PAS/LWPES Platform Session
Room 3007-3011, Moscone West
Chairs: Jill D. Jacobson and Gadi B. Kletter
3:00pm–4:00pm
4600A—LWPES Trans-Pacific Lecture
LWPES Award
Room 3002-3008, Moscone West
Chair: Mark Sperling, Children's Hospital of Pittsburgh, Pittsburgh, PA
Target
Audience: Geneticists, endocrinologists and molecular
biologists.
This
new lecture recognizes one outstanding scientist from the
Pacific Rim. This talk will illuminate congenital adrenal
disorders with particular focus on the relationship between
newborn screening and molecular mechanisms.
-
Congenital Adrenal Disorders:
From Newborn Screening to Molecular Mechanism
Kenji Fujieda, Asahikawa Medical College, Asahikawa, Japan
3:00pm–5:00pm
4675—Obesity I
PAS Poster Symposium
Room 2002, Moscone West
Chairs: Robert H. Lustig and Jennifer Miller
7:00pm–9:00pm
A New Paradigm for Growth
PAS Industry Sponsored Symposium
Yerba Buena Gardens Salon 8, SF Marriott
Target
Audience: Endocrinologists.
In
the past, physicians evaluating a child with short stature
focused on determining if the child had growth hormone
deficiency (GHD). Most children with GHD have low IGF-1
levels. This is referred to as secondary IGF-1 deficiency.
Children who are not GHD may also have low IGF-1 levels,
referred to as primary IGF-1 deficiency (Primary IGFD).
Children with Primary IGFD, in contrast to those with
secondary IGFD, would not be expected to respond to GH
treatment, but would require replacement with IGF-1. Now with
IGF-1 replacement therapy available, there are many questions,
surrounding the diagnosis of Primary IGFD. This symposium will
focus on the IGF-1 system, new clinical data, testing and
identification of candidates for IGF-1 treatment. Case studies
will be presented for a pragmatic approach to practicing
pediatric endocrinologists.
For
registration information please contact:
Laura McCaskill
Phone: 858-345-1103
Email: lmccaskill@tier1group.com
Supported by a grant from Tercica Pharmaceuticals
Tuesday,
May 2
8:00am–10:00am
5110A—Inflammation in Uremic
Pathophysiology
ASPN Symposium
Room 3010-3012, Moscone West
Chairs: H. William Schnaper, Northwestern University Feinberg School of
Medicine, Chicago, IL; and Robert H.K. Mak, Oregon Health and
Science University, Portland, OR
Target
Audience: Pediatric nephrologists and fellows, basic
scientists, pathologists and immunologists.
Recent
evidence has strongly suggested that the manifestations of
uremia are caused in large part by activation of inflammatory
pathways. This symposium will review the syndromic events that
can be attributed to uremic inflammation and include oxidant
injury, cytokine production and its end-organ effects on the
body tissues.
-
Oxidant Injury in ESRD
Jonathan Himmelfarb, Maine Medical Center, Portland, ME
-
MIA (Malnutrition, Inflammation,
Atherosclerosis) Syndrome in ESRD
Joel D. Kopple, Harbor-UCLA Medical Center, David Geffen School of
Medicine at UCLA, UCLA School of Public Health, Torrance,
CA
-
Leptin and Melanocortin Signaling
in Chronic Kidney Disease
Robert H.K. Mak, Oregon Health and Science University, Portland, OR
-
Molecular Pathophysiology of
Muscle Catabolism in Uremia: Effect of Acidosis and
Inflammation
William E. Mitch, Baylor College of Medicine, Houston, TX
Supported by an unrestricted educational grant from Abbott
8:00am–10:00am
5158—Endocrinology: Diabetes—Immune
Mediated
PAS Poster Symposium
Room 3020, Moscone West
Chairs: Bruce A. Boston and Susan B. Nunez
8:30am–9:45am
5200A—The Challenge of Diagnosis and
Outcome in Intersex
LWPES State of the Art Plenary
Room 3007-3011, Moscone West
Chair: Lynne Levitsky, Massachusetts General Hospital, Boston, MA
Target
Audience: Geneticists, endocrinologists and general
pediatricians.
The
attendee will be presented with an overview of intersex and
then the challenges of diagnosis and outcome will be
addressed. Many previous assumptions about outcome have proven
to be false. This should prove to be an exciting talk about a
highly controversial topic affecting pediatric
endocrinologists and geneticists.
-
The Challenge of Diagnosis and
Outcome in Intersex
Ieuan Hughes, University of Cambridge, Cambridge, UK
10:00am–11:45am
5300A—Late-Breaking Clinical Trials
LWPES Workshop
Room 3020, Moscone West
Chairs: Mitchell Geffner, Children's Hospital of Los Angeles, Los
Angeles, CA; and Lawrence Silverman, Goryeb Children's
Hospital Morristown, Morristown, NJ
Target
Audience: Pediatric endocrinologists, fellows, trainees and
geneticists.
This
session will allow investigators of major multi-center
national trials being conducted in the United States to share
their late-breaking data with the pediatric community at
large. This session will have particular appeal for trainees
and junior faculty.
-
Trial Net
Desmond A. Schatz, University of Florida, Gainesville, FL
-
STOPPT2D
Francine R. Kaufman, Children's Hospital of Los Angeles, Los Angeles,
CA
-
Histrelin Implant Study in
Children with Central Precocious Puberty
Erica A. Eugster, Indiana University, Indianapolis, IN
-
Toddler Turner Trial
Marsha L. Davenport, University of North Carolina at Chapel Hill,
Chapel Hill, NC
-
IGF-I Deficiency and Treatment
Using IGF-Based GH Dosing
Pinchas Cohen, Mattel Children's Hospital at UCLA, Los Angeles, CA
-
Discussion
10:00am–11:45am
5310A—Pitfalls in Endocrine
Assays—Results Are Not What They Seem
LWPES Workshop
Room 3000, Moscone West
Chairs: Jack Fuqua, Indiana University, Indianapolis, IN; and John
Nakamoto, Quest Diagnostics, San Juan Capistrano, CA
Target
Audience: Endocrinologists, general pediatricians and
adolescent medicine.
All
too often clinicians are encountering laboratory tests that
are difficult to interpret. Sometimes the real problem lies in
understanding the pitfalls in assays and how they are
performed. This symposium will help the clinician and
scientist understand the basis for assays and what can go
wrong with them. Many referrals to subspecialists are made due
to misinterpretation of laboratory tests or unfamiliarity with
age related norms. This symposium will have wide appeal to all
who order endocrine tests.
-
Overview
Jon M. Nakamoto, Quest Diagnostics, San Juan Capistrano, CA
-
IGF–I/GH
George M. Bright, Tercica, Inc., South San Francisco, CA
-
Adrenal Steroids and Thyroid
Jon M. Nakamoto, Quest Diagnostics, San Juan Capistrano, CA
-
Sex Steroids
Dennis M. Styne, University of California, Davis Medical Center,
Sacramento, CA
-
Discussion
10:15am–11:45am
5405—Newborn Screening: The Coming
Revolution
PAS State of the Art Plenary
Room 3001, Moscone West
Chair: Alex R. Kemper, University of Michigan, Ann Arbor, MI
Target
Audience: General pediatricians, subspecialists involved with
newborn screening, for including neonatologists,
endocrinologists, hematologists and geneticists.
Newborn
screening has resulted in dramatic improvements in the
morbidity and mortality of inherited disorders. Recent
laboratory developments have dramatically increased the number
of conditions that can be detected in early infancy. Expanding
the list of conditions has lead to unique challenges for
pediatric practices and public health systems. This symposium
will explore these new and emerging challenges.
-
Overview
Alex R. Kemper, University of Michigan, Ann Arbor, MI
-
New Technologies for Newborn
Screening
Edward R.B. McCabe, David Geffen School of Medicine at UCLA, Mattel
Children's Hospital, Los Angeles, CA
-
Meeting the Needs for
Confirmation, Counseling and Treatment
R. Rodney Howell, Miller School of Medicine at the University of Miami,
Miami, FL
-
"Treatment" Versus
"Benefit" in Evaluating the Desirability of
Expanded Newborn Screening
Don Bailey, University of North Carolina at Chapel Hill, Chapel Hill,
NC
-
Ethical Issues That Must Be
Addressed in an Expanded Newborn Screening Program
Ellen Wright Clayton, Vanderbilt University, Nashville, TN
-
Summary Comments
Michele Puryear, Maternal and Child Health Bureau, Health Resources
& Services Administration, Rockville, MD
-
Discussion
10:15am–12:15pm
5430—Obesity II
PAS Platform Session
Room 3014, Moscone West
Chairs: Michael Cabana and John N. Udall
10:15am–12:15pm
5435—Endocrinology and Diabetes—Basic
Research
PAS/LWPES Platform Session
Room 3007-3011, Moscone West
Chairs: Stephen E. Gitelman and Anna Spagnoli
1:45pm–3:45pm
5730—Obesity Symposium—The BIG Picture
PAS/LWPES Hot Topic
Room 3007-3011, Moscone West
Chairs: Janet H. Silverstein, University of Florida College of
Medicine, Gainesville, FL; and Josephine Z. Kasa-Vubu,
University of Michigan, Ann Arbor, MI
Target
Audience: General pediatrics, developmental pediatrics,
adolescent medicine, genetics, basic science, pediatric
endocrinology and health outcomes.
The
obesity epidemic continues to be a major public health threat
and a top priority for a broad range of researchers and
clinicians. This symposium will attempt to reach beyond
descriptive statistics and will focus on advances from bench
to bedside with a focus on intervention.
-
Overview
Josephine Z. Kasa-Vubu, University of Michigan, Ann Arbor, MI
-
Lessons from the Bench: Molecular
and Anatomical Models of Leptin Resistance
Martin Myers, University of Michigan, Ann Arbor, MI
-
Intensive Versus Behavior
Therapies for the Obese Child: What We Know and What We Do
Not Know
Jack Adam Yanovski, National Institutes of Health, Bethesda, MD
-
Long-Term Costs of Early Onset
Diabetes
William H. Herman,
-
Prenatal Programming of Obesity
and Obesity-Related Behaviors
Peter D. Gluckman, Liggins Institute, University of Auckland, Auckland,
New Zealand
-
Discussion
Sponsored jointly by
the Lawson Wilkins Pediatric Endocrine Society and the
Pediatric Academic Societies
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