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Saturday, April 29
8:00am–11:00am
2105—Advocacy Training Initiative—Part I
PAS Mini Course
Room 2011, Moscone West
Chairs: Alice A. Kuo, University of California Los Angeles, Los
Angeles, CA; and Philip R. Nader, University of California San
Diego, La Jolla, CA
Target Audience: Pediatric
program directors and attendees interested in advocacy.
Development of advocacy training
experiences is evolving, and there is a national need for
opportunities to bring together residents, faculty, program
directors and community partners to facilitate the development
of this nascent field. After last year’s PAS meeting, the
leadership of the APA Advocacy Training SIG and the AAP
Community Pediatrics Training Initiative agreed to collaborate
to provide a more cohesive conference experience for
participants interested in advocacy training. However, before
training experiences can be developed into residency
curricula, the variety of advocacy skills that can be used to
promote child health should be appreciated. In this part of
the first-ever ATI Conference, we will focus on skill-building
in child advocacy. Through a panel discussion, guest lecturers
and resident presentations on child advocacy projects,
participants will gain skills in various aspects of child
advocacy.
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Welcome
Alice A. Kuo, University of California Los Angeles, Los Angeles, CA
Philip R. Nader, University of
California San Diego, La Jolla, CA
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Advocacy Skills Panel Discussion
— 1–2 residents
— 1–2 community partners
Anda Kuo, University of California San Francisco, San Francisco, CA
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State Legislative Advocacy on
Behalf of Children and Pediatricians–How to be Effective
in Difficult Budget Times
Kris Calvin, American Academy of Pediatrics, California District IX
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Resident Presentations (3 Resident Presentations TBD)
Sponsored jointly by
the APA Advocacy Training SIG, the AAP Community Pediatrics
Training Initiative and the Pediatric Academic Societies
8:00am–11:00am
2171—Environmental Health
APA Special Interest Group
Room Pacific Suite B, SF Marriott
Chairs: Christine Johnson, cjohnson@nmcsd.med.navy.mil;
Robert Wright, robert.wright@channing.harvard.edu;
and Jerome Paulson, jpaulson@cnmc.org.
This year’s Environmental
Health SIG is being held jointly with the National Institute
of Environmental Health Sciences/Environmental Protection
Agency Centers for Children’s Environmental Health. These 11
centers conduct research on pediatric environmental health (PEH)
and include many scientists who are members of APA. To take
advantage of this joint meeting, this year’s SIG will
include a workshop/discussion panel on translating
environmental health research into clinical practice. This
workshop will consist of case presentations of research topics
relevant to PEH by center scientist and Pediatric
Environmental Health Subspecialty Unit (PEHSU) directors with
a discussion of their implications for physicians and their
patients. Topics will include issues relevant to lead
poisoning and its treatment, methyl mercury related fish
advisories, results of studies on air pollution and asthma and
exposure to pesticides. The workshop/discussion format will
allow attendees to bring their own “translational”
research questions for discussion as well. We hope you can
attend!
11:45am–2:45pm
2438—Pediatric Tobacco Issues
APA Special Interest Group
Room Pacific Suite B, SF Marriott
Chairs: Sophie Balk, sbalk@montefiore.org;
Susanne Tanski, susanne.e.tanski@hitchcock.org;
and Tahniat Syed, tss28@drexel.edu.
The 2006 Pediatric Tobacco Issues
Special Interest Group welcomes all those who are interested
an all aspects of tobacco as it impacts children: tobacco
cessation, parental tobacco cessation, second-hand smoke
exposure prevention, education and advocacy efforts. The
“CigSIG” provides an excellent opportunity for networking,
a platform for discussing hot topics and valuable resources
for policy/advocacy awareness and skill building.
This year, planned presentations
will include several approaches to pediatric tobacco issues,
including office efforts to promote smoking cessation and
second-hand smoke exposure reduction, tobacco-related
curricula in pediatric training programs and national efforts
in training Smoke Free Homes Champions. We will also have a
presentation from the Smoke Free Movies Campaign, as well as
new information from the domestic and international arenas
regarding media effects on teen smoking.
The meeting will also include
reports from SIG members regarding their research and advocacy
projects. New and old members, faculty and trainees are
welcome and encouraged to participate and share. Bring your
lunch for an early afternoon of presentations, lively
discussion and networking. See you in San Francisco.
12:00pm–3:00pm
2500—Advocacy Training Initiative—Part II
PAS Mini Course
Room 2011, Moscone West
Chairs: Alice A. Kuo, University of California Los Angeles, Los
Angeles, CA; and Philip R. Nader, University of California San
Diego, La Jolla, CA
Target Audience: Pediatric
program directors and attendees interested in advocacy.
Building upon the Child Advocacy
Skills in Part I of the ATI Conference, Part II will now focus
on how to incorporate these skills into meaningful residency
curricular experiences. Pediatric residents are increasingly
committed to promoting child health in arenas other than the
pediatric exam room. Programs are being called upon to provide
structured curricular experiences for residents in child
advocacy, and these experiences may build upon existing
curricula in community pediatrics or be completely separate.
New avenues for partnerships between pediatric residency
programs and community agencies can occur as a result of child
advocacy rotations or projects. This part of the conference
will give participants new ideas for child advocacy training
experiences, address the how-tos on a shoestring budget, and
present ideas for evaluating your community/advocacy
curriculum.
Please join us for the Advocacy
Training SIG from 3:15-5:15pm immediately following the
Advocacy Training Initiative.
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Welcome
Alice A. Kuo, University of California Los Angeles, Los Angeles, CA
Philip R. Nader, University of
California San Diego, La Jolla, CA
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Different Forms of Advocacy
Training Curricular Experiences
David M. Keller, University of Massachusetts Medical School, Worcester,
MA
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Implementing a Required Child
Advocacy Rotation with No Budget
Sanjeev Kumar Sriram, University of California Los Angeles, Los
Angeles, CA
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Evaluating Community/Advocacy
Educational Experiences
Jeffrey M. Kaczorowski, University of Rochester, Strong Memorial
Hospital, Rochester, NY
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Resident Poster Session
Sponsored jointly by
the APA Advocacy Training SIG, the AAP Community Pediatrics
Training Initiative and the Pediatric Academic Societies
12:00pm–3:00pm
2515—New Insights into the Pathogenesis and
Treatment of Asthma
PAS Mini Course
Room 3012, Moscone West
Chair: Ellen F. Crain, Albert Einstein College of Medicine, Jacobi
Medical Center, Bronx, NY
Target Audience: General
pediatricians, pulmonary medicine, genetics and allergists.
This mini course will highlight
new advances and developments in our understanding of
pediatric asthma and its treatment. Leading investigators will
present new information on the pharmacogenomics of asthma, the
roles of early environmental factors in the development of
asthma, advances in drug therapy, understanding of mechanisms
underlying the pathophysiology of asthma and insights into the
application of these advances to the care of children with
asthma.
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Role of Pharmacogenomics in
Asthma Management
Michael Ephraim Wechsler, Harvard Medical School, Brigham and Women's
Hospital, Boston, MA
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Early Environmental Factors in
the Development of Asthma
Fernando D. Martinez, Arizona Respiratory Center, The University of
Arizona, Tucson, AZ
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Advances in Drug Treatment of
Asthma
Stanley J. Szefler, National Jewish Medical and Research Center,
University of Colorado Health Sciences Center, Denver, CO
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Pathophysiology of Childhood
Asthma: Search for Mechanisms
Giuseppe N. Colasurdo, University of Texas-Houston Medical School,
Houston, TX
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Epidemiology and Outcomes in
Asthma
Peter J. Gergen, National Institute of Allergy and Infectious Diseases
(NIAID), Bethesda, MD
3:15pm–5:15pm
2725—Integrating Genetic Susceptibility and
Environmental Influences in Pediatric Research
PAS Topic Symposium
Room 2008, Moscone West
Chair: Bruce P. Lanphear, Cincinnati Children's Environmental Health
Center, Cincinnati Children’s Hospital Medical Center,
Cincinnati, OH
Target Audience: A broad
pediatric audience with the goal of promoting
interdisciplinary understanding and greater integration of
genetic and environmental research.
Asthma, preterm birth, ADHD and
other prevalent pediatric conditions are widely recognized to
result from interactions of environmental influences and
genetic susceptibility. Tremendous progress has been made in
measuring both environmental and genetic risk factors.
Increasingly, researchers are moving beyond ecological methods
(e.g., questionnaires, air monitoring) to directly measure in
humans hundreds of environmental chemicals, from nicotine to
metals to DDT and phthalates. Similarly, unprecedented
innovation has led rapidly to high-throughput methods that
assess DNA variation across large cohorts. New
interdisciplinary collaborations that integrate state of the
art approaches to both environmental and genetic influences
should greatly improve our ability to predict and prevent
disease and disability. Such studies will be critical for
understanding mechanistic pathways, defining susceptible
subpopulations and developing effective interventions. This
session will provide an overview of gene–environment
research, describe recent advances in biomarkers of
environmental exposure and review new methods for measuring
genetic variability.
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Gene–Environment Interaction in
Common Pediatric Conditions: Conceptual Overview and
Recent Evidence
Robert S. Kahn, Cincinnati Children’s Hospital Medical Center,
University of Cincinnati College of Medicine, Cincinnati,
OH
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Advances in Biomarkers of
Environmental Exposure in Pediatric Research
Bruce P. Lanphear, Cincinnati Children's Environmental Health Center,
Cincinnati Children’s Hospital Medical Center,
Cincinnati, OH
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Measuring Genetic Susceptibility
to the Environment: Study Designs and Genotyping Methods
Robert O. Wright, Harvard Children's Environmental Health Center,
Boston Children's Hospital and the Harvard School of
Public Health, Boston, MA
3:15pm–5:15pm
2745—Asthma: Improving Care and Outcomes
PAS Poster Symposium
Room 3012, Moscone West
Chairs: Craig M. Schramm and Stanley J. Szefler
Sunday, April 30
8:00am–10:00am
3105—From Health Services Research to
Public Policy
PAS Topic Symposium
Room 2006, Moscone West
Chair: Gary L. Freed, University of Michigan, Ann Arbor, MI
Target Audience: Investigators,
clinicians and advocacy experts.
The contribution of research
regarding children is measured in its ability to improve
children's health and well being. Research findings that
contribute to public policy efforts have the potential to
improve the lives and well being of whole communities, states
and nations of children. Understanding the nature and
appreciating the role of such work is fundamentally important
for clinicians and researchers alike.
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Overview
Gary L. Freed, University of Michigan, Ann Arbor, MI
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Using Research To Confront Power:
Can P Values Speak to Justice?
Paul H. Wise, Stanford University, Stanford, CA
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Where Research Meets Policy and
Politics: The Road to Health Reform for Children
Sara Rosenbaum, George Washington University, Washington, DC
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Linking Health and School Goals
To Address Childhood Obesity
Joseph W. Thompson, University of Arkansas Medical Sciences, Little
Rock, AR
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Addressing Children’s
Underinsurance Through Policy-Relevant Research
Matthew M. Davis, University of Michigan, Ann Arbor, MI
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Discussion
8:00am–10:00am
3135—Environmental Health: Exposures and
Outcomes
PAS Platform Session
Room 2002, Moscone West
Chairs: Ellen F. Crain and Bruce P. Lanphear
2:00pm–5:00pm
3750—Endocrine Disrupters
PAS/LWPES Mini Course
Room 3010-3012, Moscone West
Chairs: Mary M. Lee, University of Massachusetts Medical School,
Worcester, MA; and Henry Anhalt, Saint Barnabas Medical
Center, Livingston, NJ
Target Audience:
Endocrinologists, generalists, neonatologists and basic
scientists.
Concerns regarding clinical
consequences of endocrine disrupting chemicals have increased
over the past decade as researchers have documented
detrimental effects in wildlife. Federal attention to
endocrine disrupters began in earnest in 1996 when the U.S.
Congress passed the Food Quality Protection Act and amended
the Safe Drinking Water Act. These laws mandated testing to
determine if pesticides and industrial chemicals might behave
like hormones; therefore, the U.S. EPA formed the Endocrine
Disrupters Screening and Advisory Committee. In addition to
direct effects, some environmental disrupters act through
non-genomic actions, some of which persist for several
generations. This program presenting innovative studies on
mechanisms of action of endocrine disruptors will be of
critical interest to endocrinologists, both clinical and basic
scientists, as well as public health experts.
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Prenatal Programming with
Estrogen/Estrogen Mimetics
Kenneth S. Korach, National Institute of Environmental Health Sciences,
Research Triangle Park, NC
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Epigenetic Transgenerational
Actions of Endocrine Disruptors on Male Fertility and
Other Diseases
Michael K. Skinner, Washington State University, Pullman, WA
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Prenatal Programming with Native
and Environmental Steroids
Vasantha Padmanabhan, University of Michigan, Ann Arbor, MI
Sponsored jointly by
the Lawson Wilkins Pediatric Endocrine Society and the
Pediatric Academic Societies
2:00pm–5:00pm
3764—Helping Children in Disasters:
Community Training
PAS Educational Workshop
Golden Gate Hall C2, SF Marriott
Leader: Karen Olness, Cleveland, OH; Co-leader: Anna Mandalakas and
Marisa Herran
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, senior faculty,
and community practitioners.
This workshop will address the
special issues of children in disasters and provide guidelines
for child health professionals who wish to help their
communities prepare for disasters. This workshop will use a
problem based training format with appropriate case histories
to allow participants to consider decision making for children
in natural or man made disasters. Components of this training
include the problems and priorities for children in disasters,
how to identify resources in the local community that are
available for disaster-impacted children, how to mobilize
rapid responses on behalf of children, and how to reduce long
term psychological problems for children.
Objectives:
– List the special issues of
children who experience disasters.
– Provide information on preparing a community to help
children in disasters.
Format: Problem based learned
format including discussion of relevant case histories.
4:15pm–5:45pm
3810—RNA Interference, Technological
Development of siRNAs and Potential Treatments for Childhood
Diseases
PAS State of the Art Plenary
Room 3016-3018, Moscone West
Chair: R. Alan B. Ezekowitz, Harvard Medical School, Massachusetts
General Hospital, Boston, MA
Target Audience: Basic scientists
studying a broad range of childhood diseases, translational
scientists of all disciplines studying clinical implications
of basic science research, clinical scientists studying
childhood and other diseases in need of improved therapies and
clinicians interested in cutting-edge science and its medical
implications.
RNA interference is a recently
discovered, naturally occurring intracellular process that
regulates gene expression through the silencing of specific
mRNAs. Methods of harnessing this natural pathway are being
developed that allow the catalytic degradation of targeted
mRNAs using specifically designed complementary small
inhibitory RNAs (siRNA). siRNAs are being chemically modified
to acquire drug-like properties. Numerous recent high-profile
publications have provided proofs of concept that RNA
interference may be useful therapeutically. Much of the design
of these siRNAs can be accomplished bioinformatically, thus
potentially expediting drug discovery and opening new avenues
of therapy for many childhood diseases including uncommon
pediatric and orphan diseases. A discussion of the science
behind RNA interference will be followed by a presentation of
the potential practical issues in applying this technology to
disease. The program then describes two therapeutic programs
currently under way with applications to pediatric diseases. A
question-and-answer time will follow each discussion.
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The Science of RNA Interference
John J. Rossi, Beckman Research Institute of City of Hope, Duarte, CA
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RNA Interference and Its
Potential Applications for Controlling Disease
Judy Lieberman, CBR Institute for Biomedical Research and Harvard
Medical School, Boston, MA
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Silencing the VEGF Pathway with
siRNAs and the Potential Application to Retinopathy of
Prematurity
Pamela Pavco, Sirna Therapeutics, Boulder, CO
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siRNA as Therapy for Respiratory
Syncytial Virus
John P. DeVincenzo, University of Tennessee School of Medicine,
Memphis, TN
Monday, May 1
10:15am–12:15pm
4360—New Perspectives on ADHD
PAS Poster Symposium
Room 2002, Moscone West
Chairs: Marc A. Lerner and Mark L. Wolraich
12:15pm–1:15pm
4470—The National Children's Study: Status
and Future Plans
PAS/PPC Special Symposium
Room 3010-3012, Moscone West
Chair: Elena Fuentes-Afflick, University of California, San Francisco,
CA
Target Audience: Practicing
pediatricians, academic child health professionals,
researchers, administrators and policymakers who are
interested in child health across the lifespan. Professionals
interested in the impact of environmental factors on health
outcomes will also be interested.
This special symposium will
present an update on the National Children's Study, which
recently selected 7 vanguard centers and is prepared to begin
recruitment of subjects. However, the President's budget
proposal allocated no further funding and stated that the
study would be terminated at the end of the current fiscal
year. The panel presenters will discuss the current budgetary
outlook, status of the study, options to implement the study
and respond to questions from the audience.
Panelists:
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Elena Fuentes-Afflick, University of California, San Francisco, CA
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Duane Alexander, Director,
National Institute of Child Health and Human Development,
National Institutes of Health, Bethesda, MD
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Peter C. Scheidt, Director,
National Children's Study, National Institute of Child
Health and Human Development, National Institutes of
Health, Bethesda, MD
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Alan R. Fleischman, Chair,
National Children's Study Federal Advisory Committee, New
York Academy of Medicine, New York and National Institutes
of Health, Bethesda, MD
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David J. Schonfeld, Member,
National Children's Study Federal Advisory Committee and
Chair, AAP Committee on Research, Cincinnati, OH
Sponsored jointly by
the Public Policy Council and the Pediatric Academic Societies
5:15pm–6:45pm
Poster Session III
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
12:00pm–6:45pm
Author Attendance: 5:15pm–6:45pm
Level 1:
– Critical Care
– Gastroenterology
– Genetics
– Neonatal Epidemiology and Follow Up
– Neonatal Pulmonology
– Neonatology
– Nephrology
– Pulmonology
Level 2:
– Developmental–Behavioral Pediatrics
– Emergency Medicine
– General Pediatrics
– Medical Education
Tuesday, May 2
8:00am–10:00am
5100—Ethical Issues in Housing Health
Hazard Research Involving Children
PAS Topic Symposium
Room 2003-2005, Moscone West
Chair: Bernard Lo, University of California San Francisco, San
Francisco, CA
Target Audience: A broad
pediatric audience with the goal of promoting understanding of
ethical issues in conducting community-based research,
especially housing hazard research.
Children’s homes may contain
hazards that can cause lead toxicity, trigger asthma or result
in serious injuries or poisoning. A 2001 court decision, in
Grimes versus Kennedy Krieger Institute, highlighted ethical
issues in housing-related research and led to substantial
controversy and confusion. Many ethical dilemmas occur because
research participants are often poor, members of a minority
group and have few affordable housing options. Moreover,
carrying out research in the home raises unique ethical
issues. A forthcoming report from National Academies of
Science (NAS) will offer recommendations for conducting
research on this topic. This panel will present these NAS
recommendations and discuss how they might be applied to
specific projects in housing research involving children.
Specific issues to be discussed include innovations in
research design and informed consent, responding to risks
observed in the home, the role of researchers and IRBs and
community involvement in research. Audience participation will
be encouraged.
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Recommendations from the National
Academies of Science
Bernard Lo, University of California San Francisco, San Francisco, CA
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Protecting Vulnerable Research
Participants While Allowing Valuable Research To Be
Carried Out
Alan R. Fleischman, Chair, National Children's Study Federal Advisory
Committee, New York Academy of Medicine, New York and
National
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Institutes of Health, Bethesda,
MD
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Innovations in Study Design and
Informed Consent in Housing Hazard Research Involving
Children
Bruce P. Lanphear, Cincinnati Children's Environmental Health Center,
Cincinnati Children’s Hospital Medical Center,
Cincinnati, OH
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Resolving Ethical Dilemmas in
Housing Hazard Research Through Community Participation
Brenda Eskenazi, University of California Berkeley, Berkeley CA
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Discussion
10:00am–11:45am
5310A—Pitfalls in Endocrine
Assays—Results Are Not What They Seem
LWPES Workshop
Room 3000, Moscone West
Chairs: Jack Fuqua, Indiana University, Indianapolis, IN; and John
Nakamoto, Quest Diagnostics, San Juan Capistrano, CA
Target Audience:
Endocrinologists, general pediatricians and adolescent
medicine.
All too often clinicians are
encountering laboratory tests that are difficult to interpret.
Sometimes the real problem lies in understanding the pitfalls
in assays and how they are performed. This symposium will help
the clinician and scientist understand the basis for assays
and what can go wrong with them. Many referrals to
subspecialists are made due to misinterpretation of laboratory
tests or unfamiliarity with age related norms. This symposium
will have wide appeal to all who order endocrine tests.
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Overview
Jon M. Nakamoto, Quest Diagnostics, San Juan Capistrano, CA
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IGF–I/GH
George M. Bright, Tercica, Inc., South San Francisco, CA
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Adrenal Steroids and Thyroid
Jon M. Nakamoto, Quest Diagnostics, San Juan Capistrano, CA
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Sex Steroids
Dennis M. Styne, University of California, Davis Medical Center,
Sacramento, CA
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Discussion
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