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Saturday, April 29
8:00am–11:00am
2100—Adult Stem Cells—A Primer for the
Clinician
PAS/ASPHO Mini Course
Room 3014, Moscone West
Chairs: Jakub Tolar, University of Minnesota, Minneapolis, MN; and
Mervin C. Yoder, Jr., Indiana University School of Medicine,
Indianapolis, IN
Target Audience:
Hematologists/oncologists, endocrinologists, basic scientists
and neurologists.
Adult stem cells represent a
technology that is being intensively investigated currently,
and this research may have wide implications for human health.
This mini course will focus on recent research and potential
applications in human health.
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Introduction
Jakub Tolar, University of Minnesota, Minneapolis, MN
Mervin C. Yoder, Indiana
University School of Medicine, Indianapolis, IN
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Multipotent Adult Progenitor
Cell: Hype or Reality?
Catherine M. Verfaillie, University of Minnesota, Minneapolis, MN
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Mesenchymal Stem Cell: Harnessing
the Power of Adult Stem Cells To Repair Tissues
Darwin Prockop, Tulane University Health Science Center, New Orleans,
LA
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Hierarchy of Endothelial
Progenitors in Human Blood and Blood Vessels
David A. Ingram, Indiana University School of Medicine, Indianapolis,
IN
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Cancer Stem Cell: Concept of
Human Leukemic Development
Craig T. Jordan, James P. Wilmot Cancer Center, University of Rochester
School of Medicine, Rochester, NY
Sponsored jointly by
the American Society of Pediatric Hematology/Oncology and the
Pediatric Academic Societies
8:00am–11:00am
2125—New Considerations for the Growth Rate
of the Preterm Infant: Too Fast or Not Fast Enough?—A Review
of the Evidence
PAS Mini Course
Room 3002-3008, Moscone West
Chairs: Frank R. Greer, University of Wisconsin, Madison, WI; and
William W. Hay, Jr., University of Colorado, Aurora, CO
Target Audience: Neonatologists,
hospitalists who take care of preterm infants, nutritionists
and general pediatricians.
Recent nutritional emphasis in
the NICU has been to achieve the normal intrauterine growth
rate with more aggressive nutritional support for the low
birth weight infant. In general, this has been difficult to
achieve, and new evidence from long-term follow up studies
shows that preterm infants are at an increased risk of
developing the metabolic syndrome including obesity, type 2
diabetes and cardiovascular disease. This implies that the
organs in the early life of the preterm infant may be
programmed adversely by nutritional therapy. This raises the
questions of how fast these infants should grow (including
catch up growth), the importance of the composition of this
growth and the urgency for defining the necessary balance
between growth of the brain and the rest of the body.
Ultimately, providers may want to revise the long-term and
short-term goals for feeding very low birth weight or
extremely low birth weight infants. This mini course will
present evidence to help answer these questions and provide
discussion about related practice recommendations.
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Overview
Frank R. Greer, University of Wisconsin, Madison, WI
William W. Hay, University of
Colorado Health Sciences Center, Aurora, CO
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Macronutrient Requirements for
Growth of Preterm Infants—Upper and Lower Limits
(Energy, Fat, CHO, Protein)
Scott C. Denne, Indiana University School of Medicine, James Whitcomb
Riley Hospital, Indianapolis, IN
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Aggressive Nutritional Support of
the Preterm Infant Revisited—Evidence for Efficacy and
Safety
Patti J. Thureen, University of Colorado Health Sciences Center,
Denver, CO
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Adverse Outcomes of Rapid Somatic
Growth and Alterations of Body Composition in the Low
Birth Weight Infant
Frank R. Greer, University of Wisconsin, Madison, WI
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Fatty Acids and Neuronal
Development
Susan E. Carlson, University of Kansas Medical Center, Kansas City, KS
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Iron and Development of the Brain
Michael K. Georgieff, University of Minnesota School of Medicine,
Minneapolis, MN
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Nutritional Influences on
Structural and Functional Maturation of the Developing
Brain During Extended Postnatal Period
Steve H. Zeisel, The University of North Carolina, Chapel Hill, NC
8:00am–12:00pm
2180A—LWPES Plenary Session I
LWPES Plenary Session
Room 3007-3009, Moscone West
Chairs: Lynne Levitsky, Massachusetts General Hospital, Boston, MA;
Henry Anhalt, Saint Barnabas Medical Center, Livingston, NJ;
and Alan D. Rogol, University of Virginia, Charlottesville, VA
Target Audience:
Endocrinologists, nephrologists, cardiologists, general
pediatricians, immunologists, geneticists and molecular
biologists.
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Opening Remarks
Lynne L. Levitsky, Massachusetts General Hospital, Boston, MA
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Lawson Wilkins Lecture:
Recent years have witnessed a
significant revision of the traditional view of fat cells
as simple stores of excess energy. Studies in the
speaker's lab as well as many others have clearly
demonstrated that adipocytes produce and regulate many
metabolic and hormonal signals, which generate profound
effects on systemic endocrine equilibrium. In his earlier
studies, he also demonstrated that these cells exhibit an
inflammatory capacity that is abnormal in obesity and key
to the pathogenesis of insulin resistance and diabetes.
Recently, he identified a key molecular mechanism
underlying the link between inflammatory responses and
insulin action. This pathway involves obesity-related
activation of the serine, threonine kinase, JNK, and the
consequent inhibition of insulin receptor signaling via
phosphorylation of a substrate of insulin receptor, IRS-1.
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Integration of Metabolic and
Inflammatory Pathways in Metabolic Disease
Gokhan S. Hotamisligil, Harvard School of Public Health, Boston, MA
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Robert Blizzard Lecture:
One of the greatest questions
asked of physicians caring for children with autoimmune
diabetes is "why did this happen?" This session
will unravel some of the mysteries surrounding the
etiology and pathogenesis of autoimmune diabetes from an
investigator who has dedicated his life to this issue.
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On the Unravelling of the
Etiopathogenesis of Type 1 Diabetes: Are We Stuck or
Are We Winning?
Gian Franco Bottazzo, Ospedale Pediatrico Bambino Gesú, Scientific
Institute, Rome, Italy
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Break
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Esoterix Lecture:
The attendee will familiarize
him/herself with newer molecular mechanisms of growth
failure that are due to abnormalities in receptor and
post-receptor translation of GH signaling.
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Molecular Mechanisms and Defects
in Growth Hormone Receptor Signaling
Peter Rotwein, Oregon Health and Science University, Portland, OR
10:30am–12:30pm
2340—Necrotizing Enterocolitis
PAS Platform Session
Room 3022, Moscone West
Chairs: Cheryl E. Gariepy and B U.K. Li
12:00pm–3:00pm
2505—Embryonic Stem Cells: A Primer for
Clinicians
PAS Mini Course
Room 3014, Moscone West
Chair: Michael T. Longaker, Stanford University, Stanford, CA
Embryonic stem cells offer
incredible promise for treating diseases affecting both
children and adults. This mini course will provide an overview
of stem cells and a basic understanding of how to derive human
embryonic stem cells, recent research and ethical
considerations. After attending this session, attendee will
have a better understanding of: 1) what are embryonic stem
cells; 2) how human embryonic stem cells are derived; 3)
recent progress in human embryonic stem cell research; 4)
ethical considerations in human embryonic stem cells.
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Stem Cells: Embryonic, Adult and
Cancer
Michael T. Longaker, Stanford University, Stanford, CA
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What It Takes Clinically To Get
an Embryonic Stem Cell
Linda C. Giudice, University of California, San Francisco, San
Francisco, CA
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What Can You Do with an Embryonic
Stem Cell in Research
Renee Reijo Pera, University of California, San Francisco, San
Francisco, CA
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Ethical and Oversight
Considerations in Human Embryonic Stem Cell Research
Hank Greely, Stanford University, Stanford, CA
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Panel Discussion
Supported in part by an unrestricted educational grant from
Treuman Katz Center for Pediatric Bioethics - Seattle
Children's Hospital
2:15pm–5:15pm
2700—Educating Pediatric Fellows in a
Competency-Based World
PAS/APPD Mini Course
Room 2007, Moscone West
Chairs: Susan Guralnick, Stony Brook University Medical Center, Stony
Brook, NY; and Joseph Gilhooly, Oregon Health and Science
University, Portland, OR
Target Audience: Attendees
involved with fellowship programs.
Competency-based education is now
the standard for residency education. Residency programs have
integrated the ACGME Core Competencies into their curricula
and assessment methods. It is now time for fellowships to
enter the “competency” arena, and there is much to be
accomplished. This program will focus on several areas of
fellowship education including: the new RRC common
requirements for subspecialty training, development of a
competency-based fellowship curriculum, competency-based
assessment tools, and pediatric subspecialty fellows as
teachers. Attendees are encouraged to bring tools and ideas
for discussion and development. Attendees should leave with
useful materials to bring back to their home programs.
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Overview
Susan Guralnick, Stony Brook University Medical Center, Stony Brook, NY
Joseph Gilhooly, Oregon Health
& Science University, Portland, OR
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A Brave New World! New Common
Requirements for Subspecialty Training—Implementing the
Competencies
Carol Carraccio, Professor of Pediatrics and Associate Chair for
Education, University of Maryland School of Medicine,
Baltimore, MD
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"Survivor ACGME"—Fellowship
Competencies in Action
Joseph Gilhooly, Oregon Health & Science University, Portland, OR
John D. Mahan, Children’s
Hospital, The Ohio State University, Columbus, OH
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Turning to Fellows as Teachers:
From Curricula to Evaluation
Nancy D. Spector, St. Christopher's Hospital for Children,
Philadelphia, PA
Susan Guralnick, Stony Brook
University Medical Center, Stony Brook, NY
Henry Anhalt, Saint Barnabas Medical Center, Livingston,
NJ
Sponsored jointly by
the Lawson Wilkins Pediatric Endocrine Society and the
Pediatric Academic Societies
2:15pm–5:15pm
2705—Vitamin D: More Than Just Calcium and
Bone
PAS/LWPES Mini Course
Room 3007-3009, Moscone West
Chairs: Catherine M. Gordon, Children's Hospital of Boston, Boston, MA;
and Linda A. DiMeglio, Indiana University, Indianapolis, IN
Target Audience: General
pediatricians, gastroenterologists, endocrinologists and
hematologists/oncologists.
The understanding of the role of
vitamin D in health and illness is becoming more complex. Both
skeletal and extra-skeletal actions have been described, and
vitamin D analogs are being explored for their anti-proliferative
effects. The attendee will gain both clinically relevant
epidemiological knowledge as well as review the calcemic and
non-calcemic actions of Vitamin D.
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What Is the Evidence for Vitamin
D Deficiency in Children?
Frank R. Greer, University of Wisconsin, Madison, WI
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Vitamin D and Extra-Skeletal
Actions in Health
Michael F. Holick, Boston University School of Medicine, Boston, MA
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Non-calcemic Actions of Vitamin D
Receptor Ligands
Sunil Nagpal, Women's Health & Musculoskeletal Biology,
Collegeville PA
Sponsored jointly by
the Lawson Wilkins Pediatric Endocrine Society and the
Pediatric Academic Societies
3:15pm–5:15pm
2735—Update on Therapeutic Monoclonal
Antibodies
PAS Topic Symposium
Room 3014, Moscone West
Chair: E. Richard Stiehm, UCLA School of Medicine, Los Angeles, CA
Target Audience: Immunologists,
rheumatologists, hematologists, oncologists and general
pediatricians.
The first talk will be an
overview of the various therapeutic monoclonals and some
general principles of their use. Then a discussion of
Rituximab in refractory immune cytopenias and other disorders
will be presented. Then the use of anti-tumor necrosis factor
treatment including infliximab and adalimumab (Ramicade and
Humira) for rheumatic diseases in children. The final talk
will discuss the adverse effects of these therapies and some
projections for the future. Discussion will be held after each
presentation.
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Overview
E. Richard Stiehm, Mattel Children's Hospital at UCLA, Los Angeles, CA
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Use of Anti-CD20 (Rituximab) in
Hematology and Autoimmunity
James B. Bussel, New York Hospital, Cornell Medical Center, New York,
NY
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Use of Anti-TNF and Other
Cytokine Inhibitors in Rheumatology and Related Illnesses
Christy Irene Sandborg, Stanford University Medical Center, Stanford,
CA
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The Downside and Future of
Monoclonal Antibody Therapy
Susan Lee, University of California, San Diego, CA
3:15pm–5:15pm
2751—Neonatal Fetal Nutrition and
Metabolism I
PAS Platform Session
Room 3022, Moscone West
Chairs: David H. Adamkin and Ronnie Guillet
3:15pm–5:15pm
2757—Nutrition and Behavior
PAS Poster Symposium
Room 3024, Moscone West
Chairs: Conrad R. Cole and Timothy A. Sentongo
3:45pm–5:15pm
2785A—Celiac Disease for the
Non-gastroenterologist
LWPES Workshop
Room 3010, Moscone West
Chair: Michelle M. Pietzak, Children's Hospital of Los Angeles, Los
Angeles, CA
Target Audience:
Gastroenterologists and endocrinologists.
Celiac disease affects
approximately 10-15% of children with diabetes. Often times
the screening tests are vexing. This workshop is aimed at
clarifying the disease process and how to diagnose it.
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Celiac Disease for the
Non-gastroenterologist
Michelle M. Pietzak, Children's Hospital of Los Angeles, Los Angeles,
CA
3:45pm–5:15pm
2790A—Hyperthyroidism
LWPES Workshop
Room 3000, Moscone West
Chair: Scott A. Rivkees, Yale School of Medicine, New Haven, CT
Target Audience: Generalists.
Much controversy exists about the
most effective and safest treatments for hyperthyroidism in
children. This workshop will clarify some of the newer
evidence based approaches to the diagnosis and management of
hyperthyroidism, with a special emphasis on radioactive
ablation.
Sunday, April 30
7:00am–8:00am
3025—Pediatric Gastroenterology—A 30-Year
Perspective
PAS Meet the Professor
Yerba Buena Gardens Salon 15, SF Marriott
This session is designed to
provide trainees and junior faculty with insight and advice
concerning the pursuit of an academic career in pediatric
gastroenterology, hepatology and nutrition. During an
interactive discussion, we will offer an analysis of the
opportunities and challenges in this rapidly evolving field,
relying on a personal 30-year historical perspective. We will
review important clinical and research advances as well as key
events in the evolution of this subspecialty. We will provide
advice concerning integration of basic and applied research
into a well-structured and aligned academic career.
8:00am–10:00am
3110—Probiotics in Necrotizing
Enterocolitis—Their Clinical Effect and Possible Mechanisms
PAS/ASPR/JPS/NASPGHAN Topic Symposium
Room 3003-3005, Moscone West
Chairs: W. Allan Walker, Harvard Medical School, Boston, MA; and
Yuichiro Yamashiro, Juntendo University School of Medicine,
Tokyo, Japan
Target Audience: Neonatologists,
gastroenterologists, pediatric surgeons, NICU nurses and
bacteriologists in perinatal medicine.
Necrotizing enterocolitis (NEC)
is a serious gastrointestinal disease seen predominantly in
very low birth weight (VLBW) and extremely low birth weight (ELBW)
infants. NEC is probably a complex, multifactorial disease.
Currently, the precise pathogenic mechanisms remain to be
elucidated; however, clinical use of probiotics has been
reported to be useful for preventing NEC development in VLBW
and ELBW infants. This session will provide us the current
knowledge about the role of probiotics in the management of
NEC.
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Fifteen-Year's Experience of
Early Administration of Bifidobacterium Breve to Preterm
Infants
H. Kitajima, Osaka Medical Center and Research Institute for Maternal
and Child Health, Osaka, Japan
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Oral Probiotics Reduces Incidence
of NEC in VLBW Infants
H. C. Lin, China Medical University, Taichung, Taiwan
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Effects of Probiotics on the
Immunological Development and Short Chain Fatty Acids in
ELBW and VLBW Infants
Yoshikazu Ohtsuka, Juntendo University School of Medicine, Bunkyo-ku,
Japan
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Possible Role of Probiotic
Supplementation for Prevention from NEC
Michael S. Caplan, Northwestern University, Evanston, IL
Sponsored jointly by
the Asian Society for Pediatric Research; Japan Pediatric
Society; North American Society for Pediatric
Gastroenterology, Hepatology & Nutrition and the Pediatric
Academic Societies
8:00am–10:00am
3125—Developmental Origins of Adult
Disease—Metabolism
PAS Platform Session
Room 3010-3012, Moscone West
Chairs: William W. Hay and Rebecca A. Simmons
12:00pm–1:30pm
3438A—Milk Club
Human Milk: From Laboratory to Clinic
Club
Room 3014, Moscone West
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Current Human Milk Immunology
Research That Will Alter Clinical Practice
David S. Newburg, Massachusetts General Hospital, Boston, MA
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Case Presentations and Discussion
with Pediatric Experts in Breastfeeding Medicine
Carol L. Wagner, Medical University of South Carolina, Charleston, SC
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Milk Club Business Meeting
Contact for information:
Carol L. Wagner, MD
Medical University of South Carolina
Phone: 843-792-8829
Email: wagnercl@musc.edu
4:15pm–5:45pm
3810—RNA Interference, Technological
Development of siRNAs and Potential Treatments for Childhood
Diseases
PAS State of the Art Plenary
Room 3016-3018, Moscone West
Chair: R. Alan B. Ezekowitz, Harvard Medical School, Massachusetts
General Hospital, Boston, MA
Target Audience: Basic scientists
studying a broad range of childhood diseases, translational
scientists of all disciplines studying clinical implications
of basic science research, clinical scientists studying
childhood and other diseases in need of improved therapies and
clinicians interested in cutting-edge science and its medical
implications.
RNA interference is a recently
discovered, naturally occurring intracellular process that
regulates gene expression through the silencing of specific
mRNAs. Methods of harnessing this natural pathway are being
developed that allow the catalytic degradation of targeted
mRNAs using specifically designed complementary small
inhibitory RNAs (siRNA). siRNAs are being chemically modified
to acquire drug-like properties. Numerous recent high-profile
publications have provided proofs of concept that RNA
interference may be useful therapeutically. Much of the design
of these siRNAs can be accomplished bioinformatically, thus
potentially expediting drug discovery and opening new avenues
of therapy for many childhood diseases including uncommon
pediatric and orphan diseases. A discussion of the science
behind RNA interference will be followed by a presentation of
the potential practical issues in applying this technology to
disease. The program then describes two therapeutic programs
currently under way with applications to pediatric diseases. A
question-and-answer time will follow each discussion.
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The Science of RNA Interference
John J. Rossi, Beckman Research Institute of City of Hope, Duarte, CA
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RNA Interference and Its
Potential Applications for Controlling Disease
Judy Lieberman, CBR Institute for Biomedical Research and Harvard
Medical School, Boston, MA
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Silencing the VEGF Pathway with
siRNAs and the Potential Application to Retinopathy of
Prematurity
Pamela Pavco, Sirna Therapeutics, Boulder, CO
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siRNA as Therapy for Respiratory
Syncytial Virus
John P. DeVincenzo, University of Tennessee School of Medicine,
Memphis, TN
4:15pm–6:15pm
3850—Human Milk and Breastfeeding
PAS Poster Symposium
Room 3001, Moscone West
Chairs: Sheela R. Geraghty and Ardythe L. Morrow
Monday, May 1
8:00am–10:00am
4136—Nutritional Disorders—Mechanisms
PAS Platform Session
Room 3000, Moscone West
Chairs: Conrad R. Cole and B U.K. Li
8:00am–11:00am
4150—The Skinny on the Adipocyte
PAS/LWPES Mini Course
Room 3010-3012, Moscone West
Chairs: Silva A. Arslanian, University of Pittsburgh, Pittsburgh, PA;
and Robert H. Lustig, University of California, San Francisco,
CA
Target Audience: General
pediatricians, gastroenterologists, endocrinologists,
cardiologists, pulmonologists and adolescent medicine
specialists.
Over the past five years much has
been learned about the adipocyte. The ability of the adipocyte
to function as an endocrine gland, elaborating inflammatory
cytokines that result in free radical formation and premature
apoptosis of the beta cell, is a relatively new concept. This
mini course will comprehensively address many of the newest
concepts in adipocyte function and their impact on health and
disease. Further discussion will include new concepts on the
interactions of IGF-II and other peptides' interactions with
the adipocyte. Lastly, there will be a call for new approaches
to the pediatric obesity epidemic.
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Adipose Tissue as an Endocrine
Organ
Susan Fried, University of Maryland School of Medicine, Baltimore VA
Medical Center, Baltimore, MD
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Obesity and Inflammation
Christopher Hug, Whitehead Institute and Children's Hospital,
Cambridge, MA
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Effects of GH, IGF-I and Insulin
Therapies on Adiposity
Zvi Laron, Schneider Children's Medical Center of Israel, Petah Tikva,
Isreal
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Pathology and Sequelae of
Childhood Obesity in Adult Life
Dennis M. Styne, University of California, Davis Medical Center,
Sacramento, CA
Sponsored jointly by
the Lawson Wilkins Pediatric Endocrine Society and the
Pediatric Academic Societies
9:00am–12:00pm
4256—Nutrition
APA Special Interest Group
Room Pacific Suite H, SF Marriott
Chairs: Sandy Hassink, shassink@nemours.org;
and Robert Karp, robert.karp@downstate.edu.
The Nutrition SIG will continue
with its emphasis on nutrition education in residency. Our
project, "A Teacher's Guide to Pediatric Nutrition,"
is readily available at http://downstate.edu/peds/pednutrition.
The model of "stepping stone education" is used with
a primer, "Pediatric Nutrition Notes," as its
foundation. A set of five introductions, Part 2, provide the
tools for usage. Part 3 is a set of eight modules on
pathophysiology, prevention evaluation and treatment of
obesity through childhood. Part 4 contains more than 25
case-based teaching modules on disease processes affected by
nutrition. The Teacher's Guide concludes with a module on
evaluation of teaching applicable to any subject. This
includes use of structured clinical observation for resident
evaluation of taking a diet history and providing guidance.
Faculty and residents are invited
to a 2-hour program with continental breakfast to explore use
of the Teacher's Guide. We will provide model programs
evaluating use of the Teacher's Guide for achieving basic
skills of taking histories and providing guidance.
Participants will join us for presentations, discussion and
continental breakfast. Registration is not necessary. Queries
are welcome by robert.karp@downstate.edu.
10:15am–12:15pm
4345—Intestinal Inflammation
PAS Poster Symposium
Room 3014, Moscone West
Chairs: Edward J. Hoffenberg and Elizabeth Mannick
12:00pm–1:30pm
4430A—Perinatal Nutrition and Metabolism
Club
Club
Room 2009-2011, Moscone West
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Probiotics and Development of
Intestinal Host Defense
W. Allan Walker, Departments of Pediatrics and Nutrition, Harvard
Medical School, Boston, MA
Contact for information:
Jane McGowan, M.D.
The Johns Hopkins Hospital
Phone: 410-955-4565
Email: jmcgowan@jhmi.edu
Supported in part by a restricted educational grant from
Ross Products Division, Abbott Laboratories
12:00pm–6:45pm
Commercial Exhibits Open and Posters
Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West
Posters Available for Viewing:
12:00pm–6:45pm
Author Attendance: 5:15pm–6:45pm
Level 1:
– Critical Care
– Gastroenterology
– Genetics
– Neonatal Epidemiology and Follow Up
– Neonatal Pulmonology
– Neonatology
– Nephrology
– Pulmonology
Level 2:
– Developmental–Behavioral Pediatrics
– Emergency Medicine
– General Pediatrics
– Medical Education
3:00pm–5:00pm
4620—Hirschsprung’s Disease and Chronic
Constipation: Medical and Surgical Approaches
PAS/NASPGHAN Topic Symposium
Room 3014, Moscone West
Chairs: B U.K. Li, Children's Memorial Hospital, Northwestern
University School of Medicine, Chicago, IL; and Melvin B.
Heyman, University of California San Francisco, San Francisco,
CA
Target Audience: General
pediatricians, pediatric gastroenterologists, pediatric
surgeons and developmental biologists.
This symposium will focus on a
common yet challenging problem constipation: the clinical,
diagnostic, genetic and surgical aspects of Hirschsprung’s
disease; and diagnostic testing, medical and surgical
treatment of chronic constipation. In Hirschsprung’s
disease, the clinical presentation (red flags) of, diagnostic
testing for and genetic mutations found will be discussed.
Surgical approaches including standard staged pull-thrus,
single stage repairs, laparoscopic approaches and
post-surgical obstructions will be reviewed. In chronic
constipation, the differential diagnosis and diagnostic
testing (findings in anorectal and colonic manometry, MRI and
bead transit studies) will be presented. Medical and surgical
therapeutic approaches will cover education, behavioral and
biofeedback therapy, medical treatment (disimpaction and
maintenance therapy) and antegrade enemas delivered via
cecostomies. The specific approaches applicable to a general
pediatric practice use will be identified.
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Clinical and Genetics Aspects of
Hirschsprung's Disease
Cheryl E. Gariepy, University of Michigan Health System, Ann Arbor, MI
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Surgical Approaches to
Hirschsprung's Disease
Daniel H. Teitelbaum, University of Michigan Hospitals, Ann Arbor, MI
-
Diagnostic Approaches to Chronic
Constipation
Samuel Nurko, Children's Hospital and Harvard University, Boston, MA
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Therapeutic Approaches to Chronic
Constipation
Warren P. Bishop, Children's Hospital of Iowa, University of Iowa, Iowa
City, Iowa
Sponsored jointly by
the American Pediatric Surgical Association; the North
American Society for Pediatric Gastroenterology, Hepatology
and Nutrition; and the Pediatric Academic Societies
3:00pm–5:00pm
4680—Neonatal Fetal Nutrition and
Metabolism II
PAS Platform Session
Room 3007-3011, Moscone West
Chairs: Patti J. Thureen and Carol L. Wagner
5:15pm–6:45pm
Poster Session III
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
12:00pm–6:45pm
Author Attendance: 5:15pm–6:45pm
Level 1:
– Critical Care
– Gastroenterology
– Genetics
– Neonatal Epidemiology and Follow Up
– Neonatal Pulmonology
– Neonatology
– Nephrology
– Pulmonology
Level 2:
– Developmental–Behavioral Pediatrics
– Emergency Medicine
– General Pediatrics
– Medical Education
Tuesday, May 2
8:00am–10:00am
5105—Not All Near-Term Infants Are Born
Equal
PAS Topic Symposium
Room 3002-3008, Moscone West
Chairs: Lucky Jain, Emory University, Atlanta, GA; and Tonse N.K. Raju,
National Institute of Child Health and Human Development,
Rockville, MD
Target Audience: Neonatologists
and pediatricians.
Infants born at >34 weeks and
<38 weeks are often presumed to be mature and treated at
par with term infants. However, there is considerable
epidemiologic information to show that these infants have
considerably higher rates of NICU admissions and are at risk
for serious morbidity and death. Causes of morbidity include
delayed respiratory transition and surfactant deficiency,
hyperbilirubinemia, hypothermia, hypoglycemia and poor
initiation of feeding, etc. This symposium is designed to
review the physiological events related to neonatal transition
at birth and the pitfalls in the transition of a near-term
infant. The symposium should create awareness among
neonatologists and pediatricians for these morbidities and
suggest ways to overcome them.
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Overview
Lucky Jain, Emory University, Atlanta, GA
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Epidemiology and Overview of
Near-Term Births
Tonse N.K. Raju, National Institute of Child Health and Human
Development, Rockville, MD
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Respiratory Transition and
Morbidity in Near-Term Infants
Lucky Jain, Emory University, Atlanta, GA
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Brain Maturation and Pathology in
Near-Term Infants
Hannah Kinney, Harvard University, Boston, MA
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Hyperbilirubinemia and
Kernicterus in Near-Term Infants
Vinod K. Bhutani, Stanford University School of Medicine, Stanford, CA
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Post-Discharge Morbidity and
Rehospitalization in Near-Term Infants
Gabriel J. Escobar, Kaiser Permanente, Oakland, CA
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Discussion
Supported by an unrestricted educational grant from INO
Therapeutics
10:15am–12:15pm
5425—A Spectrum of Neurodevelopmental
Disabilities
PAS Poster Symposium
Room 2006, Moscone West
Chairs: Bruce K. Shapiro and Robert G. Voigt
1:45pm–3:45pm
5720—Autosomal Recessive Polycystic Kidney
Disease (ARPKD): New Insights and Clinical Perspectives
PAS/ASPN/NASPGHAN Topic Symposium
Room 3010-3012, Moscone West
Chairs: Philip Rosenthal, University of California, San Francisco, San
Francisco, CA; and Lisa M. Guay-Woodford, University of
Alabama at Birmingham, Birmingham, AL
Target Audience: Pediatricians,
pediatric nephrologists, pediatric gastroenterologists,
neonatalogists and developmental biologists.
ARPKD is a developmental disorder
of the kidneys and liver caused by mutations in the PKHD1
gene. Fibrocystin/polyductin, the protein encoded by PKHD1, is
expressed on the primary cilia of renal and bile duct
epithelial cells. Several lines of evidence indicate that the
PKHD1 transcriptional profile is complex with extensive splice
variants. While the function of these transcripts and the
polypeptides that they encode is not well understood, these
proteins seem to play critical roles in establishing and
maintaining the tubular architecture. This symposium will
discuss the complex transcriptional profile of PKHD1 and the
role of these gene products in renal as well as biliary
epithelia. Given that ARPKD has a high perinatal mortality due
to oligohydramnios and resultant respiratory insufficiency,
current concepts regarding the interplay between the
developing kidney, the placenta and the developing lung will
be discussed. Finally, a clinical perspective based on the
on-going NHGRI-sponsored natural history study will focus on
ARPKD-associated morbidities and disease progression.
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Transcriptional Complexity of
PKHD1: Implications for Development and Disease
Pathogenesis
Gregory G. Germino, Johns Hopkins University, Baltimore, MD
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Pathobiology of Biliary Epithelia
in ARPKD
Tatyana Masyuk, Mayo Clinic College of Medicine, Rochester, MN
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Oligohydramnios: Current Concepts
and Implications for Pulmonary Development
F. Sessions Cole, Washington University School of Medicine, St. Louis
Children's Hospital, St. Louis, MO
-
Report on the NIH ARPKD/CHF
Natural History Study
Meral Gunay-Aygun, National Human Genome Research Institute (NHGRI),
Bethesda, MD
Sponsored jointly by
the American Society of Pediatric Nephrology; the North
American Society for Pediatric Gastroenterology, Hepatology
and Nutrition; and the Pediatric Academic Societies
1:45pm–3:45pm
5730—Obesity Symposium—The BIG Picture
PAS/LWPES Hot Topic
Room 3007-3011, Moscone West
Chairs: Janet H. Silverstein, University of Florida College of
Medicine, Gainesville, FL; and Josephine Z. Kasa-Vubu,
University of Michigan, Ann Arbor, MI
Target Audience: General
pediatrics, developmental pediatrics, adolescent medicine,
genetics, basic science, pediatric endocrinology and health
outcomes.
The obesity epidemic continues to
be a major public health threat and a top priority for a broad
range of researchers and clinicians. This symposium will
attempt to reach beyond descriptive statistics and will focus
on advances from bench to bedside with a focus on
intervention.
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Overview
Josephine Z. Kasa-Vubu, University of Michigan, Ann Arbor, MI
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Lessons from the Bench: Molecular
and Anatomical Models of Leptin Resistance
Martin Myers, University of Michigan, Ann Arbor, MI
-
Intensive Versus Behavior
Therapies for the Obese Child: What We Know and What We Do
Not Know
Jack Adam Yanovski, National Institutes of Health, Bethesda, MD
-
Long-Term Costs of Early Onset
Diabetes
William H. Herman,
-
Prenatal Programming of Obesity
and Obesity-Related Behaviors
Peter D. Gluckman, Liggins Institute, University of Auckland, Auckland,
New Zealand
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Discussion
Sponsored jointly by
the Lawson Wilkins Pediatric Endocrine Society and the
Pediatric Academic Societies
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