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Saturday, April 29
8:00am–11:00am
2130—Newborn Hearing Screening: From the
Bedside to Beyond
PAS/PIDS Mini Course
Room 3010, Moscone West
Chairs: Mark R. Schleiss and Lisa Ann Schimmenti, University of
Minnesota Medical School, Minneapolis, MN
Target Audience: General
pediatricians, geneticists and infectious disease specialists.
Sensorineural hearing loss (SNHL)
in infants is the most common birth defect, and early
detection improves outcome. Evidence from the CDC reveals that
less than one half of screened babies are followed up. One
possible reason is the low positive predictive value of
bedside screening. There is a critical need to augment current
strategies to prevent late diagnosis of SNHL. One solution is
to propose second-tier testing for the most common causes of
SNHL, as the most common causes of newborn hearing loss are
infectious and genetic. Of infectious causes, cytomegalovirus
(CMV) is the most common. Evidence of CMV infection can be
found in 1% of newborns, with 10–15% developing hearing loss
or other CNS abnormalities. Of the genetic causes, mutations
in GJB2/GJB6 are the most common and are identified in up to
one half of individuals with SNHL. The goal of this program
will be to examine evidence for inclusion of infectious and
genetic screening to augment current newborn screening
protocols.
-
Diagnostic Evaluation and
Management of Childhood Hearing Loss
Margaret Alene Kenna, Children's Hospital Boston, Boston, MA
-
Range of Mutations in
GJB2-Associated Hearing Loss
Lisa Ann Schimmenti, University of Minnesota Medical School,
Minneapolis, MN
-
Congenital Cytomegalovirus
Infection and Hearing Loss
Karen B. Fowler, University of Alabama at Birmingham, Birmingham, AL
-
Newborn Hearing Screening:
Audiologic Assessment
Yvonne Sininger, University of California Los Angeles, Los Angeles, CA
Sponsored jointly by
the Pediatric Infectious Diseases Society and the Pediatric
Academic Societies
12:00pm–3:00pm
2520—Pediatric Assessment of Sexual Abuse:
State of the Science 2006
PAS Mini Course
Room 3011, Moscone West
Chair: Vince Palusci, Wayne State University School of Medicine,
Hospital of Michigan, Detroit, MI
This three-hour mini course will
address the medical evaluation of child sexual abuse in the
pediatric setting. The topics that will be addressed are:
– Physical sequelae of sexual
abuse: What’s new and how has the literature of the past 10
years shaped this field.
– Medical conditions that mimic sexual abuse: What a
clinician must know about anogenital medical conditions and
congenital findings.
– Sexually transmitted diseases in children: Beyond
cultures, DNA amplification techniques in children and the
newest recommendations for HIV post assault prophylaxis will
be presented.
-
Overview
Vincent J. Palusci, Wayne State University School of Medicine, Hospital
of Michigan, Detroit, MI
-
Interpretation of Medical
Findings in Suspected Child Sexual Abuse: Update 2006
Joyce Adams, University of California San Diego Medical Center, San
Diego, CA
-
Mimics of Sexual Abuse
Lori Frasier, University of Utah School of Medicine, Salt Lake City UT
-
Sexually Transmitted Diseases in
Children: Beyond Cultures, DNA Amplification Technology
Nancy Denny Kellogg, University of Texas San Antonio, San Antonio, TX
12:30pm–2:30pm
2540—Neonatal Infections
PAS Platform Session
Room 3003-3005, Moscone West
Chairs: Henrietta S. Bada and Jill E. Baley
1:00pm–3:00pm
2600—Update on Treatment Options for Acute
Otitis Media
PAS/PIDS Hot Topic
Room 2009, Moscone West
Chairs: Tasnee Chonmaitree, University of Texas Medical Branch,
Galveston, TX; and Jerome O. Klein, Boston University School
of Medicine, Boston, MA
Target Audience: Pediatricians,
pediatric infectious disease specialists and anyone treating
otitis media in children.
Otitis media is the most common
disease seen in pediatric practice and the main reason for
antibiotic prescriptions for children. The practice guidelines
from the American Academy of Pediatrics (AAP) and the American
Academy of Family Physicians (AAFP) provided an option for
management of non-severe acute otitis media (AOM) with
observation rather than antibiotic treatment. While these
guidelines start to affect practice management of AOM, many
issues on treatment are still unresolved.
The symposium will address
important issues regarding the updated treatment of AOM: 1)
analyze the guideline recommendations and antibiotic choices;
2) present results on watchful waiting studies that came out
after the guidelines and how to select non-severe AOM cases;
3) answer the questions on whether symptomatic drugs and
adjunctive treatment should be used in place of antibiotics;
4) discuss whether withholding antibiotics affects recurrence
of the disease.
-
AOM Treatment: Making Sense of
the AAP/AAFP Guidelines
Jerome O. Klein, Boston University School of Medicine, Boston, MA
-
Watchful Waiting in Non-severe
AOM: How To Select Cases, and Does It Work in Young
Children?
David P. McCormick, University of Texas Medical Branch at Galveston,
Galveston, TX
-
Antihistamine and
Corticosteroids: Do They Have Any Role in AOM Treatment?
Tasnee Chonmaitree, University of Texas Medical Branch, Galveston, TX
-
Recurrent AOM—Is It Influenced
by Antibiotics?
Ron Dagan, Soroka University Medical Center, Beer Sheva, Israel
-
Discussion
Sponsored jointly by
the Pediatric Infectious Diseases Society and the Pediatric
Academic Societies
2:15pm–5:15pm
2700—Educating Pediatric Fellows in a
Competency-Based World
PAS/APPD Mini Course
Room 2007, Moscone West
Chairs: Susan Guralnick, Stony Brook University Medical Center, Stony
Brook, NY; and Joseph Gilhooly, Oregon Health and Science
University, Portland, OR
Target Audience: Attendees
involved with fellowship programs.
Competency-based education is now
the standard for residency education. Residency programs have
integrated the ACGME Core Competencies into their curricula
and assessment methods. It is now time for fellowships to
enter the “competency” arena, and there is much to be
accomplished. This program will focus on several areas of
fellowship education including: the new RRC common
requirements for subspecialty training, development of a
competency-based fellowship curriculum, competency-based
assessment tools, and pediatric subspecialty fellows as
teachers. Attendees are encouraged to bring tools and ideas
for discussion and development. Attendees should leave with
useful materials to bring back to their home programs.
-
Overview
Susan Guralnick, Stony Brook University Medical Center, Stony Brook, NY
Joseph Gilhooly, Oregon Health
& Science University, Portland, OR
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A Brave New World! New Common
Requirements for Subspecialty Training—Implementing the
Competencies
Carol Carraccio, Professor of Pediatrics and Associate Chair for
Education, University of Maryland School of Medicine,
Baltimore, MD
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"Survivor ACGME"—Fellowship
Competencies in Action
Joseph Gilhooly, Oregon Health & Science University, Portland, OR
John D. Mahan, Children’s
Hospital, The Ohio State University, Columbus, OH
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Turning to Fellows as Teachers:
From Curricula to Evaluation
Nancy D. Spector, St. Christopher's Hospital for Children,
Philadelphia, PA
Susan Guralnick, Stony Brook
University Medical Center, Stony Brook, NY
Sponsored jointly by
the Association of Pediatric Program Directors and the
Pediatric Academic Societies
Supported by an unrestricted educational grant from Dey,
L.P.
3:15pm–5:15pm
2735—Update on Therapeutic Monoclonal
Antibodies
PAS Topic Symposium
Room 3014, Moscone West
Chair: E. Richard Stiehm, UCLA School of Medicine, Los Angeles, CA
Target Audience: Immunologists,
rheumatologists, hematologists, oncologists and general
pediatricians.
The first talk will be an
overview of the various therapeutic monoclonals and some
general principles of their use. Then a discussion of
Rituximab in refractory immune cytopenias and other disorders
will be presented. Then the use of anti-tumor necrosis factor
treatment including infliximab and adalimumab (Ramicade and
Humira) for rheumatic diseases in children. The final talk
will discuss the adverse effects of these therapies and some
projections for the future. Discussion will be held after each
presentation.
-
Overview
E. Richard Stiehm, Mattel Children's Hospital at UCLA, Los Angeles, CA
-
Use of Anti-CD20 (Rituximab) in
Hematology and Autoimmunity
James B. Bussel, New York Hospital, Cornell Medical Center, New York,
NY
-
Use of Anti-TNF and Other
Cytokine Inhibitors in Rheumatology and Related Illnesses
Christy Irene Sandborg, Stanford University Medical Center, Stanford,
CA
-
The Downside and Future of
Monoclonal Antibody Therapy
Susan Lee, University of California, San Diego, CA
3:15pm–5:15pm
2753—Neonatal Infectious Diseases
PAS/PIDS Poster Symposium
Room 3003-3005, Moscone West
Chairs: Deborah A. Lewinsohn and John V. Williams
4:00pm–7:30pm
Commercial Exhibits Open and Posters
Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West
Posters Available for Viewing:
4:00pm–7:30pm
Author Attendance: 5:15pm–7:15pm
Level 1:
– Developmental Biology
– Endocrinology
– Hematology–Oncology
– Neonatal Infectious Diseases
– Neonatology
– Nephrology
Level 2:
– Cardiology
– Developmental–Behavioral Pediatrics
– General Pediatrics
– Medical Education
– Neurology
5:15pm–7:15pm
Poster Session I and PAS Opening Reception
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
4:00pm–7:30pm
Author Attendance: 5:15pm–7:15pm
Level 1:
– Developmental Biology
– Endocrinology
– Hematology–Oncology
– Neonatal Infectious Diseases
– Neonatology
– Nephrology
Level 2:
– Cardiology
– Developmental–Behavioral Pediatrics
– General Pediatrics
– Medical Education
– Neurology
Includes
-
SPR Student Research Award:
Resuscitation of Non-Viable Infants: Will
Neonatologists[apos] Practice Change After the Born-Alive
Infant Protection Act?
Mya Sendowski, University of California, San Francisco, CA
Sunday, April 30
7:00am–8:00am
3040—Infectious Diseases
PAS Meet the Professor
Yerba Buena Gardens Salon 12, SF Marriott
This session is designed to
provide trainees and junior faculty with insight and advice
concerning the pursuit of an academic career in pediatric
infectious diseases. Attention will be given to describing
approaches to obtaining the best possible training in clinical
infectious diseases, epidemiology, as well as in basic and
applied research in the field of pediatric infectious
diseases. The importance and value of mentoring will be
discussed.
8:00am–10:00am
3100—Advances in Pathogenesis, Diagnosis
and Management of Kawasaki Disease
PAS/PIDS Topic Symposium
Room 3001, Moscone West
Chairs: Marian Melish, University of Hawaii, Kapiolani Children's
Hospital, Honolulu, HI; and Stanford T. Shulman, Children's
Memorial Hospital, Northwestern University, Feinberg School of
Medicine, Chicago, IL
Target Audience: Infectious
disease specialists, cardiologists, rheumatologists,
immunologists and primary care pediatricians.
Cloning the IgA antibody response
in acute Kawasaki Disease has led to exciting new insights
into the etiology and pathogenesis of this enigmatic illness.
The diagnosis of incomplete Kawasaki Disease remains a
significant clinical problem, and new guidelines have been
published to help the clinician in making this diagnosis.
Approximately 10–15% of children with acute Kawasaki Disease
do not respond to conventional intravenous gammaglobulin and
aspirin therapy, and new data regarding treatment with
steroids and Remicade are emerging. Knowledge regarding
optimal management of cardiac complications and long-term
outcome continues to evolve as patients diagnosed with
Kawasaki Disease in the 1970s and 1980s age.
-
Overview
Marian E. Melish, University of Hawaii, Kapiolani Children's Hospital,
Honolulu, HI
-
IgA Response in Acute Kawasaki
Disease Targets Inclusion Bodies in Acute Kawasaki Disease
Bronchial Epithelium
Anne H. Rowley, Northwestern University, Children's Memorial Hospital,
Chicago, IL
-
Clinical Dilemma of Diagnosing
Incomplete Kawasaki Disease
Jane C. Burns, University of California, San Diego, CA
-
Treatment of Refractory Kawasaki
Disease
Stanford T. Shulman, Children's Memorial Hospital, Northwestern
University, Feinberg School of Medicine, Chicago, IL
-
Management of Cardiac
Complications and Long-Term Outcome
Jane W. Newburger, Harvard University, Children’s Hospital of Boston,
Boston, MA
Sponsored jointly by
the Pediatric Infectious Diseases Society and the Pediatric
Academic Societies
8:00am–10:00am
3110—Probiotics in Necrotizing
Enterocolitis—Their Clinical Effect and Possible Mechanisms
PAS/ASPR/JPS/NASPGHAN Topic Symposium
Room 3003-3005, Moscone West
Chairs: W. Allan Walker, Harvard Medical School, Boston, MA; and
Yuichiro Yamashiro, Juntendo University School of Medicine,
Tokyo, Japan
Target Audience: Neonatologists,
gastroenterologists, pediatric surgeons, NICU nurses and
bacteriologists in perinatal medicine.
Necrotizing enterocolitis (NEC)
is a serious gastrointestinal disease seen predominantly in
very low birth weight (VLBW) and extremely low birth weight (ELBW)
infants. NEC is probably a complex, multifactorial disease.
Currently, the precise pathogenic mechanisms remain to be
elucidated; however, clinical use of probiotics has been
reported to be useful for preventing NEC development in VLBW
and ELBW infants. This session will provide us the current
knowledge about the role of probiotics in the management of
NEC.
-
Fifteen-Year's Experience of
Early Administration of Bifidobacterium Breve to Preterm
Infants
H. Kitajima, Osaka Medical Center and Research Institute for Maternal
and Child Health, Osaka, Japan
-
Oral Probiotics Reduces Incidence
of NEC in VLBW Infants
H. C. Lin, China Medical University, Taichung, Taiwan
-
Effects of Probiotics on the
Immunological Development and Short Chain Fatty Acids in
ELBW and VLBW Infants
Yoshikazu Ohtsuka, Juntendo University School of Medicine, Bunkyo-ku,
Japan
-
Possible Role of Probiotic
Supplementation for Prevention from NEC
Michael S. Caplan, Northwestern University, Evanston, IL
Sponsored jointly by
the Asian Society for Pediatric Research; Japan Pediatric
Society; North American Society for Pediatric
Gastroenterology, Hepatology & Nutrition and the Pediatric
Academic Societies
8:00am–10:00am
3140—General Pediatrics II
PAS Platform Session
Room 2007, Moscone West
Chairs: Christine L. Johnson and Elisa A. Zenni
8:00am–11:00am
3252—HIV/AIDS
APA Special Interest Group
Room Pacific Suite B, SF Marriott
Chairs: Nancy Hutton, nhutton@jhmi.edu;
and Lois C. Howland, lois.howland@umassmed.edu.
This year the HIV/AIDS SIG will
hold a working meeting to focus on pediatric resident
education. Antiretroviral treatment for children and
adolescents with HIV is now a highly specialized field. But
general pediatricians care for the broader population of
infants, children and adolescents affected by HIV. Key areas
of generalist responsibility include management of HIV-exposed
newborns, HIV counseling and testing in different age groups,
communication with children about HIV and providing support
for bereaved children and siblings. Our meeting goal is to
outline key competencies in generalist HIV education that
respond to the ACGME core competencies and to consider next
steps in curriculum development and dissemination.
11:00am–4:00pm
Commercial Exhibits Open and Posters
Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West
Posters Available for Viewing:
11:00am–4:00pm
Author Attendance: 12:00pm–2:00pm
Level 1:
– Allergy, Immunology and Rheumatology
– Developmental-Behavioral Pediatrics
– Endocrinology
– Infectious Diseases
– General Pediatrics
– Hematology–Oncology
Level 2:
– Cardiology
– Neonatal Neurology
– Neonatology
12:00pm–2:00pm
Poster Session II
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
11:00am–4:00pm
Author Attendance: 12:00pm–2:00pm
Level 1:
– Allergy, Immunology and Rheumatology
– Developmental-Behavioral Pediatrics
– Endocrinology
– Infectious Diseases
– General Pediatrics
– Hematology–Oncology
Level 2:
– Cardiology
– Neonatal Neurology
– Neonatology
Includes
-
SPR Fellow's Basic Research
Award: Myopalladin Mutations and Inherited
Cardiomyopathies
Enkhsaikhan Purevjav, Baylor College of Medicine, Houston, TX
-
SPR Clinical Research Award:
Accelerated Development in the Visual Areas of Preterm
Infants? A Voxel-Based Morphometry Study on Diffusion
Tensor MR Imaging (DTI)
Maria Miranda, Copenhagen University Hospital, Hvidovre, Denmark
-
SPR Fellow's Clinical Research
Award: Novel Genotyping Technology To Classify Childhood
Leukemia
Joshua D. Schiffman, Stanford University, Palo Alto, CA
-
SPR House Officer Research Award:
Erythropoietin Protein Expression in the Developing Human
Eye
Shrena Patel, University of New Mexico, Albuquerque, NM
2:00pm–4:00pm
3705—Infections at the
Maternal–Placental–Fetal Interface: Immunopathogenesis of
Group B Streptococcus, Listeria monocytogenes and
Cytomegalovirus
PAS/PIDS Topic Symposium
Room 3022-3024, Moscone West
Chairs: John R. Schreiber, University of Minnesota Medical School and
University of Minnesota Children's Hospital/Fairview,
Minneapolis, MN; and Robert F. Pass, University of Alabama at
Birmingham, Birmingham, AL
Target Audience: Neonatologists,
infectious disease specialists, immunologists, developmental
biologists and general pediatricians.
Infections in newborns commonly
result from acquisition either during the delivery process or
transplacentally. The host and pathogen factors that
contribute to acquisition of infections at the
maternal–placental–fetal interface are poorly understood.
This symposium will review the basic science and
immunopathogenesis of three diverse pathogens that all share
the ability to cause infections at the placental level:
cytomegalovirus, group B streptococcus, and Listeria
monocytogenes.
-
Intrauterine Cytomegalovirus
Infection, Transplacental Spread of Virus and Control by
Maternal Immunity
Lenore Pereira, University of California San Francisco, San Francisco,
CA
-
Host and Bacterial Factors in
Invasive Group B Streptococcal Infection
Craig E. Rubens, University of Washington, Seattle, WA
-
Listeriosis in the Pregnant
Guinea Pig: A Model of Vertical Transmission
Daniel A. Portnoy, University of California Berkeley, Berkeley, CA
-
Discussion
Sponsored jointly by
the Pediatric Infectious Diseases Society and the Pediatric
Academic Societies
4:15pm–5:45pm
3810—RNA Interference, Technological
Development of siRNAs and Potential Treatments for Childhood
Diseases
PAS State of the Art Plenary
Room 3016-3018, Moscone West
Chair: R. Alan B. Ezekowitz, Harvard Medical School, Massachusetts
General Hospital, Boston, MA
Target Audience: Basic scientists
studying a broad range of childhood diseases, translational
scientists of all disciplines studying clinical implications
of basic science research, clinical scientists studying
childhood and other diseases in need of improved therapies and
clinicians interested in cutting-edge science and its medical
implications.
RNA interference is a recently
discovered, naturally occurring intracellular process that
regulates gene expression through the silencing of specific
mRNAs. Methods of harnessing this natural pathway are being
developed that allow the catalytic degradation of targeted
mRNAs using specifically designed complementary small
inhibitory RNAs (siRNA). siRNAs are being chemically modified
to acquire drug-like properties. Numerous recent high-profile
publications have provided proofs of concept that RNA
interference may be useful therapeutically. Much of the design
of these siRNAs can be accomplished bioinformatically, thus
potentially expediting drug discovery and opening new avenues
of therapy for many childhood diseases including uncommon
pediatric and orphan diseases. A discussion of the science
behind RNA interference will be followed by a presentation of
the potential practical issues in applying this technology to
disease. The program then describes two therapeutic programs
currently under way with applications to pediatric diseases. A
question-and-answer time will follow each discussion.
-
The Science of RNA Interference
John J. Rossi, Beckman Research Institute of City of Hope, Duarte, CA
-
RNA Interference and Its
Potential Applications for Controlling Disease
Judy Lieberman, CBR Institute for Biomedical Research and Harvard
Medical School, Boston, MA
-
Silencing the VEGF Pathway with
siRNAs and the Potential Application to Retinopathy of
Prematurity
Pamela Pavco, Sirna Therapeutics, Boulder, CO
-
siRNA as Therapy for Respiratory
Syncytial Virus
John P. DeVincenzo, University of Tennessee School of Medicine,
Memphis, TN
4:15pm–6:15pm
3820—New Resident Work Hours and Quality
Care—Synergistic or Antagonistic?
PAS/PPC State of the Art Plenary
Room 2006, Moscone West
Chair: Richard E. Behrman, Federation of Pediatric Organizations, Inc.,
Menlo Park, CA
The session will identify and
address continuing issues regarding resident work hours
specifically and the general climate in which resident
training occurs in light of the recent ACGME limits on
resident work hours. In particular, panelists will discuss
what impact the changes are having on both the quality of
patient care and the quality of resident education in
pediatrics. Participants will hear from three different
perspectives, representing the Accreditation Council for
Graduate Medical Education (ACGME), Resident Review Committee
(RRC) and directors of pediatric residency programs.
-
Overview
Richard E. Behrman, Federation of Pediatric Organizations, Inc., Menlo
Park, CA
-
ACGME Perspective
David C. Leach, Accreditation Council for Graduate Medical Education,
Chicago, IL
-
Residency Review Committee
Perspective
M. Douglas Jones, Professor, Department of Pediatrics, Section of
Neonatology, University of Colorado School of Medicine,
Denver, CO
-
Pediatric Program Director's
Perspective
Theodore Sectish, Stanford University Medical School, Palo Alto, CA
-
Discussion
Sponsored jointly by
the Public Policy Council, the Public Policy Advocacy
Committee of the Ambulatory Pediatric Association and the
Pediatric Academic Societies
4:15pm–6:15pm
3850—Human Milk and Breastfeeding
PAS Poster Symposium
Room 3001, Moscone West
Chairs: Sheela R. Geraghty and Ardythe L. Morrow
4:15pm–6:15pm
3855—Infectious Diseases I
PAS/PIDS Platform Session
Room 3022-3024, Moscone West
Chairs: Sheldon L. Kaplan and David W. Kimberlin
6:00pm–7:15pm
3940A—Neonatal Sepsis Club
Club
Room 3016-3018, Moscone West
-
The Intravenous Immunoglobulins:
Current and Future Role in the NICU
William Tarnow-Mordi, The Children's Hospital Westmead, Sydney,
Australia
-
Panel and Audience Discussion
-
Panelists
Carol J. Baker, Baylor College of Medicine, Houston, TX
Barbara J. Stoll, Emory
University School of Medicine, Atlanta, GA
Leonard E. Weisman
Contact for information:
David Kaufman, M.D.
University of Virginia Children's Hospital
Phone: 434-924-9114
Email: davidkaufman@virginia.edu
Monday, May 1
6:00am–8:00am
Respiratory Viruses in the Development and
Exacerbation of Asthma: Re-examining the Impact of Influenza
and the Benefits of Immunization
PAS Industry Sponsored Symposium
Yerba Buena Gardens Salon 7, SF Marriott
Target Audience: Infectious
diseases.
Asthma is the most common chronic
pediatric disorder affecting nearly 6 million U.S. children
under age 18. It accounts for over 640,000 annual emergency
room visits and is the third leading cause of hospitalization
in children.
The Centers for Disease Control
and Prevention and other major medical and public health
groups recommend influenza vaccination for all children with
asthma. Yet, studies show even in the best years, only
one-third are vaccinated.
Annual influenza vaccination is
vital for all children with asthma, regardless of severity, to
protect them from influenza and its complications.
The symposium will highlight the
need for routine influenza vaccination for children with
asthma, examine how to define the asthmatic child and review
the importance of increasing recognition of the impact of
influenza in this high-risk population.
For registration information
please contact:
Dimara Almeida
Phone: (212) 886-2250
E-mail: rsvp@asthmaflu.com
A CME Satellite
Symposium sponsored by the National Foundation for Infectious
Diseases
Supported by a grant from Sanofi Pasteur
8:00am–10:00am
4130—Infectious Diseases II
PAS/PIDS Platform Session
Room 3001, Moscone West
Chairs: Kathryn M. Edwards and Michael A. Gerber
12:15pm–1:15pm
4470—The National Children's Study: Status
and Future Plans
PAS/PPC Special Symposium
Room 3010-3012, Moscone West
Chair: Elena Fuentes-Afflick, University of California, San Francisco,
CA
Target Audience: Practicing
pediatricians, academic child health professionals,
researchers, administrators and policymakers who are
interested in child health across the lifespan. Professionals
interested in the impact of environmental factors on health
outcomes will also be interested.
This special symposium will
present an update on the National Children's Study, which
recently selected 7 vanguard centers and is prepared to begin
recruitment of subjects. However, the President's budget
proposal allocated no further funding and stated that the
study would be terminated at the end of the current fiscal
year. The panel presenters will discuss the current budgetary
outlook, status of the study, options to implement the study
and respond to questions from the audience.
Panelists
-
Elena Fuentes-Afflick, University of California, San Francisco, CA
-
Duane Alexander, Director,
National Institute of Child Health and Human Development,
National Institutes of Health, Bethesda, MD
-
Peter C. Scheidt, Director,
National Children's Study, National Institute of Child
Health and Human Development, National Institutes of
Health, Bethesda, MD
-
Alan R. Fleischman, Chair,
National Children's Study Federal Advisory Committee, New
York Academy of Medicine, New York and National Institutes
of Health, Bethesda, MD
-
David J. Schonfeld, Member,
National Children's Study Federal Advisory Committee and
Chair, AAP Committee on Research, Cincinnati, OH
Sponsored jointly by
the Public Policy Council and the Pediatric Academic Societies
1:00pm–2:45pm
4500—March of Dimes Prize in Developmental
Biology Lecture
PAS Award
Room 3002-3008, Moscone West
Dr. Varshavsky is a pioneer in
the study of ubiquitin, a tiny protein that has a very big
job. Ubiquitin (from the Latin ubique meaning
"everywhere," the source of the word
"ubiquitous") is so named because it is essential to
nearly every major activity in the life cycle of cells,
including cell growth and division during embryo development,
DNA repair, programmed cell death, immune response, and the
nervous system. The ubiquitin system is the housekeeping
mechanism by which the cell maintains a proper and healthy
balance of proteins. Ubiquitin's role was unknown until the
1980s, when Dr. Varshavsky and colleagues elucidated it. This
discovery revolutionized our understanding of the control of
human cells, and ubiquitin quickly became one of the major
areas of study in genetics, developmental biology, cell
biology, and biochemistry. Today ubiquitin is a cornerstone of
medical research into the causes and treatments of birth
defects, neurodegenerative disease, infections, and cancer.
Dr. Varshavsky receives the 2006 March of Dimes Prize for
revealing and characterizing the biological significance of
the ubiquitin system in the regulation of living cells.
-
Regulation by Proteolysis: The
N-End Rule Pathway in Yeast and Mammals
Alexander Varshavsky, Smits Professor of Cell Biology, California
Institute of Technology, Pasadena, CA
Presented by the
March of Dimes Birth Defects Foundation
2:00pm–4:00pm
4580—Application of Translational Science
to Vaccinology: Varicella-Zoster Virus and Human
Papillomavirus
PAS/PIDS State of the Art Plenary
Room 3003-3005, Moscone West
Chairs: Ann M. Arvin, Stanford University School of Medicine, Stanford,
CA; and Anna-Barbara Moscicki, University of California, San
Francisco, CA
Target Audience: Infectious
disease specialists, primary care pediatricians, immunologists
and adolescent medicine physicians.
One of the major goals of
infectious diseases research is to understand the pathogenesis
of disease and to use this knowledge to prevent the illness
through vaccination. An understanding of varicella
pathogenesis led to the development of a successful vaccine,
and further insights into long-term success of the vaccine and
the future of varicella immunization are emerging. A more
recent success story is that of human papillomavirus, in which
basic science studies of pathogenesis led to the development
of vaccines based on virus-like particles. These two examples
serve as models of the success of translational science in
combating infectious diseases.
-
New Insights into Varicella-Zoster
Virus Pathogenesis
Ann M. Arvin, Stanford University School of Medicine, Stanford, CA
-
MMRV and the Future of
Immunization Against Varicella-Zoster Virus
Anne A. Gershon, Columbia University, New York, NY
-
Pathogenesis of Human
Papillomavirus Infections
Anna-Barbara Moscicki, University of California, San Francisco, CA
-
Development of Virus-like
Particles for Immunization Against Human Papillomavirus
John T. Schiller, National Cancer Institute, National Institutes of
Health, Bethesda, MD
Sponsored jointly by
the Pediatric Infectious Diseases Society and the Pediatric
Academic Societies
3:00pm–5:00pm
4690—Sepsis: Pathogenesis and Outcomes
PAS Platform Session
Room 3000, Moscone West
Chairs: John H. Arnold and Joseph A. Carcillo
4:00pm–5:00pm
4700A—PIDS 3rd Annual Stanley A. Plotkin
Lectureship in Vaccinology
PIDS Alliance Society
Room 3003-3005, Moscone West
Chair: Joseph W. St. Geme, III, Duke University School of Medicine,
Durham, NC
The Pediatric Infectious Diseases
Society has established the Stanley A. Plotkin Lectureship in
Vaccinology to honor Dr. Plotkin, the Society's "Founding
Father." The lecture, which takes place at the annual
PIDS meeting, is sponsored by Sanofi Pasteur. Dr. Plotkin was
medical director at sanofi pasteur and remains a medical and
scientific advisor. The inaugural lecture was delivered by Dr.
Plotkin in 2004.
-
Introduction
Larry K. Pickering, National Immunization Program, Centers for Disease
Control and Prevention, Atlanta, GA
-
The Role of Measles Elimination
in Development of a National Immunization Program
Walter A. Orenstein, Emory University School of Medicine, Atlanta, GA
Supported by an unrestricted educational grant from sanofi
pasteur
5:00pm–6:00pm
4750A—PIDS Business Meeting
PIDS Business Meeting
Room 3003-3005, Moscone West
6:15pm
4950A—PIDS Annual Awards Dinner and Banquet
PIDS Dinner
Ralston Ballroom, Palace Hotel
Ticket Required - inquire through
the PIDS Office at 703-299-6764
Tuesday, May 2
8:00am–10:00am
5130A—Neonatal Infectious Diseases in
Developing Countries—Part I
PGPR Symposium
Room 3016-3018, Moscone West
Co-Chairs: Alvin Zipursky, The Hospital for Sick Children, Toronto,
Canada; and Stephen Wall, Senior Research Manager, Saving
Newborn Lives, Washington, DC
Target Audience: Researchers and
clinicians interested and/or involved in all aspects of the
study of neonatal infectious disease, in any setting.
The Programme for Global
Paediatric Research (PGPR) includes paediatric researchers,
societies, and other organizations committed to child health.
It was formed in January 2004 to address the disparity between
the scientific research resources available in high-income
countries and the quantity of scientific research focused on
the health of children in mid- and low-income countries. PGPR
works at the centre of a global network to inform, educate,
facilitate international research cooperation and
collaboration, and acts as an advocate for research to improve
the health of all children. This three-part symposium will
focus on the serious problem of neonatal infectious diseases
in developing countries. Parts 1 and 3 will be comprised of
expert presentations providing an overview of the problem,
instances of work that is being done in the area, and
region-specific information. Part 2 will feature platform
presentations from selected abstracts on issues included in
the study of neonatal infectious diseases in developing
countries. At the PGPR workshop on Wednesday, May 3 colleagues
from high-, mid- and low-income countries, who are working in
fields related to neonatal infectious diseases, will meet in
order to examine the critical issues and establish clear plans
for collaborative study and other action. One of the expected
outcomes of the workshop will be a preliminary statement of
research needs and directions related to neonatal infectious
diseases in developing countries.
-
Neonatal Infections in the
Developing World: An Overview
Barbara J. Stoll, Emory University School of Medicine, Atlanta, GA
-
Healthcare Associated Neonatal
Infections and Antimicrobial Resistance in Developing
Countries
Anita Zaidi, Aga Khan University Hospital, Karachi, Pakistan
-
Diagnosis and Antibiotic Therapy
of Neonatal Infections by Health Care Workers
Abhay T. Bang, The Society for Education, Action and Research in
Community Health (SEARCH), Gadchiroli, Maharashtra, India
-
Global Partnerships for
Infectious Disease Research: A Focus on Pediatric Studies
of Dengue in Nicaragua
Eva Harris, School of Public Health, University of California,
Berkeley, CA
10:00am–2:00pm
Commercial Exhibits Open and Posters
Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West
Posters Available for Viewing:
10:00am–2:00pm
Author Attendance: 12:00pm–1:30pm
Level 1:
– Adolescent Medicine
– Emergency Medicine
– Epidemiology
– General Pediatrics
– Infectious Diseases
– Neonatal Epidemiology and Follow Up
Level 2:
– Neonatal Pulmonology
– Neonatology
10:15am–11:45am
5400—Campaign To Save 100K Lives: What It
Means for Child Health
PAS State of the Art Plenary
Room 3024, Moscone West
Chair: Charles J. Homer, National Initiative for Children's Healthcare
Quality (NICHQ), Boston, MA; Connie
Crowley Ganser, National Initiative for Children's Healthcare
Quality (NICHQ), Cambridge, MA; and Paul Kurtin, Children's
Hospital San Diego, San Diego, CA
Target Audience: Hospital-based
pediatricians across a wide array of specialties.
In December 2004, the Institute
for Healthcare Improvement launched a campaign to save 100K
lives through targeted improvements in care. Shortly after the
launch, the National Initiative for Children’s Healthcare
Quality, Children’s Hospital Corporation of America and the
National Association of Children’s Hospitals and Related
Institutions convened to identify whether these changes could
cause comparable improvements in health care for children and
promote that effort. This session will review the science
behind these interventions, describe the programs and
implementation efforts to advance these and future directions
for such safety and quality campaigns.
-
The Campaign Approach to Quality
Improvement
Connie Crowley Ganser, National Initiative for Children's Healthcare
Quality (NICHQ), Cambridge, MA
-
Bloodstream Infections
W. Charles Huskins, Mayo Clinic, Rochester, MN
-
Rapid Response Teams
Glenn Billman, Children's Hospitals and Clinics of Minneapolis/St.
Paul, Minneapolis, MN
-
Ventilator Acquired Pneumonia and
Adverse Drug Events
Paul Kurtin, Children's Hospital San Diego, San Diego, CA
-
Where Do We Go from Here? The
Pediatric Campaign
Charles J. Homer, National Initiative for Children's Healthcare Quality
(NICHQ), Cambridge, MA
-
Discussion
10:15am–12:15pm
5450—Neonatal Infectious Diseases in
Developing Countries
PAS/PGPR Platform Session
Room 3016-3018, Moscone West
Chairs: Shoo K. Lee and Pablo J. Sanchez
12:00pm–1:30pm
Poster Session IV
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
10:00am–2:00pm
Author Attendance: 12:00pm–1:30pm
Level 1:
– Adolescent Medicine
– Emergency Medicine
– Epidemiology
– General Pediatrics
– Infectious Diseases
– Neonatal Epidemiology and Follow Up
Level 2:
– Neonatal Pulmonology
– Neonatology
Includes
-
SPR Student Research Award: Metal
Contamination of Blood Bank Blood
Allison Blatz, Case Western Reserve University, Rainbow Babies &
Children's Hospital, Cleveland, OH
-
SPR House Officer Research Award:
Pathogenesis of Measles Virus Infection in Simian
Immunodefiency Virus-Infected, Measles Virus-Vaccinated
Rhesus Monkeys
Sallie R Permar, Children's Hospital and Boston Medical Center, Boston,
MA
1:30pm–3:30pm
5700A—Neonatal Infectious Diseases in
Developing Countries—Part II
PGPR Symposium
Room 3016-3018, Moscone West
Co-Chairs: José Ignacio Santos Preciado, Hospital Infantil de México
Federico Gómez, Mexico City, Mexico; and Mark Schliess,
University of Minnesota, Minneapolis-St. Paul, MN
Target Audience: Researchers and
clinicians interested and/or involved in all aspects of the
study of neonatal infectious disease, in any setting.
The Programme for Global
Paediatric Research (PGPR) includes paediatric researchers,
societies, and other organizations committed to child health.
It was formed in January 2004 to address the disparity between
the scientific research resources available in high-income
countries and the quantity of scientific research focused on
the health of children in mid- and low-income countries. PGPR
works at the centre of a global network to inform, educate,
facilitate international research cooperation and
collaboration, and acts as an advocate for research to improve
the health of all children. This three-part symposium will
focus on the serious problem of neonatal infectious diseases
in developing countries. Parts 1 and 3 will be comprised of
expert presentations providing an overview of the problem,
instances of work that is being done in the area, and
region-specific information. Part 2 will feature platform
presentations from selected abstracts on issues included in
the study of neonatal infectious diseases in developing
countries. At the PGPR workshop on Wednesday, May 3 colleagues
from high-, mid- and low-income countries, who are working in
fields related to neonatal infectious diseases, will meet in
order to examine the critical issues and establish clear plans
for collaborative study and other action. One of the expected
outcomes of the workshop will be a preliminary statement of
research needs and directions related to neonatal infectious
diseases in developing countries.
-
Cutaneous Innate Immunity
Steven B. Hoath, Children's Hospital, Cincinnati, OH
-
Preventing Neonatal Infections
Through Skin Barrier Therapy
Gary L. Darmstadt, Johns Hopkins University, Baltimore, MD
-
Experiences with Neonatal
Infectious Diseases in Low-Income Countries—Uganda
Margaret Nakakeeto, Mulago Hospital, Kampala, Uganda
-
Experiences with Neonatal
Infectious Diseases in Low-Income Countries—Caribbean
Nations
Upton Allen, The Hospital for Sick Children, Toronto, Ontario, Canada
1:45pm–3:45pm
5725—Meet the Red Book Committee: Update on
New Vaccines
PAS/PIDS Hot Topic
Room 3014, Moscone West
Chairs: Sarah S. Long, Drexel University College of Medicine and St.
Christopher’s Hospital for Children, Philadelphia, PA; Larry
K. Pickering, Emory University School of Medicine, Atlanta,
GA; David Kimberlin, University of Alabama, Birmingham, AL;
and Henry Bernstein, Dartmouth Medical School, Lebanon, NH
Target Audience: Primary care
pediatricians, infectious diseases physicians and adolescent
medicine physicians.
Vaccines represent the best
return on investment in health care resources. Currently, this
is a dynamic time for new vaccine development and licensure.
Recent changes in the vaccine schedule include the development
and licensure of new rotavirus vaccines, meningococcal
conjugate vaccines, acellular pertussis vaccines for use in
adolescents, papillomavirus, hepatitis A vaccines for
1-year-olds and a new “combination” vaccines (including
mumps-measles-rubella-varicella). Human papillomavirus vaccine
is expected to be licensed. To update physicians in practice,
the American Academy of Pediatrics will co-sponsor a symposium
on new vaccines, entitled “Red Book Update: New Vaccines”.
Topics to be discussed include
the newly licensed products listed above, as well as new
indications and uses of existing vaccines.
Sponsored jointly by
the Pediatric Infectious Diseases Society and the Pediatric
Academic Societies
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