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Saturday, April 29
8:00am–11:00am
2100—Adult Stem Cells—A Primer for the
Clinician
PAS/ASPHO Mini Course
Room 3014, Moscone West
Chairs: Jakub Tolar, University of Minnesota, Minneapolis, MN; and
Mervin C. Yoder, Jr., Indiana University School of Medicine,
Indianapolis, IN
Target Audience:
Hematologists/oncologists, endocrinologists, basic scientists
and neurologists.
Adult stem cells represent a
technology that is being intensively investigated currently,
and this research may have wide implications for human health.
This mini course will focus on recent research and potential
applications in human health.
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Introduction
Jakub Tolar, University of Minnesota, Minneapolis, MN
Mervin C. Yoder, Indiana
University School of Medicine, Indianapolis, IN
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Multipotent Adult Progenitor
Cell: Hype or Reality?
Catherine M. Verfaillie, University of Minnesota, Minneapolis, MN
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Mesenchymal Stem Cell: Harnessing
the Power of Adult Stem Cells To Repair Tissues
Darwin Prockop, Tulane University Health Science Center, New Orleans,
LA
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Hierarchy of Endothelial
Progenitors in Human Blood and Blood Vessels
David A. Ingram, Indiana University School of Medicine, Indianapolis,
IN
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Cancer Stem Cell: Concept of
Human Leukemic Development
Craig T. Jordan, James P. Wilmot Cancer Center, University of Rochester
School of Medicine, Rochester, NY
Sponsored jointly by
the American Society of Pediatric Hematology/Oncology and the
Pediatric Academic Societies
8:00am–11:00am
2105—Advocacy Training Initiative—Part I
PAS Mini Course
Room 2011, Moscone West
Chairs: Alice A. Kuo, University of California Los Angeles, Los
Angeles, CA; and Philip R. Nader, University of California San
Diego, La Jolla, CA
Target Audience: Pediatric
program directors and attendees interested in advocacy.
Development of advocacy training
experiences is evolving, and there is a national need for
opportunities to bring together residents, faculty, program
directors and community partners to facilitate the development
of this nascent field. After last year’s PAS meeting, the
leadership of the APA Advocacy Training SIG and the AAP
Community Pediatrics Training Initiative agreed to collaborate
to provide a more cohesive conference experience for
participants interested in advocacy training. However, before
training experiences can be developed into residency
curricula, the variety of advocacy skills that can be used to
promote child health should be appreciated. In this part of
the first-ever ATI Conference, we will focus on skill-building
in child advocacy. Through a panel discussion, guest lecturers
and resident presentations on child advocacy projects,
participants will gain skills in various aspects of child
advocacy.
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Welcome
Alice A. Kuo, University of California Los Angeles, Los Angeles, CA
Philip R. Nader, University of
California San Diego, La Jolla, CA
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Advocacy Skills Panel Discussion
— 1–2 residents
— 1–2 community partners
Anda Kuo, University of California San Francisco, San Francisco, CA
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State Legislative Advocacy on
Behalf of Children and Pediatricians–How to be Effective
in Difficult Budget Times
Kris Calvin, American Academy of Pediatrics, California District IX
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Resident Presentations (3
Resident Presentations TBD)
Sponsored jointly by
the APA Advocacy Training SIG, the AAP Community Pediatrics
Training Initiative and the Pediatric Academic Societies
10:30am–12:30pm
2325—General Pediatrics I
PAS Platform Session
Room 2009, Moscone West
Chairs: Howard Bauchner and Cynthia Christy
12:00pm–3:00pm
2500—Advocacy Training Initiative—Part II
PAS Mini Course
Room 2011, Moscone West
Chairs: Alice A. Kuo, University of California Los Angeles, Los
Angeles, CA; and Philip R. Nader, University of California San
Diego, La Jolla, CA
Target Audience: Pediatric
program directors and attendees interested in advocacy.
Building upon the Child Advocacy
Skills in Part I of the ATI Conference, Part II will now focus
on how to incorporate these skills into meaningful residency
curricular experiences. Pediatric residents are increasingly
committed to promoting child health in arenas other than the
pediatric exam room. Programs are being called upon to provide
structured curricular experiences for residents in child
advocacy, and these experiences may build upon existing
curricula in community pediatrics or be completely separate.
New avenues for partnerships between pediatric residency
programs and community agencies can occur as a result of child
advocacy rotations or projects. This part of the conference
will give participants new ideas for child advocacy training
experiences, address the how-tos on a shoestring budget, and
present ideas for evaluating your community/advocacy
curriculum.
Please join us for the Advocacy
Training SIG from 3:15-5:15pm immediately following the
Advocacy Training Initiative.
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Welcome
Alice A. Kuo, University of California Los Angeles, Los Angeles, CA
Philip R. Nader, University of
California San Diego, La Jolla, CA
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Different Forms of Advocacy
Training Curricular Experiences
David M. Keller, University of Massachusetts Medical School, Worcester,
MA
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Implementing a Required Child
Advocacy Rotation with No Budget
Sanjeev Kumar Sriram, University of California Los Angeles, Los
Angeles, CA
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Evaluating Community/Advocacy
Educational Experiences
Jeffrey M. Kaczorowski, University of Rochester, Strong Memorial
Hospital, Rochester, NY
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Resident Poster Session
Sponsored jointly by
the APA Advocacy Training SIG, the AAP Community Pediatrics
Training Initiative and the Pediatric Academic Societies
12:00pm–3:00pm
2505—Embryonic Stem Cells: A Primer for
Clinicians
PAS Mini Course
Room 3014, Moscone West
Chair: Michael T. Longaker, Stanford University, Stanford, CA
Embryonic stem cells offer
incredible promise for treating diseases affecting both
children and adults. This mini course will provide an overview
of stem cells and a basic understanding of how to derive human
embryonic stem cells, recent research and ethical
considerations. After attending this session, attendee will
have a better understanding of: 1) what are embryonic stem
cells; 2) how human embryonic stem cells are derived; 3)
recent progress in human embryonic stem cell research; 4)
ethical considerations in human embryonic stem cells.
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Stem Cells: Embryonic, Adult and
Cancer
Michael T. Longaker, Stanford University, Stanford, CA
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What It Takes Clinically To Get
an Embryonic Stem Cell
Linda C. Giudice, University of California, San Francisco, San
Francisco, CA
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What Can You Do with an Embryonic
Stem Cell in Research
Renee Reijo Pera, University of California, San Francisco, San
Francisco, CA
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Ethical and Oversight
Considerations in Human Embryonic Stem Cell Research
Hank Greely, Stanford University, Stanford, CA
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Panel Discussion
Supported in part by an unrestricted educational grant from
Treuman Katz Center for Pediatric Bioethics - Seattle
Children's Hospital
12:00pm–3:00pm
2520—Pediatric Assessment of Sexual Abuse:
State of the Science 2006
PAS Mini Course
Room 3011, Moscone West
Chair: Vince Palusci, Wayne State University School of Medicine,
Hospital of Michigan, Detroit, MI
This three-hour mini course will
address the medical evaluation of child sexual abuse in the
pediatric setting. The topics that will be addressed are:
– Physical sequelae of sexual
abuse: What’s new and how has the literature of the past 10
years shaped this field.
– Medical conditions that mimic sexual abuse: What a
clinician must know about anogenital medical conditions and
congenital findings.
– Sexually transmitted diseases in children: Beyond
cultures, DNA amplification techniques in children and the
newest recommendations for HIV post assault prophylaxis will
be presented.
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Overview
Vincent J. Palusci, Wayne State University School of Medicine, Hospital
of Michigan, Detroit, MI
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Interpretation of Medical
Findings in Suspected Child Sexual Abuse: Update 2006
Joyce Adams, University of California San Diego Medical Center, San
Diego, CA
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Mimics of Sexual Abuse
Lori Frasier, University of Utah School of Medicine, Salt Lake City UT
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Sexually Transmitted Diseases in
Children: Beyond Cultures, DNA Amplification Technology
Nancy Denny Kellogg, University of Texas San Antonio, San Antonio, TX
1:00pm–3:00pm
2615—Injury Prevention I
PAS Platform Session
Room 2006, Moscone West
Chairs: Elizabeth A. Edgerton-Gabriele and Robert J. Vinci
5:15pm–7:15pm
Poster Session I and PAS Opening Reception
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
4:00pm–7:30pm
Author Attendance: 5:15pm–7:15pm
Level 1:
– Developmental Biology
– Endocrinology
– Hematology–Oncology
– Neonatal Infectious Diseases
– Neonatology
– Nephrology
Level 2:
– Cardiology
– Developmental–Behavioral Pediatrics
– General Pediatrics
– Medical Education
– Neurology
Includes:
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SPR Student Research Award:
Resuscitation of Non-Viable Infants: Will
Neonatologists[apos] Practice Change After the Born-Alive
Infant Protection Act?
Mya Sendowski, University of California, San Francisco, CA
Sunday, April 30
8:00am–10:00am
3140—General Pediatrics II
PAS Platform Session
Room 2007, Moscone West
Chairs: Christine L. Johnson and Elisa A. Zenni
8:00am–11:00am
3200—Sports Medicine—Caring for the Young
Athlete
PAS/APPD Mini Course
Room 2008, Moscone West
Chair: Robert S. McGregor, St. Christopher's Hospital for Children,
Philadelphia, PA
"Sports medicine, not a
matter of life and death…it’s much more important than
that” is a bit overstated. However, some estimates suggest
pediatricians in training receive little more than 5 hours of
clinical training. This creates a generation of pediatric
clinicians and pediatric educators who didn't get it.
We suggest the time has come for
a mini course designed to address some basic concepts, as well
as more current controversial areas to attempt to catch-up the
contemporary pediatrician, and to provide a curricular base
for the pediatric educator.
Topics will include: the female
athlete, ergogenic substance use and abuse and current medical
issues including concussion guidelines. The course will
conclude with case discussions combined with live video
projection of pertinent physical examination techniques.
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Overview
Robert S. McGregor, St. Christopher's Hospital for Children,
Philadelphia, PA
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Female Athlete Issues
Jordan Daniel Metzl, Hospital for Special Surgery, New York, NY
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Ergogenic Substance Use, Abuse
and Cases
Cynthia Rose LaBella, Institute for Sports Medicine, Children's
Memorial Hospital, Chicago, IL
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Medical Considerations and
Concussion Management
Rani S. Gereige, University of South Florida/ All Childrens' Hospital,
St. Petersburg, FL
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Selected Sports Medicine Cases
with Video Feed
Rani S. Gereige, University of South Florida/ All Childrens' Hospital,
St. Petersburg, FL
Robert S. McGregor, St. Christopher's Hospital for
Children, Philadelphia, PA
Cynthia Rose LaBella, Institute for Sports Medicine,
Children's Memorial Hospital, Chicago, IL
Jordan Daniel Metzl, Hospital for Special Surgery, New
York, NY
Sponsored jointly by
the Association of Pediatric Program Directors and the
Pediatric Academic Societies
2:00pm–5:00pm
3780—Child Abuse
APA Special Interest Group
Room Pacific Suite I, SF Marriott
Chair: Cindy Christian, christian@email.chop.edu.
Greetings once again from
Philadelphia, Pennsylvania. Again this year, the Child Abuse
SIG is being co-sponsored by the AAP section on child abuse.
I’d like to thank my friends at the AAP for their time and
assistance. I am very excited about the program that is coming
together and invite everyone to join us for interesting
learning and conversation.
We will start our session with a
presentation by Jordan Greenbaum, MD, on the clinical
presentation, pathology and pathophysiology of asphyxiation. I
have heard her present on the topic, and I am sure we will all
learn a great deal from her presentation. After a short, but
always welcome break, we will focus on a topic that is
important but not often discussed among child abuse
physicians—the issue of neonatal drug exposure, screening
and child welfare involvement. We will have a panel
presentation, followed by an open discussion of approaches and
controversies. Finally, we will continue to offer young
physicians (and those young at heart) an opportunity to
present research. Please join us for good conversation and
learning. And feel free to email me (Christian@email.chop.edu)
with any ideas or suggestions. See you back In San Francisco!
Co-sponsored with the
AAP Section on Child Abuse
4:15pm–5:45pm
3805—Fetal Homeland Security: New Insights
into Old Threats
PAS State of the Art Plenary
Room 3002-3008, Moscone West
Chairs: Phil W. Shaul, University of Texas Southwestern Medical Center,
Dallas, TX; and Rashmin C. Savani, University of Texas
Southwestern Medical Center, Dallas, TX
Target Audience: Neonatologists,
pediatricians and researchers interested in perinatal biology.
In addition to premature birth,
there are a select number of maternal conditions that have
marked negative impact on the well being of the fetus and
newborn. This symposium will highlight recent advances in our
understanding of these classical threats to our most
vulnerable pediatric patient population.
First, new knowledge of the
mechanisms by which maternal diabetes alters embryonic and
fetal development will be discussed. Second, the newly
discovered role of circulating anti-angiogenic proteins of
placental origin in the pathogenesis of preeclampsia will be
presented. Finally, novel mechanisms by which biochemical
events in the fetal lung trigger the initiation of labor will
be discussed. Further advances in each of these realms will
ultimately lead to new therapies to protect the fetus and
yield healthy outcomes at term.
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Mechanisms by Which Maternal
Diabetes Modifies Embryonic and Fetal Development
Kelle H. Moley, Washington University School of Medicine, St. Louis, MO
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Role of Circulating Anti-angiogenic
Proteins of Placental Origin in the Pathogenesis of
Preeclampsia
S. Ananth Karumanchi, Harvard Medical School, Beth Isreal Deaconess
Medical Center, Boston, MA
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Fetal–Maternal Signaling in the
Initiation of Labor
Carole R. Mendelson, University of Texas Southwestern Medical Center,
Dallas, TX
4:15pm–5:45pm
3810—RNA Interference, Technological
Development of siRNAs and Potential Treatments for Childhood
Diseases
PAS State of the Art Plenary
Room 3016-3018, Moscone West
Chair: R. Alan B. Ezekowitz, Harvard Medical School, Massachusetts
General Hospital, Boston, MA
Target Audience: Basic scientists
studying a broad range of childhood diseases, translational
scientists of all disciplines studying clinical implications
of basic science research, clinical scientists studying
childhood and other diseases in need of improved therapies and
clinicians interested in cutting-edge science and its medical
implications.
RNA interference is a recently
discovered, naturally occurring intracellular process that
regulates gene expression through the silencing of specific
mRNAs. Methods of harnessing this natural pathway are being
developed that allow the catalytic degradation of targeted
mRNAs using specifically designed complementary small
inhibitory RNAs (siRNA). siRNAs are being chemically modified
to acquire drug-like properties. Numerous recent high-profile
publications have provided proofs of concept that RNA
interference may be useful therapeutically. Much of the design
of these siRNAs can be accomplished bioinformatically, thus
potentially expediting drug discovery and opening new avenues
of therapy for many childhood diseases including uncommon
pediatric and orphan diseases. A discussion of the science
behind RNA interference will be followed by a presentation of
the potential practical issues in applying this technology to
disease. The program then describes two therapeutic programs
currently under way with applications to pediatric diseases. A
question-and-answer time will follow each discussion.
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The Science of RNA Interference
John J. Rossi, Beckman Research Institute of City of Hope, Duarte, CA
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RNA Interference and Its
Potential Applications for Controlling Disease
Judy Lieberman, CBR Institute for Biomedical Research and Harvard
Medical School, Boston, MA
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Silencing the VEGF Pathway with
siRNAs and the Potential Application to Retinopathy of
Prematurity
Pamela Pavco, Sirna Therapeutics, Boulder, CO
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siRNA as Therapy for Respiratory
Syncytial Virus
John P. DeVincenzo, University of Tennessee School of Medicine,
Memphis, TN
4:15pm–6:15pm
3860—Injury Prevention II
PAS Platform Session
Room 2007, Moscone West
Chairs: Brian D. Johnston and Mary C. Pierce
Monday, May 1
9:00am–12:00pm
4252—Injury Control
APA Special Interest Group
Room Pacific Suite A, SF Marriott
Chairs: Shari Barkin, sbarkin@wfubmc.edu; and Brian Johnston, bdj@u.washington.edu.
The Injury Control SIG convenes
those individuals interested in the area of injury control at
all stages of idea development and project implementation.
During this session you will hear reports about what your
colleagues are doing around the country in injury control.
There will be time for constructive discussion after each of
these brief presentations. We will also discuss ways to create
an active network to stay informed about our colleagues areas
of injury expertise and develop working collaborations beyond
the annual meeting.
10:15am–12:15pm
4335—General Pediatrics III
PAS Platform Session
Room 2008, Moscone West
Chairs: Charles Feild and Lydia M. Furman
5:15pm–6:45pm
Poster Session III
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
12:00pm–6:45pm
Author Attendance: 5:15pm–6:45pm
Level 1:
– Critical Care
– Gastroenterology
– Genetics
– Neonatal Epidemiology and Follow Up
– Neonatal Pulmonology
– Neonatology
– Nephrology
– Pulmonology
Level 2:
– Developmental–Behavioral Pediatrics
– Emergency Medicine
– General Pediatrics
– Medical Education
Tuesday, May 2
8:00am–10:00am
5100—Ethical Issues in Housing Health
Hazard Research Involving Children
PAS Topic Symposium
Room 2003-2005, Moscone West
Chair: Bernard Lo, University of California San Francisco, San
Francisco, CA
Target Audience: A broad
pediatric audience with the goal of promoting understanding of
ethical issues in conducting community-based research,
especially housing hazard research.
Children’s homes may contain
hazards that can cause lead toxicity, trigger asthma or result
in serious injuries or poisoning. A 2001 court decision, in
Grimes versus Kennedy Krieger Institute, highlighted ethical
issues in housing-related research and led to substantial
controversy and confusion. Many ethical dilemmas occur because
research participants are often poor, members of a minority
group and have few affordable housing options. Moreover,
carrying out research in the home raises unique ethical
issues. A forthcoming report from National Academies of
Science (NAS) will offer recommendations for conducting
research on this topic. This panel will present these NAS
recommendations and discuss how they might be applied to
specific projects in housing research involving children.
Specific issues to be discussed include innovations in
research design and informed consent, responding to risks
observed in the home, the role of researchers and IRBs and
community involvement in research. Audience participation will
be encouraged.
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Recommendations from the National
Academies of Science
Bernard Lo, University of California San Francisco, San Francisco, CA
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Protecting Vulnerable Research
Participants While Allowing Valuable Research To Be
Carried Out
Alan R. Fleischman, Chair, National Children's Study Federal Advisory
Committee, New York Academy of Medicine, New York and
National Institutes of Health, Bethesda,
MD
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Innovations in Study Design and
Informed Consent in Housing Hazard Research Involving
Children
Bruce P. Lanphear, Cincinnati Children's Environmental Health Center,
Cincinnati Children’s Hospital Medical Center,
Cincinnati, OH
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Resolving Ethical Dilemmas in
Housing Hazard Research Through Community Participation
Brenda Eskenazi, University of California Berkeley, Berkeley CA
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Discussion
12:00pm–1:30pm
Poster Session IV
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
10:00am–2:00pm
Author Attendance: 12:00pm–1:30pm
Level 1:
– Adolescent Medicine
– Emergency Medicine
– Epidemiology
– General Pediatrics
– Infectious Diseases
– Neonatal Epidemiology and Follow Up
Level 2:
– Neonatal Pulmonology
– Neonatology
Includes
:
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SPR Student Research Award: Metal
Contamination of Blood Bank Blood
Allison Blatz, Case Western Reserve University, Rainbow Babies &
Children's Hospital, Cleveland, OH
12:00pm–1:30pm
—Poster Session IV
PAS Poster Session
Room Levels 1 and 2, Moscone West
Includes
Posters Available for Viewing:
10:00am–2:00pm
Author Attendance: 12:00pm–1:30pm
Level 1:
– Adolescent Medicine
– Emergency Medicine
– Epidemiology
– General Pediatrics
– Infectious Diseases
– Neonatal Epidemiology and Follow Up
Level 2:
– Neonatal Pulmonology
– Neonatology
Includes:
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SPR House Officer Research Award:
Pathogenesis of Measles Virus Infection in Simian
Immunodefiency Virus-Infected, Measles Virus-Vaccinated
Rhesus Monkeys
Sallie R Permar, Children's Hospital and Boston Medical Center, Boston,
MA
1:45pm–3:45pm
5750—General Pediatrics V
PAS Platform Session
Room 3001, Moscone West
Chairs: Paul M. Darden and David P. McCormick
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