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Friday, April 28
5:00pm–6:00pm
1610A—Thrombosis—Going with the Flow:
Anticoagulation Issues in Children with Congenital Heart
Disease
ASPHO Workshop
Golden Gate Hall B2-3, SF Marriott
Chairs: Patricia Massicotte, University of Alberta Hospital, Edmonton,
AB, Canada; and Lori Luchtman-Jones, Washington University,
St. Louis, MO
Warfarin is commonly used in
children with congenital heart disease (CHD). There are many
challenges with the use of this anticoagulant in children.
Ultimate dosing depends on the individuals genetic
composition. Child-focused education on warfarin will improve
compliance, efficacy and safety. The hematologist with
expertise in anticoagulation can provide child-focused
education on anticoagulation and offer the cardiovascular team
management solutions for managing the complex issues
associated with anticoagulation in children with CHD.
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Case Study and Discussion
Therese Giglia, Schneider Children's Hospital, New Hyde Park, NY
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Child-Focused Education Package:
Warfarin
Mary Bauman, Stollery Children's Hospital, Edmonton, AB, Canada
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Pharmacogenomics of Warfarin
Lori Luchtman-Jones, Washington University, St. Louis, MO
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Keep the Flow: Hematologists as
Part of the Cardiovascular Team in Children with
Congenital Heart Disease
Therese Giglia, Schneider Children's Hospital, New Hyde Park, NY
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Panel Discussion
Saturday, April 29
8:00am–11:00am
2100—Adult Stem Cells—A Primer for the
Clinician
PAS/ASPHO Mini Course
Room 3014, Moscone West
Chairs: Jakub Tolar, University of Minnesota, Minneapolis, MN; and
Mervin C. Yoder, Jr., Indiana University School of Medicine,
Indianapolis, IN
Target Audience:
Hematologists/oncologists, endocrinologists, basic scientists
and neurologists.
Adult stem cells represent a
technology that is being intensively investigated currently,
and this research may have wide implications for human health.
This mini course will focus on recent research and potential
applications in human health.
-
Introduction
Jakub Tolar, University of Minnesota, Minneapolis, MN
Mervin C. Yoder, Indiana
University School of Medicine, Indianapolis, IN
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Multipotent Adult Progenitor
Cell: Hype or Reality?
Catherine M. Verfaillie, University of Minnesota, Minneapolis, MN
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Mesenchymal Stem Cell: Harnessing
the Power of Adult Stem Cells To Repair Tissues
Darwin Prockop, Tulane University Health Science Center, New Orleans,
LA
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Hierarchy of Endothelial
Progenitors in Human Blood and Blood Vessels
David A. Ingram, Indiana University School of Medicine, Indianapolis,
IN
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Cancer Stem Cell: Concept of
Human Leukemic Development
Craig T. Jordan, James P. Wilmot Cancer Center, University of Rochester
School of Medicine, Rochester, NY
Sponsored jointly by
the American Society of Pediatric Hematology/Oncology and the
Pediatric Academic Societies
8:00am–11:00am
2125—New Considerations for the Growth Rate
of the Preterm Infant: Too Fast or Not Fast Enough?—A Review
of the Evidence
PAS Mini Course
Room 3002-3008, Moscone West
Chairs: Frank R. Greer, University of Wisconsin, Madison, WI; and
William W. Hay, Jr., University of Colorado, Aurora, CO
Target Audience: Neonatologists,
hospitalists who take care of preterm infants, nutritionists
and general pediatricians.
Recent nutritional emphasis in
the NICU has been to achieve the normal intrauterine growth
rate with more aggressive nutritional support for the low
birth weight infant. In general, this has been difficult to
achieve, and new evidence from long-term follow up studies
shows that preterm infants are at an increased risk of
developing the metabolic syndrome including obesity, type 2
diabetes and cardiovascular disease. This implies that the
organs in the early life of the preterm infant may be
programmed adversely by nutritional therapy. This raises the
questions of how fast these infants should grow (including
catch up growth), the importance of the composition of this
growth and the urgency for defining the necessary balance
between growth of the brain and the rest of the body.
Ultimately, providers may want to revise the long-term and
short-term goals for feeding very low birth weight or
extremely low birth weight infants. This mini course will
present evidence to help answer these questions and provide
discussion about related practice recommendations.
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Overview
Frank R. Greer, University of Wisconsin, Madison, WI
William W. Hay, University of
Colorado Health Sciences Center, Aurora, CO
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Macronutrient Requirements for
Growth of Preterm Infants—Upper and Lower Limits
(Energy, Fat, CHO, Protein)
Scott C. Denne, Indiana University School of Medicine, James Whitcomb
Riley Hospital, Indianapolis, IN
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Aggressive Nutritional Support of
the Preterm Infant Revisited—Evidence for Efficacy and
Safety
Patti J. Thureen, University of Colorado Health Sciences Center,
Denver, CO
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Adverse Outcomes of Rapid Somatic
Growth and Alterations of Body Composition in the Low
Birth Weight Infant
Frank R. Greer, University of Wisconsin, Madison, WI
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Fatty Acids and Neuronal
Development
Susan E. Carlson, University of Kansas Medical Center, Kansas City, KS
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Iron and Development of the Brain
Michael K. Georgieff, University of Minnesota School of Medicine,
Minneapolis, MN
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Nutritional Influences on
Structural and Functional Maturation of the Developing
Brain During Extended Postnatal Period
Steve H. Zeisel, The University of North Carolina, Chapel Hill, NC
8:00am–11:00am
2130—Newborn Hearing Screening: From the
Bedside to Beyond
PAS/PIDS Mini Course
Room 3010, Moscone West
Chairs: Mark R. Schleiss and Lisa Ann Schimmenti, University of
Minnesota Medical School, Minneapolis, MN
Target Audience: General
pediatricians, geneticists and infectious disease specialists.
Sensorineural hearing loss (SNHL)
in infants is the most common birth defect, and early
detection improves outcome. Evidence from the CDC reveals that
less than one half of screened babies are followed up. One
possible reason is the low positive predictive value of
bedside screening. There is a critical need to augment current
strategies to prevent late diagnosis of SNHL. One solution is
to propose second-tier testing for the most common causes of
SNHL, as the most common causes of newborn hearing loss are
infectious and genetic. Of infectious causes, cytomegalovirus
(CMV) is the most common. Evidence of CMV infection can be
found in 1% of newborns, with 10–15% developing hearing loss
or other CNS abnormalities. Of the genetic causes, mutations
in GJB2/GJB6 are the most common and are identified in up to
one half of individuals with SNHL. The goal of this program
will be to examine evidence for inclusion of infectious and
genetic screening to augment current newborn screening
protocols.
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Diagnostic Evaluation and
Management of Childhood Hearing Loss
Margaret Alene Kenna, Children's Hospital Boston, Boston, MA
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Range of Mutations in
GJB2-Associated Hearing Loss
Lisa Ann Schimmenti, University of Minnesota Medical School,
Minneapolis, MN
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Congenital Cytomegalovirus
Infection and Hearing Loss
Karen B. Fowler, University of Alabama at Birmingham, Birmingham, AL
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Newborn Hearing Screening:
Audiologic Assessment
Yvonne Sininger, University of California Los Angeles, Los Angeles, CA
Sponsored jointly by
the Pediatric Infectious Diseases Society and the Pediatric
Academic Societies
9:00am–11:00am
2196—Modulators of Bronchopulmonary
Dysplasia
PAS Platform Session
Room 3003-3005, Moscone West
Chairs: Suhas G. Kallapur and Lawrence M. Nogee
Supported by an unrestricted educational grant from Dey,
L.P.
10:30am–12:30pm
2315—Brain Metabolism and Injury:
Mechanisms of Neuronal Injury and Neuroprotection
PAS Poster Symposium
Room 3024, Moscone West
Chairs: John D.E. Barks and Jeremy D. Marks
10:30am–12:30pm
2340—Necrotizing Enterocolitis
PAS Platform Session
Room 3022, Moscone West
Chairs: Cheryl E. Gariepy and B U.K. Li
12:00pm–3:00pm
2505—Embryonic Stem Cells: A Primer for
Clinicians
PAS Mini Course
Room 3014, Moscone West
Chair: Michael T. Longaker, Stanford University, Stanford, CA
Embryonic stem cells offer
incredible promise for treating diseases affecting both
children and adults. This mini course will provide an overview
of stem cells and a basic understanding of how to derive human
embryonic stem cells, recent research and ethical
considerations. After attending this session, attendee will
have a better understanding of: 1) what are embryonic stem
cells; 2) how human embryonic stem cells are derived; 3)
recent progress in human embryonic stem cell research; 4)
ethical considerations in human embryonic stem cells.
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Stem Cells: Embryonic, Adult and
Cancer
Michael T. Longaker, Stanford University, Stanford, CA
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What It Takes Clinically To Get
an Embryonic Stem Cell
Linda C. Giudice, University of California, San Francisco, San
Francisco, CA
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What Can You Do with an Embryonic
Stem Cell in Research
Renee Reijo Pera, University of California, San Francisco, San
Francisco, CA
-
Ethical and Oversight
Considerations in Human Embryonic Stem Cell Research
Hank Greely, Stanford University, Stanford, CA
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Panel Discussion
Supported in part by an unrestricted educational grant from
Treuman Katz Center for Pediatric Bioethics - Seattle
Children's Hospital
12:30pm–2:30pm
2540—Neonatal Infections
PAS Platform Session
Room 3003-3005, Moscone West
Chairs: Henrietta S. Bada and Jill E. Baley
1:00pm–3:00pm
2610—Genetics and Epigenetics of Neonatal
Disease
PAS Platform Session
Room 3022, Moscone West
Chairs: Aaron Hamvas and Jeffrey C. Murray
1:00pm–3:00pm
2630—Neurology
PAS Platform Session
Room 3020, Moscone West
Chairs: Anne M. Comi and Yvonne W. Wu
1:00pm–3:00pm
2635—Respiratory Mechanics at the
Bedside—NICU
PAS Platform Session
Room 3002-3008, Moscone West
Chairs: Robert E. Fleming and Howard W. Kilbride
2:15pm–5:15pm
2700—Educating Pediatric Fellows in a
Competency-Based World
PAS/APPD Mini Course
Room 2007, Moscone West
Chairs: Susan Guralnick, Stony Brook University Medical Center, Stony
Brook, NY; and Joseph Gilhooly, Oregon Health and Science
University, Portland, OR
Target Audience: Attendees
involved with fellowship programs.
Competency-based education is now
the standard for residency education. Residency programs have
integrated the ACGME Core Competencies into their curricula
and assessment methods. It is now time for fellowships to
enter the “competency” arena, and there is much to be
accomplished. This program will focus on several areas of
fellowship education including: the new RRC common
requirements for subspecialty training, development of a
competency-based fellowship curriculum, competency-based
assessment tools, and pediatric subspecialty fellows as
teachers. Attendees are encouraged to bring tools and ideas
for discussion and development. Attendees should leave with
useful materials to bring back to their home programs.
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Overview
Susan Guralnick, Stony Brook University Medical Center, Stony Brook, NY
Joseph Gilhooly, Oregon Health
& Science University, Portland, OR
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A Brave New World! New Common
Requirements for Subspecialty Training—Implementing the
Competencies
Carol Carraccio, Professor of Pediatrics and Associate Chair for
Education, University of Maryland School of Medicine,
Baltimore, MD
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"Survivor ACGME"—Fellowship
Competencies in Action
Joseph Gilhooly, Oregon Health & Science University, Portland, OR
John D. Mahan, Children’s
Hospital, The Ohio State University, Columbus, OH
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Turning to Fellows as Teachers:
From Curricula to Evaluation
Nancy D. Spector, St. Christopher's Hospital for Children,
Philadelphia, PA
Susan Guralnick, Stony Brook
University Medical Center, Stony Brook, NY
Sponsored jointly by
the Association of Pediatric Program Directors and the
Pediatric Academic Societies
Supported by an unrestricted
educational grant from Dey, L.P.
3:15pm–5:15pm
2725—Integrating Genetic Susceptibility and
Environmental Influences in Pediatric Research
PAS Topic Symposium
Room 2008, Moscone West
Chair: Bruce P. Lanphear, Cincinnati Children's Environmental Health
Center, Cincinnati Children’s Hospital Medical Center,
Cincinnati, OH
Target Audience: A broad
pediatric audience with the goal of promoting
interdisciplinary understanding and greater integration of
genetic and environmental research.
Asthma, preterm birth, ADHD and
other prevalent pediatric conditions are widely recognized to
result from interactions of environmental influences and
genetic susceptibility. Tremendous progress has been made in
measuring both environmental and genetic risk factors.
Increasingly, researchers are moving beyond ecological methods
(e.g., questionnaires, air monitoring) to directly measure in
humans hundreds of environmental chemicals, from nicotine to
metals to DDT and phthalates. Similarly, unprecedented
innovation has led rapidly to high-throughput methods that
assess DNA variation across large cohorts. New
interdisciplinary collaborations that integrate state of the
art approaches to both environmental and genetic influences
should greatly improve our ability to predict and prevent
disease and disability. Such studies will be critical for
understanding mechanistic pathways, defining susceptible
subpopulations and developing effective interventions. This
session will provide an overview of gene–environment
research, describe recent advances in biomarkers of
environmental exposure and review new methods for measuring
genetic variability.
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Gene–Environment Interaction in
Common Pediatric Conditions: Conceptual Overview and
Recent Evidence
Robert S. Kahn, Cincinnati Children’s Hospital Medical Center,
University of Cincinnati College of Medicine, Cincinnati,
OH
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Advances in Biomarkers of
Environmental Exposure in Pediatric Research
Bruce P. Lanphear, Cincinnati Children's Environmental Health Center,
Cincinnati Children’s Hospital Medical Center,
Cincinnati, OH
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Measuring Genetic Susceptibility
to the Environment: Study Designs and Genotyping Methods
Robert O. Wright, Harvard Children's Environmental Health Center,
Boston Children's Hospital and the Harvard School of
Public Health, Boston, MA
3:15pm–5:15pm
2730—Mechanisms of Hypertension in the
Molecular Era
PAS/ASPN/IPHA/LWPES Topic Symposium
Room 2003-2005, Moscone West
Chairs: Bruce Z. Morgenstern, Phoenix Children's Hospital, Phoenix, AZ;
and Julie R. Ingelfinger, Massachusetts General Hospital,
Boston, MA
Target Audience: General
pediatricians, nephrologists, endocrinologists and
neonatologists.
Our understanding of the
pathophysiology of hypertension has been changing rapidly due
to advances in molecular genetics, most notably the
identification of several single-gene defects that cause
hypertension. This session will update participants on the
latest advances in our knowledge of molecular mechanisms of a
variety of forms of hypertension.
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Role of Dopamine Receptors
Pedro A. Jose, Georgetown University Medical Center, Washington, DC
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Perinatal Programming and the
Development of Hypertension
Lori Woods, Oregon Health & Science University, Portland, OR
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Low Renin Hypertension in
Childhood
Maria I. New, Mount Sinai School of Medicine, New York, NY
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WNK Kinases and Blood Pressure
Regulation
Richard Lifton, Yale University School of Medicine, New Haven, CT
Sponsored jointly by
the American Society of Pediatric Nephrology, the
International Pediatric Hypertension Association, the Lawson
Wilkins Pediatric Endocrine Society and the Pediatric Academic
Societies
3:15pm–5:15pm
2751—Neonatal Fetal Nutrition and
Metabolism I
PAS Platform Session
Room 3022, Moscone West
Chairs: David H. Adamkin and Ronnie Guillet
3:15pm–5:15pm
2753—Neonatal Infectious Diseases
PAS/PIDS Poster Symposium
Room 3003-3005, Moscone West
Chairs: Deborah A. Lewinsohn and John V. Williams
3:15pm–5:15pm
2755—Neonatal Medicine: Clinical Trials I
PAS Platform Session
Room 3002-3008, Moscone West
Chairs: Namasivayam Ambalavanan and Reese H. Clark
3:15pm–5:15pm
2757—Nutrition and Behavior
PAS Poster Symposium
Room 3024, Moscone West
Chairs: Conrad R. Cole and Timothy A. Sentongo
3:15pm–5:15pm
2768—So You Want To Do International
Research?
PAS Educational Workshop
Golden Gate Hall B1, SF Marriott
Leader: Linda Wright, Rockville, MD; Co-leaders: Jose Belizan, Waldemar
Carlo, Jeanne McDermott, Elizabeth McClure and Cyril Engmann
Target Audience: Trainees,
fellows, junior faculty, and mid-level faculty.
Almost all (99%) of maternal and
infant deaths worldwide occur in low and middle-income
countries. Conducting research in these countries has many
rewards and challenges, which are often daunting for
investigators trying to apply for NIH support. This workshop
will describe the process of applying for research support
from NIH, how review is done and funding decisions made, how
to enhance the likelihood of success and NIH's priorities for
research. We will also discuss the design and conduct of
studies in these settings, how to identify appropriate partner
countries and collaborate with local investigators and
government organizations as well as how to address three
important areas for international research, strengthening
local research capacity, scaling up proven interventions, and
facilitating sustainability.
Objectives:
– To increase participants
understanding of issues related to the design and
implementation of clinical trials in low and middle-income
countries
– To increase participants skills in writing a protocol for
research in another country
– To increase participants knowledge of funding
opportunities for research in low and middle-income countries
Format: The format will be
didactic presentations with extensive question-and-answer
session.
3:45pm–5:15pm
2790A—Hyperthyroidism
LWPES Workshop
Room 3000, Moscone West
Chair: Scott A. Rivkees, Yale School of Medicine, New Haven, CT
Target Audience: Generalists.
Much controversy exists about the
most effective and safest treatments for hyperthyroidism in
children. This workshop will clarify some of the newer
evidence based approaches to the diagnosis and management of
hyperthyroidism, with a special emphasis on radioactive
ablation.
3:45pm–5:15pm
2795A—Neonatal Diabetes
LWPES Workshop
Room 3001, Moscone West
Chair: Mark A. Sperling, Children's Hospital of Pittsburgh, Pittsburgh,
PA
Target Audience: Endocrinologists
and neonatologists.
Over the past few years much has
been learned about the pathogenesis of neonatal diabetes. This
workshop will impart knowledge on important considerations in
the diagnosis and work-up of this rare condition.
4:00pm–7:30pm
Commercial Exhibits Open and Posters
Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West
Posters Available for Viewing:
4:00pm–7:30pm
Author Attendance: 5:15pm–7:15pm
Level 1:
– Developmental Biology
– Endocrinology
– Hematology–Oncology
– Neonatal Infectious Diseases
– Neonatology
– Nephrology
Level 2:
– Cardiology
– Developmental–Behavioral Pediatrics
– General Pediatrics
– Medical Education
– Neurology
5:15pm–7:15pm
Poster Session I and PAS Opening Reception
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
4:00pm–7:30pm
Author Attendance: 5:15pm–7:15pm
Level 1:
– Developmental Biology
– Endocrinology
– Hematology–Oncology
– Neonatal Infectious Diseases
– Neonatology
– Nephrology
Level 2:
– Cardiology
– Developmental–Behavioral Pediatrics
– General Pediatrics
– Medical Education
– Neurology
Includes:
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SPR Student Research Award:
Resuscitation of Non-Viable Infants: Will Neonatologists'
Practice Change After the Born-Alive Infant Protection
Act?
Mya Sendowski, University of California, San Francisco, CA
7:15pm–8:30pm
2960A—Neonatal Hemodynamics Club
Club
Golden Gate Hall A1-3, SF Marriott
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Relative Adrenal Insufficiency in
the Preterm and Term Infant
Kristi L. Watterberg, University of New Mexico Health Sciences Center,
Albuquerque, NM
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Cardiac Function and Its
Relationship to Serum Cortisol, Inflammation, Pulmonary
Acuity and Hydrocortisone Therapy in Sick ELBW Infants
Cynthia H. Cole, Harvard Medical School, Boston, MA
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Discussion
Istvan Seri, MD, PhD
Children’s Hospital Los Angeles, University of Southern
California
Phone: 323-669-5932
Email: iseri@chla.usc.edu
Supported by an unrestricted educational grant from Dey LP
Sunday, April 30
6:00am–8:00am
Surfactant Therapy—Where Are We and Where
Do We Go from Here?
PAS Industry Sponsored Symposium
Yerba Buena Gardens Salon 8, SF Marriott
Target Audience: Neonatologists.
Respiratory distress syndrome (RDS)
results from insufficient levels of endogenous surfactant.
Surfactant therapy, when used as treatment or prophylaxis,
significantly reduces morbidity and mortality. New synthetic
protein-containing products promise to emerge soon as a viable
therapeutic strategy in the prevention of RDS. Neonatologists
and other pediatric health care professionals need to have a
thorough and up-to-date understanding of current and emerging
products to make the most informed clinical decisions for
their patients.
This symposium will focus on the
current role of exogenous surfactant therapy in neonatology.
Speakers will review the composition and function of this
class of compounds. Faculty also will discuss the clinical
status of current animal-derived and future protein-containing
synthetic surfactant therapies, including comparative trials
and meta-analyses, as well as studies of various ventilation
strategies in conjunction with surfactant therapy.
Additionally, speakers will describe potential new
applications of surfactant therapy.
For information please contact:
(Please note that pre-registration is not required)
Danielle Krasny
Phone: (215) 860-2202
Email: danielle.krasny@thomson.com
This activity is
jointly sponsored by Thomson Professional Postgraduate Service
and Thomson Scientific Connexions
Supported
by a grant from Discovery Laboratories, Inc.
7:00am–8:00am
3045—Neonatology:
There Are Many Ways to Get to Rome (or Omaha or…)
PAS Meet the Professor
Yerba Buena Gardens Salon 10, SF Marriott
This interactive session will
explore the proposition that the route that one chooses to
success in an academic environment is less important than the
way one makes the journey. The important principles of making
the trip are simple. They are easier to measure than to
master.
8:00am–10:00am
3110—Probiotics in Necrotizing
Enterocolitis—Their Clinical Effect and Possible Mechanisms
PAS/ASPR/JPS/NASPGHAN Topic Symposium
Room 3003-3005, Moscone West
Chairs: W. Allan Walker, Harvard Medical School, Boston, MA; and
Yuichiro Yamashiro, Juntendo University School of Medicine,
Tokyo, Japan
Target Audience: Neonatologists,
gastroenterologists, pediatric surgeons, NICU nurses and
bacteriologists in perinatal medicine.
Necrotizing enterocolitis (NEC)
is a serious gastrointestinal disease seen predominantly in
very low birth weight (VLBW) and extremely low birth weight (ELBW)
infants. NEC is probably a complex, multifactorial disease.
Currently, the precise pathogenic mechanisms remain to be
elucidated; however, clinical use of probiotics has been
reported to be useful for preventing NEC development in VLBW
and ELBW infants. This session will provide us the current
knowledge about the role of probiotics in the management of
NEC.
-
Fifteen-Year's Experience of
Early Administration of Bifidobacterium Breve to Preterm
Infants
H. Kitajima, Osaka Medical Center and Research Institute for Maternal
and Child Health, Osaka, Japan
-
Oral Probiotics Reduces Incidence
of NEC in VLBW Infants
H. C. Lin, China Medical University, Taichung, Taiwan
-
Effects of Probiotics on the
Immunological Development and Short Chain Fatty Acids in
ELBW and VLBW Infants
Yoshikazu Ohtsuka, Juntendo University School of Medicine, Bunkyo-ku,
Japan
-
Possible Role of Probiotic
Supplementation for Prevention from NEC
Michael S. Caplan, Northwestern University, Evanston, IL
Sponsored jointly by
the Asian Society for Pediatric Research; Japan Pediatric
Society; North American Society for Pediatric
Gastroenterology, Hepatology & Nutrition and the Pediatric
Academic Societies
8:00am–10:00am
3125—Developmental Origins of Adult
Disease—Metabolism
PAS Platform Session
Room 3010-3012, Moscone West
Chairs: William W. Hay and Rebecca A. Simmons
8:00am–10:00am
3153—Late-Breaker Abstract Session I:
Clinical Trials in Neonatology
PAS Platform Session
Room 3022-3024, Moscone West Convention Center
Chairs: Lucky Jain and Robin H. Steinhorn
The "Late-Breaker"
sessions will include reports on clinical trials and other
important and significant pediatric research, which might not
have been ready for reporting at the time of the winter
abstract deadline. There are two sessions during the meeting.
Session II is on Monday, May 1, from 10:15am to 12:15pm. The
sessions will include presentations in the areas of
noenatology, basic science and clinical research in several
clinical areas. Please be sure to review the content so you
don't miss these very special sessions!
The abstracts selected for this
session were not available at press time, but are included as
a separate piece with this program, onsite from the
Information Desk on Level 1 of Moscone West, and are also
posted on the PAS website at www.pas-meeting.org (after April
1).
10:15am–12:00pm
3350—APS Presidential Plenary and Awards
APS Presidential Plenary
Room 3002-3008, Moscone West
Chair: David K. Stevenson, Stanford University School of Medicine, Palo
Alto, CA
*The Joseph W. St. Geme, Jr.
Leadership Award is presented by the Federation of Pediatric
Organizations on behalf of the Ambulatory Pediatric
Association, American Academy of Pediatrics, American Board of
Pediatrics, American Pediatric Society, Association of Medical
School Pediatric Department Chairmen, Association of Pediatric
Program Directors and Society for Pediatric Research.
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2006 APS Presidential Address
David K. Stevenson, Harold K. Faber Professor of Pediatrics, Vice Dean
and Senior Associate Dean for Academic Affairs, Stanford
University School of Medicine; Director, Charles B. and
Ann L. Johnson Center for Pregnancy and Newborn Services;
Chief, Division of Neonatal and Developmental Medicine,
Lucile Packard Children's Hospital at Stanford, Palo Alto,
CA
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New Member Outstanding Science
Award—Epithelial Branching and the Origins of Kidney
Malformation
Norman D. Rosenblum, Professor of Paediatrics and Canada Research Chair
in Developmental Nephrology, Division of Nephrology &
Program in Developmental Biology, The Hospital for Sick
Children, Toronto, Ontario, Canada
-
Introduction, John Howland
Awardee
Frederick J. Suchy, Herbert H. Lehman Professor of Pediatrics and
Chair, Department of Pediatrics, Mount Sinai School of
Medicine, New York, NY
-
54th Annual John Howland Award
Kurt Hirschhorn, Professor of Pediatrics, Human Genetics and Medicine,
Chairman Emeritus, Department of Pediatrics, Mount Sinai
School of Medicine, New York, NY
-
Introduction, Joseph W. St. Geme,
Jr. Leadership Award
Carol Carraccio, Professor of Pediatrics and Associate Chair for
Education, University of Maryland School of Medicine,
Baltimore, MD
-
Joseph W. St. Geme, Jr.
Leadership Award*
Carol D. Berkowitz, Professor of Clinical Pediatrics, David Geffen
School of Medicine at UCLA, Torrance, CA
11:00am–4:00pm
Commercial Exhibits Open and Posters
Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West
Posters Available for Viewing:
11:00am–4:00pm
Author Attendance: 12:00pm–2:00pm
Level 1:
– Allergy, Immunology and Rheumatology
– Developmental-Behavioral Pediatrics
– Endocrinology
– Infectious Diseases
– General Pediatrics
– Hematology–Oncology
Level 2:
– Cardiology
– Neonatal Neurology
– Neonatology
12:00pm–1:30pm
3440A—Perinatal Brain Club
Hypothermia as a Neuroprotective Strategy in Term Infants
Club
Room 3022-3024, Moscone West
-
Introduction
Jeffrey M. Perlman, Weill Cornell Medical College, New York, NY
-
Hypothermia and Neuroprotection—Future
Strategies Based on Experimental Observations
Marianne Thoresen, University of Bristol, Bristol, England, UK
-
Hypothermia as a Neuroprotective
Strategy—Translating Science into Clinical Practice:
What Are the Hidden Obstacles?
Lu-Ann Papile, University of New Mexico Health Science Center,
Albuquerque, New Mexico
-
Discussion
Contact for information:
Jeff Perlman, MD
Weill Cornell Medical College
Phone: 212-746-3533
Email: jmp2007@med.cornell.edu
12:00pm–2:00pm
Poster Session II
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
11:00am–4:00pm
Author Attendance: 12:00pm–2:00pm
Level 1:
– Allergy, Immunology and Rheumatology
– Developmental-Behavioral Pediatrics
– Endocrinology
– Infectious Diseases
– General Pediatrics
– Hematology–Oncology
Level 2:
– Cardiology
– Neonatal Neurology
– Neonatology
Includes:
-
SPR Fellow's Basic Research
Award: Myopalladin Mutations and Inherited
Cardiomyopathies
Enkhsaikhan Purevjav, Baylor College of Medicine, Houston, TX
-
SPR Clinical Research Award:
Accelerated Development in the Visual Areas of Preterm
Infants? A Voxel-Based Morphometry Study on Diffusion
Tensor MR Imaging (DTI)
Maria Miranda, Copenhagen University Hospital, Hvidovre, Denmark
-
SPR Fellow's Clinical Research
Award: Novel Genotyping Technology To Classify Childhood
Leukemia
Joshua D. Schiffman, Stanford University, Palo Alto, CA
-
SPR House Officer Research Award:
Erythropoietin Protein Expression in the Developing Human
Eye
Shrena Patel, University of New Mexico, Albuquerque, NM
2:00pm–4:00pm
3705—Infections at the
Maternal–Placental–Fetal Interface: Immunopathogenesis of
Group B Streptococcus, Listeria monocytogenes and
Cytomegalovirus
PAS/PIDS Topic Symposium
Room 3022-3024, Moscone West
Chairs: John R. Schreiber, University of Minnesota Medical School and
University of Minnesota Children's Hospital/Fairview,
Minneapolis, MN; and Robert F. Pass, University of Alabama at
Birmingham, Birmingham, AL
Target Audience: Neonatologists,
infectious disease specialists, immunologists, developmental
biologists and general pediatricians.
Infections in newborns commonly
result from acquisition either during the delivery process or
transplacentally. The host and pathogen factors that
contribute to acquisition of infections at the
maternal–placental–fetal interface are poorly understood.
This symposium will review the basic science and
immunopathogenesis of three diverse pathogens that all share
the ability to cause infections at the placental level:
cytomegalovirus, group B streptococcus, and Listeria
monocytogenes.
-
Intrauterine Cytomegalovirus
Infection, Transplacental Spread of Virus and Control by
Maternal Immunity
Lenore Pereira, University of California San Francisco, San Francisco,
CA
-
Host and Bacterial Factors in
Invasive Group B Streptococcal Infection
Craig E. Rubens, University of Washington, Seattle, WA
-
Listeriosis in the Pregnant
Guinea Pig: A Model of Vertical Transmission
Daniel A. Portnoy, University of California Berkeley, Berkeley, CA
-
Discussion
Sponsored jointly by
the Pediatric Infectious Diseases Society and the Pediatric
Academic Societies
2:00pm–4:00pm
3718—Fetal Origins of Adult Disease
PAS Poster Symposium
Room 3001, Moscone West
Chairs: David W. Boyle and Jeffrey L. Segar
2:00pm–4:00pm
3722—Neonatal Lung Inflammation: Mechanisms
and Clinical Implications
PAS Platform Session
Room 3014, Moscone West
Chairs: Rose M. Viscardi and Stephen E. Welty
Supported by an unrestricted educational grant from Dey,
L.P.
2:00pm–4:00pm
3724—Neonatal Medicine: Clinical Trials II
PAS Platform Session
Room 3002-3008, Moscone West
Chairs: Ricki F. Goldstein and Robert M. Ward
2:00pm–4:00pm
3726—Neonatal Neurology: MRI and aEEG in
the NICU
PAS Poster Symposium
Room 3020, Moscone West
Chairs: Linda S. de Vries and Terrie E. Inder
2:00pm–4:00pm
3732—Pulmonary and Cardiac Development:
Transcriptional Control and Stem Cells
PAS Platform Session
Room 2004, Moscone West
Chairs: Lawrence M. Nogee and George A. Porter
Includes:
-
SPR Student Research Award:
Critical Requirement of C/EBP[alpha] for Lung Maturation
and Function
Prithy Martis, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
2:00pm–5:00pm
3740—AAP Presidential Plenary and First
Annual Silverman Lecture
AAP Presidential Plenary
Room 3007-3011, Moscone West
Chair: Errol R. Alden, American Academy of Pediatrics, Elk Grove
Village, IL
Target Audience: Scientists and
clinicians interested in the translation of research and
evidence-based principles into health policy and practice.
-
AAP Presidential Address
Eileen M. Ouellette, President, American Academy of Pediatrics, Elk
Grove Village, IL
-
The Community Pediatrics Training
Initiative: Quality Resident Education in Community
Pediatrics
Jeffrey M. Kaczorowski, University of Rochester, Strong Memorial
Hospital, Rochester, NY
-
The Scientific Underpinnings of
Preventive Services for Children: The Bright Futures
Project
Paula M. Duncan, University of Vermont, Burlington, VT
-
The Evidence Base Underlying
Pay-for-Performance Initiatives
Paul V. Miles, The American Board of Pediatrics, Chapel Hill, NC
-
First Annual William A. Silverman
MD Lecture:
From Disasters to Triumphs—Lessons Learned in the
Evolution of Neonatology as a Subspecialty
Avroy A. Fanaroff, Case Western Reserve University School of Medicine,
Cleveland, OH
The Silverman Lecture
is sponsored by the AAP Section on Perinatal Pediatrics
2:00pm–5:00pm
3765—High-Fidelity Pediatric Simulation:
Setting a National Human Performance and Patient Safety
Research and Training Agenda
PAS Educational Workshop
Yerba Buena Gardens Salon 2, SF Marriott
Leader: Louis Halamek, Palo Alto, CA; Co-leaders: Mary Patterson,
Joseph Lopreiato
Target Audience: Trainees,
fellows, junior faculty, and mid-level faculty, senior
faculty.
The goal of this workshop is to
bring together those who are interested in using high fidelity
multidisciplinary pediatric simulation to improve the training
of healthcare professionals and in establishing the evidence
base to support the use of this methodology. This will be an
interactive panel-led session coupled with video presentations
and small breakout group discussions that will allow
participants to identify the elements of a national
simulation-based research and training agenda and a strategy
for implementation of such a plan. Participants will learn
what they can do on the local and national levels to validate
and disseminate its use.
Objectives:
– Define high fidelity
simulation.
– Describe the unique challenges of pediatric simulation.
– Understand why a national research and training agenda is
indicated.
– Develop the major elements of this agenda and develop an
action plan.
Format: I plan to use the three
panelists to lead a facilitated, interactive discussion with
the audience in order to accomplish the workshop objectives
(setting a national agenda and creating an action plan).
2:00pm–5:00pm
3792—Newborn Nursery
APA Special Interest Group
Room Pacific Suite H, SF Marriott
Chair: Linda Meloy, lmeloy@mail2.vcu.edu.
Our meeting will consist of a
focus on topics discussed through our list serve and will
generate research projects and exhibit projects of best care.
The top priority of our Newborn Nursery SIG listed by survey
is education, and we will continue to address our educational
competencies for the newborn nursery for both third-year
medical students and residents. The model that John Olsson
introduced last year provided a foundation for further
discussion. Other members have suggested developing a CD of
important articles and links, such as Tony Burgos’ bilitool
to be provided to our nurseries to provide a core of medical
knowledge for our learners. We plan to collect a number of
these items through our list serve prior to the meeting.
Administrative areas important in
our nurseries are communication between the obstetricians and
pediatricians of important data, such as prenatal ultrasounds,
GBS status, prenatal labs and the presence or absence of
chorioamniotitis. We seek to discover best practice in our
nurseries and exchange solutions to the communication gaps.
Computerized solutions and other forms of communication will
be explored.
As a group of newborn nurseries,
Becky Collins, Kaye Gable and John Olsson seek to define the
current practice of the thermal care of newborns of
gestational age 34 to 37 weeks and the best use of isolettes
in our nurseries. We would like to examine the length of stay,
growth and complications of early use, no use and late use. We
would like to develop evidence-based guidelines.
As a group, we seek to discuss
current clinical dilemmas in our practice. The continued
struggle of using risk factors and sepsis markers to improve
detection and exclusion of sepsis in our nurseries will be
updated. Patricia Hannon will share the results of her survey
on current cord care. Car seat trials in the term nursery will
be discussed by Mark Vining.
An open question time on
discharge and follow up on newborn bilirubin with Jeffrey
Maisels will be a highlight of the session.
4:15pm–5:45pm
3805—Fetal Homeland Security: New Insights
into Old Threats
PAS State of the Art Plenary
Room 3002-3008, Moscone West
Chairs: Phil W. Shaul, University of Texas Southwestern Medical Center,
Dallas, TX; and Rashmin C. Savani, University of Texas
Southwestern Medical Center, Dallas, TX
Target Audience: Neonatologists,
pediatricians and researchers interested in perinatal biology.
In addition to premature birth,
there are a select number of maternal conditions that have
marked negative impact on the well being of the fetus and
newborn. This symposium will highlight recent advances in our
understanding of these classical threats to our most
vulnerable pediatric patient population.
First, new knowledge of the
mechanisms by which maternal diabetes alters embryonic and
fetal development will be discussed. Second, the newly
discovered role of circulating anti-angiogenic proteins of
placental origin in the pathogenesis of preeclampsia will be
presented. Finally, novel mechanisms by which biochemical
events in the fetal lung trigger the initiation of labor will
be discussed. Further advances in each of these realms will
ultimately lead to new therapies to protect the fetus and
yield healthy outcomes at term.
-
Mechanisms by Which Maternal
Diabetes Modifies Embryonic and Fetal Development
Kelle H. Moley, Washington University School of Medicine, St. Louis, MO
-
Role of Circulating Anti-angiogenic
Proteins of Placental Origin in the Pathogenesis of
Preeclampsia
S. Ananth Karumanchi, Harvard Medical School, Beth Isreal Deaconess
Medical Center, Boston, MA
-
Fetal–Maternal Signaling in the
Initiation of Labor
Carole R. Mendelson, University of Texas Southwestern Medical Center,
Dallas, TX
4:15pm–5:45pm
3810—RNA Interference, Technological
Development of siRNAs and Potential Treatments for Childhood
Diseases
PAS State of the Art Plenary
Room 3016-3018, Moscone West
Chair: R. Alan B. Ezekowitz, Harvard Medical School, Massachusetts
General Hospital, Boston, MA
Target Audience: Basic scientists
studying a broad range of childhood diseases, translational
scientists of all disciplines studying clinical implications
of basic science research, clinical scientists studying
childhood and other diseases in need of improved therapies and
clinicians interested in cutting-edge science and its medical
implications.
RNA interference is a recently
discovered, naturally occurring intracellular process that
regulates gene expression through the silencing of specific
mRNAs. Methods of harnessing this natural pathway are being
developed that allow the catalytic degradation of targeted
mRNAs using specifically designed complementary small
inhibitory RNAs (siRNA). siRNAs are being chemically modified
to acquire drug-like properties. Numerous recent high-profile
publications have provided proofs of concept that RNA
interference may be useful therapeutically. Much of the design
of these siRNAs can be accomplished bioinformatically, thus
potentially expediting drug discovery and opening new avenues
of therapy for many childhood diseases including uncommon
pediatric and orphan diseases. A discussion of the science
behind RNA interference will be followed by a presentation of
the potential practical issues in applying this technology to
disease. The program then describes two therapeutic programs
currently under way with applications to pediatric diseases. A
question-and-answer time will follow each discussion.
-
The Science of RNA Interference
John J. Rossi, Beckman Research Institute of City of Hope, Duarte, CA
-
RNA Interference and Its
Potential Applications for Controlling Disease
Judy Lieberman, CBR Institute for Biomedical Research and Harvard
Medical School, Boston, MA
-
Silencing the VEGF Pathway with
siRNAs and the Potential Application to Retinopathy of
Prematurity
Pamela Pavco, Sirna Therapeutics, Boulder, CO
-
siRNA as Therapy for Respiratory
Syncytial Virus
John P. DeVincenzo, University of Tennessee School of Medicine,
Memphis, TN
4:15pm–6:15pm
3850—Human Milk and Breastfeeding
PAS Poster Symposium
Room 3001, Moscone West
Chairs: Sheela R. Geraghty and Ardythe L. Morrow
4:15pm–6:15pm
3865—Neonatal Neurology—Neural Stem Cells
and Neurotrophins
PAS Poster Symposium
Room 3020, Moscone West
Chairs: Sandra E. Juul and Patrick S. McQuillen
4:15pm–6:15pm
3870—Neonatal Public Health
PAS Poster Symposium
Room 3014, Moscone West
Chairs: Henrietta S. Bada and Robert A. Sinkin
Includes:
-
Douglas K. Richardson Award for
Perinatal and Pediatric Healthcare Research
Marie C. McCormick, Harvard School of Public Health and Harvard Medical
School, Boston, MA
4:15pm–6:15pm
3875—Neonatal Pulmonary Hypertension
PAS Poster Symposium
Room 2002, Moscone West
Chairs: Steven H. Abman and Bernard Thebaud
6:00pm–7:15pm
3940A—Neonatal Sepsis Club
Club
Room 3016-3018, Moscone West
Contact for information:
David Kaufman, M.D.
University of Virginia Children's Hospital
Phone: 434-924-9114
Email: davidkaufman@virginia.edu
-
The Intravenous Immunoglobulins:
Current and Future Role in the NICU
William Tarnow-Mordi, The Children's Hospital Westmead, Sydney,
Australia
-
Panel and Audience Discussion
Panelists
Carol J. Baker, Baylor College of Medicine, Houston, TX
Barbara J. Stoll, Emory University School of Medicine,
Atlanta, GA
Leonard E. Weisman
7:00pm–9:00pm
Preventing Allergies— Preserving Quality of
Life
PAS Industry Sponsored Symposium
Golden Gate Hall B1-2, SF Marriott
Target Audience:
Allergy/Immunologists, gastroenterologists, neonatologists.
Preventing Allergies –
Preserving Quality of Life, will focus on allergy issues in
the pediatric population and provide clinicians with valuable
information to help them understand the key contributing
factors behind the increase in allergic disease worldwide.
Faculty will present the hypothesis that childhood
sensitization to foods and allergens can lead to allergies in
later life.
The harmful effect that allergies
have on a child’s physical and emotional well-being and on
the family’s quality of life will also be thoroughly
discussed. The goal of treatment, therefore, is to prevent
allergies from developing.
One way to accomplish this goal
is to follow recommendations for proper nutrition in infants
and children. Exclusive breastfeeding for 4-6 months, use of
special formulas, and delayed introduction of solids are among
the methods to be discussed.
Clinicians attending this
symposium will learn new strategies for preventing infant and
childhood allergies that they can put into practice
immediately.
For registration information
please contact:
Haymarket Medical Continuing Education
Phone: (800) 636-1668
Email: preventingallergies@haymarketmedical.com
Supported by a grant from Nestle, USA
Monday, May 1
8:00am–9:45am
4134—Neonatal Pharmacology
PAS Platform Session
Room 3014, Moscone West
Chairs: Joyce M. Koenig and Augusto Sola
8:00am–10:00am
4105—MRI of the Brain in Neonates
PAS Topic Symposium
Room 3022-3024, Moscone West
Chairs: Terrie E. Inder and Jeff J. Neil, St. Louis Children's
Hospital, St. Louis, MO
Target Audience: Neonatologists,
neurologists, radiologists and trainees.
Magnetic resonance (MR) imaging
remains a rapidly evolving field, particularly in its
application to newborn infants. This symposium will first
review the basics of MR imaging methods (including
conventional and diffusion MR imaging) and then highlight
clinical applications of these methods to common neonatal
clinical conditions in the term and premature infant. The
talks will be targeted to clinicians and aimed to address key
clinical questions such as:
– In which infants should I
undertake an MR scan in my NICU?
– What are the strengths and weakness of MRI/CT/cranial
ultrasound?
– How can I undertake MR imaging in my institution—safety,
image sequences and interpretation?
– When should I undertake an MR scan in the term or
premature infant?
– What do the abnormalities in the MR scan mean for
long-term neurological outcome?
– How should I use this information in my clinical practice
in the NICU?
– Where is MR imaging taking us in the next 10 years in
newborn medicine?
-
A-B-C of M-R-I
Jeffrey J. Neil, Washington University and St. Louis Children's
Hospital, St. Louis, MO
-
Application of MR Imaging to the
Term Infant
Mary Rutherford, Hammersmith Hospital, London, UK
-
Application of MR Imaging to the
Preterm Infant
Terrie E. Inder, Washington University and St. Louis Children's
Hospital, St. Louis, MO
-
X-Y-Z- of M-R-I—The Future with
Advanced MR Methods
Petra S. Huppi, Children's Hospital, University of Geneva, Geneva,
Switzerland
8:00am–10:00am
4132—Mechanisms of Neonatal Lung Injury
PAS Platform Session
Room 3003-3005, Moscone West
Chairs: Vineet Bhandari and Vasanth H.S. Kumar
8:00am–10:00am
4136—Nutritional Disorders—Mechanisms
PAS Platform Session
Room 3000, Moscone West
Chairs: Conrad R. Cole and B U.K. Li
9:00am–12:00pm
4242—Well Child Care for the Premature
Infant
PAS Educational Workshop
Yerba Buena Gardens Salon 15, SF Marriott
Leader: Ricki Goldstein, Durham, NC; Co-leader: William Malcolm
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, senior faculty,
and community practitioners
After a brief overview of the
common problems encountered by premature infants after
discharge, this interactive workshop will engage the audience
in the utilization of a new premature infant well-child check
list being developed for office or clinic visits during the
first 2 years of life. Several videos of pediatric well-child
visits will be viewed which demonstrate common scenarios
involving abnormal motor development and feeding patterns.
After viewing each video, the workshop participants will
complete either a standard checklist used in a pediatric
practice or the one specifically designed for former premature
infants. The key questions or observations used to detect
various problems will be identified and indications for early
intervention will be discussed.
Objectives:
– To become familiar with the
common medical problems encountered by premature infants after
discharge
– To recognize the red flags for early motor and feeding
problems in premature infants after discharge
– To recognize indications for referring a premature infant
for early intervention services
Format: (1) Video presentation of
well child visit demonstrating various problems in premature
infants; (2) participants to complete a new check list
designed to detect various problems encountered in the
premature infant; and (3) roundtable discussion of advantages
and problems with new check list.
10:15am–12:15pm
4300—SPR Presidential Plenary and Awards
SPR Presidential Plenary
Room 3002-3008, Moscone West
Chair: Philip W. Shaul, University of Texas Southwestern Medical
Center, Dallas, TX
-
SPR Award Presentations
-
Student Research Awards
Allison Blatz, Case Western Reserve University, Rainbow Babies &
Children's Hospital, Cleveland, OH
Mya Sendowski, University of
California, San Francisco, CA
Karin Batalden, Mayo Medical School, College of
Medicine, Rochester, MN
Prithy Martis, Cincinnati Children's Hospital Medical
Center, Cincinnati, OH
Silvia Gonzaga, Children's Hospital of Philadelphia,
PA
Suzanne Schubbert, University of California, San
Francisco, CA
-
House Officer Research Award
Sallie R Permar, Children's Hospital and Boston Medical Center, Boston,
MA
Keri Anne Cohn, The Children's
Hospital of Philadelphia, PA
Shrena Patel, University of New Mexico, Albuquerque,
NM
-
Fellow's Basic Research Award
Camille Fung, David Geffen School of Medicine at UCLA, Los Angeles, CA
Michael Hunter, Yale University
School of Medicine, New Haven, CT
Enkhsaikhan Purevjav, Baylor College of Medicine,
Houston, TX
-
Fellow's Clinical Research Awards
Deepika Bhatla, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
Maria Miranda, Copenhagen
University Hospital, Hvidovre, Denmark
Joshua D. Schiffman, Stanford University, Palo Alto,
CA
-
David G. Nathan Award in
Hematology/Oncology
Su Young Kim, National Institutes of Health, Bethesda, MD
-
Japan Pediatric Society Fellow
Awards
Hiroyuki Ishiguro, Tokai University School of Medicine, Isehara,
Kanagawa, Japan
Kyo Okada, Hino Municipal
Hospital, Hino, Tokyo, Japan
Yuka Wada, National Research Institute for Child
Health and Development, Setagaya, Tokyo, Japan
-
Douglas K. Richardson Award for
Perinatal and Pediatric Healthcare Research
Marie C. McCormick, Harvard School of Public Health and Harvard Medical
School, Boston, MA
-
Richard D. Rowe Award in
Perinatal Cardiology
Yong Zhao, Gladstone Institute of Cardiovascular Disease, University of
California San Francisco
-
Young Investigator Award and
Lecture:
Protective and Non-protective Immune Responses Against
Paramyxoviruses: Understanding Atypical Measles and
Enhanced Respiratory Syncytial Virus Disease
Fernando Pedro Polack, Johns Hopkins University, Baltimore, MD
-
Maureen Andrew Mentor Award and
Lecture
Donna M. Ferriero, University of California, San Francisco, CA
-
SPR Distinguished Service Award
Thomas A. Hazinski, Vanderbilt University School of Medicine,
Nashville, TN
-
E. Mead Johnson Awards for
Research in Pediatrics and Lectures:
-
Molecular Basis for Development
of Human B Cell Responses to Viruses
James E. Crowe, Professor of Pediatrics, Microbiology and Immunology,
Ingram Professor, Vanderbilt University Medical
Center, Nashville, TN
-
Cell Division, Genome Stability
and Cancer
David Pellman, The Ted Williams Senior Investigator, Dana-Farber Cancer
Institute and Children’s Hospital, Boston, MA,
Associate Professor of Pediatrics, Harvard Medical
School, Boston, MA
-
Presidential Address
Philip W. Shaul, University of Texas Southwestern Medical Center,
Dallas, TX
*The E. Mead Johnson Awards are
supported by an educational grant from Mead Johnson
Nutritionals
10:15am–12:15pm
4345—Intestinal Inflammation
PAS Poster Symposium
Room 3014, Moscone West
Chairs: Edward J. Hoffenberg and Elizabeth Mannick
10:15am–12:15pm
4350—Mechanisms of Brain Injury
PAS Poster Symposium
Room 3020, Moscone West
Chairs: Maria Delivoria-Papadopoulos and Jeffrey M. Perlman
10:15am–12:15pm
4355—Neurodevelopmental Outcomes of NICU
Graduates
PAS Poster Symposium
Room 3022-3024, Moscone West
Chairs: Scott A. Lorch and Michele C. Walsh
10:15am–12:15pm
4365—Nitric Oxide and Oxygen: A Marriage
Made in Heaven or Hell?
PAS Poster Symposium
Room 3003-3005, Moscone West
Chairs: Satyan Lakshminrusimha and Leif D. Nelin
12:00pm–1:00pm
4410A—23rd Annual Audrey K. Brown
Kernicterus Symposium
Club
Room 2003-2007, Moscone West
Chairs: David K. Stevenson, Stanford University School of Medicine,
Stanford, CA; William J. Cashore, Women and Infants Hospital
of Rhode Island, Providence, RI; and Vinod K. Bhutani,
Stanford University School of Medicine, Stanford, CA
-
Organic Anion Transporter Protein
2 Gene Polymorphisms and Neonatal Hyperbilirubinemia
Jon F. Watchko, Division of Newborn Medicine, Department of Pediatrics,
University of Pittsburgh School of Medicine, Pittsburgh,
PA
-
The Potential Role of Unbound
Bilirubin Measurements for the Management of Jaundiced
Newborns
Charles E. Ahlfors, L.W. Ligand, Vashon, WA
Contact for information:
David K. Stevenson, M.D.
Stanford University School of Medicine
Phone: 650-723-5711
E-mail: dstevenson@stanford.edu
Supported in part by an unrestricted
educational grant from Natus Medical, Inc.
12:00pm–1:30pm
4430A—Perinatal Nutrition and Metabolism
Club
Club
Room 2009-2011, Moscone West
-
Probiotics and Development of
Intestinal Host Defense
W. Allan Walker, Departments of Pediatrics and Nutrition, Harvard
Medical School, Boston, MA
Contact for information:
Jane McGowan, M.D.
The Johns Hopkins Hospital
Phone: 410-955-4565
Email: jmcgowan@jhmi.edu
Supported
in part by a restricted educational grant from Ross Products
Division, Abbott Laboratories
12:00pm–6:45pm
Commercial Exhibits Open and Posters
Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West
Posters Available for Viewing:
12:00pm–6:45pm
Author Attendance: 5:15pm–6:45pm
Level 1:
– Critical Care
– Gastroenterology
– Genetics
– Neonatal Epidemiology and Follow Up
– Neonatal Pulmonology
– Neonatology
– Nephrology
– Pulmonology
Level 2:
– Developmental–Behavioral Pediatrics
– Emergency Medicine
– General Pediatrics
– Medical Education
12:15pm–1:15pm
4470—The National Children's Study: Status
and Future Plans
PAS/PPC Special Symposium
Room 3010-3012, Moscone West
Chair: Elena Fuentes-Afflick, University of California, San Francisco,
CA
Target Audience: Practicing
pediatricians, academic child health professionals,
researchers, administrators and policymakers who are
interested in child health across the lifespan. Professionals
interested in the impact of environmental factors on health
outcomes will also be interested.
This special symposium will
present an update on the National Children's
Study, which recently selected 7
vanguard centers and is prepared to
begin recruitment of subjects.
However, the President's budget proposal
allocated no further funding and
stated that the study would be
terminated at the end of the
current fiscal year. The panel presenters
will discuss the current
budgetary outlook, status of the study, options
to implement the study and
respond to questions from the audience.
Panelists
Elena Fuentes-Afflick, University of California, San Francisco, CA
Peter C. Scheidt, Director,
National Children's Study, National Institute of Child Health
and Human Development, National Institutes of Health,
Bethesda, MD
Alan R. Fleischman, Chair, National Children's Study Federal
Advisory Committee, New York Academy of Medicine, New York and
National Institutes of Health, Bethesda, MD
David J. Schonfeld, Member, National Children's Study Federal
Advisory Committee and Chair, AAP Committee on Research,
Cincinnati, OH
Sponsored jointly by
the Public Policy Council and the Pediatric Academic Societies
3:00pm–4:00pm
4600A—LWPES Trans-Pacific Lecture
LWPES Award
Room 3002-3008, Moscone West
Chair: Mark Sperling, Children's Hospital of Pittsburgh, Pittsburgh, PA
Target Audience: Geneticists,
endocrinologists and molecular biologists.
This new lecture recognizes one
outstanding scientist from the Pacific Rim. This talk will
illuminate congenital adrenal disorders with particular focus
on the relationship between newborn screening and molecular
mechanisms.
-
Congenital Adrenal Disorders:
From Newborn Screening to Molecular Mechanism
Kenji Fujieda, Asahikawa Medical College, Asahikawa, Japan
3:00pm–5:00pm
4620—Hirschsprung’s Disease and Chronic
Constipation: Medical and Surgical Approaches
PAS/NASPGHAN Topic Symposium
Room 3014, Moscone West
Chairs: B U.K. Li, Children's Memorial Hospital, Northwestern
University School of Medicine, Chicago, IL; and Melvin B.
Heyman, University of California San Francisco, San Francisco,
CA
Target Audience: General
pediatricians, pediatric gastroenterologists, pediatric
surgeons and developmental biologists.
This symposium will focus on a
common yet challenging problem constipation: the clinical,
diagnostic, genetic and surgical aspects of Hirschsprung’s
disease; and diagnostic testing, medical and surgical
treatment of chronic constipation. In Hirschsprung’s
disease, the clinical presentation (red flags) of, diagnostic
testing for and genetic mutations found will be discussed.
Surgical approaches including standard staged pull-thrus,
single stage repairs, laparoscopic approaches and
post-surgical obstructions will be reviewed. In chronic
constipation, the differential diagnosis and diagnostic
testing (findings in anorectal and colonic manometry, MRI and
bead transit studies) will be presented. Medical and surgical
therapeutic approaches will cover education, behavioral and
biofeedback therapy, medical treatment (disimpaction and
maintenance therapy) and antegrade enemas delivered via
cecostomies. The specific approaches applicable to a general
pediatric practice use will be identified.
-
Clinical and Genetics Aspects of
Hirschsprung's Disease
Cheryl E. Gariepy, University of Michigan Health System, Ann Arbor, MI
-
Surgical Approaches to
Hirschsprung's Disease
Daniel H. Teitelbaum, University of Michigan Hospitals, Ann Arbor, MI
-
Diagnostic Approaches to Chronic
Constipation
Samuel Nurko, Children's Hospital and Harvard University, Boston, MA
-
Therapeutic Approaches to Chronic
Constipation
Warren P. Bishop, Children's Hospital of Iowa, University of Iowa, Iowa
City, Iowa
Sponsored jointly by
the American Pediatric Surgical Association; the North
American Society for Pediatric Gastroenterology, Hepatology
and Nutrition; and the Pediatric Academic Societies
3:00pm–5:00pm
4662—Standardizing Prescription of Fluids
and Medications in the NICU: Principles, Practical Tools and
Applications
PAS Educational Workshop
Yerba Buena Gardens Salon 3, SF Marriott
Leader: Joaquim Pinheiro, Albany, NY; Co-leaders: Amy Mitchell, Vinay
Vaidya
Target Audience: Trainees,
fellows, junior faculty, mid-level faculty, senior faculty,
community practitioners, pharmacists, and nurses.
Emphasis on patient safety has
led some NICUs to implement standardized dosing methods,
replacing customized fluid and medication dosing in neonates.
JCAHO has mandated a transition from
"rule-of-6"-based prescription to standardized
concentrations. Without national standards, NICU practitioners
are struggling to comply with the mandate.
Workshop goals are to review
principles of error prevention in NICU, focusing on
standardized methods of prescription and administration. The
leaders will share their experience with paper, electronic and
logistic systems for standardizing fluid, medication and TPN
prescription.
Objectives:
– Participants will learn a
variety of practices and tools used to implement standardized
prescription in NICUs.
– Participants will have practiced multidisciplinary
development of solutions to standardized prescription relevant
to their institutions.
– Participants will learn about computerized methods for
rapid implementation of standardized infusions.
Format: Short presentations,
question-and-answer periods, and problem solving in groups.
3:00pm–5:00pm
4670—Brain Metabolism and Injury
PAS Platform Session
Room 3020, Moscone West
Chairs: Steven P. Miller and Frances J. Northington
Includes:
-
SPR Fellow's Basic Research
Award: The Neuron-Glia Lactate Shuttle Protects
Neurological Function in Neuron-Specific Glucose
Deficiency
Camille Fung, David Geffen School of Medicine at UCLA, Los Angeles, CA
3:00pm–5:00pm
4680—Neonatal Fetal Nutrition and
Metabolism II
PAS Platform Session
Room 3007-3011, Moscone West
Chairs: Patti J. Thureen and Carol L. Wagner
3:00pm–5:00pm
4685—Neonatal Pulmonary Hypertension: Novel
Mechanisms and Therapies
PAS Poster Symposium
Room 3022-3024, Moscone West
Chairs: Judy L. Aschner and Robin H. Steinhorn
5:15pm–6:45pm
Poster Session III
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
12:00pm–6:45pm
Author Attendance: 5:15pm–6:45pm
Level 1:
– Critical Care
– Gastroenterology
– Genetics
– Neonatal Epidemiology and Follow Up
– Neonatal Pulmonology
– Neonatology
– Nephrology
– Pulmonology
Level 2:
– Developmental–Behavioral Pediatrics
– Emergency Medicine
– General Pediatrics
– Medical Education
6:45pm–8:00pm
4980A—Lung Club
Club
Yerba Buena Gardens Salon 7, SF Marriott
Is There a Role for Inhaled
Nitric Oxide in the Prevention of Chronic Lung Disease in the
Preterm Infant
John P. Kinsella, University of Colorado School of Medicine, Children's
Hospital, Denver, CO
Contact for information:
Roberta A. Ballard, M.D.
Children's Hospital of Philadelphia
Phone: 215-590-1653
Email: ballard@email.chop.edu
Richard J. Martin
Rainbow Babies & Children's Hospital
Phone: 216-844-3387
Email: rxm6@po.cwru.edu
Supported in part by an unrestricted
educational grant from Ross Products Division, Abbott
Laboratories
Tuesday, May 2
8:00am–10:00am
5105—Not All Near-Term Infants Are Born
Equal
PAS Topic Symposium
Room 3002-3008, Moscone West
Chairs: Lucky Jain, Emory University, Atlanta, GA; and Tonse N.K. Raju,
National Institute of Child Health and Human Development,
Rockville, MD
Target Audience: Neonatologists
and pediatricians.
Infants born at >34 weeks and
<38 weeks are often presumed to be mature and treated at
par with term infants. However, there is considerable
epidemiologic information to show that these infants have
considerably higher rates of NICU admissions and are at risk
for serious morbidity and death. Causes of morbidity include
delayed respiratory transition and surfactant deficiency,
hyperbilirubinemia, hypothermia, hypoglycemia and poor
initiation of feeding, etc. This symposium is designed to
review the physiological events related to neonatal transition
at birth and the pitfalls in the transition of a near-term
infant. The symposium should create awareness among
neonatologists and pediatricians for these morbidities and
suggest ways to overcome them.
-
Overview
Lucky Jain, Emory University, Atlanta, GA
-
Epidemiology and Overview of
Near-Term Births
Tonse N.K. Raju, National Institute of Child Health and Human
Development, Rockville, MD
-
Respiratory Transition and
Morbidity in Near-Term Infants
Lucky Jain, Emory University, Atlanta, GA
-
Brain Maturation and Pathology in
Near-Term Infants
Hannah Kinney, Harvard University, Boston, MA
-
Hyperbilirubinemia and
Kernicterus in Near-Term Infants
Vinod K. Bhutani, Stanford University School of Medicine, Stanford, CA
-
Post-Discharge Morbidity and
Rehospitalization in Near-Term Infants
Gabriel J. Escobar, Kaiser Permanente, Oakland, CA
-
Discussion
Supported
by an unrestricted educational grant from INO Therapeutics
8:00am–10:00am
5130A—Neonatal Infectious Diseases in
Developing Countries—Part I
PGPR Symposium
Room 3016-3018, Moscone West
Co-Chairs: Alvin Zipursky, The Hospital for Sick Children, Toronto,
Canada; and Stephen Wall, Senior Research Manager, Saving
Newborn Lives, Washington, DC
Target Audience: Researchers and
clinicians interested and/or involved in all aspects of the
study of neonatal infectious disease, in any setting.
The Programme for Global
Paediatric Research (PGPR) includes paediatric researchers,
societies, and other organizations committed to child health.
It was formed in January 2004 to address the disparity between
the scientific research resources available in high-income
countries and the quantity of scientific research focused on
the health of children in mid- and low-income countries. PGPR
works at the centre of a global network to inform, educate,
facilitate international research cooperation and
collaboration, and acts as an advocate for research to improve
the health of all children. This three-part symposium will
focus on the serious problem of neonatal infectious diseases
in developing countries. Parts 1 and 3 will be comprised of
expert presentations providing an overview of the problem,
instances of work that is being done in the area, and
region-specific information. Part 2 will feature platform
presentations from selected abstracts on issues included in
the study of neonatal infectious diseases in developing
countries. At the PGPR workshop on Wednesday, May 3 colleagues
from high-, mid- and low-income countries, who are working in
fields related to neonatal infectious diseases, will meet in
order to examine the critical issues and establish clear plans
for collaborative study and other action. One of the expected
outcomes of the workshop will be a preliminary statement of
research needs and directions related to neonatal infectious
diseases in developing countries.
-
Neonatal Infections in the
Developing World: An Overview
Barbara J. Stoll, Emory University School of Medicine, Atlanta, GA
-
Healthcare Associated Neonatal
Infections and Antimicrobial Resistance in Developing
Countries
Anita Zaidi, Aga Khan University Hospital, Karachi, Pakistan
-
Diagnosis and Antibiotic Therapy
of Neonatal Infections by Health Care Workers
Abhay T. Bang, The Society for Education, Action and Research in
Community Health (SEARCH), Gadchiroli, Maharashtra, India
-
Global Partnerships for
Infectious Disease Research: A Focus on Pediatric Studies
of Dengue in Nicaragua
Eva Harris, School of Public Health, University of California,
Berkeley, CA
8:00am–10:00am
5166—Lung Development and Alveolarization
PAS Poster Symposium
Room 3003-3005, Moscone West
Chairs: Lawrence S. Prince and A. Keith Tanswell
Includes:
8:00am–10:00am
5168—Oxidants, Antioxidants and the Battles
They Wage
PAS Poster Symposium
Room 3014, Moscone West
Chairs: Jonathan M. Davis and Charles V. Smith
8:30am–9:45am
5200A—The Challenge of Diagnosis and
Outcome in Intersex
LWPES State of the Art Plenary
Room 3007-3011, Moscone West
Chair: Lynne Levitsky, Massachusetts General Hospital, Boston, MA
Target Audience: Geneticists,
endocrinologists and general pediatricians.
The attendee will be presented
with an overview of intersex and then the challenges of
diagnosis and outcome will be addressed. Many previous
assumptions about outcome have proven to be false. This should
prove to be an exciting talk about a highly controversial
topic affecting pediatric endocrinologists and geneticists.
-
The Challenge of Diagnosis and
Outcome in Intersex
Ieuan Hughes, University of Cambridge, Cambridge, UK
10:00am–12:00pm
5350—Revisiting NICU's Old Standbys: What's
the Evidence?
PAS Hot Topic
Room 3002-3008, Moscone West
Chairs: David Edwards, Hammersmith, UK; and Kristi L. Watterberg,
University of New Mexico, Albuquerque, NM
Target Audience: Neonatologists.
Although research continues to
promote advances in neonatal medicine, much of neonatal
practice is still not necessarily evidence-based. In this
session, we will take a look at several common neonatal
practices and the evidence that does–or does not–support
their use.
-
Sodium Bicarbonate for Metabolic
Acidosis: Basic Therapy or Basically Useless Therapy?
Judy L. Aschner, Vanderbilt University Medical Center, Nashville, TN
-
Transfusions in Premature
Infants: Too Much of a Good Thing or Not Enough?
Robin K. Ohls, University of New Mexico School of Medicine,
Albuquerque, NM
-
Preterm Circulatory Compromise:
Which Inotrope in Which Baby?
Nick Evans, Royal Prince Alfred Hospital and University of Sydney,
Australia
-
Analgesia in the Premature
Infant: Controlling Their Pain or Ours?
Johannes N. van den Anker, Children's National Medical Center,
Washington, DC
-
Discussion
10:00am–2:00pm
Commercial Exhibits Open and Posters
Available for Viewing
PAS Exhibits
Levels 1 and 2, Moscone West
Posters Available for Viewing:
10:00am–2:00pm
Author Attendance: 12:00pm–1:30pm
Level 1:
– Adolescent Medicine
– Emergency Medicine
– Epidemiology
– General Pediatrics
– Infectious Diseases
– Neonatal Epidemiology and Follow Up
Level 2:
– Neonatal Pulmonology
– Neonatology
10:15am–11:45am
5405—Newborn Screening: The Coming
Revolution
PAS State of the Art Plenary
Room 3001, Moscone West
Chair: Alex R. Kemper, University of Michigan, Ann Arbor, MI
Target Audience: General
pediatricians, subspecialists involved with newborn screening,
for including neonatologists, endocrinologists, hematologists
and geneticists.
Newborn screening has resulted in
dramatic improvements in the morbidity and mortality of
inherited disorders. Recent laboratory developments have
dramatically increased the number of conditions that can be
detected in early infancy. Expanding the list of conditions
has lead to unique challenges for pediatric practices and
public health systems. This symposium will explore these new
and emerging challenges.
-
Overview
Alex R. Kemper, University of Michigan, Ann Arbor, MI
-
New Technologies for Newborn
Screening
Edward R.B. McCabe, David Geffen School of Medicine at UCLA, Mattel
Children's Hospital, Los Angeles, CA
-
Meeting the Needs for
Confirmation, Counseling and Treatment
R. Rodney Howell, Miller School of Medicine at the University of Miami,
Miami, FL
-
"Treatment" Versus
"Benefit" in Evaluating the Desirability of
Expanded Newborn Screening
Don Bailey, University of North Carolina at Chapel Hill, Chapel Hill,
NC
-
Ethical Issues That Must Be
Addressed in an Expanded Newborn Screening Program
Ellen Wright Clayton, Vanderbilt University, Nashville, TN
-
Summary Comments
Michele Puryear, Maternal and Child Health Bureau, Health Resources
& Services Administration, Rockville, MD
-
Discussion
10:15am–12:15pm
5425—A Spectrum of Neurodevelopmental
Disabilities
PAS Poster Symposium
Room 2006, Moscone West
Chairs: Bruce K. Shapiro and Robert G. Voigt
12:00pm–1:30pm
Poster Session IV
PAS Poster Session
Room Levels 1 and 2, Moscone West
Posters Available for Viewing:
10:00am–2:00pm
Author Attendance: 12:00pm–1:30pm
Level 1:
– Adolescent Medicine
– Emergency Medicine
– Epidemiology
– General Pediatrics
– Infectious Diseases
– Neonatal Epidemiology and Follow Up
Level 2:
– Neonatal Pulmonology
– Neonatology
Includes:
-
SPR Student Research Award: Metal
Contamination of Blood Bank Blood
Allison Blatz, Case Western Reserve University, Rainbow Babies &
Children's Hospital, Cleveland, OH
-
SPR House Officer Research Award:
Pathogenesis of Measles Virus Infection in Simian
Immunodefiency Virus-Infected, Measles Virus-Vaccinated
Rhesus Monkeys
Sallie R Permar, Children's Hospital and Boston Medical Center, Boston,
MA
12:45pm–3:45pm
5650—Recent Advances in Understanding and
Treating Neonatal Chronic Lung Disease
PAS Hot Topic
Room 3002-3008, Moscone West
Chairs: Richard D. Bland, Stanford University School of Medicine,
Stanford, CA; and Bernard Thebaud, University of Alberta,
Edmonton, AB, Canada
Target Audience: Neonatologists
involved in the care of premature infants, pulmonologists and
general pediatricians who care for children suffering the ill
effects of neonatal chronic lung disease and clinician
scientists with a research interest in normal and disordered
development of the lung and its circulation.
A symposium to honor Dr. William
Northway and Dr. Jacqueline Coalson for their seminal
discoveries of bronchopulmonary dysplasia (BPD) in human
babies and premature baboons, as we approach the 40th
anniversary of Dr. Northway’s initial description of BPD and
the 25th anniversary of Dr. Coalson’s initial papers on the
Southwest Foundation’s authentic model of BPD in non-human
primates. The program will focus on recent advances in the
basic biology of lung development, its dysregulation in BPD
and implications for novel treatment strategies. The intent is
to improve understanding of the mechanisms that regulate the
formation of alveoli, pulmonary capillaries and extracellular
matrix components in the developing lung, with consideration
of some of the adverse conditions that may contribute to
impaired lung growth and development in BPD. This knowledge
will provide rationale for introducing novel strategies to
help treat or prevent neonatal chronic lung disease.
-
Introduction
Alan H. Jobe, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH
-
BPD in Babies: An Historical
Perspective
William H. Northway, Lucile Salter Packard Hospital, Palo Alto, CA
-
BPD in Baby Baboons: An Evolving
Saga
Jacqueline J. Coalson, UT Health Sciences Center at San Antonio, San
Antonio, TX
-
Lung Septation and Its
Dysregulation in BPD
Jacques R. Bourbon, Universite Paris XII - Faculte de Medecine, Creteil,
France
-
Lung Angiogenesis and Its
Dysregulation in BPD
Steven H. Abman, University of Colorado School of Medicine, The
Children’s Hospital, Denver, CO
-
Lung Elastin and Its
Dysregulation in BPD
Richard D. Bland, Stanford University School of Medicine, Stanford, CA
-
Novel Ways To Treat or Prevent
BPD
Bernard Thebaud, University of Alberta, Edmonton, Alberta, Canada
1:30pm–3:30pm
5700A—Neonatal Infectious Diseases in
Developing Countries—Part II
PGPR Symposium
Room 3016-3018, Moscone West
Co-Chairs: José Ignacio Santos Preciado, Hospital Infantil de México
Federico Gómez, Mexico City, Mexico; and Mark Schliess,
University of Minnesota, Minneapolis-St. Paul, MN
Target Audience: Researchers and
clinicians interested and/or involved in all aspects of the
study of neonatal infectious disease, in any setting.
The Programme for Global
Paediatric Research (PGPR) includes paediatric researchers,
societies, and other organizations committed to child health.
It was formed in January 2004 to address the disparity between
the scientific research resources available in high-income
countries and the quantity of scientific research focused on
the health of children in mid- and low-income countries. PGPR
works at the centre of a global network to inform, educate,
facilitate international research cooperation and
collaboration, and acts as an advocate for research to improve
the health of all children. This three-part symposium will
focus on the serious problem of neonatal infectious diseases
in developing countries. Parts 1 and 3 will be comprised of
expert presentations providing an overview of the problem,
instances of work that is being done in the area, and
region-specific information. Part 2 will feature platform
presentations from selected abstracts on issues included in
the study of neonatal infectious diseases in developing
countries. At the PGPR workshop on Wednesday, May 3 colleagues
from high-, mid- and low-income countries, who are working in
fields related to neonatal infectious diseases, will meet in
order to examine the critical issues and establish clear plans
for collaborative study and other action. One of the expected
outcomes of the workshop will be a preliminary statement of
research needs and directions related to neonatal infectious
diseases in developing countries.
-
Cutaneous Innate Immunity
Steven B. Hoath, Children's Hospital, Cincinnati, OH
-
Preventing Neonatal Infections
Through Skin Barrier Therapy
Gary L. Darmstadt, Johns Hopkins University, Baltimore, MD
-
Experiences with Neonatal
Infectious Diseases in Low-Income Countries—Uganda
Margaret Nakakeeto, Mulago Hospital, Kampala, Uganda
-
Experiences with Neonatal
Infectious Diseases in Low-Income Countries—Caribbean
Nations
Upton Allen, The Hospital for Sick Children, Toronto, Ontario, Canada
1:45pm–3:45pm
5720—Autosomal Recessive Polycystic Kidney
Disease (ARPKD): New Insights and Clinical Perspectives
PAS/ASPN/NASPGHAN Topic Symposium
Room 3010-3012, Moscone West
Chairs: Philip Rosenthal, University of California, San Francisco, San
Francisco, CA; and Lisa M. Guay-Woodford, University of
Alabama at Birmingham, Birmingham, AL
Target Audience: Pediatricians,
pediatric nephrologists, pediatric gastroenterologists,
neonatalogists and developmental biologists.
ARPKD is a developmental disorder
of the kidneys and liver caused by mutations in the PKHD1
gene. Fibrocystin/polyductin, the protein encoded by PKHD1, is
expressed on the primary cilia of renal and bile duct
epithelial cells. Several lines of evidence indicate that the
PKHD1 transcriptional profile is complex with extensive splice
variants. While the function of these transcripts and the
polypeptides that they encode is not well understood, these
proteins seem to play critical roles in establishing and
maintaining the tubular architecture. This symposium will
discuss the complex transcriptional profile of PKHD1 and the
role of these gene products in renal as well as biliary
epithelia. Given that ARPKD has a high perinatal mortality due
to oligohydramnios and resultant respiratory insufficiency,
current concepts regarding the interplay between the
developing kidney, the placenta and the developing lung will
be discussed. Finally, a clinical perspective based on the
on-going NHGRI-sponsored natural history study will focus on
ARPKD-associated morbidities and disease progression.
-
Transcriptional Complexity of
PKHD1: Implications for Development and Disease
Pathogenesis
Gregory G. Germino, Johns Hopkins University, Baltimore, MD
-
Pathobiology of Biliary Epithelia
in ARPKD
Tatyana Masyuk, Mayo Clinic College of Medicine, Rochester, MN
-
Oligohydramnios: Current Concepts
and Implications for Pulmonary Development
F. Sessions Cole, Washington University School of Medicine, St. Louis
Children's Hospital, St. Louis, MO
-
Report on the NIH ARPKD/CHF
Natural History Study
Meral Gunay-Aygun, National Human Genome Research Institute (NHGRI),
Bethesda, MD
Sponsored jointly by
the American Society of Pediatric Nephrology; the North
American Society for Pediatric Gastroenterology, Hepatology
and Nutrition; and the Pediatric Academic Societies
1:45pm–3:45pm
5755—Neonatal Brain Injury: How Can We Do
More Good Than Harm?
PAS Platform Session
Room 3003-3005, Moscone West
Chairs: Sylvain Chemtob and Augusto Sola
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