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Saturday, April 29
8:00am–11:00am
2125—New Considerations for the Growth Rate
of the Preterm Infant: Too Fast or Not Fast Enough?—A Review
of the Evidence
PAS Mini Course
Room 3002-3008, Moscone West
Chairs: Frank R. Greer, University of Wisconsin, Madison, WI; and
William W. Hay, Jr., University of Colorado, Aurora, CO
Target Audience: Neonatologists,
hospitalists who take care of preterm infants, nutritionists
and general pediatricians.
Recent nutritional emphasis in
the NICU has been to achieve the normal intrauterine growth
rate with more aggressive nutritional support for the low
birth weight infant. In general, this has been difficult to
achieve, and new evidence from long-term follow up studies
shows that preterm infants are at an increased risk of
developing the metabolic syndrome including obesity, type 2
diabetes and cardiovascular disease. This implies that the
organs in the early life of the preterm infant may be
programmed adversely by nutritional therapy. This raises the
questions of how fast these infants should grow (including
catch up growth), the importance of the composition of this
growth and the urgency for defining the necessary balance
between growth of the brain and the rest of the body.
Ultimately, providers may want to revise the long-term and
short-term goals for feeding very low birth weight or
extremely low birth weight infants. This mini course will
present evidence to help answer these questions and provide
discussion about related practice recommendations.
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Overview
Frank R. Greer, University of Wisconsin, Madison, WI
William W. Hay, University of
Colorado Health Sciences Center, Aurora, CO
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Macronutrient Requirements for
Growth of Preterm Infants—Upper and Lower Limits
(Energy, Fat, CHO, Protein)
Scott C. Denne, Indiana University School of Medicine, James Whitcomb
Riley Hospital, Indianapolis, IN
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Aggressive Nutritional Support of
the Preterm Infant Revisited—Evidence for Efficacy and
Safety
Patti J. Thureen, University of Colorado Health Sciences Center,
Denver, CO
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Adverse Outcomes of Rapid Somatic
Growth and Alterations of Body Composition in the Low
Birth Weight Infant
Frank R. Greer, University of Wisconsin, Madison, WI
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Fatty Acids and Neuronal
Development
Susan E. Carlson, University of Kansas Medical Center, Kansas City, KS
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Iron and Development of the Brain
Michael K. Georgieff, University of Minnesota School of Medicine,
Minneapolis, MN
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Nutritional Influences on
Structural and Functional Maturation of the Developing
Brain During Extended Postnatal Period
Steve H. Zeisel, The University of North Carolina, Chapel Hill, NC
11:45am–2:45pm
2424—Treatment of the Metabolic Syndrome in
Children and Adolescents
PAS Educational Workshop
Golden Gate Hall A1, SF Marriott
Leader: J. Darrell Nesmith, Little Rock, AR; Co-leaders: Alba Morales,
Mohammad Ilyas, Lisa Lubsch
Target Audience:
Endocrinologists, trainees, fellows, junior faculty, mid-level
faculty, senior faculty, and community practitioners.
The rise in pediatric obesity and
metabolic syndrome is well established. Less understood for
the pediatrician is the treatment of the metabolic syndrome.
In this workshop, we aim to: 1) briefly discuss the
epidemiology of the metabolic syndrome in children and
adolescents, 2) discuss non-pharmacologic and pharmacologic
treatment of the metabolic syndrome, and 3) review a stepped
approach in treating adolescents with the metabolic syndrome.
This workshop will be largely
case-based. Come prepared to devise treatment plans in a small
group setting. Participants are invited to bring their own
cases for discussion.
Participants will:
– Learn the epidemiology of the
metabolic syndrome in children and adolescents.
– Become familiar with existing treatment guidelines for
components of the metabolic syndrome in children and
adolescents.
– Identify gaps in the literature regarding treatment
guidelines of the metabolic syndrome in children and
adolescents.
– Consider pharmacologic treatment options of metabolic
syndrome treatment based on the available evidence.
Format: A short didactic
presentation will be given on diabetes, hypertension, and
dyslipidemia treatments from a diabetologist, nephrologist,
and endocrinologist respectively. Existing published
guidelines will be presented while gaps in the literature
regarding treatment will be discussed. Following these short
didactic presentations, small groups (at tables) will work on
cases which will be presented, and a treatment plan will be
derived by each group. At the end of these roundtable work
group discussions, the group as a whole will discuss the
treatment plans. Actual cases will be used when possible (with
appropriate de-identifiers) and their treatment plans
discussed.
3:15pm–5:15pm
2764—Pediatric Overweight: Bringing It Home
PAS Educational Workshop
Golden Gate Hall A2, SF Marriott
Leader: Joan Griffith, Lexington, KY; Co-leaders: Starr Gantz and Aaron
Beighle
Target Audience: Junior,
mid-level and senior faculty and community practitioners.
Increased awareness of the danger
of physical inactivity and overweight has not appeared to
reverse the pediatric overweight epidemic. This workshop will
provide an overview of pediatric overweight, discuss the
demographics and third-party reimbursement rates of a central
Kentucky university-based initiative, utilize data from a
research study to initiate a roundtable discussion on an
approach to pediatric overweight, identify simple ways to
implement the 2005 Dietary Guidelines for managing overweight
children and demonstrate ways to motivate children/parents to
become more physically active.
Objectives:
– Develop a positive approach
toward managing pediatric overweight.
– Discuss the 2005 Dietary Guidelines for overweight
children.
– Demonstrate methods for increasing participation in
physical activity.
Format: 1, Review data from the
first year of a university-based pediatric weight management
clinic and research study; 2, case presentations; 3,
demonstration of motivational approach for increasing physical
activity in children/parent; 4, roundtable discussion; and 5,
question-and-answer session.
5:15pm–6:00pm
2800—Clinical Pediatric Hypertension
PAS/ASPN/IPHA Poster Symposium
Room 2004, Moscone West
Chairs: Stephen R. Daniels and Deborah P. Jones
Sponsored jointly by
the International Pediatric Hypertension Association and the
American Society of Pediatric Nephrology
Sunday, April 30
8:00am–10:00am
3105—From Health Services Research to
Public Policy
PAS Topic Symposium
Room 2006, Moscone West
Chair: Gary L. Freed, University of Michigan, Ann Arbor, MI
Target Audience: Investigators,
clinicians and advocacy experts.
The contribution of research
regarding children is measured in its ability to improve
children's health and well being. Research findings that
contribute to public policy efforts have the potential to
improve the lives and well being of whole communities, states
and nations of children. Understanding the nature and
appreciating the role of such work is fundamentally important
for clinicians and researchers alike.
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Overview
Gary L. Freed, University of Michigan, Ann Arbor, MI
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Using Research To Confront Power:
Can P Values Speak to Justice?
Paul H. Wise, Stanford University, Stanford, CA
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Where Research Meets Policy and
Politics: The Road to Health Reform for Children
Sara Rosenbaum, George Washington University, Washington, DC
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Linking Health and School Goals
To Address Childhood Obesity
Joseph W. Thompson, University of Arkansas Medical Sciences, Little
Rock, AR
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Addressing Children’s
Underinsurance Through Policy-Relevant Research
Matthew M. Davis, University of Michigan, Ann Arbor, MI
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Discussion
8:00am–10:00am
3125—Developmental Origins of Adult
Disease—Metabolism
PAS Platform Session
Room 3010-3012, Moscone West
Chairs: William W. Hay and Rebecca A. Simmons
8:00am–11:00am
3256—Obesity
APA Special Interest Group
Pacific Suite I, SF Marriott
Chairs: Jennifer Bass, yenbass@aol.com;
and Sandy Hassink, shassink@nemours.org.
Treatment of Childhood Obesity: A
Case-Based Approach
A panel of obesity clinicians
will address the practical aspects of obesity treatment in a
clinical case-based approach. A variety of clinical scenarios
and vignettes will be presented for discussion, with
opportunities for role playing and audience participation. The
cases will cover issues relating to childhood overweight and
obesity for a variety of ages and developmental stages. Some
of the issues included will be readiness for change, behavior
modification and other strategies, medications and screening
and treatment of co-morbid conditions.
12:00pm–2:00pm
Poster Session II
PAS Poster Session
Room Levels 1 and 2, Moscone West
Posters Available for Viewing:
11:00am–4:00pm
Author Attendance: 12:00pm–2:00pm
Level 1:
– Allergy, Immunology and Rheumatology
– Developmental-Behavioral Pediatrics
– Endocrinology
– Infectious Diseases
– General Pediatrics
– Hematology–Oncology
Level 2:
– Cardiology
– Neonatal Neurology
– Neonatology
Includes:
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SPR Clinical Research Award:
Accelerated Development in the Visual Areas of Preterm
Infants? A Voxel-Based Morphometry Study on Diffusion
Tensor MR Imaging (DTI)
Maria Miranda, Copenhagen University Hospital, Hvidovre, Denmark
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SPR Fellow's Basic Research
Award: Myopalladin Mutations and Inherited
Cardiomyopathies
Enkhsaikhan Purevjav, Baylor College of Medicine, Houston, TX
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SPR Fellow's Clinical Research
Award: Novel Genotyping Technology To Classify Childhood
Leukemia
Joshua D. Schiffman, Stanford University, Palo Alto, CA
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SPR House Officer Research Award:
Erythropoietin Protein Expression in the Developing Human
Eye
Shrena Patel, University of New Mexico, Albuquerque, NM
2:00pm–4:00pm
3712—Adolescent Medicine II
PAS Poster Symposium
Room 2002, Moscone West
Chairs: Elizabeth M. Ozer and Sheryl A. Ryan
4:15pm–6:15pm
3850—Human Milk and Breastfeeding
PAS Poster Symposium
Room 3001, Moscone West
Chairs: Sheela R. Geraghty and Ardythe L. Morrow
Monday, May 1
8:00am–11:00am
4150—The Skinny on the Adipocyte
PAS/LWPES Mini Course
Room 3010-3012, Moscone West
Chairs: Silva A. Arslanian, University of Pittsburgh, Pittsburgh, PA;
and Robert H. Lustig, University of California, San Francisco,
CA
Target Audience: General
pediatricians, gastroenterologists, endocrinologists,
cardiologists, pulmonologists and adolescent medicine
specialists.
Over the past five years much has
been learned about the adipocyte. The ability of the adipocyte
to function as an endocrine gland, elaborating inflammatory
cytokines that result in free radical formation and premature
apoptosis of the beta cell, is a relatively new concept. This
mini course will comprehensively address many of the newest
concepts in adipocyte function and their impact on health and
disease. Further discussion will include new concepts on the
interactions of IGF-II and other peptides' interactions with
the adipocyte. Lastly, there will be a call for new approaches
to the pediatric obesity epidemic.
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Adipose Tissue as an Endocrine
Organ
Susan Fried, University of Maryland School of Medicine, Baltimore VA
Medical Center, Baltimore, MD
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Obesity and Inflammation
Christopher Hug, Whitehead Institute and Children's Hospital,
Cambridge, MA
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Effects of GH, IGF-I and Insulin
Therapies on Adiposity
Zvi Laron, Schneider Children's Medical Center of Israel, Petah Tikva,
Isreal
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Pathology and Sequelae of
Childhood Obesity in Adult Life
Dennis M. Styne, University of California, Davis Medical Center,
Sacramento, CA
Sponsored jointly by
the Lawson Wilkins Pediatric Endocrine Society and the
Pediatric Academic Societies
9:00am–12:00pm
4256—Nutrition
APA Special Interest Group
Room Pacific Suite H, SF Marriott
Chairs: Sandy Hassink, shassink@nemours.org;
and Robert Karp, robert.karp@downstate.edu.
The Nutrition SIG will continue
with its emphasis on nutrition education in residency. Our
project, "A Teacher's Guide to Pediatric Nutrition,"
is readily available at http://downstate.edu/peds/pednutrition.
The model of "stepping stone education" is used with
a primer, "Pediatric Nutrition Notes," as its
foundation. A set of five introductions, Part 2, provide the
tools for usage. Part 3 is a set of eight modules on
pathophysiology, prevention evaluation and treatment of
obesity through childhood. Part 4 contains more than 25
case-based teaching modules on disease processes affected by
nutrition. The Teacher's Guide concludes with a module on
evaluation of teaching applicable to any subject. This
includes use of structured clinical observation for resident
evaluation of taking a diet history and providing guidance.
Faculty and residents are invited
to a 2-hour program with continental breakfast to explore use
of the Teacher's Guide. We will provide model programs
evaluating use of the Teacher's Guide for achieving basic
skills of taking histories and providing guidance.
Participants will join us for presentations, discussion and
continental breakfast. Registration is not necessary. Queries
are welcome by robert.karp@downstate.edu.
12:00pm–1:30pm
4430A—Perinatal Nutrition and Metabolism
Club
Club
Room 2009-2011, Moscone West
Contact for information:
Jane McGowan, M.D.
The Johns Hopkins Hospital
Phone: 410-955-4565
Email: jmcgowan@jhmi.edu
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Probiotics and Development of
Intestinal Host Defense
W. Allan Walker, Departments of Pediatrics and Nutrition, Harvard
Medical School, Boston, MA
Supported in part by a restricted educational grant from
Ross Products Division, Abbott Laboratories
3:00pm–5:00pm
4675—Obesity I
PAS Poster Symposium
Room 2002, Moscone West
Chairs: Robert H. Lustig and Jennifer Miller
5:15pm–6:45pm
Poster Session III
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
12:00pm–6:45pm
Author Attendance: 5:15pm–6:45pm
Level 1:
– Critical Care
– Gastroenterology
– Genetics
– Neonatal Epidemiology and Follow Up
– Neonatal Pulmonology
– Neonatology
– Nephrology
– Pulmonology
Level 2:
– Developmental–Behavioral Pediatrics
– Emergency Medicine
– General Pediatrics
– Medical Education
Tuesday, May 2
8:00am–10:00am
5110A—Inflammation in Uremic
Pathophysiology
ASPN Symposium
Room 3010-3012, Moscone West
Chairs: H. William Schnaper, Northwestern University Feinberg School of
Medicine, Chicago, IL; and Robert H.K. Mak, Oregon Health and
Science University, Portland, OR
Target Audience: Pediatric
nephrologists and fellows, basic scientists, pathologists and
immunologists.
Recent evidence has strongly
suggested that the manifestations of uremia are caused in
large part by activation of inflammatory pathways. This
symposium will review the syndromic events that can be
attributed to uremic inflammation and include oxidant injury,
cytokine production and its end-organ effects on the body
tissues.
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Oxidant Injury in ESRD
Jonathan Himmelfarb, Maine Medical Center, Portland, ME
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MIA (Malnutrition, Inflammation,
Atherosclerosis) Syndrome in ESRD
Joel D. Kopple, Harbor-UCLA Medical Center, David Geffen School of
Medicine at UCLA, UCLA School of Public Health, Torrance,
CA
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Leptin and Melanocortin Signaling
in Chronic Kidney Disease
Robert H.K. Mak, Oregon Health and Science University, Portland, OR
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Molecular Pathophysiology of
Muscle Catabolism in Uremia: Effect of Acidosis and
Inflammation
William E. Mitch, Baylor College of Medicine, Houston, TX
Supported by an unrestricted educational grant from Abbott
8:00am–10:00am
5154—Developmental–Behavioral Pediatrics
PAS Platform Session
Room 2007, Moscone West
Chairs: Karen Ratliff-Schaub and Martin T. Stein
8:00am–10:00am
5162—General Pediatrics IV
PAS Platform Session
Room 2008, Moscone West
Chairs: Jeffrey M. Devries and Susan Feigelman
10:15am–12:15pm
5430—Obesity II
PAS Platform Session
Room 3014, Moscone West
Chairs: Michael Cabana and John N. Udall
10:15am–12:15pm
5435—Endocrinology and Diabetes—Basic
Research
PAS/LWPES Platform Session
Room 3007-3011, Moscone West
Chairs: Stephen E. Gitelman and Anna Spagnoli
12:00pm–1:30pm
Poster Session IV
PAS Poster Session
Levels 1 and 2, Moscone West
Posters Available for Viewing:
10:00am–2:00pm
Author Attendance: 12:00pm–1:30pm
Level 1:
– Adolescent Medicine
– Emergency Medicine
– Epidemiology
– General Pediatrics
– Infectious Diseases
– Neonatal Epidemiology and Follow Up
Level 2:
– Neonatal Pulmonology
– Neonatology
Includes:
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SPR Student Research Award: Metal
Contamination of Blood Bank Blood
Allison Blatz, Case Western Reserve University, Rainbow Babies &
Children's Hospital, Cleveland, OH
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SPR House Officer Research Award:
Pathogenesis of Measles Virus Infection in Simian
Immunodefiency Virus-Infected, Measles Virus-Vaccinated
Rhesus Monkeys
Sallie R Permar, Children's Hospital and Boston Medical Center, Boston,
MA
1:45pm–3:45pm
5730—Obesity Symposium—The BIG Picture
PAS/LWPES Hot Topic
Room 3007-3011, Moscone West
Chairs: Janet H. Silverstein, University of Florida College of
Medicine, Gainesville, FL; and Josephine Z. Kasa-Vubu,
University of Michigan, Ann Arbor, MI
Target Audience: General
pediatrics, developmental pediatrics, adolescent medicine,
genetics, basic science, pediatric endocrinology and health
outcomes.
The obesity epidemic continues to
be a major public health threat and a top priority for a broad
range of researchers and clinicians. This symposium will
attempt to reach beyond descriptive statistics and will focus
on advances from bench to bedside with a focus on
intervention.
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Overview
Josephine Z. Kasa-Vubu, University of Michigan, Ann Arbor, MI
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Lessons from the Bench: Molecular
and Anatomical Models of Leptin Resistance
Martin Myers, University of Michigan, Ann Arbor, MI
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Intensive Versus Behavior
Therapies for the Obese Child: What We Know and What We Do
Not Know
Jack Adam Yanovski, National Institutes of Health, Bethesda, MD
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Long-Term Costs of Early Onset
Diabetes
William H. Herman,
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Prenatal Programming of Obesity
and Obesity-Related Behaviors
Peter D. Gluckman, Liggins Institute, University of Auckland, Auckland,
New Zealand
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Discussion
Sponsored jointly by
the Lawson Wilkins Pediatric Endocrine Society and the
Pediatric Academic Societies
1:45pm–3:45pm
5750—General Pediatrics V
PAS Platform Session
Room 3001, Moscone West
Chairs: Paul M. Darden and David P. McCormick
1:45pm–3:45pm
5760—Underserved Populations II
PAS Platform Session
Room 3000, Moscone West
Chairs: David M. Keller and Ronald C. Samuels
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