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Sunday, May 02, 2010
3:15 PM - 5:15 PM |
| Session Number: 2700 |
| Emerging Role of Epigenetics in Pediatrics |
| PAS State of the Art Plenary |
| Vancouver Convention Centre ~ 118 |
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| Target Audience: Basic and translational scientists examining the alterations in gene expression patterns mediating by epigenetic phenomenon and clinicians involved in neonatology, neurodevelopmental and immunologic outcomes. |
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| Objectives:
- Understand the molecular mechanisms by which external signals initiate epigenetic changes to influence gene expression and thus, the biologic phenotype [br]- Understand the role of epigenetics in modifying immune responses [br]- Learn about innovative research approaches to modeling epigenetic mechanisms regulating disease phenotypes in order to identify novel therapeutic targets |
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| Chairs: Mala R. Chinoy, Pennsylvania State College of Medicine, Hershey, PA and Robert H. Lane, University of Utah, Salt Lake City, UT |
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| Increasingly, epigenetics is being identified as one of the key molecular mechanism by which external and internal signals alter gene expression patterns to influence the biologic phenotype. Building on the work of basic scientists in Developmental and Cancer Biology, translational scientists are beginning to elucidate the epigenetic influences in a number of diseases highly relevant to pediatrics. As the existing knowledge advances, investigators are able to identify and understand the roles of enzymes responsible for mediating these changes in order to target them therapeutically. This session is intended to describe the epigenetic mechanisms regulating alterations in immune response to cardiopulmonary bypass, development of asthma, and following toxicologic exposures, and introduce the concept of targeting methylation enzymes to modulate these responses. |
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Robert H. Lane
University of Utah, Salt Lake City, UT |
| 3:15 PM - |
Role of Epigenetics in Pediatric Diseases
Mala R. Chinoy
Tuffs University School of Medicine, Boston, MA |
| 3:25 PM - |
Placental Insufficiency and Its Affect on Cerebral Epigenetics, Gene Expression, and Phenotype
Robert H. Lane
University of Utah, Salt Lake City, UT |
| 3:50 PM - |
Epigenetic Regulation of Immunoparalysis
Timothy Thomas Cornell
C.S. Mott Children[apos]s Hospital, University of Michigan, Ann Arbor, MI |
| 4:15 PM - |
Modeling Epigenetic Regulation of Neurodevelopmental Disorders To Identify Therapeutic Targets
Stormy Chamberlain
University of Connecticut Health Center, Farmington, CT |
| 4:40 PM - |
Toxico-Epigenetics: Modulation of Gene Expression in Stem Cells and Cell-Cell Communication during the Totality of Human Development
James Trosko
College of Human Medicine, Michigan State University, East Lansing, MI |
| 5:05 PM - |
Discussion
Discussion
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