State-of-the-Art Plenary

Chair: Gary Fleisher, Children's Hospital, Boston

This session will examine the major impact of trauma in pediatric healthcare and discuss recent research fundings that have enhanced our understanding of the process. Topics will range from the biology of the traumatized patient to social issues related to handgun violence.

• Frederick P. Rivara, Harborview Injury Prevention and Research Center, University of Washington Pediatric
  Trauma: Risks, Costs & Consequences
• Arthur L. Kellerman, Rollins School of Public Health, Emory University
  Preventing Firearm Injuries Among Children: What Works?
• Mitchell P. Fink, Beth Israel Deaconess Medical Center
  Trauma: Mechanisms Leading to Organ System Dysfunction

Emerging & Re-Emerging Infectious Diseases***
Saturday, May 3, 1:15 pm - 2:45 pm

Chair: Jerome O. Klein
Boston University School of Medicine

Numerous publications intended for medical and general public consumption describe emerging infectious diseases or detail the re-emergence of infections which had, in recent years, been considered to be well controlled. This session is devoted to a detailed discussion of several of these infections that have significant worldwide impact on morbidity and mortality.

• Diane Wara, University of California, San Francisco
  Pediatric HIV - A Chronic Illness: Update on Diagnosis & Treatment
• Jeffrey Starke, Baylor College of Medicine, Texas Children's Hospital
  Tuberculosis: An Old Dog with New Tricks

The Resistant Pneumonococcus

• Elaine I. Tuomanen, St. Jude's Children's Research Hospital
  The Resistant Pneumococcus: Changes in the Molecular Mechanisms of Disease
• Jerome O. Klein, Boston University School of Medicine
  Resistant Pneumococcal Infections: Treatment and Prevention

The Future of Biomedical Research*
Sunday, May 4, 8:00 am - 9:30 am

Chair: Harris Jacobs
Yale University School of Medicine

One speaker from the NIH, one from government and one from industry will provide the Societies with their views on this topic. Each will offer their perspective on the role of their institution in shaping the manner in which biomedical research is conducted.

• Francis S. Collins, National Center for Human Genome Research
  The Human Genome Project: Impact on Research and Clinical Medicine
• Congressman John Porter, Chairman, Subcommittee on Labor, U.S. House of Representatives
  The Availability and Distribution of Federal Research Dollars
• C. Thomas Caskey, Merck Research Laboratories
  The Bio-Genome Drives Therapy Strategies

The Future of Pediatric Research/Education with Governmental Reform*

Sunday, May 4, 4:15 pm - 5:45 pm

Chair: Myron Genel
Governmental Affairs, Yale University School of Medicine

• Speaker to be Announced

Genetics of Autoimmunity: From Bench to Bedside
Saturday, May 3, 1:15 pm - 2:45 pm

Chair: Harris Jacobs
Yale University School of Medicine

Sponored by the March of Dimes Birth Defects Foundation

Recent advances in gene mapping have allowed the identification of genes involved in polygenic disorders such as autoimmunity. This session will use Type I Diabetes as an example. The first speaker will discuss general approaches to mapping polygenic disorders. The second speaker will describe the application of their information to the pathogenesis and prevention of Type I Diabetes in a mouse model, the NOD mouse. The third speaker will provide a clinical perspective indicating the relevance of the basic research in the first two talks.

• Richard P. Lifton, Yale University School of Medicine
  Mapping Polygenic Disorders
• Hugh O. McDevitt, Stanford University
  How MHC Class II and III Genes Predispose to Type I Diabetes
• George S. Eisenbarth, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center
  Prediction and Prevention Type I Diabetes

Linking Molecular Biology & Early Diagnosis**
Sunday, May 4, 12:30 pm - 2:00 pm

Chair: Rudolph L. Leibel
Rockefeller University

The revolution in molecular biology has changed the potential for diagnosis and treatment of many inherited and acquired diseases. This session will examine the contribution of molecular biology to our fundamental approach to obesity, behavior and development, and prevention of infectious diseases.

• Rudolph L. Leibel, Rockefeller University
  Molecular Physiology of Weight Regulation
• Fred D. Ledley, Gene Medicine, Inc.
  Nucleic Acid Vaccines
• Michael E. Greenberg, Children's Hospital, Boston, Harvard Medical School
  The Genetic Control of a Complex Behavior

Mitochondria and Human Disease
Monday, May 5, 2:30 pm - 4:00 pm

Chair: Arnold W. Strauss
Washington University and St. Louis Children's Hospital

Mitochondria generate energy for cellular functions, they are the body's power packs. Mitochondrial functions are the products of both the mitochondrial genome and the nuclear genome. In the past 10 years, genetic defects in mitochondrial functions have been discovered in humans. This session focuses on mitochondrial biogenesis, defects in mitochondrial proteins, and the role of mitochondrial energetics in human disease.

• Eric A. Shoubridge, Montreal Neurological Institute, McGill University
  Transmission and Segregation of Mitochondrial DNA: Of Mice and Women
• Douglas Wallace, Emory University School of Medicine
  Arnold W. Strauss, Washington University and St. Louis Children's Hospital
  The Many Faces of Mitochondrial Fatty Acid Oxidation Disorders

Molecular Insights in Clinical Bone Disease**
Monday, May 5, 2:30 pm - 4:00 pm

Chairs: Craig B. Langman
Northwestern University, Children's Memorial Hospital &

Ron G. Rosenfeld, Doernbecher Children's Hospital, Oregon Health Sciences University

This symposium will bring the audience a new understanding of some common and uncommon diseases, including kidney stone formation, hypercalciuria, failure of bone remodeling, and rickets with hypercalcemia by providing a new understanding of basic molecular and genetic defects which underlie them. The range of biology to be covered will include the subjects of local growth factors, the role of G-coupled receptors, and ion channels as they pertain to bone and kidney. An increased understanding of these processes will allow the clinician to refine the phenotype of some common and uncommon disorders, while providing the basic scientist new insights into state-of-the-art bone cell biology.

• Harold Varmus, National Institutes of Health
  The Role of Src Kinases in Osteoclasts
• Harald Jueppner, Massachusetts General Hospital
  Role of PTH-rp and its Receptor in Bone Development and Disease
• Steven Scheinman, SUNY - Health Science Center at Syracuse
  Chloride Channels and Kidney Stone Disease

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* Sponsored jointly by the Pediatric Academic Societies
** Sponsored jointly by the Pediatric Academic Societies and American Academy of Pediatrics
*** Sponsored jointly by the Pediatric Academic Societies and Pediatric Infectious Diseases Society