Bronchopulmonary Dysplasia: Lessons from
Experimental Models
Tuesday, May 6, 8:15 am - 10:15 am
Chair: Thomas Hazinski
Vanderbilt University Medical Center
Despite major advances in the management of
surfactant deficiency, bronchopulmonary dysplasia
remains a major morbidity associated with preterm
birth. Several different animal models are providing
new insights into the pathogenesis and evolution of
chronic injury to the developing lung. This symposium
will focus on the use of acute and chronic animal
models for the study of mechanisms underlying
bronchopulmonary dysplasia. The speakers will address
the roles of inflammation, vascular injury, and
alveolar septation in the evolution of chronic lung
injury.
- Jacqueline J. Coalson, University
of Texas Health Science Center at San Antonio
The Evolution of Acute and Chronic Lung
Injury in the Premature Baboon
- Donald Massaro, Lung Biology
Laboratory, Georgetown University School of
Medicine
The Experimental Induction of Alveolus
Formation for Therapeutic Purposes
- Richard Bland, University of
Utah Health Science Center
Insights on the Pulmonary Circulation in
Preterm Lambs with Chronic Lung Injury
Developmental Biology: Insights for Human
Disease
Monday, May 5, 4:00 pm - 6:00 pm
Chair: Larry J. Shapiro
University of California, San Francisco
Insights derived from basic developmental biology
have proven useful to the understanding of complex
human disease. An increasing number of inherited
human disorders with altered morphogenesis can be
attributed to mutations in transcription factors,
receptors, signaling molecules, growth factors,
adhesion molecules, transporters, enzymes, and
structural proteins. The identification of these
mutations has often followed the careful analysis of
natural or engineered models in the mouse or other
species used in basic development biology. This
symposium will focus on examples of Ainborn errors of
human development@ that have elucidated as a result
of conserved genetic control of development across
species. The field of molecular dysmorphology will be
reviewed and two examples of mutations in
developmentally important molecules leading to human
disease will be discussed in greater detail.
- Charles J. Epstein, University of
California, San Francisco
Molecular Dysmorphology
- Valeria Marigo, T.I.G.E.M.,
Milano, Italy
Sonic Hedgehog Signaling in Development and
Mutations in Human Disease
- Masahsi Yanagasawa, Howard Hughes
Medical Institute, University of Texas
Southwestern Medical Center
Endothelin Pathway in Neural Crest
Development: Identifying Human Disease Gene
by Accident
Fetal Medicine: Indications for Intervention
and Implications for Adult Disease
Saturday, May 3, 3:00 pm - 5:00 pm
Chair: Samuel Hawgood
University of California, San Francisco
This symposium will focus on the fetus as a target
for research and clinical intervention. Recent
developments in epidemiology, molecular medicine,
fetal diagnosis, and surgical technique are being
utilized in innovative experimental fetal therapy
programs. The speakers will address (1) epidemiologic
evidence implicating the intrauterine environment and
fetal growth as determinants of disease in adult
life; (2) the rationale, potential, technical
challenges, and results associated with direct
surgical and medical interventions on the fetus; and
(3) the ethical and potential economic impact of
recent developments in the emerging field of fetal
medicine.
- David Barker, University of
Southampton, Southhampton General Hospital
The Fetal Origins of Disease
- Alan Flake, University of
Pennsylvania
Therapeutic Interventions for the Fetus
- John Lantos, University of Chicago,
LaRabida Hospital
Fetal Medicine: A Promising Market or a
Dangerous Morass?
Growth & Exercise: Research Frontiers and
New Clinical Applications*
Monday, May 5, 4:00 pm - 6:00 pm
Chair: Daniel M. Cooper
Connecticut Children's Medical Center
For both healthy children and those with chronic
diseases, the ability to engage in play, exercise,
and other physical activities is an essential
component of daily life. There is growing awareness
that physical activity and exercise are linked to the
growth process through a variety of physiological and
molecular mechanism. The goal of this Symposium is to
review the exciting new research exploring the ways
in which growth may be regulated by physical activity
in children and adolescents. New insights into the
maturation of fundamental cardiorespiratory and
energy metabolic responses will be presented, and
will be linked with research into the nature of
spontaneous physical activity in healthy children.
The mechanisms that link exercise with the process of
growth will be highlighted with a particular emphasis
on the role of growth hormone, insulin-like growth
factor-I, and their respective binding proteins. New
and exciting developments into the mix of catabolic and
anabolic responses to exercise training in children
and adolescents will be presented. A particular
emphasis will also be on the role of exercise and
nutrition in the development of bone tissue during
growth. The final portion of the symposia will focus
on the ways in which programs of exercise can be used
therapeutically in children with chronic diseases and
disabilities. We will tie new insights into the
mechanisms that link exercise with tissue growth to
ways in which exercise can enhance health and
rehabilitation.
- Dan M. Cooper, Connecticut
Children's Medical Center, University of
Connecticut Health Center
Dynamic Responses to Physical Activity in
Children: Maturational Effects
- Alon Eliakim, Connecticut
Children's Medical Center, University of
Connecticut Health Center
Exercise and Growth: GH, IGF-1, and Beyond
- Susan Barr, University of British
Columbia, School of Family and Nutritional
Sciences
Exercise, Bones and Children: The Dynamic
Interaction
- Oded Bar-Or, McMaster University,
Children's Exercise and Nutrition Center
New Therapeutic Roles for Exercise in
Children with Disease and Disabilities
Molecular Genetics of Diabetes**
Sunday, May 4, 2:00 pm - 4:00 pm
Chairs: Dennis BierUSDA/ARS Children's
Nutrition Research Center
Kenneth C. Copeland, Baylor College of
Medicine
Speakers will provide the most current information
on the search for the genes responsible for Type 1
and Type 2 Diabetes Mallitus.
- Patrick Concannon, Virginia Mason
Research Center
Genome Wide Searches for IDDM Susceptibility
Genes
- M. Alan Permutt, Washington
University School of Medicine
Strategies for Uncovering the Molecular
Genetic Basis for Non-Insultin Dependent
Diabetes
- Simeon Taylor, National Institutes
of Health
The Genetics of Insulin Resistance Syndromes
________________________________________
* Sponsored jointly by the Pediatric
Academic Societies
** Sponsored jointly by the Pediatric Academic Societies
and Lawson Wilkins Pediatric Endocrine Society
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