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1998
Pediatric Academic Societies' Annual Meeting
May
1-5, 1998 - New Orleans Convention Center |
TOPIC
SYMPOSIA
- Chemokines and
Cytokines in Infection and Inflammation -
(date to be determined in February)
Chair: Margaret
K. Hostetter, University of Minnesota,
Minneapolis
Response to
infection or an inflammatory stimulus is dependent on
the nature of the stimulus and a communications
network between the cellular sensors of infection and
cells of the inflammatory and immune response.
Chemokines, cytokines and their receptors are key
players in this network. The speakers in this
symposium will address advances in our understanding
of the initial cellular response to infection and the
role of molecules which make up the signaling
pathways between microbes, the cells they first
contact and the effector cells of the immune
response.
Craig Gerard, Children’s
Hospital, Boston
Chemokines and Viral Host Defense
Bruce Beutler,
Howard Hughes Medical Institute, University of
Texas Southwestern at Dallas
Genetics of Endotoxin Response
Martin
Kagnoff, University of California San Diego
Epithelia cells sensors and signals for infection
and inflammation
- Genes and Behavior - Sunday, May 3, 8:30 am
- 10:30 am
Chair: Walter Miller, University of
California, San Francisco
Sponsored in part by an
educational grant from Pharmacia & Upjohn
Recent advances
in genetics and the biology of human development have
suggested a role for inheritance in human behavior,
personality traits and cognition. Understanding the
molecular basis of these complex characteristics
remains a major challenge. The speakers in this
symposium will address advances in the study of genes
regulating behavior from a clinical and basic
perspective.
David Skuse, Institute
of Child Health, University College, London, England
Imprinting, the X-chromosome and "the male
brain"
Dean Hamer, National
Cancer Institute
Genes for Human Personality and Behavior
Marc G. Caron,
Duke University Medical Center
- Innate Immunity: The
First Line of Defense - (date to be determined
in February)
Chair: Sam
Hawgood, University of California San
Francisco
Innate immunity
refers to a means of pathogen recognition and defense
that is based on a system of highly conserved
pattern- recognition molecules that are not generally
considered part of the acquired cellular or humoral
system. In evolutionary terms the innate immune
system is ancient but recent discoveries have
highlighted the complexity and importance of this
primitive system of host defense. The innate immune
system remains the first line of hose defense in
humans, and may be of paramount importance before the
acquired system has fully developed or when acquired
immunity is disarmed by inherited defects or disease.
Innate immunity may have the additional role of
sorting self from non-self and determining which
antigen the acquired immune system responds to. This
session will review the scope of innate immune
defenses highlighting the potential role of recently
discovered serum and pulmonary surfactant proteins in
protection from infection. Mechanisms of innate
immunity may be of particular importance to the
preterm neonate generally deficient in most aspects
of acquired immunity.
Charles A.
Janeway, Howard Hughes Medical Institute, Yale
University School of Medicine
The Role of Innate Immunity in the Development of
the Adaptive Immune Response
Alan B.
Ezekowitz, Massachusetts General Hospital
& Harvard Medical School
Pattern Recognition in Innate Immunity
Jo Rae Wright,
Duke University Medical Center
Pulmonary Surfactant: A Front Line of Lung Host
Defense
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