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STATE-OF-THE-ART PLENARY |
SUNDAY, MAY 2, 2:30 PM - 4:00 PM
Childhood Obesity**
Chair: Patricia
Donohoue, University
of Iowa Hospitals and Clinics, Iowa City
The session will consist of three presentations from leaders in the field. 1) Evidence supporting a major genetic influence on obesity, as well as recent advances that suggest a major genetic influence on obesity, as well as recent advances in our understanding of genetic defects causing obesity in rodents and humans will be presented. 2) The major determinants of energy expenditure and physical activity in children from different at risk populations, including body size and body composition as well as factors such as parental obesity and gestational diabetics will be reviewed. 3) Recent epidemiologic data on childhood risk factors will be reviewed, and implications of these data for formulating obesity prevention strategies will be discussed.
2:30 pm --- Genetic
Determinants of Obesity
Rudy Leibel, Columbia University
College of Physicians & Surgeons, New York
3:00 pm ---
Determinants of Energy Expenditure and Physical Activity
in Children: Results from Pima Indians
Arline Salby, National Institutes of Health
3:30 pm --- The
Epidemiology of Childhood Obesity: Implications for
Prevention
Bob Whitaker, Children’s
Hospital Medical Center, Cincinnati
Mechanisms of Human Malformation
Chair: Kenneth Lyons Jones, University
of California, San Diego
Recent applications of molecular genetic technologies to the study of mammalian development are providing dramatic insights into fundamental mechanisms of normal as well as aberrant development. The laboratories of each of the invited speakers are at the cutting edge of such discoveries and their presentations will provide an extraordinary view of the state-of-the-art in this dynamic and critical area, so vital to pediatric medicine.
How Do Hox Genes
Specify Our Body Plan?
Mario Capecchi, Howard Hughes
Medical Institute, University of Utah, Salt Lake City
Developmental
Patterning Molecules and the Control of Conserved
Functions: From Model Organisms to Man
William J. McGinnis, University of
California, San Diego
Molecular Basis of
Asymmetry during Vertebrate Embryogenesis
Juan Carlos Izpisua Belmonte, The
Salk Institute for Biological Studies, La Jolla
State Child Health Insurance
Programs (SCHIP) and Medicaid: Implications for Research*
Chair: James M. Perrin, Massachusetts
General Hospital
The new State Child Health Insurance Programs (SCHIP) represent a major new investment in child health insurance across the country. States have the choice of expanding their current Medicaid programs by increasing age and income eligibility or of developing new insurance programs for uninsured children not eligible for Medicaid. The next few years will see the largest expansion in children’s access to health care. What are the research agendas (access, health services, quality, outcomes) that arise from this program; what should the pediatric research community do to increase quality and quantity of research; how can pediatric researchers interact effectively with policymakers at state and Federal levels to help shape these new programs?
Monitoring Expanded
Health Insurance for Children
Paul W. Newacheck, Institute
for Health Policy Studies and Department of Pediatrics,
University of California, San Francisco
California’s
Innovations in SCHIP: Access and Monitoring
Lorraine U. Brown, Managed
Risk Medical Insurance Board, California Healthy Families
Program, Sacramento
Implementing SCHIP:
Interactions of Policy and Research
Sara Rosenbaum, George
Washington University, Center for Health Policy Research,
Washington, DC
MONDAY, MAY 3, 3:00 PM - 4:30 PM
Matching the Drug to the Patient:
Genetic, Developmental, and Environmental Effects on Drug
Responses
Chair: Thomas Hazinski, Vanderbilt
University Medical School, Nashville
Advances in pharmacology and genetics have increased our understanding of individual responses to drugs. In this state of the art session, three nationally recognized experts will discuss recently discovered genetic and environmental mechanisms which explain why drugs such as opiods, chemotherapeutic agents, and cisapride are effective for some patients and toxic for others.
Effects of Ethnicity
on Drug Metabolism and Drug Response
Alastair JJ Wood, Vanderbilt University School
of Medicine, Nashville
Cancer
Pharmacogenomics: Why Chemotherapy is Like Pinball?
Fred Ledley, Variagenics, Inc., Cambridge
Drug and
Environmental Effects on a Cardiac Potassium Channel
Gene: The Cisapride Controversy
Tom Klitzner, Mattel Children’s Hospital,
UCLA, Los Angeles
Human Genome Project: An Update
Chair: Maynard
Olson, University of Washington, Seattle
This State of the Art Plenary session will focus on how molecular genetics research will be changed by the availability of the human genome complete sequence, current applications of genome technology in human clinical research, and ethical issues in genetic research in children.
How will the
Sequencing of the Human Genome Change Biomedical
Research?
Maynard Olson, University of Washington,
Seattle
Application of
Genetic Strategies and Human Genome Project Resources for
the Identification of Human Disease Genes
Val C. Sheffield, Howard Hughes Medical
Institute, University of Iowa, Iowa City
Genetic Testing in
Children: Ethics Issues of Research and Clinical Practice
Benjamin S. Wilfond, University of Arizona,
Tuscon
Report of the Task Force of the
Future of Pediatric Education II *
Chairs: Jimmy Simon, Wake Forest
University School of Medicine, Winston-Salem
Russell W. Chesney, University of
Tennessee, Memphis College of Medicine, Memphis
Sweeping societal changes (e.g. racial and ethnic diversity, single parent families, working parents, tobacco usage, firearms, violence) and changes in child health care (new vaccines, antibiotic resistance, the human genome project, psychopharmacology, diagnosis and therapy of serious conditions -acute and chronic- in an ambulatory setting) will have a vast impact on pediatric education. These changes will alter how the medical student, the pediatric resident, the subspecialty fellow, the practicing general and subspecialty pediatrician (both early and later in their careers) and other members of the child health team will be educated. This session will discuss the background of this Task Force, those recommendations that have arisen from the ongoing deliberations of the Task Force, the data gathered, the impact of the various working groups, as well as communications from public presentations and web site responses. We will specifically focus on those recommendations which are controversial or for which there is not a consensus of opinion. We will also discuss a process of implementation, evaluation and follow-up of the Task Force final recommendations. Further information is available at www.aap.org/profed/fopel.htm
Jimmy Simon, Wake Forest University School of Medicine, Winston-Salem
Russell Chesney, University of Tennessee, Memphis College of Medicine, Memphis
Errol Alden, American Academy of Pediatrics, Elk Grove Village
TUESDAY, MAY 4, 11:30 AM - 1:00 PM
Fetal and Neonatal Medicine:
Control and Disorders of Lung Growth
Chair: David Carlton, University of
Utah, Salt Lake City
Abnormalities in the growth and development of the fetal lung and the fetal pulmonary vasculature remain major causes of neonatal mortality and morbidity. Pulmonary hypoplasia is found in as many as 20% of all neonatal autopsies. Speakers in this session will review the relationship between fetal lung expansion and lung growth, the embryology and pathogenesis of congenital diaphragmatic (a major cause of fatal lung hypoplasia), and factors important in postnatal remodeling of abnormal pulmonary vasculature.
Fetal Lung
Development: Roles of Mechanical and Metabolic Factors
Richard Harding, Monash University, Melbourne,
Australia
Pathogenesis of
Experimental Diaphragmatic Hernia
John Greer, University of Alberta, Edmonton
Developmental
Changes in the Pulmonary Vascular Response to Injury
Kurt Stenmark, University of Colorado Health
Science Center, Denver
Molecular Pathogenesis of
Infectious Diseases
Chair: Mike
Tosi, Mount Sinai Medical Center, New York
The diversity of microorganisms, from prions to bacteria to yeast, and the role they play at the molecular and biochemical level in the pathogenesis of a variety of infectious diseases will be presented by three world-renowned speakers, with unsurpassable expertise in their field.
Role of Prions in
the Pathogenesis of the Spongiform Encephalopathies
Fred E. Cohen, University of
California, San Francisco
Molecular
Pathogenesis of Salmonella Infections
Samuel I. Miller, University of
Washington, Seattle
Molecular
Pathogenesis of Candida Infections
Margaret K. Hostetter, Child Health
Research Center, Yale University, New Haven
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Last Modified: April 06, 2000