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TOPIC SYMPOSIA |
SUNDAY, MAY 2, 4:00 PM - 6:00 PM
Susceptibility to Cancer
Chair: Alan
D’Andrea, Children’s Hospital and
Dana Farber Cancer Institute, Boston
The speakers in this session will discuss the clinical and molecular aspects of various human genetic syndromes, resulting in increased susceptibility to cancer. Also, specific chromosome translocations underlying various human cancers will be considered. While these human syndromes are rare, they offer broad insights into stem cell biology and the development of cancers in the general population.
4:00 pm ---
Tyrosinemia Type I and Fanconi Anemia: Two Inherited
Cancer Susceptibility Syndromes
Markus Grompe, Oregon Health
Sciences University, Portland
4:40 pm ---
Li-Fraumeni Syndrome and the p53 Gene
Thea Tlsty, University of
California, San Francisco
5:20 pm ---
Chromosome Breakage and Leukemia
Michael Cleary, Stanford School of
Medicine, Palo Alto
Development in Vitamin D
Metabolism and Rickets**
Chairs: Uri Alon, Children’s Mercy
Hospital, Kansas City and Joseph Gertner,
Serona Laboratories, Inc., Norwell, MA
This Topic Symposium will address new advances in our understanding of the pathophysiology and management of rickets.
X-linked
Hypophosphatemic Rickets
Thomas O. Carpenter, Yale University
School of Medicine, New Haven
Molecular Regulation
and Mutations of the Vitamin D 1-Alpha Hydroxylase Gene
Anthony Portale, University
of California, San Francisco
Treatment of Rickets
Uri Alon, Children’s Mercy
Hospital, Kansas City
MONDAY, MAY 3, 8:00 AM - 10:00 AM
Advances in Cognitive
Neurosciences*
Chair: Donna Ferriero, University of
California, San Francisco
Cognitive disorders affecting language, learning and behavior effect a broad range of pediatric patients. Speakers in this session will address recent advances in the development and function of the fetal cortex, especially in regard to actions of steroids, insights into cognitive disorders derived from advanced neuro-imaging techniques and new methods of neuro-rehabilitation using computer technology for specifically language impaired children.
Neuroscience Based
Training Ameliorates Language Impairment
Michael Merzenich, University of California,
San Francisco
Neuro-imaging in
Cognitive Disorders
Pauline Filipek, University of California,
Irvine
Neurosteroids and
Cortical Development
Synthia Mellon, University of California, San
Francisco
Apoptosis
Chair: Roberta
Gottlieb, Scripps Research Institute, San Diego
New discoveries in the mechanisms of programmed cell death will be reviewed. The essential nature of apoptosis in mammalian development and current and future application of these discoveries to clinical medicine will be presented.
8:00 am ---
Mitochondria: Ignition Chamber for Apoptosis
Roberta Gottlieb, Scripps Research
Institute, San Diego
8:40 am ---
Caspases and Cell Death
Guy Salvesen, Burnham Institute, San Diego
9:20 am ---
Identification of Components of the Cell Death Pathway
Vishva Dixit, Genentech, Inc., San Francisco
TUESDAY, MAY 4, 8:00 AM - 10:00 AM
Cytokine Receptor Defects
Chair: Jennifer
M. Puck, National Center for Human Genome
Research, Bethesda
This topic symposium will acquaint pediatricians with this growing list of cytokine receptor defects, their clinical features, molecular bases and means of diagnosis. A portion of the session will also be devoted to an update on the status of gene therapy for one of these defects.
X-linked SCID: A
Cytokine Receptor Defect as a Target for Gene Therapy
Jennifer M. Puck, National Center for Human
Genome Research, Bethesda
Jak3: Role in
Cytokine Signaling and the Pathogenesis of SCID
John J. O’Shea, National Institute of
Arthritis, Musculoskeletal and Skin Diseases, Bethesda
"Just Say No To
Bugs: The Interferon Gamma Pathway"
Steven M. Holland, Laboratory
of Host Defenses, National Institute of
Allergy and Infectious Diseases, NIH, Bethesda
* Sponsored jointly by the Pediatric Academic Societies
** Sponsored by the American Pediatric Society, Society for Pediatric Research, American Society of Pediatric Nephrology, and the Lawson Wilkins Pediatric Endocrine Society
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Last Modified: April 06, 2000