Pediatric Academic Societies and American Academy of Pediatrics Joint Meeting May 12-16, 2000 Hynes Convention Center, Boston

Expanded Schedules for: Friday Saturday Sunday Tuesday Schedule-at-a-Glance Affiliate Societies & Clubs MONDAY, MAY 15

TOPIC SYMPOSIA

¨Vaccine Dialogue
Chairs: Sarah S. Long, St. Christopher’s Hospital for Children, MCP Hahnemann University School of Medicine, Philadelphia and Ron Dagan, Soroka University Medical Center, Beer-Sheva, Israel

In this interactive dialogue, speakers will engage the audience in discussion of highly important and timely issues related to vaccines. In part one, speakers will discuss latest information regarding the development and performance of conjugate pneumococcal and meningococcal vaccines, as well as the challenges of developing and evaluating novel combination vaccines. In part two, speakers will lead discussions of inherent tensions in implementing vaccine strategies that maximize benefits of scientific discoveries and protect individuals, the public and policy.

Mapping the Future of Bacterial and Combination Vaccines
Implementation of Pneumococcal and Meningococcal Conjugate Vaccines: Steven B. Black, Vaccine Study Center, Kaiser Permanente Medical Center, Oakland
Challenges of Combination Vaccines: Kathryn M. Edwards, Vanderbilt University School of Medicine, Vanderbilt Children's Hospital, Nashville

Matching Scientific Progress and Public Trust
Monitoring Achievements and Risks of Vaccine Programs: Walter A. Orenstein, National Immunization Program, Centers for Disease Control and Prevention, Atlanta
Current State of Confidence and Concern: Samuel L. Katz, Duke University Medical Center, Durham

Sponsored Jointly with the Pediatric Infectious Diseases Society

Supported in part by an educational grant from Wyeth-Lederle Vaccine and Merck Vaccine Division

SUBSPECIALTIES/THEMES
(Original Science Abstract Programs)

• Allergy, Immunology and Rheumatology I
• Cardiology: Genetic Basis of Heart Disease and Development
• Clinical Bioethics
• Clinical Research in Emerging Countries
• Control of Breathing
• Cytokines and Signaling Molecules II
• Neonatal Nutrition and Metabolism II
• Neonatal Pulmonology: Control of Pulmonary Vascular Tone
• Neurodevelopmental Disabilities I
• Neurology - Basic Science
• Sickle Cell and Endothelial Cell Interface

RICHARD E. ROWE AWARD
Richard E. Rowe Award Presentation - Mark W. Russell:
In vivo Transactivation of the alphaB Crystallin Promoter by Cardiac Transcription Factors Involved in Early Heart Development

APA PRESIDENTIAL PLENARY & ARMSTRONG LECTURE

Presidential Address: Ellen F. Crain, Albert Einstein College of Medicine, Bronx
Armstrong Lecture: Greenpeace

STATE OF THE ART PLENARY

¨Gene-Based Understanding of X-linked Primary Immunodeficiency Disorders
Chair: Rebecca H. Buckley, Duke University Medical Center, Durham

This session can bring all pediatricians up-to-date on the astounding information explosion in this area and point out how correction may be possible for most of these diseases for which the molecular basis is known. It will also emphasize the key role pediatricians have in identifying these patients prior to the development of serious infections.

X-linked Severe Combined Immunodeficiency
Jennifer M. Puck, National Human Genome Research Institute/NIH, Bethesda

Wiskott-Aldrich Syndrome
Hans D. Ochs, University of Washington School of Medicine, Seattle

X-linked Lymphoproliferative Disease
Cox Terhorst, BIDMC/Harvard Medical School, Boston

Supported by the National Institute of Child Health & Human Development

¨Gene Defects and Kids’ Heart Disease
Chair: Arnold W. Strauss, Washington University and St. Louis Children's Hospital, St. Louis

Until 10 years ago, etiologies and pathogenesis of heart disease in children were poorly understood. This symposium focuses on recent discoveries of gene defects in children with congenital heart disease, abnormalities of situs determination, arrhythmias, and cardiomyopathy. The causes of many forms of pediatric heart disease as single gene defects at multiple loci will be discussed.

Genetic Causes of Congenital Heart Disease
Christine Seidman, Howard Hughes Medical Institute/Brigham and Women's Hospital, Boston

Genes and Left-Right Asymmetry
Martina Brueckner, Yale School of Medicine, New Haven

Genes Causing Pediatric Arrhythmias
Jeffrey A. Towbin, Baylor College of Medicine, Texas Children's Hospital, Houston

¨Pediatrics in the New Millennium: Compelling Issues in Public Policy - 7th Annual Public Policy Plenary
Chair: Myron Genel, Yale University School of Medicine, New Haven

This is the 7th annual Public Policy Plenary Symposium organized and sponsored by the Public Policy Council, which coordinates public policy activities for the APS, SPR and AMSPDC, in collaboration with the APA Public Affairs Committee. The year 2000 program will look forward to the new millennium and broadly examine the outlook for children’s health in three vital areas: (1) access to health care (2) testing and access of children to drugs and devices and (3) the pipeline for pediatric physician-investigators and the future of academic pediatrics. We have set aside significant time at the conclusion of the speakers’ formal presentations to permit interactive dialogue between members of the panel and the audience.

Children’s Access to Health Care - Removing the Financial Barrier
Joel J. Alpert, Immediate Past President of the American Academy of Pediatrics and Past President of the Ambulatory Pediatric Association, Boston University School of Medicine

Increasing Pediatric Access to Medical Therapies
Jane E. Henney, Commissioner, Food and Drug Administration, Rockville

The Pipeline of Physician-Scientist in Pediatrics
Leon E. Rosenberg, Princeton University; Lasker Trust/Funding First; and Former Dean, Yale University School of Medicine

Supported in part by an educational grant from the Columbus Children's Hospital, Columbus, Ohio

LUNCH BREAK

SPR BUSINESS MEETING
Members Only

TOPIC SYMPOSIA

¨The Environment and Children’s Health
Chair: Ellen F. Crain, Albert Einstein College of Medicine, Bronx

Rates of childhood asthma, cancer, ADHD, and poor school performance are increasing, and there is growing evidence that environmental disruption plays an important role in these trends. Exposure to lead continues to affect children’s health, and exposure to pesticides and chemicals is increasing. Few pediatricians understand the extent of these threats to their patients’ health, and fewer still have incorporated environmental health into their practice or advocacy activities. The goals of this symposium are to provide an overview of what is known about several key environmental threats to children’s health and to introduce evidence that interaction with the natural environment may have a positive impact on children’s health.

Pesticides, PCB’s, and Endocrine Disruptors: What is the Evidence That They Threaten Children’s Health?
Philip J. Landrigan, Mount Sinai School of Medicine, New York

What is Known About Air Quality and Children’s Respiratory Health?
Jonathan Samet, Johns Hopkins University, School of Hygiene & Public Health, Baltimore

Play in the Natural Environment: Preliminary Evidence of its Contributions to Children’s Health
Robin C. Moore, North Carolina State University, School of Design, Raleigh

¨Novel Treatments for Blood Disease
Chair: Alan D. D’Andrea, Dana Farber Cancer Institute, Boston

In this session we will evaluate new clinical trials and novel approaches in gene therapy and immunotherapy for pediatric blood diseases. While these approaches are applicable to rare subpopulations of patients, over time the insights gained in these studies may be adapted to patients in the general population. In the process of designing and executing these clinical trials, these pediatric investigators have made many basic discoveries related to viral vector design and the regulation of the human immune system.

Gene Therapy for Hemophilia
Mark Kay, Stanford University, Stanford

Immune Modulation in Bone Marrow Transplantation
Eva Guinan, Children's Hospital, Boston/Dana-Farber Cancer Institute, Boston

Gene Therapy for Primary Immunodeficiencies
Robertson Parkman, Children's Hospital, Los Angeles

SUBSPECIALTIES/THEMES
(Original Science Abstract Programs)

• Adolescent Medicine II
• Allergy, Immunology and Rheumatology II
• Developmental Biology I
• Dysmorphology and Teratology
• Education: Student
• General Pediatrics III
• Hypoxic/Ischemic Encephalopathy and Protective Mechanisms
• Immunizations: Health Services Research
• Neonatology: Disease-Oriented Research II
• Neonatal Immunology and Hematology II
• Neurodevelopmental Disabilities II
• Pulmonary Vascular Biology

TOPIC SYMPOSIUM

¨Infections in the NICU: State of the Art, 2000
Chair: Richard F. Jacobs, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock

This multidisciplinary session will provide participants with a state-of-the-art update on the epidemiology, microbiology, clinical presentations, diagnostic and management issues related to infections in the NICU. The three lecture-style presentations will include an update of the non-antibiotic treatment issues in the septic newborn. Participants will review an updated evaluation of the current evidence for efficacy on the use of recombinant hematopoietic growth factors, intravenous immune globulin, and granulocyte transfusions in the NICU. The second lecture will focus on the current state of the art related to nosocomial infections in the NICU. The final lecture will focus on fungal infections in the NICU and will provide information on the clinical presentation, diagnostic workup, and treatment in newborns. There will be question and answer opportunities after each lecture with a panel discussion at the end of the workshop. The goal of the session will be to provide the participants with the latest analysis of non-antibiotic or anti-fungal therapy in newborns and an update on nosocomial and fungal infections in the NICU.

The Use of Recombinant Hematopoietic Growth Factors, Intravenous Immune Globulin, and Granulocyte Transfusions in the NICU: Weighing the Evidence of Efficacy.
Robert D. Christensen, University of Florida School of Design, Gainesville

Nosocomial Infections in the NICU: Causes and Cures
Carol J. Baker, Baylor College of Medicine, Houston

Fungal Infection in the Newborn: Suspect It, Detect It, Correct It.
Margaret K. Hostetter, Yale University School of Medicine, New Haven

STATE OF THE ART PLENARY

¨Achieving Good Health For the World’s Children
Chairs: Errol R. Alden, American Academy of Pediatrics, Elk Grove Village, and Jane Schaller, New England Medical Center, Boston

The health of the world’s children is important to the future of the world. This plenary session will explore basic principles of world health for children and suggest ways in which pediatricians all over the world can work together to achieve better and brighter futures for all of our children. The concept of a world community of pediatricians bearing a collective responsibility for the health of children will be explored. Existing standards will be discussed, including training and professional standards of our pediatric profession around the world, concepts of medical ethics which govern our behavior as physicians, and concepts of children’s rights which exist in international law and define world standards for the treatment of children. Adopting a broad definition of child health which includes physical, mental, and social health, the disease burdens of children around the world now and in the 21st century will be presented, along with some concepts of how these burdens might be lessened. Finally, the roles that pediatricians can play in humanitarian response to emergencies and disasters will be presented. Time will be allowed for discussion from members of the audience, who are encouraged to think about these issues in advance and be prepared to add their voices to the discussion.

World Community: Children and Pediatricians, A Collective Responsibility
Robert Haggerty, University of Rochester School of Medicine & Dentistry, Rochester

World Standards: Professional Standards, Medical Ethics, Children’s Rights
Jane G. Schaller, New England Medical Center, Boston

World Health: Disease Burdens for Children Now and in the 21st Century
Jerry Coovadia, University of Natal, South Africa

World Disasters: the Special Needs of Children
Karen Olness, Rainbow Babies and Children’s Hospital, Cleveland

Supported by an educational grant from Johnson & Johnson Pediatrics Institute

¨The Biologic, Sociologic and Psychologic Impact of Stress in Childhood
Chair: Jack P. Shonkoff, The Heller Graduate School, Brandeis University, Waltham

The impact of stress on the physical and mental health of adults has been extensively studied. Recent research has begun to examine its impact on children at all levels of their development. This state-of-the-art symposium examines current research and concepts on the impact of stress on the developing brain, on bio-behavioral responses in children, and in children in difficult social environments. Leading researchers in each of these areas will present aspects of their research that relates to cutting edge concepts in their field.

Molecules and Mechanisms of the Neuroendocrine Response to Stress During Early Postnatal Life: New Insights
Tallie Z. Baram, University of California at Irvine

Psychobiologic Reactivity to Stress: Implications for Pediatric Morbidities
W. Thomas Boyce, School of Public Health & Institute of Human Development, University of California, Berkeley

The Effects of Early Social Deprivation on Children
Felton Earls, Harvard School of Public Health, Cambridge

¨Mechanisms of Asthma and Other Allergic Diseases
Chair: Lanny J. Rosenwasser, University of Colorado Health Science Center and the National Jewish Hospital and Research Center

This session will present the latest information on 1) the role of the mast cell in asthma and other allergic diseases 2) the role of 1L-13 in asthma and 3) the genetics of asthma and other allergic diseases.

Update on Mast Cell Biology and Its Role in Allergic Diseases
Joshua Boyce, Harvard Medical School, Boston

Role of 1L-13 in Asthma
Marsha Wills-Karp, Johns Hopkins University, Baltimore

Genetics of Asthma and Other Allergic Diseases
Lanny Rosenwasser, University of Colorado Health Science Center and the National Jewish Hospital and Research Center

¨Molecular Genetics in Pediatric Practice
Chairs: Michael M. Kaback, Children’s Hospital and Health Center and the University of California, San Diego and Judith G. Hall, University of British Columbia, Vancouver

This session will address some of the dramatic recent developments in molecular genetics and their relevance to modern pediatric practice. These powerful and pervasive technologies will be addressed from a "forest" point of view, indicating how these innovations may impact diagnosis, treatment, and counseling in various sectors of pediatric practice. Molecular genetic methodologies have implications not only for classic inborn errors of metabolism and clearly defined genetic disorders, but are now becoming pivotal in the characterization of presymptomatic conditions and in defining predispositions to many common disorders which manifest both in childhood and/or adult life. The implications of these technologic advances are vast. From oncology to infectious disease--from congenital malformations to behavioral aberrations--these powerful new technologies are altering, and will continue to alter, the nature of medical practice.

Introduction and Overview
Judith G. Hall, University of British Columbia, Vancouver

The Technology of Molecular Genetics: Diagnosis, Prognosis, Intervention
Bradley Popovich, Oregon Health Science University, Portland

Molecular Mechanisms of Genetic Disease
David Valle, John Hopkins University School of Medicine, Baltimore

Molecular Genetics: Applications to and Implications for Patient Care
Larry J. Shapiro, University of California, San Francisco

POSTER SESSION IV

APA BOARD/AWARDEE DINNER

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Last Modified: April 27, 2000