Pediatric Academic Societies and American Academy of Pediatrics Joint Meeting May 12-16, 2000 Hynes Convention Center, Boston

Expanded Schedules for: Friday Sunday Monday Tuesday Schedule-at-a-Glance Affiliate Societies & Clubs SATURDAY, MAY 13

TOPIC SYMPOSIA

¨Computers in Medicine: From the Health Center to the Home to the Genome
Chair: Gary Fleisher, Children’s Hospital, Harvard Medical School, Boston

From molecular biology to clinical care, computers will play a decisive role in pediatrics in the next millennium. This symposium will address the technological solutions for the storage and dissemination of medical information. The translation of basic scientific discoveries into clinical practice and issues related to social concerns, access, privacy, and security will be discussed.

Information Infrastructure for the Next Generation Medicine
Isaac S. Kohane, Harvard Medical School, Boston

Health Applications on the Web: Access, Privacy, and Safety
Kenneth D. Mandl, Children's Hospital, Boston

Bioinformatics in Support of Molecular Medicine
Russ B. Altman, Stanford University, Stanford

¨Genetics of Sexual Differentiation and Gender Assignment
Chair: Kenneth Copeland, University College of Medicine, Oklahoma City

This session will cover recent advances in molecular genetics relevant to sexual differentiation and their impact on management of children with ambiguous genitalia.

Genes, Gonads and Germ Cells
David Page, Howard Hughes Medical Institute, Whitehead Institute of Biomedical Research, Cambridge

Cell Signaling in Sexual Differentiation
Andrew P. McMahon, Harvard University, Boston

"Genes to Gender: Impact of Molecular Biology on Management of Ambiguous Genitalia"
Charmian Quigley, Eli Lilly and Co. and Indiana University, Indianapolis

Sponsored Jointly with the Lawson Wilkins Pediatric Endocrine Society and the AAP Section on Endocrinology

SUBSPECIALTIES/THEMES
(Original Science Abstract Programs)

• Behavioral Pediatrics I
• Brain Development - Mechanisms
• Epidemiology
• Fetal and Neonatal Nutrition and Metabolism I
• General Pediatrics I
• Historical Perspectives
• Infectious Diseases I: Viral Diseases
• Neonatal - Patient Oriented Research I
• Nephrology: Development and Disease
• Newborn: Health Services Research
• Pulmonary Inflammation
• The Ethics and Genetics of Inborn Errors of Metabolism

TOPIC SYMPOSIA

¨Ion Channels and Disease
Chair: Lisa M. Guay-Woodford, University of Alabama at Birmingham

The highly regulated transport of sodium, potassium, and chloride ions is essential in the proper functioning of a diverse array of organ systems. Single gene defects which disrupt these transport processes underlie a variety of renal, cardiac, and neuromuscular disorders. This symposium will discuss how recent elucidation of these genetic defects provide insights into the molecular pathogenesis of these disorders and suggest roles for these transport pathways in more complex disorders such as hypertension, kidney stone formation, acquired cardiac arrhythmias and seizure disorders.

Sodium Channels: Function and Dysfunction
Alfred L. George, Vanderbilt University Medical Center, Nashville

Chloride Channels - The Role of Mutations in Renal and Neuromuscular Disorders
Rajesh Thakker, Nuffield Department of Med., University of Oxford , Oxford, United Kingdom

Potassium Channels: Structural Basis for Function and Disease
Stephen A.N. Goldstein, Yale University School of Medicine, New Haven

Sponsored Jointly with the American Society of Pediatric Nephrology

¨Child Health Services Research: Scientific Opportunities and Methods
Chair: Larry Kleinman, Lehigh Valley Hospital, Allentown

This session will discuss child health services research as an emerging field of applied science. The session will highlight both scientific opportunities and accomplishments. Dr. Kleinman will frame the context of health services research as an applied science. Dr. Simpson will elaborate on the continuum of child health services research, and the relationship of this work to the agenda of the Agency for Healthcare Research and Quality, and a principal federal agency for health services research. Dr. Stein will speak on the state-of-the-art in measuring the health and well being of children, emphasizing the methodological foundations of the work. Dr. Homer will address scientific methods in the quality of health care, from concept to measurement, to improvement and then back to measurement. The session will acknowledge specific controversies in the field and provide ample opportunity for discussion among participants and panelists.

Applied Science and the Context of Child Health Services Research
Larry Kleinman, Lehigh Valley Hospital, Penn State College of Medicine, Allentown

Child Health Services Research: Its Scope and Continuum
Lisa Simpson, Agency for Healthcare Research and Quality, Chevy Chase

Using Health Status Assessment in Children as an Outcome
Ruth E. Stein, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx

Quality of Care and Improving the Delivery of Child Health Services
Charles J. Homer, National Initiative for Children’s Healthcare Quality, Boston

SUBSPECIALTIES/THEMES
(Original Science Abstract Programs)

• Adolescent Medicine I
• Behavioral Pediatrics II
• Clinical Cardiology
• Clinical Neurology Update
• Cytokines and Signaling Molecules I
• Developmental Aspects of Pulmonary Growth and Vascular Reactions
• Endocrinology and Metabolism I
• General Pediatrics: Infectious Disease
• Genetic Basis of Metabolic Nutritional Disorders
• Infectious Diseases II: Viral Diseases
• Neonatal Follow-up
• Violence: A Family Affair

LUNCH BREAK

APA LUNCHEONS
Regional Chairs
Fellows
SIG Chairs

COMMERCIAL EXHIBITS OPEN AND POSTERS AVAILABLE FOR VIEWING
Available for viewing - 12:30 pm - 7:15 pm
Author Attendance - 5:00 pm - 7:15 pm

APS PRESIDENTIAL PLENARY - HOWLAND AWARD
Presidential Address - Rebecca H. Buckley, Duke University School of Medicine
John Howland Award Presentation - Samuel A. Katz

JOSEPH W. ST. GEME, JR. LEADERSHIP AWARD
Joseph W. St. Geme, Jr. Award Presentation - Evan Charney, Dept. of Pediatrics, University of Massachusetts Medical Center, Shrewsbury
St. Geme Awardee Introduced by: Kenneth B. Roberts, Professor of Pediatrics, University of North Carolina School of Medicine, Greensboro

Presented on behalf of the American Pediatric Society, American Academy of Pediatrics, American Board of Pediatrics, Ambulatory Pediatric Association, Association of Pediatric Program Directors, Association of Medical School Pediatric Department Chairman and Society for Pediatric Research

STATE OF THE ART PLENARY

¨Cell and Organ Transplantation
Chair: David M. Briscoe, Children’s Hospital, Boston

Advances in solid organ transplantation have substantially improved the long-term prognosis for children with failure of several different organ systems. Three internationally-recognized speakers will discuss the state-of-the-art in pediatric solid organ transplantation, the cutting edge approaches for achieving long-term graft survival, and the clinical promise of new alternatives such as tissue engineering and stem cell delivery.

Advances in Pediatric Solid Organ Transplantation: Accomplishments and Challenges
Oscar Salvatierra, Stanford University School of Medicine, Stanford

Transplant Immunology: Progress Towards Inducing Tolerance
Alan M. Krensky, Stanford University School of Medicine, Stanford

Current and Future Clinical Applications of Tissue Engineering
Anthony Atala, Harvard Medical School; Children’s Hospital, Boston

¨The Developing Brain and Human Disease
Chair: Joseph J. Volpe, Children’s Hospital, Harvard Medical School, Boston

The three outstanding speakers in this session will explore the exciting boundary between advances in developmental genetics of the brain and clinical medicine. An understanding of the developmental determinants of neuronal fate has led to a new molecular understanding of several inherited diseases of the human brain involving abnormalities in brain patterning and neuronal organization and migration. Exciting recent findings have challenged the depressing notion that regeneration and/or replacement of developmentally deficient or damaged brain is impossible. The convergence of information on neuronal fate and neural stem cells raises the very real possibility of exciting new cell-based therapies for a range of congenital and acquired diseases of the human brain.

Genetic Control of Neuronal Fate in the Developing Brain
Robert F. Hevner, Langley Porter Psychiatric Institute, University of California, San Francisco

Genetic Basis of Abnormal Neuronal Migration in the Human Brain
Christopher Walsh, Harvard Medical School, Boston

Neural Stem Cells and Therapy of Disorders of the Developing Nervous System
Evan Y. Snyder, Harvard Medical School, Children’s Hospital, Boston

Supported by an educational grant from the March of Dimes Birth Defects Foundation

¨Hormones, Nutrient Substrates, and Metabolism: Critical Changes at Birth
Chair: Ora Pescovitz, Riley Hospital for Children, Indianapolis

Many essential metabolic changes take place following birth, stimulated by developmental processes, hormones, and by the rapidly changing diet as the infant starts consuming milk. Insulin secretion, for example increases, especially in response to meal associated nutrients. Persistent hyperinsulinemia, however, leads to recurrent and severe hypoglycemia. Advances in pancreatic b-cell biology have helped sort out how persistent hyperinsulinemia occurs, with the potential for new, more specific therapy. The influx of lipids from milk requires increased capacity for lipid metabolism, particularly oxidation. This, however, requires the development of enzymes and transport proteins to move the fatty acids into the mitochondria. Failure of these processes leads to organ failure, most notably in the heart. Many important amino acids also take on new roles. Glutamine, for example, shifts from producing glutamate in the fetus for placental metabolism, becoming an important substrate for gluconeogenesis and a regulator of gut and muscle development. Each of these topics will be discussed by experts in neonatal metabolism.

Neonatal Insulin Secretion and Persistent Hyperinsulinemia of Infancy
Pamela Thomas, University of Michigan, Ann Arbor

From Glucose to Fat: The Neonatal Metabolic Transition
Arnold Strauss, Washington University and St. Louis Children's Hospital, St. Louis

Glutamine: Role in the Fetus and Low Birthweight Infant
Josef Neu, University of Florida, Gainesville

Sponsored Jointly with the Lawson Wilkins Pediatric Endocrine Society

¨Pathogenesis of Viral Respiratory Infections
Chair: Mark R. Denison, Vanderbilt University Medical Center, Nashville

Viruses interact intimately with the host cell environment from the time of initial contact through assembly and release of new infectious virus particles. During infection viruses use preexisting host cell components, modify the intracellular environment, and use mechanisms to avoid host cell immunity in order facilitate their replication and survive to be transmitted to new hosts. The symposium will explore specific aspects of the pathogenesis of four respiratory viral pathogens; the coronaviruses, parainfluenza viruses, influenza virus, and respiratory syncytial virus. The symposium speakers will describe unique features of the replication, cell biology or immune response of each virus and how understanding of molecular mechanisms of pathogenesis provides critical information in efforts to prevent or treat viral respiratory infections.

Cellular Pathogenesis of Coronavirus Infections
Mark R. Denison, Vanderbilt University Medical Center, Nashville

Receptor Mediated Entry of Paramyxoviruses
Anne Moscona, Mount Sinai School of Medicine, New York

Molecular Determinants of Influenza Virus Virulence
Kanta Subbarao, Centers for Disease Control, Atlanta

Neonatal Immune Response to Respiratory Syncytial Virus
James E. Crowe, Jr., Vanderbilt University School of Medicine, Nashville

Supported by an educational grant from ICN Pharmaceuticals

POSTER SESSION II

APS MEMBER DINNER IN HONOR OF THE HOWLAND AWARDEE
By Invitation - APS Members only

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Last Modified: April 06, 2000