Pediatric Academic Societies and American Academy of Pediatrics Joint Meeting May 12-16, 2000 Hynes Convention Center, Boston

Friday, May 12

9:00 am - 12:00 noon - MINI COURSES

¨Asthma and Food Allergy: Bench to Bedside (Part I of II)
Chair: D. Michael Foulds, University of Texas Health Science Center at San Antonio

Asthma: Bench to Bedside
This session will review the current knowledge on the pathogenesis of asthma and the implications for treatment. Recent developments in pharmacotherapeutic agents will be reviewed. Community-based intervention programs will be discussed.

Asthma: Molecular Immunology Updates
Patricia Finn, Brigham and Women’s Hospital, Harvard Medical School, Boston

Advances in Pharmacotherapy of Asthma in Children
Joshua Boyce, Brigham and Women’s Hospital, Massachusetts General Hospital, Boston

Asthma Intervention Programs: Do They Work?
Pamela Wood, University of Texas Health Science Center at San Antonio, San Antonio

(Part II of this is program is scheduled on Friday, May 12, from 1:00 PM - 4:00 PM)

Supported by an educational grant from Merck & Co.

1:00 pm - 4:00 pm - MINI COURSES

¨Asthma and Food Allergy: Bench to Bedside (Part II of II)
Chair: D. Michael Foulds, University of Texas Health Science Center, San Antonio

GI Immunology and Food Allergies: An Update
This session will focus on current topics and controversies in food allergy in the pediatric population. Topics will include a review of gastrointestinal immunology and the practical evaluation of suspected food allergy. Relevant cases will be presented and discussed.

An Update on the Immunopathophysiologic Basis of Food Allergy
W. Allen Walker, Harvard Medical School, Children’s Hospital, Boston

Gastrointestinal Food Allergic Disorders
Hugh Sampson, Mount Sinai School of Medicine, New York

(Part I of this is program is scheduled on Friday, May 12, from 9:00 AM - 12:00 Noon)

4:15 pm - 6:15 pm - POSTER SESSION I AND OPENING RECEPTION

Saturday, May 13

8:00 am - 10:00 am - TOPIC SYMPOSIUM

¨Computers in Medicine: From the Health Center to the Home to the Genome
Chair: Gary Fleisher, Children’s Hospital, Harvard Medical School, Boston

From molecular biology to clinical care, computers will play a decisive role in pediatrics in the next millennium. This symposium will address the technological solutions for the storage and dissemination of medical information. The translation of basic scientific discoveries into clinical practice and issues related to social concerns, access, privacy, and security will be discussed.

Information Infrastructure for the Next Generation Medicine
Isaac S. Kohane, Harvard Medical School, Boston

Health Applications on the Web: Access, Privacy, and Safety
Kenneth D. Mandl, Children's Hospital, Boston

Bioinformatics in Support of Molecular Medicine
Russ B. Altman, Stanford University, Stanford

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Pulmonary Inflammation (Poster Symposia)

10:15 am - 12:15 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Cytokines and Signaling Molecules I (Platform)

1:30 pm - 2:30 pm - APS PRESIDENTIAL PLENARY - HOWLAND AWARD
Presidential Address - Rebecca H. Buckley, Duke University School of Medicine
John Howland Award Presentation - Samuel A. Katz

2:30 pm - 3:00 pm - JOSEPH W. ST. GEME, JR. LEADERSHIP AWARD
Joseph W. St. Geme, Jr. Award Presentation - Evan Charney, Dept. of Pediatrics, University of Massachusetts Medical Center, Shrewsbury
St. Geme Awardee Introduced by: Kenneth B. Roberts, Professor of Pediatrics, University of North Carolina School of Medicine, Greensboro

Presented on behalf of the American Pediatric Society, American Academy of Pediatrics, American Board of Pediatrics, Ambulatory Pediatric Association, Association of Pediatric Program Directors, Association of Medical School Pediatric Department Chairman and Society for Pediatric Research

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨Cell and Organ Transplantation
Chair: David M. Briscoe, Children’s Hospital, Boston

Advances in solid organ transplantation have substantially improved the long-term prognosis for children with failure of several different organ systems. Three internationally-recognized speakers will discuss the state-of-the-art in pediatric solid organ transplantation, the cutting edge approaches for achieving long-term graft survival, and the clinical promise of new alternatives such as tissue engineering and stem cell delivery.

Advances in Pediatric Solid Organ Transplantation: Accomplishments and Challenges
Oscar Salvatierra, Stanford University School of Medicine, Stanford

Transplant Immunology: Progress Towards Inducing Tolerance
Alan M. Krensky, Stanford University School of Medicine, Stanford

Current and Future Clinical Applications of Tissue Engineering
Anthony Atala, Harvard Medical School; Children’s Hospital, Boston

¨Pathogenesis of Viral Respiratory Infections
Chair: Mark R. Denison, Vanderbilt University Medical Center, Nashville

Viruses interact intimately with the host cell environment from the time of initial contact through assembly and release of new infectious virus particles. During infection viruses use preexisting host cell components, modify the intracellular environment, and use mechanisms to avoid host cell immunity in order facilitate their replication and survive to be transmitted to new hosts. The symposium will explore specific aspects of the pathogenesis of four respiratory viral pathogens; the coronaviruses, parainfluenza viruses, influenza virus, and respiratory syncytial virus. The symposium speakers will describe unique features of the replication, cell biology or immune response of each virus and how understanding of molecular mechanisms of pathogenesis provides critical information in efforts to prevent or treat viral respiratory infections.

Cellular Pathogenesis of Coronavirus Infections
Mark R. Denison, Vanderbilt University Medical Center, Nashville

Receptor Mediated Entry of Paramyxoviruses
Anne Moscona, Mount Sinai School of Medicine, New York

Molecular Determinants of Influenza Virus Virulence
Kanta Subbarao, Centers for Disease Control, Atlanta

Neonatal Immune Response to Respiratory Syncytial Virus
James E. Crowe, Jr., Vanderbilt University School of Medicine, Nashville

Supported by an educational grant from ICN Pharmaceuticals

5 pm - 7:15 pm - POSTER SESSION II

Sunday, May 14

10:15 am - 12:00 noon - SPR PRESIDENTIAL PLENARY & AWARDS AND E. MEAD JOHNSON AWARD LECTURES

Presidential Address: Thomas Hazinski,Vanderbilt University Medical Center

Student Awards: Kyle Cowan, Aaron M. Milstone, Christine Siambani

House Officer Awards: Douglas D. Fraser, Paul J. Galardy, Matthew A. Saxonhouse

Fellow Basic Awards: Christopher E. Belcher, Elif Erkan, Syed Zaidi

Fellow Clinical Awards: Michael J. Ackerman, Okan Elidemir, Mika Ramet

David Nathan Award: Lisa Wang

Young Investigator Award Lecture:
Brendan Lee - Identification of Molecular Genetic Defect for Cleidocranial Dysplasia & Nail-patella Syndrome

E. Mead Johnson Award Lectures:
Mark Kay - Seminal Scientific Contributions to the Field of Hepatic Gene Therapy
Gregg Semenza - Molecular Response to Hypoxia

1:00 pm - 2:15 pm - MARCH OF DIMES PRIZE IN DEVELOPMENTAL BIOLOGY (Fifth Annual Lecture)
Presented by the March of Dimes

Genetic Control of Programmed Cell Death in C.elegans
H. Robert Horvitz, Professor of Biology, Howard Hughes Medical Institute Investigator, Massachusetts Institute of Technology, Cambridge, MA

1:15 pm - 2:00 pm - AAP PRESIDENTIAL PLENARY & JACOBI AWARD
Presidential Address: Donald E. Cook, American Academy of Pediatrics, Elk Grove Village
Jacobi Award: Catherine DeAngelis

2:30 pm - 4:30 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Gene Regulation I (Platform)
• Neonatal Immunology and Hematology I (Platform)

4:45 pm - 6:45 pm - POSTER SESSION III

Monday, May 15

8:00 am - 10:00 am - TOPIC SYMPOSIUM

¨Vaccine Dialogue
Chairs: Sarah S. Long, St. Christopher’s Hospital for Children, MCP Hahnemann University School of Medicine, Philadelphia and Ron Dagan, Soroka University Medical Center, Beer-Sheva, Israel

In this interactive dialogue, speakers will engage the audience in discussion of highly important and timely issues related to vaccines. In part one, speakers will discuss latest information regarding the development and performance of conjugate pneumococcal and meningococcal vaccines, as well as the challenges of developing and evaluating novel combination vaccines. In part two, speakers will lead discussions of inherent tensions in implementing vaccine strategies that maximize benefits of scientific discoveries and protect individuals, the public and policy.

Mapping the Future of Bacterial and Combination Vaccines
Implementation of Pneumococcal and Meningococcal Conjugate Vaccines: Steven B. Black, Vaccine Study Center, Kaiser Permanente Medical Center, Oakland
Challenges of Combination Vaccines: Kathryn M. Edwards, Vanderbilt University School of Medicine, Vanderbilt Children's Hospital, Nashville

Matching Scientific Progress and Public Trust
Monitoring Achievements and Risks of Vaccine Programs: Walter A. Orenstein, National Immunization Program, Centers for Disease Control and Prevention, Atlanta
Current State of Confidence and Concern: Samuel L. Katz, Duke University Medical Center, Durham

Sponsored Jointly with the Pediatric Infectious Diseases Society

Supported by educational grants from Merck Vaccine Division and Wyeth-Lederle Vaccines

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Allergy, Immunology and Rheumatology I (Platform)
• Cytokines and Signaling Molecules II (Platform)

8:00 am - 10:00 am - RICHARD E. ROWE AWARD
Richard E. Rowe Award Presentation - Mark W. Russell:
In vivo Transactivation of the alphaB Crystallin Promoter by Cardiac Transcription Factors Involved in Early Heart Development

8:30 am - 12:30 pm - APA PRESIDENTIAL PLENARY & ARMSTRONG LECTURE
Presidential Address: Ellen F. Crain, Albert Einstein College of Medicine, Bronx
Armstrong Lecture: Greenpeace

10:15 am - 11:45 am - STATE OF THE ART PLENARY

¨Gene-Based Understanding of X-linked Primary Immunodeficiency Disorders
Chair: Rebecca H. Buckley, Duke University Medical Center, Durham

This session can bring all pediatricians up-to-date on the astounding information explosion in this area and point out how correction may be possible for most of these diseases for which the molecular basis is known. It will also emphasize the key role pediatricians have in identifying these patients prior to the development of serious infections.

X-linked Severe Combined Immunodeficiency
Jennifer M. Puck, National Human Genome Research Institute/NIH, Bethesda

Wiskott-Aldrich Syndrome
Hans D. Ochs, University of Washington School of Medicine, Seattle

X-linked Lymphoproliferative Disease
Cox Terhorst, BIDMC/Harvard Medical School, Boston

Supported by the National Institute of Child Health & Human Development

¨Pediatrics in the New Millennium: Compelling Issues in Public Policy - 7th Annual Public Policy Plenary
Chair: Myron Genel, Yale University School of Medicine, New Haven

This is the 7th annual Public Policy Plenary Symposium organized and sponsored by the Public Policy Council, which coordinates public policy activities for the APS, SPR and AMSPDC, in collaboration with the APA Public Affairs Committee. The year 2000 program will look forward to the new millennium and broadly examine the outlook for children’s health in three vital areas: (1) access to health care (2) testing and access of children to drugs and devices and (3) the pipeline for pediatric physician-investigators and the future of academic pediatrics. We have set aside significant time at the conclusion of the speakers’ formal presentations to permit interactive dialogue between members of the panel and the audience.

Children’s Access to Health Care - Removing the Financial Barrier
Joel J. Alpert, Immediate Past President of the American Academy of Pediatrics and Past President of the Ambulatory Pediatric Association, Boston University School of Medicine

Increasing Pediatric Access to Medical Therapies
Jane E. Henney, Commissioner, Food and Drug Administration, Rockville

The Pipeline of Physician-Scientist in Pediatrics
Leon E. Rosenberg, Princeton University; Lasker Trust/Funding First; and Former Dean, Yale University School of Medicine

Supported in part by an educational grant from the Columbus Children's Hospital, Columbus, Ohio

1:00 pm - 3:00 pm - TOPIC SYMPOSIUM

¨Novel Treatments for Blood Disease
Chair: Alan D. D’Andrea, Dana Farber Cancer Institute, Boston

In this session we will evaluate new clinical trials and novel approaches in gene therapy and immunotherapy for pediatric blood diseases. While these approaches are applicable to rare subpopulations of patients, over time the insights gained in these studies may be adapted to patients in the general population. In the process of designing and executing these clinical trials, these pediatric investigators have made many basic discoveries related to viral vector design and the regulation of the human immune system.

Gene Therapy for Hemophilia
Mark Kay, Stanford University, Stanford

Immune Modulation in Bone Marrow Transplantation
Eva Guinan, Children's Hospital, Boston/Dana-Farber Cancer Institute, Boston

Gene Therapy for Primary Immunodeficiencies
Robertson Parkman, Children's Hospital, Los Angeles

1:00 pm - 3:00 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Allergy, Immunology and Rheumatology II (Poster Symposia)
• Neonatal Immunology and Hematology II (Poster Symposia)

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨Achieving Good Health For the World’s Children
Chairs: Errol R. Alden, American Academy of Pediatrics, Elk Grove Village, and Jane Schaller, New England Medical Center, Boston

The health of the world’s children is important to the future of the world. This plenary session will explore basic principles of world health for children and suggest ways in which pediatricians all over the world can work together to achieve better and brighter futures for all of our children. The concept of a world community of pediatricians bearing a collective responsibility for the health of children will be explored. Existing standards will be discussed, including training and professional standards of our pediatric profession around the world, concepts of medical ethics which govern our behavior as physicians, and concepts of children’s rights which exist in international law and define world standards for the treatment of children. Adopting a broad definition of child health which includes physical, mental, and social health, the disease burdens of children around the world now and in the 21st century will be presented, along with some concepts of how these burdens might be lessened. Finally, the roles that pediatricians can play in humanitarian response to emergencies and disasters will be presented. Time will be allowed for discussion from members of the audience, who are encouraged to think about these issues in advance and be prepared to add their voices to the discussion.

World Community: Children and Pediatricians, A Collective Responsibility
Robert Haggerty, University of Rochester School of Medicine & Dentistry, Rochester

World Standards: Professional Standards, Medical Ethics, Children’s Rights
Jane G. Schaller, New England Medical Center, Boston

World Health: Disease Burdens for Children Now and in the 21st Century
Jerry Coovadia, University of Natal, South Africa

World Disasters: the Special Needs of Children
Karen Olness, Rainbow Babies and Children’s Hospital, Cleveland

Supported by an educational grant from Johnson & Johnson Pediatrics Institute

¨Mechanisms of Asthma and Other Allergic Diseases
Chair: Lanny J. Rosenwasser, University of Colorado Health Science Center and the National Jewish Hospital and Research Center

This session will present the latest information on 1) the role of the mast cell in asthma and other allergic diseases 2) the role of 1L-13 in asthma and 3) the genetics of asthma and other allergic diseases.

Update on Mast Cell Biology and Its Role in Allergic Diseases
Joshua Boyce, Harvard Medical School, Boston

Role of 1L-13 in Asthma
Marsha Wills-Karp, Johns Hopkins University, Baltimore

Genetics of Asthma and Other Allergic Diseases
Lanny Rosenwasser, University of Colorado Health Science Center and the National Jewish Hospital and Research Center

5:00 pm - 7:00 pm - POSTER SESSION IV

Tuesday, May 16

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Childhood Asthma (Platform)

10:15 am - 12:15 pm - POSTER SESSION V

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Last Modified: April 11, 2000