Pediatric Academic Societies and American Academy of Pediatrics Joint Meeting May 12-16, 2000 Hynes Convention Center, Boston

Friday, May 12

4:15 pm - 6:15 pm - POSTER SESSION I AND OPENING RECEPTION

Saturday, May 13

8:00 am - 10:00 am - TOPIC SYMPOSIA

¨Computers in Medicine: From the Health Center to the Home to the Genome
Chair: Gary Fleisher, Children’s Hospital, Harvard Medical School, Boston

From molecular biology to clinical care, computers will play a decisive role in pediatrics in the next millennium. This symposium will address the technological solutions for the storage and dissemination of medical information. The translation of basic scientific discoveries into clinical practice and issues related to social concerns, access, privacy, and security will be discussed.

Information Infrastructure for the Next Generation Medicine
Isaac S. Kohane, Harvard Medical School, Boston

Health Applications on the Web: Access, Privacy, and Safety
Kenneth D. Mandl, Children's Hospital, Boston

Bioinformatics in Support of Molecular Medicine
Russ B. Altman, Stanford University, Stanford

¨Genetics of Sexual Differentiation and Gender Assignment
Chair: Kenneth Copeland, University College of Medicine, Oklahoma City

This session will cover recent advances in molecular genetics relevant to sexual differentiation and their impact on management of children with ambiguous genitalia.

Genes, Gonads and Germ Cells
David Page, Howard Hughes Medical Institute, Whitehead Institute of Biomedical Research, Cambridge

Cell Signaling in Sexual Differentiation
Andrew P. McMahon, Harvard University, Boston

"Genes to Gender: Impact of Molecular Biology on Management of Ambiguous Genitalia"
Charmian Quigley, Eli Lilly and Co. and Indiana University, Indianapolis

Sponsored Jointly with the Lawson Wilkins Pediatric Endocrine Society and the AAP Section on Endocrinology

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Brain Development - Mechanisms (Poster Symposia)
• Fetal and Neonatal Nutrition and Metabolism I (Poster Symposia)
• Pulmonary Inflammation (Poster Symposia)

10:15 am - 12:15 pm - TOPIC SYMPOSIUM

¨Ion Channels and Disease
Chair: Lisa M. Guay-Woodford, University of Alabama at Birmingham

The highly regulated transport of sodium, potassium, and chloride ions is essential in the proper functioning of a diverse array of organ systems. Single gene defects which disrupt these transport processes underlie a variety of renal, cardiac, and neuromuscular disorders. This symposium will discuss how recent elucidation of these genetic defects provide insights into the molecular pathogenesis of these disorders and suggest roles for these transport pathways in more complex disorders such as hypertension, kidney stone formation, acquired cardiac arrhythmias and seizure disorders.

Sodium Channels: Function and Dysfunction
Alfred L. George, Vanderbilt University Medical Center, Nashville

Chloride Channels - The Role of Mutations in Renal and Neuromuscular Disorders
Rajesh Thakker, Nuffield Department of Med., University of Oxford , Oxford, United Kingdom

Potassium Channels: Structural Basis for Function and Disease
Stephen A.N. Goldstein, Yale University School of Medicine, New Haven

Sponsored Jointly with the American Society of Pediatric Nephrology

10:15 am - 12:15 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Developmental Aspects of Pulmonary Growth and Vascular Reactions (Platform)

1:30 pm - 2:30 pm - APS PRESIDENTIAL PLENARY - HOWLAND AWARD
Presidential Address - Rebecca H. Buckley, Duke University School of Medicine
John Howland Award Presentation - Samuel A. Katz

2:30 pm - 3:00 pm - JOSEPH W. ST. GEME, JR. LEADERSHIP AWARD
Joseph W. St. Geme, Jr. Award Presentation - Evan Charney, Dept. of Pediatrics, University of Massachusetts Medical Center, Shrewsbury
St. Geme Awardee Introduced by: Kenneth B. Roberts, Professor of Pediatrics, University of North Carolina School of Medicine, Greensboro

Presented on behalf of the American Pediatric Society, American Academy of Pediatrics, American Board of Pediatrics, Ambulatory Pediatric Association, Association of Pediatric Program Directors, Association of Medical School Pediatric Department Chairman and Society for Pediatric Research

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨Cell and Organ Transplantation
Chair: David M. Briscoe, Children’s Hospital, Boston

Advances in solid organ transplantation have substantially improved the long-term prognosis for children with failure of several different organ systems. Three internationally-recognized speakers will discuss the state-of-the-art in pediatric solid organ transplantation, the cutting edge approaches for achieving long-term graft survival, and the clinical promise of new alternatives such as tissue engineering and stem cell delivery.

Advances in Pediatric Solid Organ Transplantation: Accomplishments and Challenges
Oscar Salvatierra, Stanford University School of Medicine, Stanford

Transplant Immunology: Progress Towards Inducing Tolerance
Alan M. Krensky, Stanford University School of Medicine, Stanford

Current and Future Clinical Applications of Tissue Engineering
Anthony Atala, Harvard Medical School; Children’s Hospital, Boston

¨The Developing Brain and Human Disease
Chair: Joseph J. Volpe, Children’s Hospital, Harvard Medical School, Boston

The three outstanding speakers in this session will explore the exciting boundary between advances in developmental genetics of the brain and clinical medicine. An understanding of the developmental determinants of neuronal fate has led to a new molecular understanding of several inherited diseases of the human brain involving abnormalities in brain patterning and neuronal organization and migration. Exciting recent findings have challenged the depressing notion that regeneration and/or replacement of developmentally deficient or damaged brain is impossible. The convergence of information on neuronal fate and neural stem cells raises the very real possibility of exciting new cell-based therapies for a range of congenital and acquired diseases of the human brain.

Genetic Control of Neuronal Fate in the Developing Brain
Robert F. Hevner, Langley Porter Psychiatric Institute, University of California, San Francisco

Genetic Basis of Abnormal Neuronal Migration in the Human Brain
Christopher Walsh, Harvard Medical School, Boston

Neural Stem Cells and Therapy of Disorders of the Developing Nervous System
Evan Y. Snyder, Harvard Medical School, Children’s Hospital, Boston

Supported by an educational grant from the March of Dimes Birth Defects Foundation

5 pm - 7:15 pm - POSTER SESSION II

Sunday, May 14

8:00 am - 10:00 am - TOPIC SYMPOSIA

¨Advances in Imaging: Following Cells and Molecules
Chair: Christopher H. Contag, Stanford University School of Medicine, Stanford

Recent advances in imaging technologies have enabled in vivo molecular and cellular analyses at near micron resolution. These advances permit the evaluation of biological events in the context of intact living systems such that the interactive processes of normal physiology and pathophysiologic conditions can be revealed at the level of cells and molecules. This symposium will highlight new imaging strategies and demonstrate how these approaches can be used to answer questions that were previously inaccessible to biological investigation.

Imaging the Wiring and Re-wiring of the Developing Brain
Scott Fraser, California Institute of Technology, Pasadena

Imaging Gene Expression Patterns
Christopher H. Contag, Stanford University School of Medicine, Stanford

New Developments in Functional and Molecular Imaging
Ralph Weissleder, Massachusetts General Hospital, Boston

¨The Neurobiologic Basis of Behavior and Development
Chair: James M. Perrin, Mass General Hospital for Children, Boston

This session will describe recent work linking developmental aspects of brain function and structures with understanding of child development, developmental disabilities, and child and adolescent behavior. Expanding knowledge in areas of brain development, anatomic structures, and molecular biology of the central nervous system broaden the base for understanding clinical phenomena. New work has helped to characterize environmental and central nervous system influences on child and adolescent behavior. Recent long-term follow-up data from the Infant Health and Development Program inform regarding the predictors of outcomes for children at developmental risk.

Brain Development and Developmental Disabilities
Mark L. Batshaw, Children’s National Medical Center, George Washington University School of Medicine, Washington

Neurobiologic Representations fo the Social World: Developmental Considerations
Felton Earls, Harvard Medical School, Boston

The Infant Health and Development Project: Implications for Neurobiologic Basis of Development
Marie McCormick, Harvard School of Public Health, Boston

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Genetic Mechanisms of Disease and Aberrant Development (Platform)
• Hematology and Oncology (Platform)
• Neonatal Pulmonology I (Platform)

10:15 am - 12:00 noon - SPR PRESIDENTIAL PLENARY & AWARDS AND E. MEAD JOHNSON AWARD LECTURES

Presidential Address: Thomas Hazinski,Vanderbilt University Medical Center

Student Awards: Kyle Cowan, Aaron M. Milstone, Christine Siambani

House Officer Awards: Douglas D. Fraser, Paul J. Galardy, Matthew A. Saxonhouse

Fellow Basic Awards: Christopher E. Belcher, Elif Erkan, Syed Zaidi

Fellow Clinical Awards: Michael J. Ackerman, Okan Elidemir, Mika Ramet

David Nathan Award: Lisa Wang

Young Investigator Award Lecture:
Brendan Lee - Identification of Molecular Genetic Defect for Cleidocranial Dysplasia & Nail-patella Syndrome

E. Mead Johnson Award Lectures:
Mark Kay - Seminal Scientific Contributions to the Field of Hepatic Gene Therapy
Gregg Semenza - Molecular Response to Hypoxia

1:00 pm - 2:15 pm - MARCH OF DIMES PRIZE IN DEVELOPMENTAL BIOLOGY (Fifth Annual Lecture)
Presented by the March of Dimes

Genetic Control of Programmed Cell Death in C.elegans
H. Robert Horvitz, Professor of Biology, Howard Hughes Medical Institute Investigator, Massachusetts Institute of Technology, Cambridge, MA

1:15 pm - 2:00 pm - AAP PRESIDENTIAL PLENARY & JACOBI AWARD
Presidential Address: Donald E. Cook, American Academy of Pediatrics, Elk Grove Village
Jacobi Award: Catherine DeAngelis

2:30 pm - 4:30 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Gene Regulation I (Platform)

4:45 pm - 6:45 pm - POSTER SESSION III

Monday, May 15

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Cardiology: Genetic Basis of Heart Disease and Development (Platform)
• Neonatal Nutrition and Metabolism II (Poster Symposia)
• Neonatal Pulmonology: Control of Pulmonary Vascular Tone (Platform)
• Neurodevelopmental Disabilities I (Poster Symposia)

8:00 am - 10:00 am - RICHARD E. ROWE AWARD
Richard E. Rowe Award Presentation - Mark W. Russell:
In vivo Transactivation of the alphaB Crystallin Promoter by Cardiac Transcription Factors Involved in Early Heart Development

8:30 am - 12:30 pm - APA PRESIDENTIAL PLENARY & ARMSTRONG LECTURE
Presidential Address: Ellen F. Crain, Albert Einstein College of Medicine, Bronx
Armstrong Lecture: Greenpeace

10:15 am - 11:45 am - STATE OF THE ART PLENARY

¨Gene Defects and Kids’ Heart Disease
Chair: Arnold W. Strauss, Washington University and St. Louis Children's Hospital, St. Louis

Until 10 years ago, etiologies and pathogenesis of heart disease in children were poorly understood. This symposium focuses on recent discoveries of gene defects in children with congenital heart disease, abnormalities of situs determination, arrhythmias, and cardiomyopathy. The causes of many forms of pediatric heart disease as single gene defects at multiple loci will be discussed.

Genetic Causes of Congenital Heart Disease
Christine Seidman, Howard Hughes Medical Institute/Brigham and Women's Hospital, Boston

Genes and Left-Right Asymmetry
Martina Brueckner, Yale School of Medicine, New Haven

Genes Causing Pediatric Arrhythmias
Jeffrey A. Towbin, Baylor College of Medicine, Texas Children's Hospital, Houston

¨Pediatrics in the New Millennium: Compelling Issues in Public Policy - 7th Annual Public Policy Plenary
Chair: Myron Genel, Yale University School of Medicine, New Haven

This is the 7th annual Public Policy Plenary Symposium organized and sponsored by the Public Policy Council, which coordinates public policy activities for the APS, SPR and AMSPDC, in collaboration with the APA Public Affairs Committee. The year 2000 program will look forward to the new millennium and broadly examine the outlook for children’s health in three vital areas: (1) access to health care (2) testing and access of children to drugs and devices and (3) the pipeline for pediatric physician-investigators and the future of academic pediatrics. We have set aside significant time at the conclusion of the speakers’ formal presentations to permit interactive dialogue between members of the panel and the audience.

Children’s Access to Health Care - Removing the Financial Barrier
Joel J. Alpert, Immediate Past President of the American Academy of Pediatrics and Past President of the Ambulatory Pediatric Association, Boston University School of Medicine

Increasing Pediatric Access to Medical Therapies
Jane E. Henney, Commissioner, Food and Drug Administration, Rockville

The Pipeline of Physician-Scientist in Pediatrics
Leon E. Rosenberg, Princeton University; Lasker Trust/Funding First; and Former Dean, Yale University School of Medicine

Supported in part by an educational grant from the Columbus Children's Hospital, Columbus, Ohio

1:00 pm - 3:00 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Developmental Biology I (Platform)
• Hypoxic/Ischemic Encephalopathy and Protective Mechanisms (Platform)
• Neurodevelopmental Disabilities II (Platform)
• Pulmonary Vascular Biology (Platform)

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨Achieving Good Health For the World’s Children
Chairs: Errol R. Alden, American Academy of Pediatrics, Elk Grove Village, and Jane Schaller, New England Medical Center, Boston

The health of the world’s children is important to the future of the world. This plenary session will explore basic principles of world health for children and suggest ways in which pediatricians all over the world can work together to achieve better and brighter futures for all of our children. The concept of a world community of pediatricians bearing a collective responsibility for the health of children will be explored. Existing standards will be discussed, including training and professional standards of our pediatric profession around the world, concepts of medical ethics which govern our behavior as physicians, and concepts of children’s rights which exist in international law and define world standards for the treatment of children. Adopting a broad definition of child health which includes physical, mental, and social health, the disease burdens of children around the world now and in the 21st century will be presented, along with some concepts of how these burdens might be lessened. Finally, the roles that pediatricians can play in humanitarian response to emergencies and disasters will be presented. Time will be allowed for discussion from members of the audience, who are encouraged to think about these issues in advance and be prepared to add their voices to the discussion.

World Community: Children and Pediatricians, A Collective Responsibility
Robert Haggerty, University of Rochester School of Medicine & Dentistry, Rochester

World Standards: Professional Standards, Medical Ethics, Children’s Rights
Jane G. Schaller, New England Medical Center, Boston

World Health: Disease Burdens for Children Now and in the 21st Century
Jerry Coovadia, University of Natal, South Africa

World Disasters: the Special Needs of Children
Karen Olness, Rainbow Babies and Children’s Hospital, Cleveland

Supported by an educational grant from Johnson & Johnson Pediatrics Institute

5:00 pm - 7:00 pm - POSTER SESSION IV

Tuesday, May 16

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Cardiology: Cardiac Electrophysiology from Mouse to Man (Platform)
• Developmental Biology II (Poster Symposia)

10:15 am - 12:15 pm - POSTER SESSION V

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Last Modified: April 06, 2000