Pediatric Academic Societies and American Academy of Pediatrics Joint Meeting May 12-16, 2000 Hynes Convention Center, Boston

Thursday, May 11 and Friday, May 12

LAWSON WILKINS PEDIATRIC ENDOCRINE SOCIETY
Annual Meeting - DRAFT SCHEDULE
Sheraton Boston Hotel and Towers

Thursday, May 11

"Type 2 Diabetes in Children and Adolescents: a Public Health Emergency"
(Co-sponsored with the Endocrine Section of the AAP)

Free Evening

Friday, May 12

"Neonatal Management of Genital Ambiguity" (Co-sponsored with the Endocrine Section of the AAP)
Chair: Mel Grumbach

Outcomes in Gender Assignment:

5:30 – 6:30 LWPES Business meeting

6:30 - 8:00 LWPES Endocrine Sciences Reception

Contact for information:
Raymond L. Hintz, M.D., LWPES Secretary
Department of Pediatrics
Stanford University Medical Center, Rm S-302
Stanford, CA 94305
Phone: (650)494-8108 Fax: (650)494-3133
E-Mail: hintz@stanford.edu
URL: www.lwpes.org

Friday, May 12

4:15 pm - 6:15 pm - POSTER SESSION I AND OPENING RECEPTION

Saturday, May 13

8:00 am - 10:00 am - TOPIC SYMPOSIA

¨Computers in Medicine: From the Health Center to the Home to the Genome
Chair: Gary Fleisher, Children’s Hospital, Harvard Medical School, Boston

From molecular biology to clinical care, computers will play a decisive role in pediatrics in the next millennium. This symposium will address the technological solutions for the storage and dissemination of medical information. The translation of basic scientific discoveries into clinical practice and issues related to social concerns, access, privacy, and security will be discussed.

Information Infrastructure for the Next Generation Medicine
Isaac S. Kohane, Harvard Medical School, Boston

Health Applications on the Web: Access, Privacy, and Safety
Kenneth D. Mandl, Children's Hospital, Boston

Bioinformatics in Support of Molecular Medicine
Russ B. Altman, Stanford University, Stanford

¨Genetics of Sexual Differentiation and Gender Assignment
Chair: Kenneth Copeland, University College of Medicine, Oklahoma City

This session will cover recent advances in molecular genetics relevant to sexual differentiation and their impact on management of children with ambiguous genitalia.

Genes, Gonads and Germ Cells
David Page, Howard Hughes Medical Institute, Whitehead Institute of Biomedical Research, Cambridge

Cell Signaling in Sexual Differentiation
Andrew P. McMahon, Harvard University, Boston

"Genes to Gender: Impact of Molecular Biology on Management of Ambiguous Genitalia"
Charmian Quigley, Eli Lilly and Co. and Indiana University, Indianapolis

Sponsored Jointly with the Lawson Wilkins Pediatric Endocrine Society and the AAP Section on Endocrinology

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Fetal and Neonatal Nutrition and Metabolism I (Poster Symposia)

10:15 am - 12:15 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Endocrinology and Metabolism I (Platform)

1:30 pm - 2:30 pm - APS PRESIDENTIAL PLENARY - HOWLAND AWARD
Presidential Address - Rebecca H. Buckley, Duke University School of Medicine
John Howland Award Presentation - Samuel A. Katz

2:30 pm - 3:00 pm - JOSEPH W. ST. GEME, JR. LEADERSHIP AWARD
Joseph W. St. Geme, Jr. Award Presentation - Evan Charney, Dept. of Pediatrics, University of Massachusetts Medical Center, Shrewsbury
St. Geme Awardee Introduced by: Kenneth B. Roberts, Professor of Pediatrics, University of North Carolina School of Medicine, Greensboro

Presented on behalf of the American Pediatric Society, American Academy of Pediatrics, American Board of Pediatrics, Ambulatory Pediatric Association, Association of Pediatric Program Directors, Association of Medical School Pediatric Department Chairman and Society for Pediatric Research

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨Hormones, Nutrient Substrates, and Metabolism: Critical Changes at Birth
Chair: Ora Pescovitz, Riley Hospital for Children, Indianapolis

Many essential metabolic changes take place following birth, stimulated by developmental processes, hormones, and by the rapidly changing diet as the infant starts consuming milk. Insulin secretion, for example increases, especially in response to meal associated nutrients. Persistent hyperinsulinemia, however, leads to recurrent and severe hypoglycemia. Advances in pancreatic b-cell biology have helped sort out how persistent hyperinsulinemia occurs, with the potential for new, more specific therapy. The influx of lipids from milk requires increased capacity for lipid metabolism, particularly oxidation. This, however, requires the development of enzymes and transport proteins to move the fatty acids into the mitochondria. Failure of these processes leads to organ failure, most notably in the heart. Many important amino acids also take on new roles. Glutamine, for example, shifts from producing glutamate in the fetus for placental metabolism, becoming an important substrate for gluconeogenesis and a regulator of gut and muscle development. Each of these topics will be discussed by experts in neonatal metabolism.

Neonatal Insulin Secretion and Persistent Hyperinsulinemia of Infancy
Pamela Thomas, University of Michigan, Ann Arbor

From Glucose to Fat: The Neonatal Metabolic Transition
Arnold Strauss, Washington University and St. Louis Children's Hospital, St. Louis

Glutamine: Role in the Fetus and Low Birthweight Infant
Josef Neu, University of Florida, Gainesville

Sponsored Jointly with the Lawson Wilkins Pediatric Endocrine Society

5 pm - 7:15 pm - POSTER SESSION II

Sunday, May 14

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Endocrinology and Metabolism II (Platform)
• Hematology and Oncology (Platform)

10:15 am - 12:00 noon - SPR PRESIDENTIAL PLENARY & AWARDS AND E. MEAD JOHNSON AWARD LECTURES

Presidential Address: Thomas Hazinski,Vanderbilt University Medical Center

Student Awards: Kyle Cowan, Aaron M. Milstone, Christine Siambani

House Officer Awards: Douglas D. Fraser, Paul J. Galardy, Matthew A. Saxonhouse

Fellow Basic Awards: Christopher E. Belcher, Elif Erkan, Syed Zaidi

Fellow Clinical Awards: Michael J. Ackerman, Okan Elidemir, Mika Ramet

David Nathan Award: Lisa Wang

Young Investigator Award Lecture:
Brendan Lee - Identification of Molecular Genetic Defect for Cleidocranial Dysplasia & Nail-patella Syndrome

E. Mead Johnson Award Lectures:
Mark Kay - Seminal Scientific Contributions to the Field of Hepatic Gene Therapy
Gregg Semenza - Molecular Response to Hypoxia

1:00 pm - 2:15 pm - MARCH OF DIMES PRIZE IN DEVELOPMENTAL BIOLOGY (Fifth Annual Lecture)
Presented by the March of Dimes

Genetic Control of Programmed Cell Death in C.elegans
H. Robert Horvitz, Professor of Biology, Howard Hughes Medical Institute Investigator, Massachusetts Institute of Technology, Cambridge, MA

1:15 pm - 2:00 pm - AAP PRESIDENTIAL PLENARY & JACOBI AWARD
Presidential Address: Donald E. Cook, American Academy of Pediatrics, Elk Grove Village
Jacobi Award: Catherine DeAngelis

2:30 pm - 4:30 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Endocrinology III: Insulin Deficiency/Insulin Resistance/Obesity (Poster Symposia)

4:45 pm - 6:45 pm - POSTER SESSION III

Monday, May 15

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Neonatal Nutrition and Metabolism II (Poster Symposia)

8:00 am - 10:00 am - RICHARD E. ROWE AWARD
Richard E. Rowe Award Presentation - Mark W. Russell:
In vivo Transactivation of the alphaB Crystallin Promoter by Cardiac Transcription Factors Involved in Early Heart Development

8:30 am - 12:30 pm - APA PRESIDENTIAL PLENARY & ARMSTRONG LECTURE
Presidential Address: Ellen F. Crain, Albert Einstein College of Medicine, Bronx
Armstrong Lecture: Greenpeace

10:15 am - 11:45 am - STATE OF THE ART PLENARY

¨Pediatrics in the New Millennium: Compelling Issues in Public Policy - 7th Annual Public Policy Plenary
Chair: Myron Genel, Yale University School of Medicine, New Haven

This is the 7th annual Public Policy Plenary Symposium organized and sponsored by the Public Policy Council, which coordinates public policy activities for the APS, SPR and AMSPDC, in collaboration with the APA Public Affairs Committee. The year 2000 program will look forward to the new millennium and broadly examine the outlook for children’s health in three vital areas: (1) access to health care (2) testing and access of children to drugs and devices and (3) the pipeline for pediatric physician-investigators and the future of academic pediatrics. We have set aside significant time at the conclusion of the speakers’ formal presentations to permit interactive dialogue between members of the panel and the audience.

Children’s Access to Health Care - Removing the Financial Barrier
Joel J. Alpert, Immediate Past President of the American Academy of Pediatrics and Past President of the Ambulatory Pediatric Association, Boston University School of Medicine

Increasing Pediatric Access to Medical Therapies
Jane E. Henney, Commissioner, Food and Drug Administration, Rockville

The Pipeline of Physician-Scientist in Pediatrics
Leon E. Rosenberg, Princeton University; Lasker Trust/Funding First; and Former Dean, Yale University School of Medicine

Supported in part by an educational grant from the Columbus Children's Hospital, Columbus, Ohio

1:00 pm - 3:00 pm - TOPIC SYMPOSIUM

¨The Environment and Children’s Health
Chair: Ellen F. Crain, Albert Einstein College of Medicine, Bronx

Rates of childhood asthma, cancer, ADHD, and poor school performance are increasing, and there is growing evidence that environmental disruption plays an important role in these trends. Exposure to lead continues to affect children’s health, and exposure to pesticides and chemicals is increasing. Few pediatricians understand the extent of these threats to their patients’ health, and fewer still have incorporated environmental health into their practice or advocacy activities. The goals of this symposium are to provide an overview of what is known about several key environmental threats to children’s health and to introduce evidence that interaction with the natural environment may have a positive impact on children’s health.

Pesticides, PCB’s, and Endocrine Disruptors: What is the Evidence That They Threaten Children’s Health?
Philip J. Landrigan, Mount Sinai School of Medicine, New York

What is Known About Air Quality and Children’s Respiratory Health?
Jonathan Samet, Johns Hopkins University, School of Hygiene & Public Health, Baltimore

Play in the Natural Environment: Preliminary Evidence of its Contributions to Children’s Health
Robin C. Moore, North Carolina State University, School of Design, Raleigh

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨Achieving Good Health For the World’s Children
Chairs: Errol R. Alden, American Academy of Pediatrics, Elk Grove Village, and Jane Schaller, New England Medical Center, Boston

The health of the world’s children is important to the future of the world. This plenary session will explore basic principles of world health for children and suggest ways in which pediatricians all over the world can work together to achieve better and brighter futures for all of our children. The concept of a world community of pediatricians bearing a collective responsibility for the health of children will be explored. Existing standards will be discussed, including training and professional standards of our pediatric profession around the world, concepts of medical ethics which govern our behavior as physicians, and concepts of children’s rights which exist in international law and define world standards for the treatment of children. Adopting a broad definition of child health which includes physical, mental, and social health, the disease burdens of children around the world now and in the 21st century will be presented, along with some concepts of how these burdens might be lessened. Finally, the roles that pediatricians can play in humanitarian response to emergencies and disasters will be presented. Time will be allowed for discussion from members of the audience, who are encouraged to think about these issues in advance and be prepared to add their voices to the discussion.

World Community: Children and Pediatricians, A Collective Responsibility
Robert Haggerty, University of Rochester School of Medicine & Dentistry, Rochester

World Standards: Professional Standards, Medical Ethics, Children’s Rights
Jane G. Schaller, New England Medical Center, Boston

World Health: Disease Burdens for Children Now and in the 21st Century
Jerry Coovadia, University of Natal, South Africa

World Disasters: the Special Needs of Children
Karen Olness, Rainbow Babies and Children’s Hospital, Cleveland

Supported by an educational grant from Johnson & Johnson Pediatrics Institute

¨The Biologic, Sociologic and Psychologic Impact of Stress in Childhood
Chair: Jack P. Shonkoff, The Heller Graduate School, Brandeis University, Waltham

The impact of stress on the physical and mental health of adults has been extensively studied. Recent research has begun to examine its impact on children at all levels of their development. This state-of-the-art symposium examines current research and concepts on the impact of stress on the developing brain, on bio-behavioral responses in children, and in children in difficult social environments. Leading researchers in each of these areas will present aspects of their research that relates to cutting edge concepts in their field.

Molecules and Mechanisms of the Neuroendocrine Response to Stress During Early Postnatal Life: New Insights
Tallie Z. Baram, University of California at Irvine

Psychobiologic Reactivity to Stress: Implications for Pediatric Morbidities
W. Thomas Boyce, School of Public Health & Institute of Human Development, University of California, Berkeley

The Effects of Early Social Deprivation on Children
Felton Earls, Harvard School of Public Health, Cambridge

5:00 pm - 7:00 pm - POSTER SESSION IV

Tuesday, May 16

10:15 am - 12:15 pm - POSTER SESSION V

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Last Modified: April 06, 2000