Pediatric Academic Societies and American Academy of Pediatrics Joint Meeting May 12-16, 2000 Hynes Convention Center, Boston

Friday, May 12

9:00 am - 12:00 noon - SPECIAL INTEREST GROUP

TICKETS NECESSARY FOR THIS EVENT. NO FEE IS REQUIRED BUT PRE-ENROLLMENT IS ESSENTIAL TO ATTEND.

SG01 AIDS/HIV
Chair: Nancy Hutton

Information on this SIG will be posted on our website in early 2000.

4:15 pm - 6:15 pm - POSTER SESSION I AND OPENING RECEPTION

6:15 pm - 10:15 pm - BOSTON UNIVERSITY SYMPOSIUM

New Challenges in the Treatment of Pediatric HIV
A Continuing Medical Education Program Sponsored by Boston University School of Medicine and the Department of Pediatrics - Infectious Diseases

Registration
Program will include dinner. Please call 800-688-2475 to register.

Topic Highlights
The HIV Epidemic in 2000: US and Worldwide
New Approaches to the Prevention of Vertical and Breast Milk Transmission
Antiretroviral Therapy: New Concerns about Safety
New Approaches to ART for Children
Role of HIV Genotyping in Pediatric HIV

Co-Course Directors
Stephen I. Pelton, M.D. Kenneth McIntosh, M.D.
Professor of Pediatrics Professor of Pediatrics
Boston University School of Medicine Harvard Medical School
Director, Pediatric Infectious Diseases Chief, Division of Infectious Diseases
Boston Medical Center Children’s Hospital
Boston, Massachusetts Boston, Massachusetts

Accreditation
Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Grant Support
This program is supported in part by unrestricted educational grants from Abbott Laboratories and Roxane Laboratories.

Saturday, May 13

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Infectious Diseases I: Viral Diseases (Platform)

10:15 am - 12:15 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• General Pediatrics: Infectious Disease (Platform)
• Infectious Diseases II: Viral Diseases (Platform)

1:30 pm - 2:30 pm - APS PRESIDENTIAL PLENARY - HOWLAND AWARD
Presidential Address - Rebecca H. Buckley, Duke University School of Medicine
John Howland Award Presentation - Samuel A. Katz

2:30 pm - 3:00 pm - JOSEPH W. ST. GEME, JR. LEADERSHIP AWARD
Joseph W. St. Geme, Jr. Award Presentation - Evan Charney, Dept. of Pediatrics, University of Massachusetts Medical Center, Shrewsbury
St. Geme Awardee Introduced by: Kenneth B. Roberts, Professor of Pediatrics, University of North Carolina School of Medicine, Greensboro

Presented on behalf of the American Pediatric Society, American Academy of Pediatrics, American Board of Pediatrics, Ambulatory Pediatric Association, Association of Pediatric Program Directors, Association of Medical School Pediatric Department Chairman and Society for Pediatric Research

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨Pathogenesis of Viral Respiratory Infections
Chair: Mark R. Denison, Vanderbilt University Medical Center, Nashville

Viruses interact intimately with the host cell environment from the time of initial contact through assembly and release of new infectious virus particles. During infection viruses use preexisting host cell components, modify the intracellular environment, and use mechanisms to avoid host cell immunity in order facilitate their replication and survive to be transmitted to new hosts. The symposium will explore specific aspects of the pathogenesis of four respiratory viral pathogens; the coronaviruses, parainfluenza viruses, influenza virus, and respiratory syncytial virus. The symposium speakers will describe unique features of the replication, cell biology or immune response of each virus and how understanding of molecular mechanisms of pathogenesis provides critical information in efforts to prevent or treat viral respiratory infections.

Cellular Pathogenesis of Coronavirus Infections
Mark R. Denison, Vanderbilt University Medical Center, Nashville

Receptor Mediated Entry of Paramyxoviruses
Anne Moscona, Mount Sinai School of Medicine, New York

Molecular Determinants of Influenza Virus Virulence
Kanta Subbarao, Centers for Disease Control, Atlanta

Neonatal Immune Response to Respiratory Syncytial Virus
James E. Crowe, Jr., Vanderbilt University School of Medicine, Nashville

Supported by an educational grant from ICN Pharmaceuticals

5 pm - 7:15 pm - POSTER SESSION II

Sunday, May 14

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Infectious Diseases III: Bacterial Diseases (Platform)

10:15 am - 12:00 noon - SPR PRESIDENTIAL PLENARY & AWARDS AND E. MEAD JOHNSON AWARD LECTURES

Presidential Address: Thomas Hazinski,Vanderbilt University Medical Center

Student Awards: Kyle Cowan, Aaron M. Milstone, Christine Siambani

House Officer Awards: Douglas D. Fraser, Paul J. Galardy, Matthew A. Saxonhouse

Fellow Basic Awards: Christopher E. Belcher, Elif Erkan, Syed Zaidi

Fellow Clinical Awards: Michael J. Ackerman, Okan Elidemir, Mika Ramet

David Nathan Award: Lisa Wang

Young Investigator Award Lecture:
Brendan Lee - Identification of Molecular Genetic Defect for Cleidocranial Dysplasia & Nail-patella Syndrome

E. Mead Johnson Award Lectures:
Mark Kay - Seminal Scientific Contributions to the Field of Hepatic Gene Therapy
Gregg Semenza - Molecular Response to Hypoxia

1:00 pm - 2:15 pm - MARCH OF DIMES PRIZE IN DEVELOPMENTAL BIOLOGY (Fifth Annual Lecture)
Presented by the March of Dimes

Genetic Control of Programmed Cell Death in C.elegans
H. Robert Horvitz, Professor of Biology, Howard Hughes Medical Institute Investigator, Massachusetts Institute of Technology, Cambridge, MA

1:15 pm - 2:00 pm - AAP PRESIDENTIAL PLENARY & JACOBI AWARD
Presidential Address: Donald E. Cook, American Academy of Pediatrics, Elk Grove Village
Jacobi Award: Catherine DeAngelis

1:30 pm - 4:30 pm - PEDIATRIC INFECTIOUS DISEASES SOCIETY SYMPOSIUM
Hynes Convention Center

Management of Common Infections: Experts’ Opinions with Real World Applications

Moderators:
Sarah S. Long,
St. Christopher’s Hospital for Children and MCP Hahnemann University School of Medicine, Philadelphia
Larry K. Pickering,
Center for Pediatric Research, Children’s Hospital of the King’s Daughters, Norfolk

New Insights into Kawasaki Disease
Anne H. Rowley, Associate Professor of Pediatrics and Microbiology/Immunology, Northwestern University School of Medicine, Chicago

Antiviral Agents: Clear and Present Uses
Charles G. Prober, Professor of Pediatrics, Stanford University School of Medicine, Stanford

Treatment of Otitis Media in an Era of Resistance
Stephen I. Pelton, Professor of Pediatrics, Boston University School of Medicine, Boston

Treatment of Invasive Infections in an Era of Resistance
Sheldon L. Kaplan, Professor of Pediatrics, Baylor College of Medicine, Houston

Management of Common Dermatologic Infections/Infestations
Lawrence F. Eichenfield, Associate Professor of Pediatrics and Medicine, San Diego Children’s Hospital, University of California San Diego School of Medicine, San Diego

2:30 pm - 4:30 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Gene Regulation I (Platform)

4:45 pm – 5:45 pm
PIDS Business Meeting

4:45 pm - 6:45 pm - POSTER SESSION III

6:30 pm - 10:00 pm - PIDS RECEPTION, DINNER AND AWARDS
Ticket/Registration Required to Attend

For Further Information Contact:
Andrea Weddle, PIDS Staff Coordinator
PIDS Headquarters
99 Canal Center Plaza, Suite 210
Alexandria, VA 22314
Phone: (703)299-6764 Fax: (703)299-0204
E-Mail: aweddle@idsociety.org
URL: www.pids.org

Monday, May 15

8:00 am - 10:00 am - TOPIC SYMPOSIUM

¨Vaccine Dialogue
Chairs: Sarah S. Long, St. Christopher’s Hospital for Children, MCP Hahnemann University School of Medicine, Philadelphia and Ron Dagan, Soroka University Medical Center, Beer-Sheva, Israel

In this interactive dialogue, speakers will engage the audience in discussion of highly important and timely issues related to vaccines. In part one, speakers will discuss latest information regarding the development and performance of conjugate pneumococcal and meningococcal vaccines, as well as the challenges of developing and evaluating novel combination vaccines. In part two, speakers will lead discussions of inherent tensions in implementing vaccine strategies that maximize benefits of scientific discoveries and protect individuals, the public and policy.

Mapping the Future of Bacterial and Combination Vaccines
Implementation of Pneumococcal and Meningococcal Conjugate Vaccines: Steven B. Black, Vaccine Study Center, Kaiser Permanente Medical Center, Oakland
Challenges of Combination Vaccines: Kathryn M. Edwards, Vanderbilt University School of Medicine, Vanderbilt Children's Hospital, Nashville

Matching Scientific Progress and Public Trust
Monitoring Achievements and Risks of Vaccine Programs: Walter A. Orenstein, National Immunization Program, Centers for Disease Control and Prevention, Atlanta
Current State of Confidence and Concern: Samuel L. Katz, Duke University Medical Center, Durham

Sponsored Jointly with the Pediatric Infectious Diseases Society

Supported by educational grants from Merck Vaccine Division and Wyeth-Lederle Vaccines

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Allergy, Immunology and Rheumatology I (Platform)
• Cytokines and Signaling Molecules II (Platform)

8:00 am - 10:00 am - RICHARD E. ROWE AWARD
Richard E. Rowe Award Presentation - Mark W. Russell:
In vivo Transactivation of the alphaB Crystallin Promoter by Cardiac Transcription Factors Involved in Early Heart Development

8:30 am - 12:30 pm - APA PRESIDENTIAL PLENARY & ARMSTRONG LECTURE
Presidential Address: Ellen F. Crain, Albert Einstein College of Medicine, Bronx
Armstrong Lecture: Greenpeace

10:15 am - 11:45 am - STATE OF THE ART PLENARY

¨Gene-Based Understanding of X-linked Primary Immunodeficiency Disorders
Chair: Rebecca H. Buckley, Duke University Medical Center, Durham

This session can bring all pediatricians up-to-date on the astounding information explosion in this area and point out how correction may be possible for most of these diseases for which the molecular basis is known. It will also emphasize the key role pediatricians have in identifying these patients prior to the development of serious infections.

X-linked Severe Combined Immunodeficiency
Jennifer M. Puck, National Human Genome Research Institute/NIH, Bethesda

Wiskott-Aldrich Syndrome
Hans D. Ochs, University of Washington School of Medicine, Seattle

X-linked Lymphoproliferative Disease
Cox Terhorst, BIDMC/Harvard Medical School, Boston

Supported by the National Institute of Child Health & Human Development

¨Pediatrics in the New Millennium: Compelling Issues in Public Policy - 7th Annual Public Policy Plenary
Chair: Myron Genel, Yale University School of Medicine, New Haven

This is the 7th annual Public Policy Plenary Symposium organized and sponsored by the Public Policy Council, which coordinates public policy activities for the APS, SPR and AMSPDC, in collaboration with the APA Public Affairs Committee. The year 2000 program will look forward to the new millennium and broadly examine the outlook for children’s health in three vital areas: (1) access to health care (2) testing and access of children to drugs and devices and (3) the pipeline for pediatric physician-investigators and the future of academic pediatrics. We have set aside significant time at the conclusion of the speakers’ formal presentations to permit interactive dialogue between members of the panel and the audience.

Children’s Access to Health Care - Removing the Financial Barrier
Joel J. Alpert, Immediate Past President of the American Academy of Pediatrics and Past President of the Ambulatory Pediatric Association, Boston University School of Medicine

Increasing Pediatric Access to Medical Therapies
Jane E. Henney, Commissioner, Food and Drug Administration, Rockville

The Pipeline of Physician-Scientist in Pediatrics
Leon E. Rosenberg, Princeton University; Lasker Trust/Funding First; and Former Dean, Yale University School of Medicine

Supported in part by an educational grant from the Columbus Children's Hospital, Columbus, Ohio

1:00 pm - 4:00 pm - TOPIC SYMPOSIUM

¨Infections in the NICU: State of the Art, 2000
Chair: Richard F. Jacobs, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock

This multidisciplinary session will provide participants with a state-of-the-art update on the epidemiology, microbiology, clinical presentations, diagnostic and management issues related to infections in the NICU. The three lecture-style presentations will include an update of the non-antibiotic treatment issues in the septic newborn. Participants will review an updated evaluation of the current evidence for efficacy on the use of recombinant hematopoietic growth factors, intravenous immune globulin, and granulocyte transfusions in the NICU. The second lecture will focus on the current state of the art related to nosocomial infections in the NICU. The final lecture will focus on fungal infections in the NICU and will provide information on the clinical presentation, diagnostic workup, and treatment in newborns. There will be question and answer opportunities after each lecture with a panel discussion at the end of the workshop. The goal of the session will be to provide the participants with the latest analysis of non-antibiotic or anti-fungal therapy in newborns and an update on nosocomial and fungal infections in the NICU.

The Use of Recombinant Hematopoietic Growth Factors, Intravenous Immune Globulin, and Granulocyte Transfusions in the NICU: Weighing the Evidence of Efficacy.
Robert D. Christensen, University of Florida School of Design, Gainesville

Nosocomial Infections in the NICU: Causes and Cures
Carol J. Baker, Baylor College of Medicine, Houston

Fungal Infection in the Newborn: Suspect It, Detect It, Correct It.
Margaret K. Hostetter, Yale University School of Medicine, New Haven

1:00 pm - 3:00 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Neonatology: Disease-Oriented Research II (Platform)

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨Achieving Good Health For the World’s Children
Chairs: Errol R. Alden, American Academy of Pediatrics, Elk Grove Village, and Jane Schaller, New England Medical Center, Boston

The health of the world’s children is important to the future of the world. This plenary session will explore basic principles of world health for children and suggest ways in which pediatricians all over the world can work together to achieve better and brighter futures for all of our children. The concept of a world community of pediatricians bearing a collective responsibility for the health of children will be explored. Existing standards will be discussed, including training and professional standards of our pediatric profession around the world, concepts of medical ethics which govern our behavior as physicians, and concepts of children’s rights which exist in international law and define world standards for the treatment of children. Adopting a broad definition of child health which includes physical, mental, and social health, the disease burdens of children around the world now and in the 21st century will be presented, along with some concepts of how these burdens might be lessened. Finally, the roles that pediatricians can play in humanitarian response to emergencies and disasters will be presented. Time will be allowed for discussion from members of the audience, who are encouraged to think about these issues in advance and be prepared to add their voices to the discussion.

World Community: Children and Pediatricians, A Collective Responsibility
Robert Haggerty, University of Rochester School of Medicine & Dentistry, Rochester

World Standards: Professional Standards, Medical Ethics, Children’s Rights
Jane G. Schaller, New England Medical Center, Boston

World Health: Disease Burdens for Children Now and in the 21st Century
Jerry Coovadia, University of Natal, South Africa

World Disasters: the Special Needs of Children
Karen Olness, Rainbow Babies and Children’s Hospital, Cleveland

Supported by an educational grant from Johnson & Johnson Pediatrics Institute

5:00 pm - 7:00 pm - POSTER SESSION IV

Tuesday, May 16

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Neonatal Infectious Diseases (Platform)

9:00 am - 12:00 noon - WORKSHOP

TICKETS NECESSARY FOR THIS EVENT. NO FEE IS REQUIRED BUT PRE-ENROLLMENT IS ESSENTIAL TO ATTEND.

WS47 Group A Strep: A Pathogen For Every Millennium
This program will present an overview of the important role that the group A streptococcus has played in children’s health in the past, present, and future. Newly identified diagnostic, treatment, and pathogenesis issues will be highlighted by a group of individuals who have been preeminent in this field.

M. T. Brady, The Ohio State University, Children’s Hospital, Columbus; M. A. Gerber, National Institute of Health, Bethesda; E. L. Kaplan, University of Minnesota Medical School, Department of Pediatrics, Minneapolis; S. T. Shulman, Northwestern University, Children’s Memorial Hospital, Division of Infectious Diseases, Chicago; D. L. Stevens, VA Medical Center, Boise; R. Tanz, Children’s Memorial Hospital, Chicago

10:15 am - 12:15 pm - POSTER SESSION V

12:15 pm - 2:15 pm - HOT TOPIC

¨What’s New in the Red Book?
Chair: Jon S. Abramson, Wake Forest University School of Medicine, Winston-Salem

This session will highlight substantial changes and additions in the diagnosis, treatment and prevention of infectious diseases that have been made in the Year 2000 Red Book. Some of the topics that will be discussed include meningococcal vaccine, ibuprofen and risk of systemic group A strep infection, herpes simplex disseminated and CNS disease, hepatitis A vaccine, lyme disease, mercury in vaccines, polio, rotavirus and pneumococcal disease.

Jon S. Abramson, Wake Forest University School of Medicine, Winston-Salem
Carol J. Baker, Baylor College of Medicine, Houston
Margaret Rennels, University of Maryland School of Medicine, Baltimore
Larry Pickering, Eastern Virginia Medical School, Norfolk

Supported by an educational grant from Merck Vaccine Division

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Last Modified: April 12, 2000