Pediatric Academic Societies and American Academy of Pediatrics Joint Meeting May 12-16, 2000 Hynes Convention Center, Boston

Friday, May 12

9:00 am - 12:00 noon - MINI COURSE

¨The Importance of Breastfeeding for Premature Infants: Management Issues During and After Hospital Discharge (Part I of II)
Chair: Richard J. Schanler, Baylor College of Medicine, Houston

This program for physicians providing care to premature infants is designed to provide a review of the issues surrounding long-term feeding of human milk. Topics to be covered include the neurodevelopmental outcomes of term and preterm breast-fed infants, the adequacy of human milk to advance this development, and the requirements for growth and body composition. The need for fortification and the specifics of fortification of human milk for preterm infants will be reviewed. The stress of lactation on mothers of preterm infants and how to assess this stress will be covered along with ways to initiate and promote successful, long-term breastfeeding by mothers of premature infants.

How Well Does Breast Milk Meet the Requirements of Premature Infants?
Ekhard Ziegler, University of Iowa, Iowa City

Breastfeeding and Brain Development
Richard J. Schanler, Baylor College of Medicine, Houston

Stress and Lactation: Implications for the Mother of the Premature Infant
Chantal Lau, Baylor College of Medicine, Houston

(Part II of this is program is scheduled on Friday, May 12, from 1:00 PM - 4:00 PM)

9:00 am - 12:00 noon - SPECIAL INTEREST GROUPS

TICKETS NECESSARY FOR THIS EVENT. NO FEE IS REQUIRED BUT PRE-ENROLLMENT IS ESSENTIAL TO ATTEND.

SG05 Pain in Children
Chair: Neil Schechter

This new SIG will focus on the management of pain in children, a common symptom which has only recently begun to receive attention.  Future programs will address not only new research in this area but also the translation of research into clinical practice by addressing the barriers that impede implementation. The ultimate goal is to create pediatric environments (NICU, PICU, inpatient units, ambulatory services, ED) that consider the treatment of pain and discomfort as important aspects of humane clinical care.

1:00 pm - 4:00 pm - MINI COURSES

¨The Importance of Breastfeeding for Premature Infants: Management Issues During and After Hospital Discharge (Part II of II)
Chairs: Frank R. Greer, University of Wisconsin, Madison and Richard J. Schanler, Baylor College of Medicine, Houston

This program for physicians providing care to premature infants is designed to provide a review of the issues surrounding long-term feeding of human milk. Topics to be covered include the neurodevelopmental outcomes of term and preterm breast-fed infants, the adequacy of human milk to advance this development, and the requirements for growth and body composition. The need for fortification and the specifics of fortification of human milk for preterm infants will be reviewed. The stress of lactation on mothers of preterm infants and how to assess this stress will be covered along with ways to initiate and promote successful, long-term breastfeeding by mothers of premature infants.

Does Human Milk Support Growth and Body Composition After Discharge?
Stephanie Atkinson, McMaster University, Hamilton, Ontario, Canada

The Mechanics: How to Get the Premie to the Breast and Techniques to Use at Home
Paula Meier, Rush Children’s Hospital, Chicago

Nutritional Options for the Breastfed Premature Infant After Hospital Discharge
Richard A. Ehrenkranz, Yale University School of Medicine, New Haven

(Part I of this is program is scheduled on Friday, May 12, from 9:00 AM - 12:00 Noon)

¨Ventilators and Ventilator Techniques in Newborn Infants with Acute and Chronic Lung Disease: What to Use, When, How, and What to Expect for Results
Chair: Ann R. Stark, Harvard Medical School, Children’s Hospital, Boston

This three-hour mini-course will include the basic science foundations and clinical applications related to three important aspects of neonatal ventilation. These include (1) initial management of high-risk premature infants including initial lung inflation, resuscitation, and surfactant administration, (2) ventilatory strategies to prevent chronic lung disease, and (3) ventilatory strategies for term infants with severe respiratory failure.

Initial Management of High-Risk Premature Infants, Including Resuscitation and Surfactant Administration
Alan H. Jobe, Children’s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati

Ventilatory Strategies to Prevent Chronic Lung Disease
Waldemar A. Carlo, University of Alabama at Birmingham, Birmingham

Ventilatory Strategies for Term Infants with Severe Respiratory Failure
John P. Kinsella, University of Colorado School of Medicine and the Children’s Hospital, Denver

4:15 pm - 6:15 pm - POSTER SESSION I AND OPENING RECEPTION

6:30 pm - 8:00 pm - PERINATAL NUTRITION AND METABOLISM CLUB
Sheraton Boston Hotel and Towers

Zinc Requirements for Babies and Infants
Nancy Krebs, University of Colorado School of Medicine, Denver

Topic to be determined
Michael Georgieff, University of Minnesota School of Medicine, Minneapolis

For Further Information Contact:
Rebecca Simmons, M.D.
Children’s Hospital, Philadelphia, Abramson Research Center
Room 416, 34th & Civic Center Blvd.
Philadelphia, PA 19104-4318
Phone: (215)590-2895 Fax: (215)590-4267
E-mail: rsimmons@mail.med.upenn.edu

Saturday, May 13

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Brain Development - Mechanisms (Poster Symposia)
• Fetal and Neonatal Nutrition and Metabolism I (Poster Symposia)
• Infectious Diseases I: Viral Diseases (Platform)
• Neonatal - Patient Oriented Research I (Platform)
• Newborn: Health Services Research (Platform)
• Pulmonary Inflammation (Poster Symposia)

10:15 am - 12:15 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Cytokines and Signaling Molecules I (Platform)
• Developmental Aspects of Pulmonary Growth and Vascular Reactions (Platform)
• Neonatal Follow-up (Platform)

10:15 am - 12:15 pm - MILK CLUB

The role of breast milk cytokines, PAF, and PAF-AH in the pathogenesis of NEC
Mickey Caplan

Should breastfed babies be measured on the same growth charts as formula fed infants?
Cutberto Garza

Case presentations of breast feeding problems
Wendy Slusser

Contact for information:
Tom Cleary, M.D.
Department of Pediatrics, University of Texas Medical School
JFB 1.739, 6431 Fannin, Houston, TX 77030
Phone: (713) 500-5714 Fax: (713)500-5688
E-Mail: tcleary@ped1.med.uth.tmc.edu

12:15 pm - 1:15 pm - KERNICTERUS SYMPOSIUM
Hynes Convention Center

Moderators:
Audrey K. Brown, M.D., William J. Cashore, M.D., and David K. Stevenson, M.D.

Genetic Polymorphisims in the Control of Bilirubin Conjugation
Michael Kaplan, M.D.
Ernest Beutler, M.D.

Issues in Non-Invasive Bilirubin Monitoring
Vinod Bhutani, M.D.

Why Should We Abandon the Term "Physiologic Jaundice?
M. Jeffrey Maisels, M.B, BCh.

For further information contact:
David K. Stevenson, M.D.
Neonatal & Developmental Medicine
Stanford University School of Medicine
750 Welch Road, Suite 315, Palo Alto, CA 94305
Phone: (415)723-5711 Fax: (415)725-8351
E-Mail: dstevenson@stanford.edu

1:30 pm - 2:30 pm - APS PRESIDENTIAL PLENARY - HOWLAND AWARD
Presidential Address - Rebecca H. Buckley, Duke University School of Medicine
John Howland Award Presentation - Samuel A. Katz

2:30 pm - 3:00 pm - JOSEPH W. ST. GEME, JR. LEADERSHIP AWARD
Joseph W. St. Geme, Jr. Award Presentation - Evan Charney, Dept. of Pediatrics, University of Massachusetts Medical Center, Shrewsbury
St. Geme Awardee Introduced by: Kenneth B. Roberts, Professor of Pediatrics, University of North Carolina School of Medicine, Greensboro

Presented on behalf of the American Pediatric Society, American Academy of Pediatrics, American Board of Pediatrics, Ambulatory Pediatric Association, Association of Pediatric Program Directors, Association of Medical School Pediatric Department Chairman and Society for Pediatric Research

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨The Developing Brain and Human Disease
Chair: Joseph J. Volpe, Children’s Hospital, Harvard Medical School, Boston

The three outstanding speakers in this session will explore the exciting boundary between advances in developmental genetics of the brain and clinical medicine. An understanding of the developmental determinants of neuronal fate has led to a new molecular understanding of several inherited diseases of the human brain involving abnormalities in brain patterning and neuronal organization and migration. Exciting recent findings have challenged the depressing notion that regeneration and/or replacement of developmentally deficient or damaged brain is impossible. The convergence of information on neuronal fate and neural stem cells raises the very real possibility of exciting new cell-based therapies for a range of congenital and acquired diseases of the human brain.

Genetic Control of Neuronal Fate in the Developing Brain
Robert F. Hevner, Langley Porter Psychiatric Institute, University of California, San Francisco

Genetic Basis of Abnormal Neuronal Migration in the Human Brain
Christopher Walsh, Harvard Medical School, Boston

Neural Stem Cells and Therapy of Disorders of the Developing Nervous System
Evan Y. Snyder, Harvard Medical School, Children’s Hospital, Boston

Supported by an educational grant from the March of Dimes Birth Defects Foundation

¨Hormones, Nutrient Substrates, and Metabolism: Critical Changes at Birth
Chair: Ora Pescovitz, Riley Hospital for Children, Indianapolis

Many essential metabolic changes take place following birth, stimulated by developmental processes, hormones, and by the rapidly changing diet as the infant starts consuming milk. Insulin secretion, for example increases, especially in response to meal associated nutrients. Persistent hyperinsulinemia, however, leads to recurrent and severe hypoglycemia. Advances in pancreatic b-cell biology have helped sort out how persistent hyperinsulinemia occurs, with the potential for new, more specific therapy. The influx of lipids from milk requires increased capacity for lipid metabolism, particularly oxidation. This, however, requires the development of enzymes and transport proteins to move the fatty acids into the mitochondria. Failure of these processes leads to organ failure, most notably in the heart. Many important amino acids also take on new roles. Glutamine, for example, shifts from producing glutamate in the fetus for placental metabolism, becoming an important substrate for gluconeogenesis and a regulator of gut and muscle development. Each of these topics will be discussed by experts in neonatal metabolism.

Neonatal Insulin Secretion and Persistent Hyperinsulinemia of Infancy
Pamela Thomas, University of Michigan, Ann Arbor

From Glucose to Fat: The Neonatal Metabolic Transition
Arnold Strauss, Washington University and St. Louis Children's Hospital, St. Louis

Glutamine: Role in the Fetus and Low Birthweight Infant
Josef Neu, University of Florida, Gainesville

Sponsored Jointly with the Lawson Wilkins Pediatric Endocrine Society

¨Pathogenesis of Viral Respiratory Infections
Chair: Mark R. Denison, Vanderbilt University Medical Center, Nashville

Viruses interact intimately with the host cell environment from the time of initial contact through assembly and release of new infectious virus particles. During infection viruses use preexisting host cell components, modify the intracellular environment, and use mechanisms to avoid host cell immunity in order facilitate their replication and survive to be transmitted to new hosts. The symposium will explore specific aspects of the pathogenesis of four respiratory viral pathogens; the coronaviruses, parainfluenza viruses, influenza virus, and respiratory syncytial virus. The symposium speakers will describe unique features of the replication, cell biology or immune response of each virus and how understanding of molecular mechanisms of pathogenesis provides critical information in efforts to prevent or treat viral respiratory infections.

Cellular Pathogenesis of Coronavirus Infections
Mark R. Denison, Vanderbilt University Medical Center, Nashville

Receptor Mediated Entry of Paramyxoviruses
Anne Moscona, Mount Sinai School of Medicine, New York

Molecular Determinants of Influenza Virus Virulence
Kanta Subbarao, Centers for Disease Control, Atlanta

Neonatal Immune Response to Respiratory Syncytial Virus
James E. Crowe, Jr., Vanderbilt University School of Medicine, Nashville

Supported by an educational grant from ICN Pharmaceuticals

5 pm - 7:15 pm - POSTER SESSION II

Sunday, May 14

8:00 am - 10:00 am - TOPIC SYMPOSIUM

¨Advances in Imaging: Following Cells and Molecules
Chair: Christopher H. Contag, Stanford University School of Medicine, Stanford

Recent advances in imaging technologies have enabled in vivo molecular and cellular analyses at near micron resolution. These advances permit the evaluation of biological events in the context of intact living systems such that the interactive processes of normal physiology and pathophysiologic conditions can be revealed at the level of cells and molecules. This symposium will highlight new imaging strategies and demonstrate how these approaches can be used to answer questions that were previously inaccessible to biological investigation.

Imaging the Wiring and Re-wiring of the Developing Brain
Scott Fraser, California Institute of Technology, Pasadena

Imaging Gene Expression Patterns
Christopher H. Contag, Stanford University School of Medicine, Stanford

New Developments in Functional and Molecular Imaging
Ralph Weissleder, Massachusetts General Hospital, Boston

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Gastroenterology (Platform)
• Neonatology: Disease-Oriented Research I (Platform)
• Neonatal Pulmonology I (Platform)
• Sudden Infant Death Syndrome (Poster Symposia)

10:15 am - 12:00 noon - SPR PRESIDENTIAL PLENARY & AWARDS AND E. MEAD JOHNSON AWARD LECTURES

Presidential Address: Thomas Hazinski,Vanderbilt University Medical Center

Student Awards: Kyle Cowan, Aaron M. Milstone, Christine Siambani

House Officer Awards: Douglas D. Fraser, Paul J. Galardy, Matthew A. Saxonhouse

Fellow Basic Awards: Christopher E. Belcher, Elif Erkan, Syed Zaidi

Fellow Clinical Awards: Michael J. Ackerman, Okan Elidemir, Mika Ramet

David Nathan Award: Lisa Wang

Young Investigator Award Lecture:
Brendan Lee - Identification of Molecular Genetic Defect for Cleidocranial Dysplasia & Nail-patella Syndrome

E. Mead Johnson Award Lectures:
Mark Kay - Seminal Scientific Contributions to the Field of Hepatic Gene Therapy
Gregg Semenza - Molecular Response to Hypoxia

1:00 pm - 2:15 pm - MARCH OF DIMES PRIZE IN DEVELOPMENTAL BIOLOGY (Fifth Annual Lecture)
Presented by the March of Dimes

Genetic Control of Programmed Cell Death in C.elegans
H. Robert Horvitz, Professor of Biology, Howard Hughes Medical Institute Investigator, Massachusetts Institute of Technology, Cambridge, MA

1:15 pm - 2:00 pm - AAP PRESIDENTIAL PLENARY & JACOBI AWARD
Presidential Address: Donald E. Cook, American Academy of Pediatrics, Elk Grove Village
Jacobi Award: Catherine DeAngelis

2:30 pm - 4:30 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Gene Regulation I (Platform)
• Neonatal Epidemiology (Platform)
• Neonatal Immunology and Hematology I (Platform)
• Neonatal Patient Oriented Research II (Platform)
• Oxidants/Antioxidants: Brain, Lung and Basic Mechanisms (Poster Symposia)

4:45 pm - 6:45 pm - POSTER SESSION III

7:00 pm - 9:00 pm - BLOOD CLUB
Sheraton Boston Hotel and Towers

TOPICS
Anemia of Prematurity
Newborn Platelet Formation
MDR Gene in Down Syndrome
Control of MYC Gene

Speakers Not Known At This Time

Contact for information:
Pedro A. de Alarcon, M.D.
University of Virginia Hospital
Pediatrics, Box, 386, Hematology/Oncology Charlottesville, VA 22908
Phone: (804)982-1930 Fax: (804)982-1927
E-Mail: pad8w@virginia.edu

6:45 pm - 8:00 pm - LUNG CLUB
Sheraton Boston Hotel and Towers

Topic to be determined

Speaker:
Phillip Ballard, Children’s Hospital of Philadelphia

Contact for information:
Thomas A. Hazinski, M.D.
Vanderbilt University Medical Center
21st & Garland Aves., S-0119 Medical Ctr. North
Nashville, TN 37232-2586
Phone: (615)343-7617 Fax: (615)343-7727
E-Mail: tom.hazinski@mcmail.vanderbilt.edu

7:00 pm - 10:00 pm - SOCIETY FOR DEVELOPMENTAL PEDIATRICS
Sheraton Boston Hotel

7:00 PM - 7:30 PM
Arnold J. Capute Award
Presented by the
AAP Section on Children with Disabilities

7:30 PM - 8:20 PM
Mechanisms of White Matter Injury in Prematures: Implications for Prevention of Disability
Alan Leviton
Harvard Medical School, Children’s Hospital, Boston, MA

8:20 PM - 9:10 PM
Permanent Hearing Loss in Neonates: Detection, Genetics and Intervention
Betty R. Vohr
Brown University School of Medicine, Providence, RI

9:10 PM - 10:00 PM
Business Meeting

For Further Information on the SDP Contact:
Frederick B. Palmer, MD
Director, Boling Center for Developmental Disabilities
University of Tennessee, Memphis
711 Jefferson Avenue, Memphis, TN 38105
Phone: (901)448-6512 Fax: (901) 448-7097
E-mail: fpalmer@utmem1.utmem.edu

Monday, May 15

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Clinical Bioethics (Platform)
• Clinical Research in Emerging Countries (Poster Symposia)
• Control of Breathing (Poster Symposia)
• Cytokines and Signaling Molecules II (Platform)
• Neonatal Nutrition and Metabolism II (Poster Symposia)
• Neonatal Pulmonology: Control of Pulmonary Vascular Tone (Platform)
• Neurodevelopmental Disabilities I (Poster Symposia)
• Neurology - Basic Science (Poster Symposia)

8:00 am - 10:00 am - RICHARD E. ROWE AWARD
Richard E. Rowe Award Presentation - Mark W. Russell:
In vivo Transactivation of the alphaB Crystallin Promoter by Cardiac Transcription Factors Involved in Early Heart Development

8:30 am - 12:30 pm - APA PRESIDENTIAL PLENARY & ARMSTRONG LECTURE
Presidential Address: Ellen F. Crain, Albert Einstein College of Medicine, Bronx
Armstrong Lecture: Greenpeace

10:15 am - 11:45 am - STATE OF THE ART PLENARY

¨Gene Defects and Kids’ Heart Disease
Chair: Arnold W. Strauss, Washington University and St. Louis Children's Hospital, St. Louis

Until 10 years ago, etiologies and pathogenesis of heart disease in children were poorly understood. This symposium focuses on recent discoveries of gene defects in children with congenital heart disease, abnormalities of situs determination, arrhythmias, and cardiomyopathy. The causes of many forms of pediatric heart disease as single gene defects at multiple loci will be discussed.

Genetic Causes of Congenital Heart Disease
Christine Seidman, Howard Hughes Medical Institute/Brigham and Women's Hospital, Boston

Genes and Left-Right Asymmetry
Martina Brueckner, Yale School of Medicine, New Haven

Genes Causing Pediatric Arrhythmias
Jeffrey A. Towbin, Baylor College of Medicine, Texas Children's Hospital, Houston

11:45 am - 12:45 pm - PERINATAL BRAIN CLUB
Hynes Convention Center

Cognitive Injury in the Premature Infant

Speakers
Joseph J Volpe, Childrens Hospital Boston
Maureen Hack, Rainbow Babies and Childrens Hospital. Cleveland

For Further Information Contact:
Jeff Perlman, M.D.
Department of Pediatrics
University of Texas Southwestern Medical Center
5323 Harry Hines Blvd., Dallas, TX 75235-9063
Phone: (214)648-2060 Fax: (214)648-2481
E-mail: jperlm@mednet.swmed.edu

1:00 pm - 3:00 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Developmental Biology I (Platform)
• Hypoxic/Ischemic Encephalopathy and Protective Mechanisms (Platform)
• Neonatology: Disease-Oriented Research II (Platform)
• Neonatal Immunology and Hematology II (Poster Symposia)
• Neurodevelopmental Disabilities II (Platform)
• Pulmonary Vascular Biology (Platform)

1:00 pm - 4:00 pm - TOPIC SYMPOSIUM

¨Infections in the NICU: State of the Art, 2000
Chair: Richard F. Jacobs, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock

This multidisciplinary session will provide participants with a state-of-the-art update on the epidemiology, microbiology, clinical presentations, diagnostic and management issues related to infections in the NICU. The three lecture-style presentations will include an update of the non-antibiotic treatment issues in the septic newborn. Participants will review an updated evaluation of the current evidence for efficacy on the use of recombinant hematopoietic growth factors, intravenous immune globulin, and granulocyte transfusions in the NICU. The second lecture will focus on the current state of the art related to nosocomial infections in the NICU. The final lecture will focus on fungal infections in the NICU and will provide information on the clinical presentation, diagnostic workup, and treatment in newborns. There will be question and answer opportunities after each lecture with a panel discussion at the end of the workshop. The goal of the session will be to provide the participants with the latest analysis of non-antibiotic or anti-fungal therapy in newborns and an update on nosocomial and fungal infections in the NICU.

The Use of Recombinant Hematopoietic Growth Factors, Intravenous Immune Globulin, and Granulocyte Transfusions in the NICU: Weighing the Evidence of Efficacy.
Robert D. Christensen, University of Florida School of Design, Gainesville

Nosocomial Infections in the NICU: Causes and Cures
Carol J. Baker, Baylor College of Medicine, Houston

Fungal Infection in the Newborn: Suspect It, Detect It, Correct It.
Margaret K. Hostetter, Yale University School of Medicine, New Haven

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨The Biologic, Sociologic and Psychologic Impact of Stress in Childhood
Chair: Jack P. Shonkoff, The Heller Graduate School, Brandeis University, Waltham

The impact of stress on the physical and mental health of adults has been extensively studied. Recent research has begun to examine its impact on children at all levels of their development. This state-of-the-art symposium examines current research and concepts on the impact of stress on the developing brain, on bio-behavioral responses in children, and in children in difficult social environments. Leading researchers in each of these areas will present aspects of their research that relates to cutting edge concepts in their field.

Molecules and Mechanisms of the Neuroendocrine Response to Stress During Early Postnatal Life: New Insights
Tallie Z. Baram, University of California at Irvine

Psychobiologic Reactivity to Stress: Implications for Pediatric Morbidities
W. Thomas Boyce, School of Public Health & Institute of Human Development, University of California, Berkeley

The Effects of Early Social Deprivation on Children
Felton Earls, Harvard School of Public Health, Cambridge

5:00 pm - 7:00 pm - POSTER SESSION IV

Tuesday, May 16

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Breastfeeding (Platform)
• Cardiology: Cardiac Electrophysiology from Mouse to Man (Platform)
• Developmental Biology II (Poster Symposia)
• Neonatal Clinical Trials (Platform)
• Neonatal Infectious Diseases (Platform)

9:00 am - 12:00 noon - WORKSHOP

TICKETS NECESSARY FOR THIS EVENT. NO FEE IS REQUIRED BUT PRE-ENROLLMENT IS ESSENTIAL TO ATTEND.

WS50 Newborn Screening: Controversies And Changes
Universal screening of newborn infants for treatable genetic and metabolic disorders is a cost effective program which has reduced pediatric morbidity and mortality substantially. This panel discussion will review the accomplishments of newborn screening. The issues of informed consent, privatization, and new technologies will be reviewed. Extension of newborn screening to disorders such as cystic fibrosis will be discussed.

This program will prepare the pediatrician to understand the change in newborn screening programs which will occur in the coming decade. As new disorders are added and technologies change, the pediatrician will be prepared to interpret results, participate as a member of the treatment team, and contribute to public debate of ethical issues.

E. McCabe, UCLA School of Medicine; Los Angeles; B. Therrell, University of Texas Health Sciences Center at San Antonio, San Antonio

10:15 am - 12:15 pm - POSTER SESSION V

12:15 pm - 2:15 pm - HOT TOPIC

¨Neonatal Controversies
Chairs: William Keenan, St. Louis University, St. Louis and William Hay, University of Colorado School of Medicine, Denver

This session will review the biology and clinical experience related to corticosteroids and the lung, and considerable time will be available for audience discussion with the speakers and a panel. The goals of the program are to review: a) the rationale, physiologic basis and possible molecular mechanisms for corticosteroid use in lung maturation and prevention of CLD, b) doses of corticosteroids, plasma levels achieved, and effects on the adrenal, c) short and long term benefits of corticosteroid and observed adverse effects, and d) recommendations for corticosteroid use and possible future studies.

Glucocorticoids for Newborn Lung Disease - Rationale for Treatment and Mechanisms
Philip L. Ballard, University of Pennsylvania, Children’s Hospital of Philadelphia
Roberta A. Ballard, Children’s Hospital of Philadelphia

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Last Modified: April 06, 2000