Pediatric Academic Societies and American Academy of Pediatrics Joint Meeting May 12-16, 2000 Hynes Convention Center, Boston

Friday, May 12

9:00 am - 12:00 noon - MINI COURSES

¨The Importance of Breastfeeding for Premature Infants: Management Issues During and After Hospital Discharge (Part I of II)
Chair: Richard J. Schanler, Baylor College of Medicine, Houston

This program for physicians providing care to premature infants is designed to provide a review of the issues surrounding long-term feeding of human milk. Topics to be covered include the neurodevelopmental outcomes of term and preterm breast-fed infants, the adequacy of human milk to advance this development, and the requirements for growth and body composition. The need for fortification and the specifics of fortification of human milk for preterm infants will be reviewed. The stress of lactation on mothers of preterm infants and how to assess this stress will be covered along with ways to initiate and promote successful, long-term breastfeeding by mothers of premature infants.

How Well Does Breast Milk Meet the Requirements of Premature Infants?
Ekhard Ziegler, University of Iowa, Iowa City

Breastfeeding and Brain Development
Richard J. Schanler, Baylor College of Medicine, Houston

Stress and Lactation: Implications for the Mother of the Premature Infant
Chantal Lau, Baylor College of Medicine, Houston

(Part II of this is program is scheduled on Friday, May 12, from 1:00 PM - 4:00 PM)

4:15 pm - 6:15 pm - POSTER SESSION I AND OPENING RECEPTION

Saturday, May 13

8:00 am - 10:00 am - TOPIC SYMPOSIA

¨Computers in Medicine: From the Health Center to the Home to the Genome
Chair: Gary Fleisher, Children’s Hospital, Harvard Medical School, Boston

From molecular biology to clinical care, computers will play a decisive role in pediatrics in the next millennium. This symposium will address the technological solutions for the storage and dissemination of medical information. The translation of basic scientific discoveries into clinical practice and issues related to social concerns, access, privacy, and security will be discussed.

Information Infrastructure for the Next Generation Medicine
Isaac S. Kohane, Harvard Medical School, Boston

Health Applications on the Web: Access, Privacy, and Safety
Kenneth D. Mandl, Children's Hospital, Boston

Bioinformatics in Support of Molecular Medicine
Russ B. Altman, Stanford University, Stanford

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Brain Development - Mechanisms (Poster Symposia)

10:15 am - 12:15 pm - TOPIC SYMPOSIUM

¨Ion Channels and Disease
Chair: Lisa M. Guay-Woodford, University of Alabama at Birmingham

The highly regulated transport of sodium, potassium, and chloride ions is essential in the proper functioning of a diverse array of organ systems. Single gene defects which disrupt these transport processes underlie a variety of renal, cardiac, and neuromuscular disorders. This symposium will discuss how recent elucidation of these genetic defects provide insights into the molecular pathogenesis of these disorders and suggest roles for these transport pathways in more complex disorders such as hypertension, kidney stone formation, acquired cardiac arrhythmias and seizure disorders.

Sodium Channels: Function and Dysfunction
Alfred L. George, Vanderbilt University Medical Center, Nashville

Chloride Channels - The Role of Mutations in Renal and Neuromuscular Disorders
Rajesh Thakker, Nuffield Department of Med., University of Oxford , Oxford, United Kingdom

Potassium Channels: Structural Basis for Function and Disease
Stephen A.N. Goldstein, Yale University School of Medicine, New Haven

Sponsored Jointly with the American Society of Pediatric Nephrology

10:15 am - 12:15 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Behavioral Pediatrics II (Platform)
• Clinical Neurology Update (Platform)

1:30 pm - 2:30 pm - APS PRESIDENTIAL PLENARY - HOWLAND AWARD
Presidential Address - Rebecca H. Buckley, Duke University School of Medicine
John Howland Award Presentation - Samuel A. Katz

2:30 pm - 3:00 pm - JOSEPH W. ST. GEME, JR. LEADERSHIP AWARD
Joseph W. St. Geme, Jr. Award Presentation - Evan Charney, Dept. of Pediatrics, University of Massachusetts Medical Center, Shrewsbury
St. Geme Awardee Introduced by: Kenneth B. Roberts, Professor of Pediatrics, University of North Carolina School of Medicine, Greensboro

Presented on behalf of the American Pediatric Society, American Academy of Pediatrics, American Board of Pediatrics, Ambulatory Pediatric Association, Association of Pediatric Program Directors, Association of Medical School Pediatric Department Chairman and Society for Pediatric Research

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨The Developing Brain and Human Disease
Chair: Joseph J. Volpe, Children’s Hospital, Harvard Medical School, Boston

The three outstanding speakers in this session will explore the exciting boundary between advances in developmental genetics of the brain and clinical medicine. An understanding of the developmental determinants of neuronal fate has led to a new molecular understanding of several inherited diseases of the human brain involving abnormalities in brain patterning and neuronal organization and migration. Exciting recent findings have challenged the depressing notion that regeneration and/or replacement of developmentally deficient or damaged brain is impossible. The convergence of information on neuronal fate and neural stem cells raises the very real possibility of exciting new cell-based therapies for a range of congenital and acquired diseases of the human brain.

Genetic Control of Neuronal Fate in the Developing Brain
Robert F. Hevner, Langley Porter Psychiatric Institute, University of California, San Francisco

Genetic Basis of Abnormal Neuronal Migration in the Human Brain
Christopher Walsh, Harvard Medical School, Boston

Neural Stem Cells and Therapy of Disorders of the Developing Nervous System
Evan Y. Snyder, Harvard Medical School, Children’s Hospital, Boston

Supported by an educational grant from the March of Dimes Birth Defects Foundation

5 pm - 7:15 pm - POSTER SESSION II

Sunday, May 14

8:00 am - 10:00 am - TOPIC SYMPOSIA

¨Advances in Imaging: Following Cells and Molecules
Chair: Christopher H. Contag, Stanford University School of Medicine, Stanford

Recent advances in imaging technologies have enabled in vivo molecular and cellular analyses at near micron resolution. These advances permit the evaluation of biological events in the context of intact living systems such that the interactive processes of normal physiology and pathophysiologic conditions can be revealed at the level of cells and molecules. This symposium will highlight new imaging strategies and demonstrate how these approaches can be used to answer questions that were previously inaccessible to biological investigation.

Imaging the Wiring and Re-wiring of the Developing Brain
Scott Fraser, California Institute of Technology, Pasadena

Imaging Gene Expression Patterns
Christopher H. Contag, Stanford University School of Medicine, Stanford

New Developments in Functional and Molecular Imaging
Ralph Weissleder, Massachusetts General Hospital, Boston

¨The Neurobiologic Basis of Behavior and Development
Chair: James M. Perrin, Mass General Hospital for Children, Boston

This session will describe recent work linking developmental aspects of brain function and structures with understanding of child development, developmental disabilities, and child and adolescent behavior. Expanding knowledge in areas of brain development, anatomic structures, and molecular biology of the central nervous system broaden the base for understanding clinical phenomena. New work has helped to characterize environmental and central nervous system influences on child and adolescent behavior. Recent long-term follow-up data from the Infant Health and Development Program inform regarding the predictors of outcomes for children at developmental risk.

Brain Development and Developmental Disabilities
Mark L. Batshaw, Children’s National Medical Center, George Washington University School of Medicine, Washington

Neurobiologic Representations fo the Social World: Developmental Considerations
Felton Earls, Harvard Medical School, Boston

The Infant Health and Development Project: Implications for Neurobiologic Basis of Development
Marie McCormick, Harvard School of Public Health, Boston

10:15 am - 12:00 noon - SPR PRESIDENTIAL PLENARY & AWARDS AND E. MEAD JOHNSON AWARD LECTURES

Presidential Address: Thomas Hazinski,Vanderbilt University Medical Center

Student Awards: Kyle Cowan, Aaron M. Milstone, Christine Siambani

House Officer Awards: Douglas D. Fraser, Paul J. Galardy, Matthew A. Saxonhouse

Fellow Basic Awards: Christopher E. Belcher, Elif Erkan, Syed Zaidi

Fellow Clinical Awards: Michael J. Ackerman, Okan Elidemir, Mika Ramet

David Nathan Award: Lisa Wang

Young Investigator Award Lecture:
Brendan Lee - Identification of Molecular Genetic Defect for Cleidocranial Dysplasia & Nail-patella Syndrome

E. Mead Johnson Award Lectures:
Mark Kay - Seminal Scientific Contributions to the Field of Hepatic Gene Therapy
Gregg Semenza - Molecular Response to Hypoxia

1:00 pm - 2:15 pm - MARCH OF DIMES PRIZE IN DEVELOPMENTAL BIOLOGY (Fifth Annual Lecture)
Presented by the March of Dimes

Genetic Control of Programmed Cell Death in C.elegans
H. Robert Horvitz, Professor of Biology, Howard Hughes Medical Institute Investigator, Massachusetts Institute of Technology, Cambridge, MA

1:15 pm - 2:00 pm - AAP PRESIDENTIAL PLENARY & JACOBI AWARD
Presidential Address: Donald E. Cook, American Academy of Pediatrics, Elk Grove Village
Jacobi Award: Catherine DeAngelis

2:30 pm - 4:30 pm - TOPIC SYMPOSIA

¨Advances and Application of Psychopharmacology in Pediatrics
Chair: Donald E. Greydanus, Michigan State University, Kalamazoo and East Lansing

The field of psychopharmacology has expanded rapidly over the past few decades. Research into psychopharmacologic management of mental disorders in children and adolescents has also expanded over the past decade. This sessions will review current research and its application to the treatment of attention deficit / hyperactivity disorder, depression in youth and juvenile bipolar disorder. The three presenting faculty are actively involved in this exciting research. In addition to a lecture format, questions from the audience will be invited.

Attention Deficit / Hyperactivity Disorder
Jefferson B. Prince, Northshore Children's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston

Juvenile Bipolar Disorder
Joseph Biederman, Harvard Medical School, Boston

Depression in Youth
Thomas J. Spencer, Harvard Medical School, Boston

¨The Biology and Disorders of Sleep
Chairs: David Gozal, Kosair Children’s Research Institute, University of Louisville School of Medicine, Louisville and Jean Paul Praud, University of Sherbrooke, Québec, Canada

This symposium aims to introduce the audience to novel and exciting concepts regarding the ontogeny of chronobiological rhythms, the genes that regulate such rhythms, and the potential implications they may have for development. In addition, the effect of sleep states on upper airway muscle function in the immature mammal will be presented as well as the implications of sleep-disordered breathing for neurocognitive function.

Timekeeping by Genes of the Circadian Clock
Amita Sehgal, Howard Hughes Medical Institute, University of Pennsylvania Medical School, Philadelphia

The Development of Circadian Rhythmicity
Scott A. Rivkees, Yale University School of Medicine, New Haven

Ontogeny of Upper Airway Muscle Function During Sleep
Jean Paul Praud, University of Sherbrooke, Québec, Canada

Neurocognitive Sequelae of Obstructive Sleep Apnea in Children
David Gozal, University of Louisville, Louisville

Supported by an educational grant from Boehringer-Ingelheim/Roxane Laboratories

2:30 pm - 4:30 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Gene Regulation I (Platform)
• Oxidants/Antioxidants: Brain, Lung and Basic Mechanisms (Poster Symposia)

4:45 pm - 6:45 pm - POSTER SESSION III

7:00 pm - 10:00 pm - SOCIETY FOR DEVELOPMENTAL PEDIATRICS
Sheraton Boston Hotel

7:00 PM - 7:30 PM
Arnold J. Capute Award
Presented by the
AAP Section on Children with Disabilities

7:30 PM - 8:20 PM
Mechanisms of White Matter Injury in Prematures: Implications for Prevention of Disability
Alan Leviton
Harvard Medical School, Children’s Hospital, Boston, MA

8:20 PM - 9:10 PM
Permanent Hearing Loss in Neonates: Detection, Genetics and Intervention
Betty R. Vohr
Brown University School of Medicine, Providence, RI

9:10 PM - 10:00 PM
Business Meeting

For Further Information on the SDP Contact:
Frederick B. Palmer, MD
Director, Boling Center for Developmental Disabilities
University of Tennessee, Memphis
711 Jefferson Avenue, Memphis, TN 38105
Phone: (901)448-6512 Fax: (901) 448-7097
E-mail: fpalmer@utmem1.utmem.edu

Monday, May 15

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Control of Breathing (Poster Symposia)
• Neurodevelopmental Disabilities I (Poster Symposia)
• Neurology - Basic Science (Poster Symposia)
• Sickle Cell and Endothelial Cell Interface (Poster Symposia)

8:00 am - 10:00 am - RICHARD E. ROWE AWARD
Richard E. Rowe Award Presentation - Mark W. Russell:
In vivo Transactivation of the alphaB Crystallin Promoter by Cardiac Transcription Factors Involved in Early Heart Development

8:30 am - 12:30 pm - APA PRESIDENTIAL PLENARY & ARMSTRONG LECTURE
Presidential Address: Ellen F. Crain, Albert Einstein College of Medicine, Bronx
Armstrong Lecture: Greenpeace

10:15 am - 11:45 am - STATE OF THE ART PLENARY

¨Pediatrics in the New Millennium: Compelling Issues in Public Policy - 7th Annual Public Policy Plenary
Chair: Myron Genel, Yale University School of Medicine, New Haven

This is the 7th annual Public Policy Plenary Symposium organized and sponsored by the Public Policy Council, which coordinates public policy activities for the APS, SPR and AMSPDC, in collaboration with the APA Public Affairs Committee. The year 2000 program will look forward to the new millennium and broadly examine the outlook for children’s health in three vital areas: (1) access to health care (2) testing and access of children to drugs and devices and (3) the pipeline for pediatric physician-investigators and the future of academic pediatrics. We have set aside significant time at the conclusion of the speakers’ formal presentations to permit interactive dialogue between members of the panel and the audience.

Children’s Access to Health Care - Removing the Financial Barrier
Joel J. Alpert, Immediate Past President of the American Academy of Pediatrics and Past President of the Ambulatory Pediatric Association, Boston University School of Medicine

Increasing Pediatric Access to Medical Therapies
Jane E. Henney, Commissioner, Food and Drug Administration, Rockville

The Pipeline of Physician-Scientist in Pediatrics
Leon E. Rosenberg, Princeton University; Lasker Trust/Funding First; and Former Dean, Yale University School of Medicine

Supported in part by an educational grant from the Columbus Children's Hospital, Columbus, Ohio

11:45 am - 12:45 pm - PERINATAL BRAIN CLUB
Hynes Convention Center

Cognitive Injury in the Premature Infant

Speakers
Joseph J Volpe, Childrens Hospital Boston
Maureen Hack, Rainbow Babies and Childrens Hospital. Cleveland

For Further Information Contact:
Jeff Perlman, M.D.
Department of Pediatrics
University of Texas Southwestern Medical Center
5323 Harry Hines Blvd., Dallas, TX 75235-9063
Phone: (214)648-2060 Fax: (214)648-2481
E-mail: jperlm@mednet.swmed.edu

1:00 pm - 3:00 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Hypoxic/Ischemic Encephalopathy and Protective Mechanisms (Platform)
• Neonatology: Disease-Oriented Research II (Platform)
• Neurodevelopmental Disabilities II (Platform)

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨Achieving Good Health For the World’s Children
Chairs: Errol R. Alden, American Academy of Pediatrics, Elk Grove Village, and Jane Schaller, New England Medical Center, Boston

The health of the world’s children is important to the future of the world. This plenary session will explore basic principles of world health for children and suggest ways in which pediatricians all over the world can work together to achieve better and brighter futures for all of our children. The concept of a world community of pediatricians bearing a collective responsibility for the health of children will be explored. Existing standards will be discussed, including training and professional standards of our pediatric profession around the world, concepts of medical ethics which govern our behavior as physicians, and concepts of children’s rights which exist in international law and define world standards for the treatment of children. Adopting a broad definition of child health which includes physical, mental, and social health, the disease burdens of children around the world now and in the 21st century will be presented, along with some concepts of how these burdens might be lessened. Finally, the roles that pediatricians can play in humanitarian response to emergencies and disasters will be presented. Time will be allowed for discussion from members of the audience, who are encouraged to think about these issues in advance and be prepared to add their voices to the discussion.

World Community: Children and Pediatricians, A Collective Responsibility
Robert Haggerty, University of Rochester School of Medicine & Dentistry, Rochester

World Standards: Professional Standards, Medical Ethics, Children’s Rights
Jane G. Schaller, New England Medical Center, Boston

World Health: Disease Burdens for Children Now and in the 21st Century
Jerry Coovadia, University of Natal, South Africa

World Disasters: the Special Needs of Children
Karen Olness, Rainbow Babies and Children’s Hospital, Cleveland

Supported by an educational grant from Johnson & Johnson Pediatrics Institute

¨The Biologic, Sociologic and Psychologic Impact of Stress in Childhood
Chair: Jack P. Shonkoff, The Heller Graduate School, Brandeis University, Waltham

The impact of stress on the physical and mental health of adults has been extensively studied. Recent research has begun to examine its impact on children at all levels of their development. This state-of-the-art symposium examines current research and concepts on the impact of stress on the developing brain, on bio-behavioral responses in children, and in children in difficult social environments. Leading researchers in each of these areas will present aspects of their research that relates to cutting edge concepts in their field.

Molecules and Mechanisms of the Neuroendocrine Response to Stress During Early Postnatal Life: New Insights
Tallie Z. Baram, University of California at Irvine

Psychobiologic Reactivity to Stress: Implications for Pediatric Morbidities
W. Thomas Boyce, School of Public Health & Institute of Human Development, University of California, Berkeley

The Effects of Early Social Deprivation on Children
Felton Earls, Harvard School of Public Health, Cambridge

5:00 pm - 7:00 pm - POSTER SESSION IV

Tuesday, May 16

9:00 am - 12:00 noon - WORKSHOPS

TICKETS NECESSARY FOR THIS EVENT. NO FEE IS REQUIRED BUT PRE-ENROLLMENT IS ESSENTIAL TO ATTEND.

WS45 Early Brain Development: From Research To Practice
This workshop will concentrate on neuroscience and developmental research in early brain and child development and the ways in which research advances can be operationalized in the practice setting. Areas to be addressed include an overview of early brain neuroscience, the effects of stress on development; developmental practices, particularly for children with less than optimal developmental possibilities; and the need to be cautious in applying research findings to early brain and child development practices.

This program is supported by an educational grant from the Johnson & Johnson Pediatric Institute.

P. Dworkin, St. Francis Hospital & Medical Center, Department of Pediatrics, Hartford; M. Gunnar, University of Minnesota, Charles Nelson, University of Minnesota; J. Shonkoff, Brandeis University; Waltham

10:15 am - 12:15 pm - POSTER SESSION V

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Last Modified: April 12, 2000