Pediatric Academic Societies and American Academy of Pediatrics Joint Meeting May 12-16, 2000 Hynes Convention Center, Boston

Friday, May 12

9:00 am - 12:00 noon - MINI COURSES

¨Asthma and Food Allergy: Bench to Bedside (Part I of II)
Chair: D. Michael Foulds, University of Texas Health Science Center at San Antonio

Asthma: Bench to Bedside
This session will review the current knowledge on the pathogenesis of asthma and the implications for treatment. Recent developments in pharmacotherapeutic agents will be reviewed. Community-based intervention programs will be discussed.

Asthma: Molecular Immunology Updates
Patricia Finn, Brigham and Women’s Hospital, Harvard Medical School, Boston

Advances in Pharmacotherapy of Asthma in Children
Joshua Boyce, Brigham and Women’s Hospital, Massachusetts General Hospital, Boston

Asthma Intervention Programs: Do They Work?
Pamela Wood, University of Texas Health Science Center at San Antonio, San Antonio

(Part II of this is program is scheduled on Friday, May 12, from 1:00 PM - 4:00 PM)

Supported by an educational grant from Merck & Co.

1:00 pm - 4:00 pm - MINI COURSES

¨Asthma and Food Allergy: Bench to Bedside (Part II of II)
Chair: D. Michael Foulds, University of Texas Health Science Center, San Antonio

GI Immunology and Food Allergies: An Update
This session will focus on current topics and controversies in food allergy in the pediatric population. Topics will include a review of gastrointestinal immunology and the practical evaluation of suspected food allergy. Relevant cases will be presented and discussed.

An Update on the Immunopathophysiologic Basis of Food Allergy
W. Allen Walker, Harvard Medical School, Children’s Hospital, Boston

Gastrointestinal Food Allergic Disorders
Hugh Sampson, Mount Sinai School of Medicine, New York

(Part I of this is program is scheduled on Friday, May 12, from 9:00 AM - 12:00 Noon)

Sponsored by Merck

¨Ventilators and Ventilator Techniques in Newborn Infants with Acute and Chronic Lung Disease: What to Use, When, How, and What to Expect for Results
Chair: Ann R. Stark, Harvard Medical School, Children’s Hospital, Boston

This three-hour mini-course will include the basic science foundations and clinical applications related to three important aspects of neonatal ventilation. These include (1) initial management of high-risk premature infants including initial lung inflation, resuscitation, and surfactant administration, (2) ventilatory strategies to prevent chronic lung disease, and (3) ventilatory strategies for term infants with severe respiratory failure.

Initial Management of High-Risk Premature Infants, Including Resuscitation and Surfactant Administration
Alan H. Jobe, Children’s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati

Ventilatory Strategies to Prevent Chronic Lung Disease
Waldemar A. Carlo, University of Alabama at Birmingham, Birmingham

Ventilatory Strategies for Term Infants with Severe Respiratory Failure
John P. Kinsella, University of Colorado School of Medicine and the Children’s Hospital, Denver

1:00 pm - 4:00 pm - WORKSHOPS

TICKETS NECESSARY FOR THIS EVENT. NO FEE IS REQUIRED BUT PRE-ENROLLMENT IS ESSENTIAL TO ATTEND.

WS11 Diagnostic Dilemmas In Pulmonology
Copies of cases that emphasize common pulmonary signs and symptoms will be distributed at the beginning of the session. You will contribute to the differential and management plan. A final handout will summarize the answers, teaching points, and readings.

H. Dorkin, New England Medical Center, Department of Pediatrics

4:15 pm - 6:15 pm - POSTER SESSION I AND OPENING RECEPTION

Saturday, May 13

8:00 am - 10:00 am - TOPIC SYMPOSIUM

¨Computers in Medicine: From the Health Center to the Home to the Genome
Chair: Gary Fleisher, Children’s Hospital, Harvard Medical School, Boston

From molecular biology to clinical care, computers will play a decisive role in pediatrics in the next millennium. This symposium will address the technological solutions for the storage and dissemination of medical information. The translation of basic scientific discoveries into clinical practice and issues related to social concerns, access, privacy, and security will be discussed.

Information Infrastructure for the Next Generation Medicine
Isaac S. Kohane, Harvard Medical School, Boston

Health Applications on the Web: Access, Privacy, and Safety
Kenneth D. Mandl, Children's Hospital, Boston

Bioinformatics in Support of Molecular Medicine
Russ B. Altman, Stanford University, Stanford

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Pulmonary Inflammation (Poster Symposia)
• The Ethics and Genetics of Inborn Errors of Metabolism (Platform)

10:15 am - 12:15 pm - TOPIC SYMPOSIUM

¨Ion Channels and Disease
Chair: Lisa M. Guay-Woodford, University of Alabama at Birmingham

The highly regulated transport of sodium, potassium, and chloride ions is essential in the proper functioning of a diverse array of organ systems. Single gene defects which disrupt these transport processes underlie a variety of renal, cardiac, and neuromuscular disorders. This symposium will discuss how recent elucidation of these genetic defects provide insights into the molecular pathogenesis of these disorders and suggest roles for these transport pathways in more complex disorders such as hypertension, kidney stone formation, acquired cardiac arrhythmias and seizure disorders.

Sodium Channels: Function and Dysfunction
Alfred L. George, Vanderbilt University Medical Center, Nashville

Chloride Channels - The Role of Mutations in Renal and Neuromuscular Disorders
Rajesh Thakker, Nuffield Department of Med., University of Oxford , Oxford, United Kingdom

Potassium Channels: Structural Basis for Function and Disease
Stephen A.N. Goldstein, Yale University School of Medicine, New Haven

Sponsored Jointly with the American Society of Pediatric Nephrology

10:15 am - 12:15 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Cytokines and Signaling Molecules I (Platform)
• Developmental Aspects of Pulmonary Growth and Vascular Reactions (Platform)

1:30 pm - 2:30 pm - APS PRESIDENTIAL PLENARY - HOWLAND AWARD
Presidential Address - Rebecca H. Buckley, Duke University School of Medicine
John Howland Award Presentation - Samuel A. Katz

2:30 pm - 3:00 pm - JOSEPH W. ST. GEME, JR. LEADERSHIP AWARD
Joseph W. St. Geme, Jr. Award Presentation - Evan Charney, Dept. of Pediatrics, University of Massachusetts Medical Center, Shrewsbury
St. Geme Awardee Introduced by: Kenneth B. Roberts, Professor of Pediatrics, University of North Carolina School of Medicine, Greensboro

Presented on behalf of the American Pediatric Society, American Academy of Pediatrics, American Board of Pediatrics, Ambulatory Pediatric Association, Association of Pediatric Program Directors, Association of Medical School Pediatric Department Chairman and Society for Pediatric Research

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨Pathogenesis of Viral Respiratory Infections
Chair: Mark R. Denison, Vanderbilt University Medical Center, Nashville

Viruses interact intimately with the host cell environment from the time of initial contact through assembly and release of new infectious virus particles. During infection viruses use preexisting host cell components, modify the intracellular environment, and use mechanisms to avoid host cell immunity in order facilitate their replication and survive to be transmitted to new hosts. The symposium will explore specific aspects of the pathogenesis of four respiratory viral pathogens; the coronaviruses, parainfluenza viruses, influenza virus, and respiratory syncytial virus. The symposium speakers will describe unique features of the replication, cell biology or immune response of each virus and how understanding of molecular mechanisms of pathogenesis provides critical information in efforts to prevent or treat viral respiratory infections.

Cellular Pathogenesis of Coronavirus Infections
Mark R. Denison, Vanderbilt University Medical Center, Nashville

Receptor Mediated Entry of Paramyxoviruses
Anne Moscona, Mount Sinai School of Medicine, New York

Molecular Determinants of Influenza Virus Virulence
Kanta Subbarao, Centers for Disease Control, Atlanta

Neonatal Immune Response to Respiratory Syncytial Virus
James E. Crowe, Jr., Vanderbilt University School of Medicine, Nashville

Supported by an educational grant from ICN Pharmaceuticals

5 pm - 7:15 pm - POSTER SESSION II

Sunday, May 14

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Neonatology: Disease-Oriented Research I (Platform)
• Neonatal Pulmonology I (Platform)
• Sudden Infant Death Syndrome (Poster Symposia)

10:15 am - 12:00 noon - SPR PRESIDENTIAL PLENARY & AWARDS AND E. MEAD JOHNSON AWARD LECTURES

Presidential Address: Thomas Hazinski,Vanderbilt University Medical Center

Student Awards: Kyle Cowan, Aaron M. Milstone, Christine Siambani

House Officer Awards: Douglas D. Fraser, Paul J. Galardy, Matthew A. Saxonhouse

Fellow Basic Awards: Christopher E. Belcher, Elif Erkan, Syed Zaidi

Fellow Clinical Awards: Michael J. Ackerman, Okan Elidemir, Mika Ramet

David Nathan Award: Lisa Wang

Young Investigator Award Lecture:
Brendan Lee - Identification of Molecular Genetic Defect for Cleidocranial Dysplasia & Nail-patella Syndrome

E. Mead Johnson Award Lectures:
Mark Kay - Seminal Scientific Contributions to the Field of Hepatic Gene Therapy
Gregg Semenza - Molecular Response to Hypoxia

1:00 pm - 2:15 pm - MARCH OF DIMES PRIZE IN DEVELOPMENTAL BIOLOGY (Fifth Annual Lecture)
Presented by the March of Dimes

Genetic Control of Programmed Cell Death in C.elegans
H. Robert Horvitz, Professor of Biology, Howard Hughes Medical Institute Investigator, Massachusetts Institute of Technology, Cambridge, MA

1:15 pm - 2:00 pm - AAP PRESIDENTIAL PLENARY & JACOBI AWARD
Presidential Address: Donald E. Cook, American Academy of Pediatrics, Elk Grove Village
Jacobi Award: Catherine DeAngelis

2:30 pm - 4:30 pm - TOPIC SYMPOSIUM

¨The Biology and Disorders of Sleep
Chairs: David Gozal, Kosair Children’s Research Institute, University of Louisville School of Medicine, Louisville and Jean Paul Praud, University of Sherbrooke, Québec, Canada

This symposium aims to introduce the audience to novel and exciting concepts regarding the ontogeny of chronobiological rhythms, the genes that regulate such rhythms, and the potential implications they may have for development. In addition, the effect of sleep states on upper airway muscle function in the immature mammal will be presented as well as the implications of sleep-disordered breathing for neurocognitive function.

Timekeeping by Genes of the Circadian Clock
Amita Sehgal, Howard Hughes Medical Institute, University of Pennsylvania Medical School, Philadelphia

The Development of Circadian Rhythmicity
Scott A. Rivkees, Yale University School of Medicine, New Haven

Ontogeny of Upper Airway Muscle Function During Sleep
Jean Paul Praud, University of Sherbrooke, Québec, Canada

Neurocognitive Sequelae of Obstructive Sleep Apnea in Children
David Gozal, University of Louisville, Louisville

Supported by an educational grant from Boehringer-Ingelheim/Roxane Laboratories

2:30 pm - 4:30 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Gene Regulation I (Platform)
• Oxidants/Antioxidants: Brain, Lung and Basic Mechanisms (Poster Symposia)

4:45 pm - 6:45 pm - POSTER SESSION III

6:45 pm - 8:00 pm - LUNG CLUB
Sheraton Boston Hotel and Towers

Topic to be determined

Speaker:
Phillip Ballard, Children’s Hospital of Philadelphia

Contact for information:
Thomas A. Hazinski, M.D.
Vanderbilt University Medical Center
21st & Garland Aves., S-0119 Medical Ctr. North
Nashville, TN 37232-2586
Phone: (615)343-7617 Fax: (615)343-7727
E-Mail: tom.hazinski@mcmail.vanderbilt.edu

Monday, May 15

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Programs)

• Control of Breathing (Poster Symposia)
• Cytokines and Signaling Molecules II (Platform)
• Neonatal Pulmonology: Control of Pulmonary Vascular Tone (Platform)

8:00 am - 10:00 am - RICHARD E. ROWE AWARD
Richard E. Rowe Award Presentation - Mark W. Russell:
In vivo Transactivation of the alphaB Crystallin Promoter by Cardiac Transcription Factors Involved in Early Heart Development

8:30 am - 12:30 pm - APA PRESIDENTIAL PLENARY & ARMSTRONG LECTURE
Presidential Address: Ellen F. Crain, Albert Einstein College of Medicine, Bronx
Armstrong Lecture: Greenpeace

10:15 am - 11:45 am - STATE OF THE ART PLENARY

¨Pediatrics in the New Millennium: Compelling Issues in Public Policy - 7th Annual Public Policy Plenary
Chair: Myron Genel, Yale University School of Medicine, New Haven

This is the 7th annual Public Policy Plenary Symposium organized and sponsored by the Public Policy Council, which coordinates public policy activities for the APS, SPR and AMSPDC, in collaboration with the APA Public Affairs Committee. The year 2000 program will look forward to the new millennium and broadly examine the outlook for children’s health in three vital areas: (1) access to health care (2) testing and access of children to drugs and devices and (3) the pipeline for pediatric physician-investigators and the future of academic pediatrics. We have set aside significant time at the conclusion of the speakers’ formal presentations to permit interactive dialogue between members of the panel and the audience.

Children’s Access to Health Care - Removing the Financial Barrier
Joel J. Alpert, Immediate Past President of the American Academy of Pediatrics and Past President of the Ambulatory Pediatric Association, Boston University School of Medicine

Increasing Pediatric Access to Medical Therapies
Jane E. Henney, Commissioner, Food and Drug Administration, Rockville

The Pipeline of Physician-Scientist in Pediatrics
Leon E. Rosenberg, Princeton University; Lasker Trust/Funding First; and Former Dean, Yale University School of Medicine

Supported in part by an educational grant from the Columbus Children's Hospital, Columbus, Ohio

1:00 pm - 3:00 pm - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Pulmonary Vascular Biology (Platform)

3:15 pm - 4:45 pm - STATE OF THE ART PLENARY

¨Achieving Good Health For the World’s Children
Chairs: Errol R. Alden, American Academy of Pediatrics, Elk Grove Village, and Jane Schaller, New England Medical Center, Boston

The health of the world’s children is important to the future of the world. This plenary session will explore basic principles of world health for children and suggest ways in which pediatricians all over the world can work together to achieve better and brighter futures for all of our children. The concept of a world community of pediatricians bearing a collective responsibility for the health of children will be explored. Existing standards will be discussed, including training and professional standards of our pediatric profession around the world, concepts of medical ethics which govern our behavior as physicians, and concepts of children’s rights which exist in international law and define world standards for the treatment of children. Adopting a broad definition of child health which includes physical, mental, and social health, the disease burdens of children around the world now and in the 21st century will be presented, along with some concepts of how these burdens might be lessened. Finally, the roles that pediatricians can play in humanitarian response to emergencies and disasters will be presented. Time will be allowed for discussion from members of the audience, who are encouraged to think about these issues in advance and be prepared to add their voices to the discussion.

World Community: Children and Pediatricians, A Collective Responsibility
Robert Haggerty, University of Rochester School of Medicine & Dentistry, Rochester

World Standards: Professional Standards, Medical Ethics, Children’s Rights
Jane G. Schaller, New England Medical Center, Boston

World Health: Disease Burdens for Children Now and in the 21st Century
Jerry Coovadia, University of Natal, South Africa

World Disasters: the Special Needs of Children
Karen Olness, Rainbow Babies and Children’s Hospital, Cleveland

Supported by an educational grant from Johnson & Johnson Pediatrics Institute

¨Mechanisms of Asthma and Other Allergic Diseases
Chair: Lanny J. Rosenwasser, University of Colorado Health Science Center and the National Jewish Hospital and Research Center

This session will present the latest information on 1) the role of the mast cell in asthma and other allergic diseases 2) the role of 1L-13 in asthma and 3) the genetics of asthma and other allergic diseases.

Update on Mast Cell Biology and Its Role in Allergic Diseases
Joshua Boyce, Harvard Medical School, Boston

Role of 1L-13 in Asthma
Marsha Wills-Karp, Johns Hopkins University, Baltimore

Genetics of Asthma and Other Allergic Diseases
Lanny Rosenwasser, University of Colorado Health Science Center and the National Jewish Hospital and Research Center

5:00 pm - 7:00 pm - POSTER SESSION IV

Tuesday, May 16

8:00 am - 10:00 am - SUBSPECIALTIES/THEMES (Original Science Abstract Program)

• Childhood Asthma (Platform)

10:15 am - 12:15 pm - POSTER SESSION V

12:15 pm - 2:15 pm - HOT TOPIC

¨Neonatal Controversies
Chairs: William Keenan, St. Louis University, St. Louis and William Hay, University of Colorado School of Medicine, Denver

This session will review the biology and clinical experience related to corticosteroids and the lung, and considerable time will be available for audience discussion with the speakers and a panel. The goals of the program are to review: a) the rationale, physiologic basis and possible molecular mechanisms for corticosteroid use in lung maturation and prevention of CLD, b) doses of corticosteroids, plasma levels achieved, and effects on the adrenal, c) short and long term benefits of corticosteroid and observed adverse effects, and d) recommendations for corticosteroid use and possible future studies.

Glucocorticoids for Newborn Lung Disease - Rationale for Treatment and Mechanisms
Philip L. Ballard, University of Pennsylvania, Children’s Hospital of Philadelphia
Roberta A. Ballard, Children’s Hospital of Philadelphia

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Last Modified: April 12, 2000