Neonatal Pulmonology and Resuscitation: Surfactant Biology and Management of RDS
Target Audience: Neonatologists, Pediatric Pulmonologists, Basic Scientists, Fellows, Junior Faculty, Associate Professors, and Scientists interested in surfactant biology and the clinical management of respiratory distress syndrome in premature infants.
A postgraduate course focusing on what is known about the surfactant system and some new ideas that illustrate there is much we do not know. The course will also include some of the recent advances in surfactant delivery and recommendations. Dr. Susan Guttentag (Vanderbilt) will start with a detailed overview: Surfactant Biology, Lamellar Body, and Surfactant Protein B Fundamentals. Several speakers will discuss some new advances in basic surfactant biology examining novel pathways (Epithelial GPR116, Jim Bridges, (NJH Denver) & Natriuretic Peptide Pathway (Rita Ryan (Case Western Reserve Univ). Updates on Surfactant Protein C, and ABCA3 biology, representing two common abnormalities in lung disease, will be provided by Michael Beers (Penn) and Jennifer Wambach (Wash U), respectively. Dr. Larry Nogee (JHU) will present on what the latest practice for Genetic testing for neonates with atypical RDS: A practical approach. Turning to some clinical data, Dr. Beena Sood (Wayne St Univ) will present her work on Phospholipid changes in clinical gastric aspirates. Short talks on the effects of maternal diabetes on the surfactant system (Hilal Yildiz Atar, Rainbow Babies & Children’s Hospital), Non-invasive Surfactant Delivery – Introducing LISA into your NICU (Allison Osborne (CCF) and SALSA: Surfactant Administration through Laryngeal or Supraglottic Airways (Kari Roberts, UMN) to improve clinical opportunities. Finally, two senior physician-scientists will round out the program by discussing the recent national guidelines for the use of surfactant for RDS ((Vineet Bhandari, Cooper Univ) and Surfactant use in non-RDS patients (Satyan Laskshminrusimha).
- Know the latest information about the surfactant system
- Know when to request genomic testing for neonates with lung disease
- Know the most current national guidelines for using surfactant for RDS
Moderators: Rita Ryan, MD, and Vineet Bhandari, MD, DM
Speakers: Susan H. Guttentag, MD, Rita Ryan, MD, MS, James Bridges, PhD, Michael Francis F. Beers, MD, Jennifer Wambach, MD, MS, Lawrence M. Nogee, MD, Beena G. Sood, MD, MS, Hilal Yildiz Atar, MD, Allison O. Ignatz-Hoover, MD, Kari Roberts, MD, Vineet Bhandari, MD, DM, Satyan Lakshminrusimha, MD FAAP
Surfactant Biology, Lamellar Body and Surfactant Protein B Fundamentals, Susan H. Guttentag, MD
What’s so special about ABCA3? Jennifer Wambach, MD, MS
Epithelial GPR116 regulates pulmonary alveolar homeostasis via Gq/11 signaling, James Bridges, PhD
What’s New in Surfactant Protein C Biology, Michael Francis F. Beers, MD
Role of Natriuretic Peptide C Receptor in surfactant secretion, Rita M. Ryan, MD
Genetic testing for neonates with atypical RDS: A practical approach, Lawrence Nogee, MD
Phospholipid changes in clinical gastric aspirates, Beena G. Sood, MD, MS
The effects of maternal diabetes on the surfactant system and RDS, Hilal Yildiz Atar, MD
Introducing LISA into your NICU, Allison O. Ignatz-Hoover, MD
SALSA: Surfactant Administration through Laryngeal or Supraglottic Airways, Kari Roberts, MD
Results from RDS-NeXT: Now we know what to do! Vineet Bhandari, MD, DM
Surfactant use in non-RDS patients, Satyan Lakshminrusimha, MD FAA
Neonatal Genetics: Genomics in Newborn Care
Neonatologists, Geneticists, Genetic counselors, NICU Fellows, Junior Faculty, Associate Professors, and Scientists interested in developing their understanding and skills to advance their research career in Neonatal Genomics
A postgraduate course focusing on the implementation of genomic care in newborns and the available clinical, translational, and research opportunities. The course will cover the entire spectrum of applications of genomic medicine in newborns. In addition to an overview, we will cover various aspects of genomics including the need for rapid sequencing, cost-effectiveness, the genetic basis of various neonatal conditions, implementation experience in the NICU, and ethical, legal, and social implications and issues of diversity and equity.
- Upon completion, participants will be able to understand how genomic applications can improve the care of newborns, especially in the NICUs.
- Upon completion, participants will be able to determine the role of rapid sequencing in the NICU, the genetic basis of various neonatal conditions, and research opportunities.
- Upon completion, participants will be able to learn about implementation experience, its cost-effectiveness, ethical, legal, and social implications, and issues of diversity and equity in genomic applications.
Moderators: Pankaj b. Agrawal, MD MMSC, and Lawrence Nogee, MD
Speakers: Pankaj b. Agrawal, MD MMSC, Bruce R. Korf, MD, PhD, Tara L. Wenger, MD, PhD, Rita Ryan, MD, Ingrid A. Holm, MD, MPH, Sarah U. Morton, MD PhD, Jennifer Wambach, MD, MS, Louis Muglia, MD, PhD, Monica Wojcik, MD MPH FAAP FACMG, Tamorah Lewis, MD, PhD, Nathaly Sweeney, MD, MPH, MS
An overview of genomic care in newborns, Pankaj b. Agrawal, MD MMSC
Genome Sequencing in the NICU: SouthSeq, Bruce R. Korf, MD, PhD
Implementation of genome sequencing in a Level IV NICU, Tara L. Wenger, MD, PhD
Blessings and pitfalls of genetic testing in Newborns, Rita M. Ryan, MD
Role of genomic sequencing in newborn screening, Ingrid A. Holm, MD, MPH
Genetic basis of congenital cardiac defects, Sarah U. Morton, MD PhD
Genetic basis of neonatal lung conditions and gene therapy approach to congenital surfactant deficiency, Jennifer Wambach, MD, MS
Genetic basis of prematurity, Louis Muglia, MD, PhD
Ethical, social and legal implications in implementing newborn genomic care, Monica H. Wojcik, MD MPH FAAP FACMG
Resolving racial, equity, and diversity issues in genomics, Tamorah R. Lewis, MD, PhD
Rapid genome sequencing and cost-effectiveness, Nathaly Sweeney, MD, MPH, MS presented by Pankaj B. Agrawal
Neonatal Neurology: Better than expected: Neurodevelopment and follow-up of NICU infants for the next half-century
Neurologists, Neonatologists, Developmental Pediatricians, Psychologists, and Trainees
This postgraduate course will discuss our recent advancements in improving neurodevelopmental outcomes in NICU graduates. Speakers will address how neonatal neuroimaging helps us to improve counseling, monitoring, and neurodevelopmental outcomes through the NICU follow-up clinic. Through real-world experiences, we will address the impact of social determinants of health and adversity on neurodevelopmental outcomes, and discuss new models of care to enable NICU follow-up clinics to improve neurodevelopmental outcomes of NICU graduates for the next half-century. Both didactic and interactive methods will be used to optimize learning and discussion between session participants.
- Identify advances to date in monitoring and improving motor and cognitive outcomes in the NICU follow-up clinic.
- Utilize neonatal neuroimaging to better guide improved surveillance, counseling, and intervention for NICU graduates in the NICU follow-up clinic.
- Identify key considerations for improving neurodevelopmental outcomes in the next half-century, including considerations of social determinants of health, adversity, and resilience.
Moderators: Emily Tam, MDCM, MAS, FRCPC, and Nathalie Maitre, MD, PhD
Speakers: Emily Tam, MDCM, MAS, FRCPC, Nathalie Maitre, MD, PhD, Mary Lauren Neel, MD, MSCI, Steven Paul Miller, MDCM MAS FRPC, Mehmet N. Cizmeci, MD, PhD, Elizabeth E. Rogers, MD, Yvette R.Johnson, MD, MPH, Jonathan S. Litt, MD, MPH, ScD
Surveillance and intervention to improve motor outcomes, Nathalie Maitre, MD, PhD
Resilience in outcomes of NICU graduates, Mary Lauren Neel, MD, MSCI
Brain imaging to improve outcomes in newborns with congenital heart disease, Steven Miller, MDCM MAS FRPC
Harnessing neuroimaging to guide our practice: an interactive review, Mehmet Cizmeci, MD, PhD
Improving neonatal follow-up locally through statewide collaboration: lessons from California, Elizabeth Rogers, MD
Addressing social determinants of health and adversity, Yvette Johnson, MD, MPH
New models of care for neonatal follow-up, Jonathan Litt, MD, MPH, ScD
Interactive Panel Discussion
Neonatal Acute Kidney Injury (AKI): From Basic and Clinical Science to Caring for Baby (and their beans) in the crib
The course will cover basic, translational, and clinical science from fetal physiology to post-discharge follow-up for neonatal AKI. The course is designed to deliver an overview of current research advances and clinical practice strategies in neonatal AKI, including the use of kidney support therapies in neonates in a variety of settings (ECMO, multiorgan failure, AKI, etc.) The speakers will aim to help foster ideas for future research, quality improvement projects, and improved care.
- Upon completion, participants will understand neonatal kidney function, the pathophysiology of neonatal AKI, the impact of prematurity, and the long-term implications of neonatal AKI.
- Upon completion, participants will understand the definition of neonatal AKI, the risk factors associated with neonatal AKI, and the epidemiology & impact of neonatal AKI.
- Learners will be exposed to state-of-the-art topics: novel AKI biomarkers, neonatal ECMO &nephrology (AKI, fluid balance, kidney support therapy (KST)), and neonatal KST.
Moderators: Alison Kent BMBS, FRACP, MD, Meredith Schuh, MD, Jeff Segar, MD, and Keia Sanderson, MD
Speakers: Jennifer Charlton, MD, MSc, Matthew Harer, MD, Danielle Soranno, MD, Prasad Devarajan, MD, FAAP, FASN, Jennifer Garcia Jetton, MD, Michelle C. Starr, MD, MPH, David Selewski, MD, MSCR, David Askenazi, MD, MSPH, Cara L. Slagle, MD, Shina Menon, MD
Nephron endowment and its impact on long-term health: prematurity AKI, and the risk for CKD, Jennifer Charlton, MD, MSc
Neonatal Kidney Function: What happens before birth, after birth, and when the kidney gets injured? Matthew Harer, MD
Pathophysiology of Neonatal Acute Kidney Injury: AKI is more than a rise in serum creatinine: it’s a multisystem disease, Danielle Soranno, MD
Can urine biomarkers help us care for neonates? Using translational science to identify biomarkers and therapeutic targets, Prasad Devarajan, MD, FAAP, FASN
AKI definition, incidence, and outcomes, Jennifer Jetton, MD
The impact of fluid balance on outcomes in neonates, Michelle Starr, MD, MPH
Acute kidney injury, kidney support therapy, and fluid balance management for neonates on extracorporeal membrane oxygenation, David Selewski, MD, MSCR
Care of the Newborn with Fluid Overload and AKI, David Askenazi, MD, MSPH
Neonatal Kidney support therapy Part 1: the neonatologist perspective, Cara Slagle, MD
Neonatal Kidney support therapy Part 2: the nephrologist perspective, Shina Menon, MD